ECSP12012318A - Inhibidores de pirazolil quinazolina cinasa - Google Patents

Inhibidores de pirazolil quinazolina cinasa

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Publication number
ECSP12012318A
ECSP12012318A ECSP12012318A ECSP12012318A EC SP12012318 A ECSP12012318 A EC SP12012318A EC SP12012318 A ECSP12012318 A EC SP12012318A EC SP12012318 A ECSP12012318 A EC SP12012318A
Authority
EC
Ecuador
Prior art keywords
pirazolil
quinazolina
cinasa
inhibitors
compounds
Prior art date
Application number
Other languages
English (en)
Inventor
Valerio Berdini
Patrick René Angibaud
Isabelle Noëlle Constance Pilatte
Jean Fernand Armand Lacrampe
Eddy Jean Edgard Freyne
Werner Constant Johan Embrechts
Alexandra Papanikos
David Charles Rees
Christopher Norbert Johnson
Christopher William Murray
Steven John Woodhead
Christopher Hamlett
Johan Erwin Edmond Weerts
Gilbert Besong
Gordon Saxty
Michael Reader
Laurence Anne Mevellec
Tom Cornelis Hortense Govaerts
Timothy Pietro Suren Perera
Ronaldusarnodushendrika Joseph Gilissen
Berthold Wroblowski
Oliver Alexis Georges Querolle
Elisabeth Thérése Jeanne Pasquier
Pascal Ghislain André Bonnet
Rhalid Akkari
Lleven Meerpoel
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of ECSP12012318A publication Critical patent/ECSP12012318A/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Abstract

La presente invención se refiere a nuevos compuestos derivados de quinoxalina, a composiciones farmacéuticas que comprenden los compuestos, a procesos para la preparación de los compuestos y al uso de los compuestos en el tratamiento de enfermedades, por ejemplo, cáncer.
ECSP12012318 2010-04-30 2012-11-29 Inhibidores de pirazolil quinazolina cinasa ECSP12012318A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32988410P 2010-04-30 2010-04-30
GB201007286A GB201007286D0 (en) 2010-04-30 2010-04-30 New compounds

Publications (1)

Publication Number Publication Date
ECSP12012318A true ECSP12012318A (es) 2013-02-28

Family

ID=42289929

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12012318 ECSP12012318A (es) 2010-04-30 2012-11-29 Inhibidores de pirazolil quinazolina cinasa

Country Status (35)

Country Link
US (6) US8895601B2 (es)
EP (3) EP3590934B1 (es)
JP (1) JP5639261B2 (es)
KR (2) KR101933843B1 (es)
CN (2) CN104725362B (es)
AP (1) AP3210A (es)
AR (1) AR080982A1 (es)
AU (2) AU2011247047B2 (es)
BR (1) BR112012027509B1 (es)
CA (1) CA2796204C (es)
CL (1) CL2012003048A1 (es)
CR (2) CR20180339A (es)
CY (2) CY1121882T1 (es)
DK (3) DK2563775T3 (es)
EA (2) EA028599B1 (es)
EC (1) ECSP12012318A (es)
ES (3) ES2621461T3 (es)
GB (1) GB201007286D0 (es)
HR (1) HRP20211675T1 (es)
HU (3) HUE056999T2 (es)
IL (1) IL222600A (es)
IN (1) IN2012MN02591A (es)
JO (1) JO3366B1 (es)
LT (3) LT2563775T (es)
ME (1) ME01825B (es)
MX (2) MX2012012414A (es)
MY (2) MY191669A (es)
NZ (1) NZ602726A (es)
PL (3) PL3178818T3 (es)
PT (3) PT3590934T (es)
RS (3) RS55863B1 (es)
SG (2) SG184966A1 (es)
SI (3) SI3590934T1 (es)
TW (1) TWI545122B (es)
WO (1) WO2011135376A1 (es)

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