DK3219705T3 - Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid - Google Patents

Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid Download PDF

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Publication number
DK3219705T3
DK3219705T3 DK17154944.7T DK17154944T DK3219705T3 DK 3219705 T3 DK3219705 T3 DK 3219705T3 DK 17154944 T DK17154944 T DK 17154944T DK 3219705 T3 DK3219705 T3 DK 3219705T3
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Prior art keywords
oxoquinolin
dimethylethyl
carboxamide
hydroxyphenyl
dihydro
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DK17154944.7T
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English (en)
Inventor
Patricia Hurter
Yuchuan Gong
Christopher R Young
Patrick Connelly
William Rowe
Adriana Costache
Mariusz Krawiec
Yushi Feng
Martin Trudeau
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Vertex Pharma
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Application filed by Vertex Pharma filed Critical Vertex Pharma
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Publication of DK3219705T3 publication Critical patent/DK3219705T3/da

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
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    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
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DK17154944.7T 2005-12-28 2006-12-28 Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid DK3219705T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75438105P 2005-12-28 2005-12-28
EP06848237.1A EP1993360B1 (en) 2005-12-28 2006-12-28 Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

Publications (1)

Publication Number Publication Date
DK3219705T3 true DK3219705T3 (da) 2020-04-14

Family

ID=38228833

Family Applications (2)

Application Number Title Priority Date Filing Date
DK17154944.7T DK3219705T3 (da) 2005-12-28 2006-12-28 Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
DK06848237.1T DK1993360T3 (da) 2005-12-28 2006-12-28 Faste former af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK06848237.1T DK1993360T3 (da) 2005-12-28 2006-12-28 Faste former af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid

Country Status (20)

Country Link
US (9) US20110064811A1 (da)
EP (3) EP3708564A1 (da)
JP (3) JP5409010B2 (da)
CN (1) CN101384172B (da)
AU (1) AU2006332726B2 (da)
BR (1) BRPI0620960A2 (da)
CA (1) CA2635581C (da)
CY (2) CY1118980T1 (da)
DK (2) DK3219705T3 (da)
ES (2) ES2790700T3 (da)
HK (1) HK1125540A1 (da)
HR (2) HRP20170682T1 (da)
HU (2) HUE049976T2 (da)
LT (2) LT1993360T (da)
ME (1) ME03786B (da)
PL (2) PL3219705T3 (da)
PT (2) PT1993360T (da)
RS (2) RS60205B1 (da)
SI (1) SI3219705T1 (da)
WO (1) WO2007079139A2 (da)

Families Citing this family (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) * 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
EP1664006A2 (en) 2003-09-06 2006-06-07 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
RU2006120549A (ru) * 2003-11-14 2007-12-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Тиазолы и оксазолы, применяемые в качестве модуляторов транспортеров арт-связывающей кассеты
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
CA2810655C (en) * 2004-06-24 2013-12-10 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
EP1912983B1 (en) 2005-08-11 2011-06-08 Vertex Pharmaceuticals, Inc. Modulators of cystic fibrosis transmembrane conductance regulator
SI2395002T1 (sl) 2005-11-08 2014-10-30 Vertex Pharmaceuticals Incorporated Farmacevtski sestavek, vsebujoč heterociklični modulator prenašalcev z ATP-vezavno kaseto
CN103214450B (zh) * 2005-12-28 2016-10-05 弗特克斯药品有限公司 作为atp-结合盒转运蛋白调节剂的1-(苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(苯基)环丙烷-甲酰胺衍生物
EP3708564A1 (en) 2005-12-28 2020-09-16 Vertex Pharmaceuticals Incorporated A solid form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
GEP20125378B (en) * 2006-03-20 2012-01-10 Vertex Pharma Pharmaceutical compositions
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
EP2007756B1 (en) 2006-04-07 2015-08-26 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
ES2377840T3 (es) 2006-05-12 2012-04-02 Vertex Pharmaceuticals, Inc. Composiciones de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolina-3-carboxamida
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5497633B2 (ja) 2007-05-09 2014-05-21 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃｆｔｒのモジュレーター
CA2696298C (en) 2007-08-24 2016-09-06 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
EP2222304A2 (en) * 2007-09-14 2010-09-01 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
ES2658064T3 (es) 2007-11-16 2018-03-08 Vertex Pharmaceuticals Incorporated Moduladores de isoquinolina de transportadores de casete de unión a ATP
PL2639223T3 (pl) 2007-12-07 2017-09-29 Vertex Pharmaceuticals Incorporated Sposób wytwarzania kwasów cykloalkilokarboksyamido-pirydyno-benzoesowych
SI2225230T1 (sl) 2007-12-07 2017-03-31 Vertex Pharmaceuticals Incorporated Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline
US20100036130A1 (en) 2007-12-07 2010-02-11 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
EA201070699A1 (ru) * 2007-12-07 2011-02-28 Вертекс Фармасьютикалз Инкорпорейтед Композиции 3-(6-(1-2,2-дифторбензо[d][1,3]диоксол-5-ил)циклопропанкарбоксамидо)-3-метилпиридин-2-ил)бензойной кислоты
CA2931134C (en) 2008-02-28 2019-07-30 Vertex Pharmaceuticals Incorporated Heteroaryl derivatives as cftr modulators
EP2262768A4 (en) * 2008-03-11 2011-03-23 Reddys Lab Ltd Dr PREPARATION OF LENALIDOMIDE
EP2980077B1 (en) 2008-03-31 2020-05-06 Vertex Pharmaceuticals Incorporated Pyridyl derivatives as cftr modulators
JP5381978B2 (ja) * 2008-04-02 2014-01-08 アステラス製薬株式会社 アミド誘導体含有医薬組成物
US20100256184A1 (en) * 2008-08-13 2010-10-07 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
EP2328618B1 (en) * 2008-08-13 2017-11-29 Vertex Pharmaceuticals Incorporated Pharmaceutical composition of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4- oxoquinoline-3-carboxamide and administration thereof
WO2010037066A2 (en) 2008-09-29 2010-04-01 Vertex Pharmaceuticals Incorporated Dosage units of 3-(6-(1-(2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
NZ592504A (en) * 2008-10-23 2013-04-26 Vertex Pharma Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide
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HRP20200708T1 (hr) 2020-07-24
BRPI0620960A2 (pt) 2011-11-29
JP5409010B2 (ja) 2014-02-05
US20110064811A1 (en) 2011-03-17
EP1993360A4 (en) 2010-12-01
PT1993360T (pt) 2017-05-25
WO2007079139A3 (en) 2008-01-17
US9139530B2 (en) 2015-09-22
US20120214841A1 (en) 2012-08-23
US20200352930A1 (en) 2020-11-12
US20230263794A1 (en) 2023-08-24
PL1993360T3 (pl) 2017-08-31
US20130317060A1 (en) 2013-11-28
LT1993360T (lt) 2017-06-12
RS60205B1 (sr) 2020-06-30

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