LT2561078T - Naujos struktūriškai sukonstruotos shrnr - Google Patents

Naujos struktūriškai sukonstruotos shrnr

Info

Publication number
LT2561078T
LT2561078T LTEP11772783.4T LT11772783T LT2561078T LT 2561078 T LT2561078 T LT 2561078T LT 11772783 T LT11772783 T LT 11772783T LT 2561078 T LT2561078 T LT 2561078T
Authority
LT
Lithuania
Prior art keywords
structurally designed
novel structurally
designed shrnas
shrnas
novel
Prior art date
Application number
LTEP11772783.4T
Other languages
English (en)
Inventor
Gregory Hannon
Sihem Cheloufi
Original Assignee
Cold Spring Harbor Laboratory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cold Spring Harbor Laboratory filed Critical Cold Spring Harbor Laboratory
Publication of LT2561078T publication Critical patent/LT2561078T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/05—Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
LTEP11772783.4T 2010-04-23 2011-04-22 Naujos struktūriškai sukonstruotos shrnr LT2561078T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32751010P 2010-04-23 2010-04-23
PCT/US2011/033615 WO2011133889A2 (en) 2010-04-23 2011-04-22 NOVEL STRUCTURALLY DESIGNED shRNAs

Publications (1)

Publication Number Publication Date
LT2561078T true LT2561078T (lt) 2019-01-10

Family

ID=44834833

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP11772783.4T LT2561078T (lt) 2010-04-23 2011-04-22 Naujos struktūriškai sukonstruotos shrnr

Country Status (14)

Country Link
US (7) US8993532B2 (lt)
EP (2) EP2561078B1 (lt)
AU (5) AU2011242576B2 (lt)
CA (1) CA2795815C (lt)
CY (1) CY1121014T1 (lt)
DK (1) DK2561078T3 (lt)
ES (1) ES2699630T3 (lt)
HR (1) HRP20182039T1 (lt)
HU (1) HUE040278T2 (lt)
LT (1) LT2561078T (lt)
PL (1) PL2561078T3 (lt)
PT (1) PT2561078T (lt)
SI (1) SI2561078T1 (lt)
WO (1) WO2011133889A2 (lt)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110201103A1 (en) * 2008-08-07 2011-08-18 University Of Southern California System For Synergetic Expression Of Multiple Small Functional RNA Elements
WO2010045659A1 (en) 2008-10-17 2010-04-22 American Gene Technologies International Inc. Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules
US9677139B2 (en) 2009-12-11 2017-06-13 Cold Spring Harbor Laboratory Genetic markers indicative of a cancer patient response to trastuzumab (herceptin)
PT2561078T (pt) 2010-04-23 2018-12-03 Cold Spring Harbor Laboratory Sharn com uma conceção estrutural inovadora
EP4328321A3 (en) 2010-10-22 2024-05-29 Cold Spring Harbor Laboratory Varietal counting of nucleic acids for obtaining genomic copy number information
CN104379744A (zh) 2012-05-26 2015-02-25 株式会社博纳克 具有递送功能的基因表达调控用单链核酸分子
WO2014085593A1 (en) 2012-11-27 2014-06-05 Children's Medical Center Corporation Targeting bcl11a distal regulatory elements for fetal hemoglobin reinduction
US9777277B2 (en) 2013-05-31 2017-10-03 Brandeis University Organic small hairpin RNAs
US10612020B2 (en) 2013-12-26 2020-04-07 Tokyo Medical University Artificial mimic miRNA for controlling gene expression, and use of same
CN106068324B (zh) 2013-12-27 2020-12-29 株式会社博纳克 控制基因表达的人工匹配型miRNA及其用途
JP6514717B2 (ja) 2014-04-25 2019-05-15 ザ チルドレンズ メディカル センター コーポレーション 異常ヘモグロビン症を治療するための組成物および方法
JP6687948B2 (ja) * 2014-07-14 2020-04-28 学校法人東京医科大学 遺伝子発現制御のための発現抑制核酸分子およびその用途
US10968451B2 (en) 2014-10-14 2021-04-06 Texas Tech University System Multiplexed shRNAs and uses thereof
CN106177990B (zh) * 2014-11-17 2020-08-28 江苏命码生物科技有限公司 一种新的前体miRNA及其在肿瘤治疗中的应用
PL3237618T3 (pl) 2014-12-24 2019-09-30 Uniqure Ip B.V. Supresja genu huntingtyny indukowana rnai
US10106791B2 (en) * 2014-12-24 2018-10-23 City Of Hope Short hairpin RNA compositions, methods of making and applications thereof
CN107109415B (zh) 2014-12-27 2021-07-09 株式会社博纳克 控制基因表达的天然型miRNA及其用途
EP3276003B1 (en) 2015-03-27 2022-07-20 Bonac Corporation Single-chain nucleic acid molecule having delivery function and gene expression control ability
ES2835861T3 (es) 2015-05-08 2021-06-23 Childrens Medical Ct Corp Direccionamiento de regiones funcionales del potenciador de BCL11A para la reinducción de hemoglobina fetal
JP6890831B2 (ja) 2015-07-08 2021-06-18 アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド Ｈｉｖ予備免疫化および免疫療法
CN113694077A (zh) 2015-08-13 2021-11-26 索马根尼科斯公司 用于伤口愈合的短小发夹rna与微rna的组合物以及方法
WO2017054085A1 (en) 2015-10-01 2017-04-06 University Of Ottawa Exosome packaging of nucleic acids
US10137144B2 (en) 2016-01-15 2018-11-27 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta T-cells
CA3011529A1 (en) 2016-01-15 2017-07-20 American Gene Technologies International Inc. Methods and compositions for the activation of gamma-delta t-cells
WO2017139065A1 (en) 2016-02-08 2017-08-17 American Gene Technologies International Inc. Hiv vaccination and immunotherapy
EP4036231A1 (en) 2016-03-09 2022-08-03 American Gene Technologies International Inc. Combination vectors and methods for treating cancer
US11976292B2 (en) 2016-06-08 2024-05-07 American Gene Technologies International Inc. Non-integrating viral delivery system and methods related thereto
WO2018009246A1 (en) 2016-07-08 2018-01-11 American Gene Technologies International Inc. Hiv pre-immunization and immunotherapy
WO2018017882A1 (en) 2016-07-21 2018-01-25 American Gene Technologies International Inc. Viral vectors for treating parkinson's disease
US11820999B2 (en) 2017-04-03 2023-11-21 American Gene Technologies International Inc. Compositions and methods for treating phenylketonuria
US10994025B2 (en) 2017-05-12 2021-05-04 Massachusetts Institute Of Technology Argonaute protein-double stranded RNA complexes and uses related thereto
US11788087B2 (en) 2017-05-25 2023-10-17 The Children's Medical Center Corporation BCL11A guide delivery
EP3652318A1 (en) 2017-07-11 2020-05-20 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
CN108118055B (zh) * 2017-12-20 2023-05-26 中国农业科学院兰州畜牧与兽药研究所 一种抑制牛FABP4基因表达的shRNA、构建载体及其应用
CA3096938A1 (en) 2018-04-10 2019-10-17 Ottawa Hospital Research Institute Microrna-based compositions and methods used in disease treatment
US20210085707A1 (en) * 2018-05-02 2021-03-25 The Children's Medical Center Corporation Improved bcl11a micrornas for treating hemoglobinopathies
BR112021000315A2 (pt) 2018-07-11 2021-08-03 Actym Therapeutics, Inc. cepas bacterianas imunoestimulantes modificadas geneticamente e seus usos
US11242528B2 (en) 2018-08-28 2022-02-08 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
WO2020053258A1 (en) * 2018-09-12 2020-03-19 Uniqure Ip B.V. Rnai induced c9orf72 suppression for the treatment of als/ftd
AU2019385598A1 (en) 2018-11-19 2021-06-03 Uniqure Ip B.V. RNAi induced reduction of ataxin-3 for the treatment of Spinocerebellar ataxia type 3
WO2020104469A1 (en) 2018-11-19 2020-05-28 Uniqure Ip B.V. Method and means to deliver mirna to target cells
EP3884067A1 (en) 2018-11-19 2021-09-29 uniQure IP B.V. A companion diagnostic to monitor the effects of gene therapy
US20230272402A1 (en) 2018-12-25 2023-08-31 Institute Of Basic Medical Sciences Chinese Academy Of Medical Sciences Small rna medicament for prevention and treatment of inflammation-related diseases and combination thereof
CN110373429A (zh) * 2019-08-01 2019-10-25 哈尔滨工业大学 一种慢病毒介导的哺乳动物细胞特异性过表达miRNA的方法
EP4031148A1 (en) 2019-09-16 2022-07-27 uniQure IP B.V. Targeting misspliced transcripts in genetic disorders
GB201919021D0 (en) 2019-12-20 2020-02-05 Reneuron Ltd Nucleic acid constructs for delivering polynucleotides into exosomes
WO2022268835A1 (en) * 2021-06-21 2022-12-29 Uniqure Biopharma B.V. Gene constructs for silencing alpha-synuclein and uses thereof
WO2023122805A1 (en) 2021-12-20 2023-06-29 Vestaron Corporation Sorbitol driven selection pressure method
WO2023237726A1 (en) 2022-06-10 2023-12-14 Pantarhei Oncology B.V. An intracellular tumor-specific variant of human zona pellucida glycoprotein 3 and nucleic acids coding therefor for use in the treatment of cancer
WO2024044850A1 (en) * 2022-08-30 2024-03-07 Feldan Bio Inc. Method and animal model for inducing bcc tumors

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391909A (en) 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4353888A (en) 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5106627A (en) 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5436146A (en) 1989-09-07 1995-07-25 The Trustees Of Princeton University Helper-free stocks of recombinant adeno-associated virus vectors
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US6080540A (en) 1990-04-20 2000-06-27 Cold Spring Harbor Laboratory Cloning of mammalian genes in microbial organisms and methods for pharmacological screening
WO1991018088A1 (en) 1990-05-23 1991-11-28 The United States Of America, Represented By The Secretary, United States Department Of Commerce Adeno-associated virus (aav)-based eucaryotic vectors
US5173414A (en) 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
AU667680B2 (en) 1991-08-07 1996-04-04 Albert Einstein College Of Medicine Of Yeshiva University Proliferation of hepatocyte precursors
US6069005A (en) 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
US5672499A (en) 1992-07-27 1997-09-30 California Institute Of Technology Immoralized neural crest stem cells and methods of making
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
US5766948A (en) 1993-01-06 1998-06-16 The Regents Of The University Of California Method for production of neuroblasts
GB9417831D0 (en) 1994-09-05 1994-10-26 Biotech & Biolog Scien Res Biological manipulation
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6627616B2 (en) 1995-12-13 2003-09-30 Mirus Corporation Intravascular delivery of non-viral nucleic acid
US6379966B2 (en) 1999-02-26 2002-04-30 Mirus Corporation Intravascular delivery of non-viral nucleic acid
US6190910B1 (en) 1996-05-21 2001-02-20 The Institute Of Physical And Chemical Research Mouse embryonic stem cell lines
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US20020016002A1 (en) 2000-01-24 2002-02-07 Jean Toma Multipotent neural stem cells from peripheral tissues and uses thereof
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
CA2307674C (en) 1997-10-30 2013-02-05 Cold Spring Harbor Laboratory Probe arrays and methods of using probe arrays for distinguishing dna
WO2001051611A1 (en) 2000-01-14 2001-07-19 Bresagen Limited Cell production
WO1999061587A1 (en) 1998-05-29 1999-12-02 Osiris Therapeutics, Inc. Human cd45+ and/or fibroblast + mesenchymal stem cells
GB9811859D0 (en) 1998-06-02 1998-07-29 Biotech & Biolog Scien Res Biological manipulation
US6129911A (en) 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
US6184035B1 (en) 1998-11-18 2001-02-06 California Institute Of Technology Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells
US6897068B2 (en) 1999-02-26 2005-05-24 Mirus Bio Corporation Polynucleotide complex delivery
CN1352696A (zh) 1999-03-10 2002-06-05 匹兹堡大学联邦制高等教育 脂肪来源的干细胞和网格
WO2001011011A2 (en) 1999-08-05 2001-02-15 Mcl Llc Multipotent adult stem cells and methods for isolation
WO2001068815A1 (en) 2000-03-14 2001-09-20 Es Cell International Pte Ltd Embryonic stem cells and neural progenitor cells derived therefrom
JP2003526367A (ja) 2000-03-16 2003-09-09 ジェネティカ インコーポレイテッド Ｒｎａ干渉の方法とｒｎａ干渉組成物
US8202846B2 (en) 2000-03-16 2012-06-19 Cold Spring Harbor Laboratory Methods and compositions for RNA interference
IL151928A0 (en) 2000-03-30 2003-04-10 Whitehead Biomedical Inst Rna sequence-specific mediators of rna interference
US20020090722A1 (en) 2000-06-15 2002-07-11 Tanja Dominko Pluripotent mammalian cells
AU785428B2 (en) 2000-08-30 2007-05-17 Maria Biotech Co., Ltd Human embryonic stem cells derived from frozen-thawed embryo
AU2002230669A1 (en) 2000-11-06 2002-05-15 The Salk Institute For Biological Studies Postmortem stem cells
US20040072343A1 (en) 2000-11-09 2004-04-15 Verma Paul John Cell reprogramming
US20030198627A1 (en) 2001-09-01 2003-10-23 Gert-Jan Arts siRNA knockout assay method and constructs
CA2462144C (en) 2001-09-28 2016-09-20 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Micro-rna molecules
WO2003064621A2 (en) 2002-02-01 2003-08-07 Ambion, Inc. HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
US20030180756A1 (en) 2002-03-21 2003-09-25 Yang Shi Compositions and methods for suppressing eukaryotic gene expression
AU2003256857A1 (en) 2002-08-08 2004-02-25 Dharmacon, Inc. Short interfering rnas having a hairpin structure containing a non-nucleotide loop
EP1556402B1 (en) 2002-09-25 2011-06-22 University of Massachusetts In vivo gene silencing by chemically modified and stable sirna
AU2003283976B2 (en) 2002-09-27 2009-12-10 Cold Spring Harbor Laboratory Cell-based RNA interference and related methods and compositions
CA2500468A1 (en) 2002-09-28 2004-04-08 Massachussets Institute Of Technology Influenza therapeutic
US8653252B2 (en) 2003-03-21 2014-02-18 Santaris Pharma A/S Short interfering RNA (siRNA) analogues
WO2004094595A2 (en) 2003-04-17 2004-11-04 Alnylam Pharmaceuticals Inc. MODIFIED iRNA AGENTS
WO2005035792A2 (en) 2003-05-23 2005-04-21 Cold Spring Harbor Laboratory Counting exact word matches in genomes
US7750144B2 (en) 2003-06-02 2010-07-06 University Of Massachusetts Methods and compositions for enhancing the efficacy and specificity of RNA silencing
EP1713912B1 (en) 2004-01-30 2013-09-18 Santaris Pharma A/S Modified short interfering rna (modified sirna)
US7851452B2 (en) 2004-03-22 2010-12-14 The Trustees Of The University Of Pennsylvania Methods of use of bcl-6-derived nucleotides to induce apoptosis
US7307067B2 (en) 2004-05-04 2007-12-11 The Board Of Trustees Of The Leland Stanford University Methods and compositions for reducing viral genome amounts in a target cell
EP1614755A1 (en) 2004-07-07 2006-01-11 ARTEMIS Pharmaceuticals GmbH Target transgenesis of short hairpin RNA expression cassette using recombinase mediated cassette exchange
US20080213891A1 (en) 2004-07-21 2008-09-04 Alnylam Pharmaceuticals, Inc. RNAi Agents Comprising Universal Nucleobases
JP2008512500A (ja) 2004-09-10 2008-04-24 ソマジェニックス インコーポレーティッド ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法
US20090186353A1 (en) 2004-10-04 2009-07-23 Rosetta Genomics Ltd. Cancer-related nucleic acids
ES2503742T3 (es) 2004-11-12 2014-10-07 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
US20060223777A1 (en) * 2005-03-29 2006-10-05 Dharmacon, Inc. Highly functional short hairpin RNA
WO2006119365A2 (en) 2005-05-02 2006-11-09 Cold Spring Harbor Laboratory Composition and methods for cancer diagnosis utilizing the mir 17-92 cluster
JP2007104969A (ja) 2005-10-13 2007-04-26 Bio Think Tank Co Ltd ショートヘアピン型ＲＮＡ（ｓｈＲＮＡ）前駆体を産生するための核酸及びその利用
EP2395012B8 (en) 2005-11-02 2018-06-06 Arbutus Biopharma Corporation Modified siRNA molecules and uses thereof
EP3091462B1 (en) 2005-12-14 2020-06-17 Cold Spring Harbor Laboratory Methods for assessing probabilistic measures of clinical outcome using genomic profiling
EP1974056A2 (en) 2005-12-14 2008-10-01 Michael H. Wigler Use of roma for characterizing genomic rearrangements
CA2635616A1 (en) 2006-01-05 2007-07-19 Carlo M. Croce Microrna expression abnormalities in pancreatic endocrine and acinar tumors
US20070281900A1 (en) 2006-05-05 2007-12-06 Nastech Pharmaceutical Company Inc. COMPOSITIONS AND METHODS FOR LIPID AND POLYPEPTIDE BASED siRNA INTRACELLULAR DELIVERY
US20070293449A1 (en) 2006-06-20 2007-12-20 Nastech Pharmaceutical Company Inc. Compositions and methods for delivery of double-stranded rna
US20090306181A1 (en) 2006-09-29 2009-12-10 Children's Medical Center Corporation Compositions and methods for evaluating and treating heart failure
JP2010512786A (ja) 2006-12-21 2010-04-30 イントラダイム コーポレイション ガンを処置するための抑制性ポリヌクレオチドの組成物および方法
WO2008095096A2 (en) 2007-01-31 2008-08-07 Immune Disease Institute Let-7 microrna and mimetics thereof as therapeutics for cancer
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
US20080293142A1 (en) * 2007-04-19 2008-11-27 The Board Of Regents For Oklahoma State University Multiple shRNA Expression Vectors and Methods of Construction
US20090036395A1 (en) 2007-04-26 2009-02-05 Davidson Beverly L Rna interference suppression of neurodegenerative diseases and methods of use thereof
WO2008150897A2 (en) 2007-05-31 2008-12-11 University Of Iowa Research Foundation Reduction of off-target rna interference toxicity
US20090124566A1 (en) 2007-06-07 2009-05-14 Duke University Methods and compositions for the treatment of erythrocyte diseases
US20090004668A1 (en) 2007-06-22 2009-01-01 The Board Of Trustees Of The Leland Stanford Junior University Pre-miRNA loop-modulated target regulation
US8841437B2 (en) 2008-06-20 2014-09-23 The Board Of Trustees Of The Leland Stanford Junior University Precursor miRNA loop-modulated target regulation
JP2010537640A (ja) 2007-08-27 2010-12-09 ボストン バイオメディカル， インコーポレイテッド マイクロｒｎａ模倣剤または阻害剤としての非対称性ｒｎａ二重鎖の組成物
WO2009055724A2 (en) 2007-10-26 2009-04-30 Cold Spring Harbor Laboratory High throughput methods for functionally determining rna interference efficiency
US20090169613A1 (en) * 2007-11-09 2009-07-02 Reznik Boris N Targeting of tumor stem cells through selective silencing of boris expression
WO2009076321A2 (en) 2007-12-07 2009-06-18 Halo-Bio Rnai Therapeutics Inc. Compositions and methods for modulating gene expression using asymmetrically-active precursor polynucleotides
US20090286242A1 (en) 2007-12-10 2009-11-19 Cold Spring Harbor Laboratory MicroRNA Expression Profiling and Uses Thereof
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US8247388B2 (en) 2008-06-06 2012-08-21 The Board Of Trustees Of The Leland Stanford Junior University Role of miRNA in T cell leukemia
EP2318528A1 (en) 2008-07-24 2011-05-11 Rxi Pharmaceuticals Corporation Rnai constructs and uses therof
CN102245772A (zh) * 2008-10-15 2011-11-16 索马根尼科斯公司 抑制基因表达的短发卡rna
US20120149593A1 (en) 2009-01-23 2012-06-14 Hicks James B Methods and arrays for profiling dna methylation
WO2011008730A2 (en) 2009-07-13 2011-01-20 Somagenics Inc. Chemical modification of small hairpin rnas for inhibition of gene expression
US9677139B2 (en) 2009-12-11 2017-06-13 Cold Spring Harbor Laboratory Genetic markers indicative of a cancer patient response to trastuzumab (herceptin)
WO2011072205A2 (en) 2009-12-11 2011-06-16 Cold Spring Harbor Laboratory Genetic markers indicative of a cancer patient response to trastuzumab (herceptin)
PT2561078T (pt) 2010-04-23 2018-12-03 Cold Spring Harbor Laboratory Sharn com uma conceção estrutural inovadora
EP4328321A3 (en) 2010-10-22 2024-05-29 Cold Spring Harbor Laboratory Varietal counting of nucleic acids for obtaining genomic copy number information

Also Published As

Publication number Publication date
US8993532B2 (en) 2015-03-31
US10329562B2 (en) 2019-06-25
EP3502254A1 (en) 2019-06-26
AU2016204409A1 (en) 2016-07-14
AU2018220005A1 (en) 2018-09-06
EP2561078B1 (en) 2018-09-19
US20120021516A1 (en) 2012-01-26
AU2020294243A1 (en) 2021-01-28
US20130179999A1 (en) 2013-07-11
PL2561078T3 (pl) 2019-02-28
US20200048633A1 (en) 2020-02-13
AU2011242576B2 (en) 2016-03-31
US9624494B2 (en) 2017-04-18
US11753641B2 (en) 2023-09-12
HRP20182039T1 (hr) 2019-02-08
US20240102010A1 (en) 2024-03-28
WO2011133889A3 (en) 2012-05-10
PT2561078T (pt) 2018-12-03
CA2795815C (en) 2018-06-26
US8273871B2 (en) 2012-09-25
EP2561078A4 (en) 2014-10-15
ES2699630T3 (es) 2019-02-12
DK2561078T3 (en) 2019-01-14
US20210254064A1 (en) 2021-08-19
HUE040278T2 (hu) 2019-02-28
CA2795815A1 (en) 2011-10-27
SI2561078T1 (sl) 2019-01-31
AU2023222924A1 (en) 2023-09-21
CY1121014T1 (el) 2019-12-11
US20150197749A1 (en) 2015-07-16
AU2011242576A1 (en) 2012-12-06
WO2011133889A2 (en) 2011-10-27
US20170342410A1 (en) 2017-11-30
EP2561078A2 (en) 2013-02-27

Similar Documents

Publication Publication Date Title
HRP20182039T1 (hr) NOVE STRUKTURNO DIZAJNIRANE MOLEKULE shRNA
DK3342786T3 (en) Anti-dll3-antistof
AP3107A (en) 5-Alkynyl-pyrimidines
EP2566479A4 (en) AZA-INDAZOLES
GB201205984D0 (en) No details
EP2640189A4 (en) 3-deutero-pomalidomide
AP2012006640A0 (en) New aminopyrazoloquinazolines
GB201112400D0 (en) No details
DK3466977T3 (en) Anti-vla-4-antistoffer
EP2651505A4 (en) ELECTROPORATION-INDUCED ELECTROSENSIBILIZATION
EP2641891A4 (en) PKC ACTIVATOR-
GB201202348D0 (en) No details
SG10201508549UA (en) Modified tamavidin
GB201105908D0 (en) No details
AU4536P (en) TB01 Tibouchina urvilleana
AU4937P (en) FlatinsulGL Myoporum insulare
AU4931P (en) FlatwaxDarkGL Chamelaucium uncinatum
AU4822P (en) FlatwaxwhiteGL Chamelaucium uncinatum
AU4932P (en) FlatwaxpinkGL Chamelaucium uncinatum
GB201010836D0 (en) Easy squeezy
GB201002829D0 (en) Novel copmounds
GB201012020D0 (en) Payloaded stability
GB201118380D0 (en) No Details
GB201202556D0 (en) No details
GB201020362D0 (en) Imuffs