DE69934227D1 - Auf beta-arabinose, und dessen analogen, basierte antisense oligonukleotide - Google Patents

Auf beta-arabinose, und dessen analogen, basierte antisense oligonukleotide

Info

Publication number
DE69934227D1
DE69934227D1 DE69934227T DE69934227T DE69934227D1 DE 69934227 D1 DE69934227 D1 DE 69934227D1 DE 69934227 T DE69934227 T DE 69934227T DE 69934227 T DE69934227 T DE 69934227T DE 69934227 D1 DE69934227 D1 DE 69934227D1
Authority
DE
Germany
Prior art keywords
relates
antisense oligonucleotides
arabinosis
analogs
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69934227T
Other languages
English (en)
Other versions
DE69934227T2 (de
Inventor
Jose Damha
A Parniak
Anne M Noronha
Christopher Wilds
Gadi Borkow
Dominique Arion
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
McGill University
Original Assignee
McGill University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McGill University filed Critical McGill University
Publication of DE69934227D1 publication Critical patent/DE69934227D1/de
Application granted granted Critical
Publication of DE69934227T2 publication Critical patent/DE69934227T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DE69934227T 1998-06-19 1999-06-17 Auf Beta-Arabinose und dessen Analoga basierte Antisense-Oligonukleotide Expired - Lifetime DE69934227T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA2241361 1998-06-19
CA2241361 1998-06-19
PCT/CA1999/000571 WO1999067378A1 (en) 1998-06-19 1999-06-17 ANTISENSE OLIGONUCLEOTIDE CONSTRUCTS BASED ON β-ARABINOFURANOSE AND ITS ANALOGUES

Publications (2)

Publication Number Publication Date
DE69934227D1 true DE69934227D1 (de) 2007-01-11
DE69934227T2 DE69934227T2 (de) 2007-10-04

Family

ID=4162575

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69934227T Expired - Lifetime DE69934227T2 (de) 1998-06-19 1999-06-17 Auf Beta-Arabinose und dessen Analoga basierte Antisense-Oligonukleotide

Country Status (6)

Country Link
US (1) US20090105467A1 (de)
EP (1) EP1088066B1 (de)
AT (1) ATE346918T1 (de)
AU (1) AU4595399A (de)
DE (1) DE69934227T2 (de)
WO (1) WO1999067378A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020013287A1 (en) * 2000-05-09 2002-01-31 Reliable Biopharmaceuticals, Inc. St Louis Missouri Polymeric compounds useful as prodrugs
CA2419563C (en) * 2000-09-06 2018-03-20 Mcgill University Chimeric antisense of arabinofuranose analogue and deoxyribose nucleotides
AU2002319033B2 (en) * 2001-07-06 2008-01-10 Pharmaxis Ltd Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals
US20050043256A1 (en) 2001-07-30 2005-02-24 Isis Pharmaceuticals, Inc. Antisense modulation of stearoyl-CoA desaturase expression
US7132529B2 (en) * 2001-07-30 2006-11-07 Isis Pharmaceuticals, Inc. Antisense modulation of stearoyl-CoA desaturase expression
AU2003202376B2 (en) 2002-02-01 2008-10-30 Mcgill University Oligonucleotides comprising alternating segments and uses thereof
CN1867576A (zh) 2003-10-24 2006-11-22 雅玛山酱油株式会社 α－1－磷酸化2－脱氧－2－氟***糖苷和2′－脱氧－2′－氟－β－D－阿糖核苷的制造方法
CA2584457C (en) 2004-10-29 2012-10-23 Topigen Pharmaceuticals Inc. Antisense oligonucleotides for treating allergy and neoplastic cell proliferation
EP3000480A1 (de) 2005-12-01 2016-03-30 ProNAi Therapeutics, Inc. Krebstherapien und dabei verwendete pharmazeutische zusammensetzungen
JP2009537118A (ja) 2006-05-19 2009-10-29 トピジェン・ファーマシューティカルズ・インコーポレーテッド ホスホジエステラーゼの発現に影響するオリゴヌクレオチド
EP2285961A4 (de) 2008-05-15 2012-10-17 Topigen Pharmaceuticals Inc Oligonukleotide zur behandlung von entzündungen und neoplastischer zellvermehrung
EP2398815A4 (de) * 2009-02-22 2013-10-16 Chemgenes Corp Synthese von ara-2'-o-methylnukleosiden, entsprechende phosphoramidite und oligonukleotide mit neuen modifikationen zur biologischen anwendung für therapeutika, diagnostika, g-tetraden-bildende oligonukleotide und apatamere
AU2011325956B2 (en) 2010-11-12 2016-07-14 The General Hospital Corporation Polycomb-associated non-coding RNAs
MX355816B (es) 2011-08-04 2018-05-02 Amgen Inc Metodo para tratar los defectos de espacio oseo.
EP2756080B1 (de) 2011-09-14 2019-02-20 Translate Bio MA, Inc. Multimere oligonukleotidverbindungen
AU2012362898B2 (en) 2011-12-28 2017-11-09 Amgen, Inc. Method of treating alveolar bone loss through the use of anti-sclerostin antibodies
AU2013262649A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating smn gene family expression
KR102028784B1 (ko) 2012-05-16 2019-10-04 트랜슬레이트 바이오 인코포레이티드 유전자 발현을 조절하기 위한 조성물 및 방법
WO2013184209A1 (en) 2012-06-04 2013-12-12 Ludwig Institute For Cancer Research Ltd. Mif for use in methods of treating subjects with a neurodegenerative disorder
KR20150087270A (ko) 2012-11-05 2015-07-29 프로나이 테라퓨틱스, 인코포레이티드 Bcl2 발현 조절에 의한 암치료용 바이오마커 이용 방법
WO2015200697A1 (en) 2014-06-25 2015-12-30 The General Hospital Corporation Targeting human satellite ii (hsatii)
DE102014221734A1 (de) * 2014-10-24 2016-04-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Messvorrichtung und System zur Schmelzkurvenanalyse eines DNA Microarrays, sowie Verwendung eines Fluoreszenzdetektorarrays zur Analyse
CA3030701A1 (en) 2016-07-11 2018-01-18 Translate Bio Ma, Inc. Nucleic acid conjugates and uses thereof
WO2019025324A1 (en) 2017-08-03 2019-02-07 Karl-Franzens-Universität Graz ANALOGUES OF PHOSPHOLIPIDS
EP3856919A4 (de) * 2018-09-26 2023-08-02 AUM LifeTech, Inc. 2' fana-modifizierte foxp3-antisense-oligonukleotide und verfahren zu deren verwendung
WO2021142245A1 (en) 2020-01-10 2021-07-15 Translate Bio, Inc. Compounds, pharmaceutical compositions and methods for modulating expression of muc5b in lung cells and tissues

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003370A1 (en) * 1988-09-28 1990-04-05 Microprobe Corporation DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE
ATE226093T1 (de) * 1991-11-26 2002-11-15 Isis Pharmaceuticals Inc Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
US5795726A (en) * 1996-11-12 1998-08-18 Millennium Pharmaceuticals, Inc. Methods for identifying compounds useful in treating type II diabetes
US5739119A (en) * 1996-11-15 1998-04-14 Galli; Rachel L. Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor MRNA
CA2419563C (en) * 2000-09-06 2018-03-20 Mcgill University Chimeric antisense of arabinofuranose analogue and deoxyribose nucleotides
AU2003202376B2 (en) * 2002-02-01 2008-10-30 Mcgill University Oligonucleotides comprising alternating segments and uses thereof

Also Published As

Publication number Publication date
ATE346918T1 (de) 2006-12-15
AU4595399A (en) 2000-01-10
EP1088066B1 (de) 2006-11-29
DE69934227T2 (de) 2007-10-04
WO1999067378A1 (en) 1999-12-29
US20090105467A1 (en) 2009-04-23
EP1088066A1 (de) 2001-04-04

Similar Documents

Publication Publication Date Title
DE69934227D1 (de) Auf beta-arabinose, und dessen analogen, basierte antisense oligonukleotide
ZA200304500B (en) Method for inhibiting the expression of a target gene and medicament for treating a tumor disease.
WO2003100017A3 (en) Oligonucleotides having modified nucleoside units
DK0731835T3 (da) Antisense-oligonukleotider med tumorigenicitetshæmmende virkning
AU5121399A (en) Rna targeted 2'-modified oligonucleotides that are conformationally preorganized
DE69734589D1 (de) Antitumor antisense sequenzen gegen h1 und r2 verbindungen von ribonukleotide reductase
DE69403642D1 (de) 7-deazapurin modifizierte oligonukleotide
DE69838449D1 (de) Aminooxy-modifizierte oligonukleotide
NO20014058L (no) TRPM-2-antisense-terapi
FI946201A (fi) Itsestabiloidut oligonukleotidit terapeuttisina aineina
DE69931029D1 (de) Optimierte antisense oligonukleotide komplementär zu dna-methyltransferase sequenzen
WO2001032832A3 (en) Antisense inhibition of nucleolin expression
HRP20100666T1 (hr) ANTI MIOZINSKA Va siRNA I DEPIGMENTACIJA KOŽE
DK1175489T3 (da) Oligonukleotider indeholdende en antisense-sekvens stabiliseret af en sekundær struktur og farmaceutiske præparater indeholdende disse oligonukleotider
EP3040423A3 (de) Mikro-rna und verwendung davon
ATE293688T1 (de) Chimerische antisense-oligonukleotide aus arabinofuranose-analogen und deoxyribose- nukleotide
WO2000008140A3 (en) Antisense oligonucleotides for the inhibition of vegf expression
MXPA03011153A (es) Adn enzimas bcl-2.
WO2001048245A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
WO2001040521A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
CA2331333A1 (en) Antisense oligonucleotide constructs based on .beta.-arabinofuranose and its analogues
Yamakawa et al. Properties of nicked and circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligodeoxynucleotides
WO2001038586A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
EP1724351A3 (de) Menschliche Kallikrein-ähnliche Gene

Legal Events

Date Code Title Description
8364 No opposition during term of opposition