US20020150921A1
(en)
*
|
1996-02-09 |
2002-10-17 |
Francis Barany |
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
|
EP1263759B1
(en)
|
1999-12-24 |
2010-09-08 |
Aventis Pharma Limited |
Azaindoles
|
YU54202A
(sh)
*
|
2000-01-18 |
2006-01-16 |
Agouron Pharmaceuticals Inc. |
Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
|
US7211594B2
(en)
|
2000-07-31 |
2007-05-01 |
Signal Pharmaceuticals, Llc |
Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
|
US20050009876A1
(en)
*
|
2000-07-31 |
2005-01-13 |
Bhagwat Shripad S. |
Indazole compounds, compositions thereof and methods of treatment therewith
|
US6897231B2
(en)
|
2000-07-31 |
2005-05-24 |
Signal Pharmaceuticals, Inc. |
Indazole derivatives as JNK inhibitors and compositions and methods related thereto
|
AU2001277621A1
(en)
*
|
2000-08-09 |
2002-03-04 |
Astrazeneca Ab |
Antiangiogenic bicyclic derivatives
|
SG174632A1
(en)
|
2000-09-11 |
2011-10-28 |
Novartis Vaccines & Diagnostic |
Quinolinone derivatives
|
DE10046029A1
(de)
|
2000-09-18 |
2002-03-28 |
Bayer Ag |
Indazole
|
ATE449763T1
(de)
|
2001-04-16 |
2009-12-15 |
Eisai R&D Man Co Ltd |
1h-indazolverbindungen die jnk hemmen
|
GB0115109D0
(en)
|
2001-06-21 |
2001-08-15 |
Aventis Pharma Ltd |
Chemical compounds
|
US7642278B2
(en)
|
2001-07-03 |
2010-01-05 |
Novartis Vaccines And Diagnostics, Inc. |
Indazole benzimidazole compounds
|
US7064215B2
(en)
|
2001-07-03 |
2006-06-20 |
Chiron Corporation |
Indazole benzimidazole compounds
|
FR2827861B1
(fr)
|
2001-07-27 |
2004-04-02 |
Aventis Pharma Sa |
Derives des indazoles ou des indoles, leur utilisation en medecine humaine et plus particulierement en cancerologie
|
US20040077702A1
(en)
*
|
2001-09-14 |
2004-04-22 |
Wen-Mei Fu |
Treatment of nuerodegenerative diseases
|
EA007430B1
(ru)
*
|
2001-09-26 |
2006-10-27 |
Фармация Италия С.П.А. |
Производные аминоиндазола, активные в качестве ингибиторов киназ, способ их получения и содержащая их фармацевтическая композиция
|
ES2292812T3
(es)
*
|
2001-10-19 |
2008-03-16 |
Ortho-Mcneil Pharmaceutical, Inc. |
2-fenil benzimidazol e imidazo-(4,5)-piridinas como inhibidores de cds1/chk2 y coadyuvantes para quimioterapia o radioterapia en el tratamiento del cancer.
|
JP5039268B2
(ja)
*
|
2001-10-26 |
2012-10-03 |
アベンティス・ファーマスーティカルズ・インコーポレイテツド |
ベンゾイミダゾールおよび類縁体および蛋白キナーゼ阻害剤としてのその使用
|
FR2831536A1
(fr)
*
|
2001-10-26 |
2003-05-02 |
Aventis Pharma Sa |
Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
|
FR2831537B1
(fr)
*
|
2001-10-26 |
2008-02-29 |
Aventis Pharma Sa |
Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation
|
US6897208B2
(en)
*
|
2001-10-26 |
2005-05-24 |
Aventis Pharmaceuticals Inc. |
Benzimidazoles
|
US7074805B2
(en)
*
|
2002-02-20 |
2006-07-11 |
Abbott Laboratories |
Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
|
US6867320B2
(en)
*
|
2002-02-21 |
2005-03-15 |
Asahi Kasei Pharma Corporation |
Substituted phenylalkanoic acid derivatives and use thereof
|
AU2003217961B2
(en)
*
|
2002-03-08 |
2008-02-28 |
Signal Pharmaceuticals, Llc |
Combination therapy for treating, preventing or managing proliferative disorders and cancers
|
FR2836914B1
(fr)
|
2002-03-11 |
2008-03-14 |
Aventis Pharma Sa |
Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
|
US7166293B2
(en)
|
2002-03-29 |
2007-01-23 |
Carlsbad Technology, Inc. |
Angiogenesis inhibitors
|
US20050119278A1
(en)
*
|
2002-05-16 |
2005-06-02 |
Che-Ming Teng |
Anti-angiogenesis methods
|
WO2003102151A2
(en)
*
|
2002-05-30 |
2003-12-11 |
Celgene Corporation |
Modulating cell differentiation and treating myeloprolifertive disorders with jnk/mkk inhibitors
|
EP1510516A4
(en)
*
|
2002-05-31 |
2005-11-02 |
Eisai Co Ltd |
PYRAZOL COMPOUND AND MEDICAL COMPOSITION CONTAINING THEM
|
JP2004075673A
(ja)
*
|
2002-06-19 |
2004-03-11 |
Mitsubishi Chemicals Corp |
化合物およびこれを用いた有機電界発光素子
|
GB0218625D0
(en)
*
|
2002-08-10 |
2002-09-18 |
Astex Technology Ltd |
Pharmaceutical compounds
|
US7186716B2
(en)
|
2002-08-12 |
2007-03-06 |
Sugen, Inc. |
3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
|
US20040087642A1
(en)
*
|
2002-10-24 |
2004-05-06 |
Zeldis Jerome B. |
Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
|
CA2508319A1
(en)
*
|
2002-12-03 |
2004-06-17 |
Kyowa Hakko Kogyo Co., Ltd. |
Jnk inhibitors
|
EP1585743B1
(en)
*
|
2002-12-19 |
2007-05-23 |
Pfizer Inc. |
2-(1h-indazol-6-ylamino)- benzamide compounds as protein kinases inhibitors useful for the treatment of ophthalmic diseases
|
US20050019366A1
(en)
*
|
2002-12-31 |
2005-01-27 |
Zeldis Jerome B. |
Drug-coated stents and methods of use therefor
|
US6933311B2
(en)
*
|
2003-02-11 |
2005-08-23 |
Abbott Laboratories |
Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
|
MXPA05008878A
(es)
*
|
2003-02-21 |
2005-10-05 |
Pfizer |
Derivados de aminotiazol sustituidos con cicloalquilo que contiene n y composiciones farmaceuticas para inhibir la proliferacion celular, y metodos para su uso.
|
ATE481402T1
(de)
*
|
2003-02-27 |
2010-10-15 |
Palau Pharma Sa |
Pyrazolopyridin-derivate
|
ES2214150B1
(es)
*
|
2003-02-27 |
2005-12-01 |
J. URIACH & CIA S.A. |
"nuevos derivados de pirazolopiridinas".
|
US7132440B2
(en)
|
2003-04-17 |
2006-11-07 |
Janssen Pharmaceutica, N.V. |
Substituted benzimidazoles and imidazo-[4,5]-pyridines
|
FR2854159B1
(fr)
*
|
2003-04-25 |
2008-01-11 |
Aventis Pharma Sa |
Nouveaux derives de l'indole, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de kdr
|
US7015233B2
(en)
*
|
2003-06-12 |
2006-03-21 |
Abbott Laboratories |
Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
|
TWI372050B
(en)
|
2003-07-03 |
2012-09-11 |
Astex Therapeutics Ltd |
(morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
|
ITRM20030355A1
(it)
*
|
2003-07-18 |
2005-01-19 |
Sigma Tau Ind Farmaceuti |
Composti ad attivita' citotossica derivati della combretastatina.
|
PL1651612T3
(pl)
|
2003-07-22 |
2012-09-28 |
Astex Therapeutics Ltd |
Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3)
|
US7008953B2
(en)
*
|
2003-07-30 |
2006-03-07 |
Agouron Pharmaceuticals, Inc. |
3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
|
JP4335212B2
(ja)
*
|
2003-07-30 |
2009-09-30 |
協和発酵キリン株式会社 |
インダゾール誘導体
|
EP1650194A4
(en)
*
|
2003-07-30 |
2008-10-01 |
Kyowa Hakko Kogyo Kk |
INHIBITOR OF PROTEIN KINASE
|
US20050090529A1
(en)
*
|
2003-07-31 |
2005-04-28 |
Pfizer Inc |
3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
|
EP1651631A1
(en)
*
|
2003-08-01 |
2006-05-03 |
Genelabs Technologies, Inc. |
Bicyclic imidazol derivatives against flaviviridae
|
US20050113576A1
(en)
*
|
2003-08-05 |
2005-05-26 |
Chih-Hung Lee |
Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
|
WO2005014554A1
(en)
*
|
2003-08-08 |
2005-02-17 |
Astex Therapeutics Limited |
1h-indazole-3-carboxamide compounds as mapkap kinase modulators
|
CA2535665A1
(en)
|
2003-08-14 |
2005-02-24 |
Asahi Kasei Pharma Corporation |
Substituted arylalkanoic acid derivative and use thereof
|
JP2005089457A
(ja)
|
2003-09-03 |
2005-04-07 |
Yung Shin Pharmaceutical Industry Co Ltd |
骨成長を促進するまたは骨吸収を阻害するための薬剤組成物
|
US6984652B2
(en)
|
2003-09-05 |
2006-01-10 |
Warner-Lambert Company Llc |
Gyrase inhibitors
|
PT1682553E
(pt)
*
|
2003-09-08 |
2010-07-29 |
Aventis Pharma Inc |
Tienopirazoles
|
ES2426288T3
(es)
*
|
2003-10-15 |
2013-10-22 |
Ube Industries, Ltd. |
Novedoso derivado de imidazol
|
ZA200603719B
(en)
*
|
2003-11-06 |
2007-09-26 |
Celgene Corp |
Methods of using and compositions comprising a JNK inhibitor for the treatment and management of asbestos-related diseases and disorders
|
WO2005046589A2
(en)
|
2003-11-07 |
2005-05-26 |
Chiron Corporation |
Pharmaceutically acceptable salts of quinolinone compounds having improved pharmaceutical properties
|
US20060179711A1
(en)
*
|
2003-11-17 |
2006-08-17 |
Aerogrow International, Inc. |
Devices and methods for growing plants
|
CA2546493A1
(en)
*
|
2003-11-19 |
2005-06-09 |
Signal Pharmaceuticals, Llc |
Indazole compounds and methods of use thereof as protein kinase inhibitors
|
US7488817B2
(en)
*
|
2004-02-02 |
2009-02-10 |
The Trustees Of The University Of Pennsylvania |
Metal complex protein kinase inhibitors
|
BRPI0509580A
(pt)
*
|
2004-03-30 |
2007-11-27 |
Pfizer Prod Inc |
combinações de inibidores de transdução de sinal
|
JPWO2005094823A1
(ja)
*
|
2004-03-30 |
2007-08-16 |
協和醗酵工業株式会社 |
Flt−3阻害剤
|
GB0409080D0
(en)
*
|
2004-04-23 |
2004-05-26 |
Biofocus Discovery Ltd |
Compounds which interact with protein kinases
|
EP1773327A1
(en)
*
|
2004-07-27 |
2007-04-18 |
Novartis AG |
Inhibitors of hsp90
|
US20070054916A1
(en)
*
|
2004-10-01 |
2007-03-08 |
Amgen Inc. |
Aryl nitrogen-containing bicyclic compounds and methods of use
|
FR2876584B1
(fr)
*
|
2004-10-15 |
2007-04-13 |
Centre Nat Rech Scient Cnrse |
Utilisation de la kenpaullone pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules
|
US20060116519A1
(en)
*
|
2004-11-17 |
2006-06-01 |
Agouron Pharmaceuticals, Inc. |
Synthesis of 5-bromo-4-methyl-pyridin-3-ylmethyl)-ethyl-carbamic acid tert-butyl ester
|
WO2006054143A1
(en)
*
|
2004-11-17 |
2006-05-26 |
Pfizer Inc. |
Polymorphs of {5-[3-(4,6-difluoro-1h-benzoimidazol-2-yl)-1h-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-ethyl-amine
|
MX2007006066A
(es)
*
|
2004-11-23 |
2007-07-11 |
Celgene Corp |
Inhibidores de jnk para el tratamiento de lesiones del snc.
|
US8110573B2
(en)
|
2004-12-30 |
2012-02-07 |
Astex Therapeutics Limited |
Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases
|
CA2594477C
(en)
|
2005-01-21 |
2016-07-12 |
Astex Therapeutics Limited |
Pharmaceutical compounds
|
CN101146532B
(zh)
|
2005-01-21 |
2012-05-09 |
阿斯泰克斯治疗有限公司 |
药物化合物
|
ES2426482T3
(es)
|
2005-01-27 |
2013-10-23 |
Kyowa Hakko Kirin Co., Ltd. |
Inhibidor de IGF-1R
|
GT200600042A
(es)
*
|
2005-02-10 |
2006-09-27 |
Aventis Pharma Inc |
Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a
|
US20070004777A1
(en)
*
|
2005-03-23 |
2007-01-04 |
Bhagwat Shripad S |
Methods for treating or preventing acute myelogenous leukemia
|
MX2007012116A
(es)
|
2005-03-29 |
2008-04-08 |
Icos Corp |
Derivados de heteroaril urea utiles para inhibir chk1.
|
WO2006130297A2
(en)
*
|
2005-04-29 |
2006-12-07 |
Celgene Corporation |
Solid forms of 1-( 5-(ih-i , 2 , 4 -triazol- 5 -yl)(1h-indazol-3-yl))-3-(2-piperidylethoxy)benzene
|
US8222413B2
(en)
|
2005-05-17 |
2012-07-17 |
Novartis Ag |
Methods for synthesizing heterocyclic compounds
|
US7541367B2
(en)
|
2005-05-31 |
2009-06-02 |
Janssen Pharmaceutica, N.V. |
3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
|
ES2580108T3
(es)
|
2005-07-11 |
2016-08-19 |
Aerie Pharmaceuticals, Inc |
Compuestos de isoquinolina
|
WO2007058626A1
(en)
*
|
2005-11-16 |
2007-05-24 |
S*Bio Pte Ltd |
Indazole compounds
|
EP2772257A1
(en)
|
2005-11-29 |
2014-09-03 |
Novartis AG |
Formulations of quinolinones
|
KR20070077468A
(ko)
*
|
2006-01-23 |
2007-07-26 |
크리스탈지노믹스(주) |
단백질 키나아제 활성을 저해하는 이미다조피리딘 유도체,이의 제조방법 및 이를 함유하는 약학 조성물
|
US20100048660A1
(en)
*
|
2006-02-10 |
2010-02-25 |
Graham Michael Wynne |
Treatment of duchenne muscular dystrophy
|
KR20080106284A
(ko)
*
|
2006-03-23 |
2008-12-04 |
에프. 호프만-라 로슈 아게 |
치환된 인다졸 유도체, 이의 제조 및 약학적 제제로서의 용도
|
CN101484427A
(zh)
|
2006-06-30 |
2009-07-15 |
协和发酵麒麟株式会社 |
Abl激酶抑制剂
|
EP2036894A4
(en)
*
|
2006-06-30 |
2011-01-12 |
Kyowa Hakko Kirin Co Ltd |
AURORA INHIBITOR
|
JPWO2008020606A1
(ja)
*
|
2006-08-16 |
2010-01-07 |
協和発酵キリン株式会社 |
血管新生阻害剤
|
EP2054390B1
(en)
*
|
2006-08-25 |
2012-04-11 |
Abbott Laboratories |
Indazole derivatives that inhibit trpv1 and uses thereof
|
CL2007002617A1
(es)
|
2006-09-11 |
2008-05-16 |
Sanofi Aventis |
Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
|
JP5235887B2
(ja)
|
2006-09-20 |
2013-07-10 |
アエリー ファーマシューティカルズ インコーポレイテッド |
Rhoキナーゼ阻害剤
|
US8916552B2
(en)
|
2006-10-12 |
2014-12-23 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
EP2073807A1
(en)
|
2006-10-12 |
2009-07-01 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
US20100022517A1
(en)
*
|
2006-12-18 |
2010-01-28 |
Richards Lori A |
Ophthalmic formulation of rho kinase inhibitor compound
|
US8071779B2
(en)
|
2006-12-18 |
2011-12-06 |
Inspire Pharmaceuticals, Inc. |
Cytoskeletal active rho kinase inhibitor compounds, composition and use
|
EP2134678A2
(en)
|
2006-12-20 |
2009-12-23 |
Abbott Laboratories |
N-(5, 6, 7, 8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as trpv1 vanilloid receptor antagonists for the treatment of pain
|
US8455513B2
(en)
|
2007-01-10 |
2013-06-04 |
Aerie Pharmaceuticals, Inc. |
6-aminoisoquinoline compounds
|
US8063089B2
(en)
*
|
2007-02-28 |
2011-11-22 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Inhibitors of nucleophosmin (NPM) and methods for inducing apoptosis
|
JPWO2008111441A1
(ja)
|
2007-03-05 |
2010-06-24 |
協和発酵キリン株式会社 |
医薬組成物
|
CN101790526A
(zh)
*
|
2007-06-08 |
2010-07-28 |
雅培制药有限公司 |
用作激酶抑制剂的5-杂芳基取代的吲唑化合物
|
US8648069B2
(en)
|
2007-06-08 |
2014-02-11 |
Abbvie Inc. |
5-substituted indazoles as kinase inhibitors
|
ES2439705T3
(es)
*
|
2007-10-25 |
2014-01-24 |
Genentech, Inc. |
Proceso para la preparación de compuestos de tienopirimidina
|
US8455514B2
(en)
|
2008-01-17 |
2013-06-04 |
Aerie Pharmaceuticals, Inc. |
6-and 7-amino isoquinoline compounds and methods for making and using the same
|
CN102036969A
(zh)
*
|
2008-03-20 |
2011-04-27 |
雅培制药有限公司 |
制造作为trpv1拮抗剂的中枢神经***药剂的方法
|
CN104710365A
(zh)
|
2008-04-28 |
2015-06-17 |
旭化成制药株式会社 |
苯丙酸衍生物及其用途
|
US8106039B2
(en)
*
|
2008-04-30 |
2012-01-31 |
The Trustees Of The University Of Pennsylvania |
Metal complex phosphatidyl-inositol-3-kinase inhibitors
|
US8450344B2
(en)
|
2008-07-25 |
2013-05-28 |
Aerie Pharmaceuticals, Inc. |
Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
|
CA2756568C
(en)
|
2009-04-06 |
2018-02-13 |
University Health Network |
Kinase inhibitors and method of treating cancer with same
|
CA2929545C
(en)
|
2009-05-01 |
2019-04-09 |
Aerie Pharmaceuticals, Inc. |
Dual mechanism inhibitors for the treatment of disease
|
CN102595899A
(zh)
*
|
2009-08-10 |
2012-07-18 |
埃皮瑟瑞克斯有限公司 |
作为wnt/b-联蛋白信号传导途径抑制剂的吲唑及其治疗用途
|
JP5763072B2
(ja)
|
2009-08-10 |
2015-08-12 |
サミュメッド リミテッド ライアビリティ カンパニー |
Wntシグナル経路のインダゾール阻害剤およびその治療的使用
|
UY33001A
(es)
|
2009-11-06 |
2011-05-31 |
Boehringer Ingelheim Int |
Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina
|
BR112012018413A2
(pt)
|
2009-12-21 |
2016-08-09 |
Samumed Llc |
1h-pirazol[3,4-b]piridinas e usos terapêuticos dos mesmos.
|
MX2012011516A
(es)
|
2010-04-06 |
2013-03-08 |
Univ Health Network |
Inhibidores de cinasa, y metodo para tratar el cancer con los mismos.
|
WO2012020725A1
(ja)
*
|
2010-08-10 |
2012-02-16 |
塩野義製薬株式会社 |
Npy y5受容体拮抗作用を有するヘテロ環誘導体
|
DK3311666T3
(da)
|
2010-08-18 |
2021-06-28 |
Biosplice Therapeutics Inc |
Diketoner og hydroxyketoner som aktivatorer af catenin-signalvejen
|
TWI537258B
(zh)
|
2010-11-05 |
2016-06-11 |
百靈佳殷格翰國際股份有限公司 |
六氫茚并吡啶及八氫苯并喹啉之芳基-及雜環芳基羰基衍生物
|
EP2796456A1
(en)
*
|
2010-12-09 |
2014-10-29 |
Amgen Inc. |
Bicyclic compounds as Pim inhibitors
|
AU2012230890A1
(en)
|
2011-03-22 |
2013-09-26 |
Amgen Inc. |
Azole compounds as Pim inhibitors
|
EP2694060A4
(en)
*
|
2011-04-01 |
2014-09-10 |
Univ Utah Res Found |
SUBSTITUTED 3- (1H-BENZO [D] IMIDAZOL-2-YL) -1H-INDAZOLE ANALOGUES AS INHIBITORS OF PDK1 KINASE
|
PL2755483T3
(pl)
|
2011-09-14 |
2019-06-28 |
Samumed, Llc |
Indazolo-3-karboksyamidy i ich zastosowanie jako inhibitorów szlaków sygnalizacji WNT/B-kateniny
|
US9469606B2
(en)
|
2011-10-25 |
2016-10-18 |
The General Hospital Corporation |
Wnt/b-catenin inhibitors and methods of use
|
PH12017500997A1
(en)
|
2012-04-04 |
2018-02-19 |
Samumed Llc |
Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
|
MA37577B1
(fr)
|
2012-05-04 |
2018-05-31 |
Samumed Llc |
1h-pyrazolo[3,4-b]pyridines et leurs utilisations thérapeutiques
|
WO2014041518A1
(en)
*
|
2012-09-14 |
2014-03-20 |
Glenmark Pharmaceuticals S.A. |
Thienopyrrole derivatives as itk inhibitors
|
JP6355648B2
(ja)
*
|
2013-01-08 |
2018-07-11 |
サミュメッド リミテッド ライアビリティ カンパニー |
Wntシグナル伝達経路の3−(ベンゾイミダゾール−2−イル)−インダゾール阻害剤およびそれらの治療的使用
|
CN104370889A
(zh)
*
|
2013-01-24 |
2015-02-25 |
韩冰 |
一类降低眼压的化合物及其制备方法和用途
|
EP2968249B1
(en)
|
2013-02-22 |
2018-11-14 |
Samumed, LLC |
Gamma-diketones as wnt/beta -catenin signaling pathway activators
|
EP2964221B1
(en)
|
2013-03-04 |
2017-12-06 |
Merck Sharp & Dohme Corp. |
Compounds inhibiting leucine-rich repeat kinase enzyme activity
|
WO2014134776A1
(en)
|
2013-03-04 |
2014-09-12 |
Merck Sharp & Dohme Corp. |
Compounds inhibiting leucine-rich repeat kinase enzyme activity
|
WO2014134772A1
(en)
|
2013-03-04 |
2014-09-12 |
Merck Sharp & Dohme Corp. |
Compounds inhibiting leucine-rich repeat kinase enzyme activity
|
WO2014134774A1
(en)
|
2013-03-04 |
2014-09-12 |
Merck Sharp & Dohme Corp. |
Compounds inhibiting leucine-rich repeat kinase enzyme activity
|
PL3811943T3
(pl)
|
2013-03-15 |
2023-06-12 |
Aerie Pharmaceuticals, Inc. |
Związek do stosowania w leczeniu zaburzeń oczu
|
ES2656475T3
(es)
|
2013-07-31 |
2018-02-27 |
Council Of Scientific & Industrial Research |
Nuevos compuestos de indazol y un proceso para la preparación de éstos
|
EP3057593B1
(en)
|
2013-10-18 |
2021-12-08 |
University Health Network |
Treatment for pancreatic cancer
|
AU2015292425B2
(en)
|
2014-07-24 |
2018-12-20 |
Beta Pharma, Inc. |
2-H-indazole derivatives as cyclin-dependent kinase (CDK) inhibitors and therapeutic uses thereof
|
KR102165385B1
(ko)
|
2014-08-20 |
2020-10-15 |
사뮤메드, 엘엘씨 |
피부 노화 및 주름의 치료 및 예방을 위한 감마-디케톤
|
WO2016040193A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
|
WO2016040185A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
|
WO2016040180A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040190A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
|
WO2016040188A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040182A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
|
WO2016040181A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040184A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
GB201506658D0
(en)
|
2015-04-20 |
2015-06-03 |
Cellcentric Ltd |
Pharmaceutical compounds
|
GB201506660D0
(en)
|
2015-04-20 |
2015-06-03 |
Cellcentric Ltd |
Pharmaceutical compounds
|
GB201511382D0
(en)
|
2015-06-29 |
2015-08-12 |
Imp Innovations Ltd |
Novel compounds and their use in therapy
|
WO2017023975A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
|
WO2017023996A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
|
US10392383B2
(en)
|
2015-08-03 |
2019-08-27 |
Samumed, Llc |
3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
WO2017023972A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
US10519169B2
(en)
|
2015-08-03 |
2019-12-31 |
Samumed, Llc |
3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
WO2017024004A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
WO2017023980A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
|
US10329309B2
(en)
|
2015-08-03 |
2019-06-25 |
Samumed, Llc |
3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
WO2017024010A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
|
US10206908B2
(en)
|
2015-08-03 |
2019-02-19 |
Samumed, Llc |
3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
|
WO2017023988A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
WO2017024021A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc |
3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
|
US10166218B2
(en)
|
2015-08-03 |
2019-01-01 |
Samumed, Llc |
3-(1H-indol-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
|
US10231956B2
(en)
|
2015-08-03 |
2019-03-19 |
Samumed, Llc |
3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
US10604512B2
(en)
|
2015-08-03 |
2020-03-31 |
Samumed, Llc |
3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof
|
US10226448B2
(en)
|
2015-08-03 |
2019-03-12 |
Samumed, Llc |
3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof
|
WO2017023993A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
CN107922349B
(zh)
*
|
2015-08-07 |
2021-05-07 |
哈尔滨珍宝制药有限公司 |
作为fgfr和vegfr抑制剂的乙烯基化合物
|
US10899757B2
(en)
|
2015-11-06 |
2021-01-26 |
Samumed, Llc |
2-(1H-indazol-3-yl)-3H-imidazo[4,5-C]pyridines and their anti-inflammatory uses thereof
|
CA3005707C
(en)
|
2015-11-17 |
2023-11-21 |
Aerie Pharmaceuticals, Inc. |
Process for the preparation of kinase inhibitors and intermediates thereof
|
US9643927B1
(en)
|
2015-11-17 |
2017-05-09 |
Aerie Pharmaceuticals, Inc. |
Process for the preparation of kinase inhibitors and intermediates thereof
|
AR108325A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
AR108326A1
(es)
|
2016-04-27 |
2018-08-08 |
Samumed Llc |
Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
|
MD3464285T2
(ro)
|
2016-06-01 |
2023-01-31 |
Biosplice Therapeutics Inc |
Procedeu pentru prepararea N-(5-(3-(7-(3-fluorfenil)-3H-imidazo[4,5-c]piridin-2-il)-1H-indazol-5-il)piridin-3-il)-3-metilbutanamidei
|
EP3483142A4
(en)
*
|
2016-07-05 |
2019-05-15 |
Guangzhou Maxinovel Pharmaceuticals Co., Ltd. |
AROMATIC ACETYLENE OR AROMATIC ETHYLENE COMPOUND, INTERMEDIATE PRODUCT, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
|
WO2018013430A2
(en)
|
2016-07-12 |
2018-01-18 |
Arisan Therapeutics Inc. |
Heterocyclic compounds for the treatment of arenavirus infection
|
US11389441B2
(en)
|
2016-08-31 |
2022-07-19 |
Aerie Pharmaceuticals, Inc. |
Ophthalmic compositions
|
MX2019004616A
(es)
*
|
2016-10-21 |
2019-11-21 |
Samumed Llc |
Métodos de uso de indazol-3-carboxamidas y su uso como inhibidores de la ruta de señalización de wnt/b-catenina.
|
MA46696A
(fr)
|
2016-11-07 |
2019-09-11 |
Samumed Llc |
Formulations injectables à dose unique prêtes à l'emploi
|
JP2020515583A
(ja)
|
2017-03-31 |
2020-05-28 |
アエリエ ファーマシューティカルズ インコーポレイテッド |
アリールシクロプロピル−アミノ−イソキノリニルアミド化合物
|
US10604514B2
(en)
|
2017-10-19 |
2020-03-31 |
Samumed, Llc |
6-(5-membered heteroaryl)isoquinolin-3-yl carboxamides and preparation and use thereof
|
WO2019084497A1
(en)
|
2017-10-27 |
2019-05-02 |
Samumed, Llc |
6- (HETEROARYL AND ARYL WITH 6 CHAINS) ISOQUINOLIN-3-YL CARBOXAMIDES, THEIR PREPARATION AND THEIR USE
|
WO2019084496A1
(en)
|
2017-10-27 |
2019-05-02 |
Samumed, Llc |
6- (HETEROARYL 5-CHAIN) ISOQUINOLIN-3-YL- (HETEROARYL 5-CHAIN) CARBOXAMIDES, PREPARATION AND USE
|
US10703748B2
(en)
|
2017-10-31 |
2020-07-07 |
Samumed, Llc |
Diazanaphthalen-3-yl carboxamides and preparation and use thereof
|
JP7293560B2
(ja)
|
2017-12-29 |
2023-06-20 |
グアンジョウ マキシノベル ファーマシューティカルズ カンパニー リミテッド |
芳香族ビニルまたは芳香族エチル系誘導体、その製造方法、中間体、薬物組成物および使用
|
AU2019224075A1
(en)
|
2018-02-23 |
2020-09-10 |
Samumed, Llc |
5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
|
US10759799B2
(en)
|
2018-06-15 |
2020-09-01 |
Samumed, Llc |
Indazole containing macrocycles and therapeutic uses thereof
|
CA3112391A1
(en)
|
2018-09-14 |
2020-03-19 |
Aerie Pharmaceuticals, Inc. |
Aryl cyclopropyl-amino-isoquinolinyl amide compounds
|
WO2020150545A1
(en)
|
2019-01-17 |
2020-07-23 |
Samumed, Llc |
Pyrazole derivatives as modulators of the wnt/b-catenin signaling pathway
|
EP4056558A4
(en)
*
|
2019-11-06 |
2023-12-27 |
Jinan University |
INDAZOLE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND ITS APPLICATIONS
|
WO2021125229A1
(ja)
*
|
2019-12-17 |
2021-06-24 |
富士フイルム株式会社 |
インダゾール化合物またはその塩および医薬組成物
|
WO2021121420A1
(zh)
*
|
2019-12-20 |
2021-06-24 |
江苏凯迪恩医药科技有限公司 |
苯并吡唑类化合物及其中间体、制备方法和应用
|
WO2021168341A1
(en)
|
2020-02-21 |
2021-08-26 |
Samumed, Llc |
Solid forms of 1-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-n,n-dimethylmethanamine
|
CN112724134B
(zh)
*
|
2021-01-14 |
2022-04-01 |
复旦大学 |
氮杂吲唑联吡啶衍生物髓细胞增殖抑制剂及其制备方法与在制药中的应用
|
WO2023240138A1
(en)
*
|
2022-06-08 |
2023-12-14 |
Blossomhill Therapeutics, Inc. |
Indazole containing macrocycles and their use
|