BR112016028567A2 - método para utilizar ligante anti-fgf23 e para tratar doença e/ou condição relacionada com fgf23 e para aumentar a remodelação óssea - Google Patents

método para utilizar ligante anti-fgf23 e para tratar doença e/ou condição relacionada com fgf23 e para aumentar a remodelação óssea

Info

Publication number
BR112016028567A2
BR112016028567A2 BR112016028567A BR112016028567A BR112016028567A2 BR 112016028567 A2 BR112016028567 A2 BR 112016028567A2 BR 112016028567 A BR112016028567 A BR 112016028567A BR 112016028567 A BR112016028567 A BR 112016028567A BR 112016028567 A2 BR112016028567 A2 BR 112016028567A2
Authority
BR
Brazil
Prior art keywords
fgf23
treating
condition
related disease
bone remodeling
Prior art date
Application number
BR112016028567A
Other languages
English (en)
Inventor
Kakkis Emil
San Martin Javier
Sudo Tomohiro
Original Assignee
Kyowa Hakko Kirin Co Ltd
Ultragenyx Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co Ltd, Ultragenyx Pharmaceutical Inc filed Critical Kyowa Hakko Kirin Co Ltd
Priority to BR122023023102-3A priority Critical patent/BR122023023102A2/pt
Publication of BR112016028567A2 publication Critical patent/BR112016028567A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00113—Growth factors
    • A61K39/001132—Fibroblast growth factors [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Abstract

a presente invenção proporciona composições e métodos para tratar uma desordem hipofosfatêmica, tal como hipofosfatêmia ligada a x (xlh). o método envolve a administração a um indivíduo de uma composição farmacêutica contendo um ligante anti-fgf23, em que o regime de dosagem do produto farmacêutico é destinado a alcançar um controle efetivo e eficiente da atividade fgf23.
BR112016028567A 2014-06-09 2015-05-29 método para utilizar ligante anti-fgf23 e para tratar doença e/ou condição relacionada com fgf23 e para aumentar a remodelação óssea BR112016028567A2 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122023023102-3A BR122023023102A2 (pt) 2014-06-09 2015-05-29 Uso de um anticorpo anti-fgf23 para o tratamento de um distúrbio hipofosfamético associado a níveis e/ou atividade anormais do fator de crescimento de fibroblastos 23 (fgf23)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462009474P 2014-06-09 2014-06-09
PCT/US2015/033226 WO2015191312A1 (en) 2014-06-09 2015-05-29 The effective and efficient control of serum phosphate for optimal bone formation

Publications (1)

Publication Number Publication Date
BR112016028567A2 true BR112016028567A2 (pt) 2018-01-30

Family

ID=54769049

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122023023102-3A BR122023023102A2 (pt) 2014-06-09 2015-05-29 Uso de um anticorpo anti-fgf23 para o tratamento de um distúrbio hipofosfamético associado a níveis e/ou atividade anormais do fator de crescimento de fibroblastos 23 (fgf23)
BR112016028567A BR112016028567A2 (pt) 2014-06-09 2015-05-29 método para utilizar ligante anti-fgf23 e para tratar doença e/ou condição relacionada com fgf23 e para aumentar a remodelação óssea

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR122023023102-3A BR122023023102A2 (pt) 2014-06-09 2015-05-29 Uso de um anticorpo anti-fgf23 para o tratamento de um distúrbio hipofosfamético associado a níveis e/ou atividade anormais do fator de crescimento de fibroblastos 23 (fgf23)

Country Status (23)

Country Link
US (4) US10639360B2 (pt)
EP (2) EP3151859B1 (pt)
JP (2) JP6808493B2 (pt)
KR (2) KR20210099180A (pt)
CN (1) CN106604743A (pt)
AR (1) AR100689A1 (pt)
AU (1) AU2015275128C1 (pt)
BR (2) BR122023023102A2 (pt)
CA (1) CA2949234C (pt)
CL (1) CL2016003179A1 (pt)
CY (1) CY1124328T1 (pt)
DK (1) DK3151859T3 (pt)
ES (1) ES2851674T3 (pt)
HR (1) HRP20210250T1 (pt)
HU (1) HUE053271T2 (pt)
LT (1) LT3151859T (pt)
MX (2) MX2016016296A (pt)
PE (1) PE20170248A1 (pt)
PL (1) PL3151859T3 (pt)
PT (1) PT3151859T (pt)
RS (1) RS61443B1 (pt)
SI (1) SI3151859T1 (pt)
WO (1) WO2015191312A1 (pt)

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HUE039448T2 (hu) 2004-04-21 2018-12-28 Alexion Pharma Inc Csontba szállító konjugátumok és alkalmazási módszerük a fehérjék csontba juttatására
PL3151859T3 (pl) 2014-06-09 2021-07-26 Ultragenyx Pharmaceutical Inc. Efektywna i skuteczna kontrola stężenia fosforanów w surowicy dla optymalnego tworzenia kości
WO2016007873A1 (en) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions and methods for treating craniosynostosis
JP6787894B2 (ja) 2014-12-05 2020-11-18 アレクシオン ファーマシューティカルズ， インコーポレイテッド 組換えアルカリホスファターゼを用いた発作の処置
AU2016211447B2 (en) 2015-01-28 2021-09-23 Alexion Pharmaceuticals, Inc. Methods of treating a subject with an alkaline phosphatase deficiency
KR102644116B1 (ko) 2015-08-17 2024-03-05 알렉시온 파마슈티칼스, 인코포레이티드 알칼린 포스파타제의 제조
JP6868617B2 (ja) 2015-09-28 2021-05-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド 低ホスファターゼ血症の組織非特異的アルカリホスファターゼ（ｔｎｓａｌｐ）酵素補充療法に有効な投薬計画の特定
JP2018533571A (ja) 2015-10-30 2018-11-15 アレクシオン ファーマシューティカルズ， インコーポレイテッド 患者の頭蓋縫合早期癒合症を治療するための方法
WO2017155569A1 (en) 2016-03-08 2017-09-14 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
US10898549B2 (en) 2016-04-01 2021-01-26 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in adolescents and adults
WO2017173413A1 (en) 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Treating muscle weakness with alkaline phosphatases
WO2017214130A1 (en) 2016-06-06 2017-12-14 Alexion Pharmaceuticals, Inc. Metal impact on manufacturing of alkaline phosphatases
WO2018035420A1 (en) 2016-08-18 2018-02-22 Alexion Pharmaceuticals, Inc. Methods for treating tracheobronchomalacia
CN106709662B (zh) * 2016-12-30 2021-07-02 山东鲁能软件技术有限公司 一种电力设备运行工况划分方法
CN110719786A (zh) 2017-03-31 2020-01-21 阿雷克森制药公司 用于治疗成人和青少年的低磷酸酯酶症(hpp)的方法
JP2021519590A (ja) 2018-03-30 2021-08-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド 糖タンパク質の製造

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PL3151859T3 (pl) 2014-06-09 2021-07-26 Ultragenyx Pharmaceutical Inc. Efektywna i skuteczna kontrola stężenia fosforanów w surowicy dla optymalnego tworzenia kości

Also Published As

Publication number Publication date
SI3151859T1 (sl) 2021-06-30
US10639360B2 (en) 2020-05-05
JP2021050226A (ja) 2021-04-01
EP3845245A1 (en) 2021-07-07
CA2949234C (en) 2022-03-22
CL2016003179A1 (es) 2017-11-03
JP6993490B2 (ja) 2022-02-03
AU2015275128A1 (en) 2016-12-08
BR122023023102A2 (pt) 2024-03-05
US11202822B2 (en) 2021-12-21
DK3151859T3 (da) 2021-02-15
MX2016016296A (es) 2017-10-12
JP2017524656A (ja) 2017-08-31
US11771748B2 (en) 2023-10-03
WO2015191312A1 (en) 2015-12-17
KR20170013993A (ko) 2017-02-07
JP6808493B2 (ja) 2021-01-06
EP3151859B1 (en) 2020-11-25
AU2015275128C1 (en) 2020-02-13
KR20210099180A (ko) 2021-08-11
AU2015275128B2 (en) 2019-10-31
CY1124328T1 (el) 2022-07-22
PE20170248A1 (es) 2017-04-14
ES2851674T3 (es) 2021-09-08
US20200330575A1 (en) 2020-10-22
CA2949234A1 (en) 2015-12-17
US20220133871A1 (en) 2022-05-05
US20150353633A1 (en) 2015-12-10
US20240115683A1 (en) 2024-04-11
HRP20210250T1 (hr) 2021-04-02
MX2021003740A (es) 2021-05-27
CN106604743A (zh) 2017-04-26
PL3151859T3 (pl) 2021-07-26
HUE053271T2 (hu) 2021-06-28
EP3151859A1 (en) 2017-04-12
PT3151859T (pt) 2021-02-03
RS61443B1 (sr) 2021-03-31
EP3151859A4 (en) 2018-01-17
LT3151859T (lt) 2021-03-25
AR100689A1 (es) 2016-10-26

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25D Requested change of name of applicant approved

Owner name: ULTRAGENYX PHARMACEUTICAL INC. (US) ; KYOWA KIRIN CO., LTD. (JP)

B25G Requested change of headquarter approved

Owner name: ULTRAGENYX PHARMACEUTICAL INC. (US) ; KYOWA KIRIN CO., LTD. (JP)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B154 Notification of filing of divisional application [chapter 15.50 patent gazette]

Free format text: O PEDIDO FOI DIVIDIDO NO BR122023023102-3 PROTOCOLO 870230097473 EM 03/11/2023 20:45.