CY1122342T1 - Ειδικοι ως προς την ακολουθια rna μεσολαβητες της παρεμβολης rna - Google Patents

Ειδικοι ως προς την ακολουθια rna μεσολαβητες της παρεμβολης rna

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Publication number
CY1122342T1
CY1122342T1 CY20191100963T CY191100963T CY1122342T1 CY 1122342 T1 CY1122342 T1 CY 1122342T1 CY 20191100963 T CY20191100963 T CY 20191100963T CY 191100963 T CY191100963 T CY 191100963T CY 1122342 T1 CY1122342 T1 CY 1122342T1
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Cyprus
Prior art keywords
fragments
specific
rna
present
targeting
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CY20191100963T
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English (en)
Inventor
Thomas Tuschl
Phillip A. Sharp
David P. Bartel
Philip D. Zamore
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Whitehead Institute For Biomedical Research
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38068195&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1122342(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Whitehead Institute For Biomedical Research filed Critical Whitehead Institute For Biomedical Research
Publication of CY1122342T1 publication Critical patent/CY1122342T1/el

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Abstract

Η παρούσα εφεύρεση άφορα κάποιο in vitro σύστημα δροσόφιλας (Drosophila) το οποίο χρησιμοποιήθηκε για να αποδειχθεί ότι dsRNA έχει μετατραπεί σε τμήματα RNA μήκους 21-23 νουκλεοτιδίων (nt). Επιπλέον, όταν τα συγκεκριμένα θραύσματα 21-23 nt καθαριστούν και προστεθούν πάλι στα εκχυλίσματα της δροσόφιλας, διαμεσολαβούν στην παρεμβολή RNA απουσία του μακριού dsRNA. Συνεπώς, τα συγκεκριμένα θραύσματα των 21-23 nt είναι ειδικοί ως προς την ακολουθία, μεσολαβητές της αποικοδόμησης RNA. Στα συγκεκριμένα θραύσματα των 21-23 nt πρέπει να υπάρχει κάποιο μοριακό σήμα, το οποίο μπορεί να είναι το συγκεκριμένο μήκος των θραυσμάτων, τα οποία προσελκύουν τους κυτταρικούς παράγοντες που συμμετέχουν στην RNAi. Η παρούσα εφεύρεση περιλαμβάνει τα συγκεκριμένα θραύσματα των 21-23 nt και τη χρήση τους για την ειδική αδρανοποίηση της γονιδιακής λειτουργίας. Η χρήση αυτών των θραυσμάτων (ή χημικώς συντιθέμενων ολιγονουκλεοτιδίων ίδιας ή παρόμοιας φύσης) επιτρέπει τη στόχευση των ειδικών mRNA που προορίζονται για να αποικοδομηθούν σε κύτταρα θηλαστικών, όπου η χρήση μακρών dsRNA για την έκλυση RNAi συνήθως δεν είναι πρακτική, πιθανόν λόγω των επιβλαβών επιδράσεων της απάντησης της ιντερφερόνης. Αυτή η ειδική στόχευση κάποιας συγκεκριμένης γονιδιακής λειτουργίας είναι χρήσιμη σε θεραπευτικές εφαρμογές και τις λειτουργίες του γονιδιώματος.
CY20191100963T 2000-03-30 2019-09-16 Ειδικοι ως προς την ακολουθια rna μεσολαβητες της παρεμβολης rna CY1122342T1 (el)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US19359400P 2000-03-30 2000-03-30
EP00126325 2000-12-01
US26523201P 2001-01-31 2001-01-31
PCT/US2001/010188 WO2001075164A2 (en) 2000-03-30 2001-03-30 Rna sequence-specific mediators of rna interference
EP20100184711 EP2345742B1 (en) 2000-03-30 2001-03-30 RNA sequence-specific mediators of RNA interference
EP20080168152 EP2028278B1 (en) 2000-03-30 2001-03-30 RNA sequence-specific mediators of RNA interference
EP01922870.9A EP1309726B2 (en) 2000-03-30 2001-03-30 Rna sequence-specific mediators of rna interference

Publications (1)

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CY1122342T1 true CY1122342T1 (el) 2021-01-27

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CY101100203T CY1109864T1 (el) 2000-03-30 2010-03-02 Ειδικοι ως προς την ακολουθια rna μεσολαβητες της παρεμβολης rna
CY20191100963T CY1122342T1 (el) 2000-03-30 2019-09-16 Ειδικοι ως προς την ακολουθια rna μεσολαβητες της παρεμβολης rna

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US (19) US20020086356A1 (el)
EP (3) EP2028278B1 (el)
JP (6) JP5500750B2 (el)
KR (3) KR20080023768A (el)
AT (1) ATE450621T2 (el)
AU (4) AU4962201A (el)
BR (1) BR0107536A (el)
CA (1) CA2404890C (el)
CY (2) CY1109864T1 (el)
DE (1) DE60140676D1 (el)
DK (2) DK2796553T3 (el)
ES (2) ES2745378T3 (el)
HK (5) HK1160669A1 (el)
IL (4) IL151928A0 (el)
NZ (2) NZ522045A (el)
PT (2) PT2796553T (el)
WO (1) WO2001075164A2 (el)

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