EA200200768A1 - Соединения индазола, фармацевтические композиции и методы модуляции или ингибирования клеточной пролиферации - Google Patents

Соединения индазола, фармацевтические композиции и методы модуляции или ингибирования клеточной пролиферации

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Publication number
EA200200768A1
EA200200768A1 EA200200768A EA200200768A EA200200768A1 EA 200200768 A1 EA200200768 A1 EA 200200768A1 EA 200200768 A EA200200768 A EA 200200768A EA 200200768 A EA200200768 A EA 200200768A EA 200200768 A1 EA200200768 A1 EA 200200768A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
pharmaceutical compositions
inhibition
modulation
cell proliferation
Prior art date
Application number
EA200200768A
Other languages
English (en)
Inventor
Зигфрид Хайнц Райх
Тед Майкл Блекман
Сьюзан Элизабет Кефарт
Уильям Генри Ромайнз III
Майкл Б. Уоллас
Original Assignee
Агурон Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Агурон Фармасьютикалз, Инк. filed Critical Агурон Фармасьютикалз, Инк.
Publication of EA200200768A1 publication Critical patent/EA200200768A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22D—CASTING OF METALS; CASTING OF OTHER SUBSTANCES BY THE SAME PROCESSES OR DEVICES
    • B22D41/00—Casting melt-holding vessels, e.g. ladles, tundishes, cups or the like
    • B22D41/50—Pouring-nozzles
    • B22D41/56—Means for supporting, manipulating or changing a pouring-nozzle
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

Описаны соединения индазола, которые модулируют и/или ингибируют клеточную пролиферацию, как например, активность протеинкиназ. Эти соединения и содержащие их фармацевтические композиции обладают способностью, в частности, вызывать модуляцию и/или ингибирование нежелательной клеточной пролиферации. Настоящее изобретение относится к терапевтическому или профилактическому использованию фармацевтических композиций, содержащих такие соединения, а также к их применению в методах лечения раковых и других заболеваний, связанных с нежелательными явлениями ангиогенеза и/или клеточной пролиферации, таких как диабетическая ретинопатия, неоваскулярная глаукома, ревматоидный артрит и псориаз, посредством введения эффективных количеств таких соединений.Отчет о международном поиске был опубликован 2001.12.27.
EA200200768A 2000-01-18 2001-01-18 Соединения индазола, фармацевтические композиции и методы модуляции или ингибирования клеточной пролиферации EA200200768A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17648400P 2000-01-18 2000-01-18
PCT/US2001/001477 WO2001053268A2 (en) 2000-01-18 2001-01-18 Indazole compounds, pharmaceutical compositions, and their use for mediating or inhibiting cell proliferation

Publications (1)

Publication Number Publication Date
EA200200768A1 true EA200200768A1 (ru) 2003-02-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200768A EA200200768A1 (ru) 2000-01-18 2001-01-18 Соединения индазола, фармацевтические композиции и методы модуляции или ингибирования клеточной пролиферации

Country Status (39)

Country Link
US (4) US6555539B2 (ru)
EP (1) EP1250326A2 (ru)
JP (1) JP2003520273A (ru)
KR (1) KR20020073505A (ru)
CN (1) CN1394205A (ru)
AP (1) AP1609A (ru)
AR (1) AR032438A1 (ru)
AU (1) AU785013B2 (ru)
BG (1) BG107011A (ru)
BR (1) BR0107783A (ru)
CA (1) CA2388885A1 (ru)
CO (1) CO5280070A1 (ru)
CR (1) CR6630A (ru)
DO (1) DOP2001000120A (ru)
DZ (1) DZ3301A1 (ru)
EA (1) EA200200768A1 (ru)
EE (1) EE200200398A (ru)
GE (1) GEP20043363B (ru)
GT (1) GT200100009A (ru)
HN (1) HN2001000007A (ru)
HR (1) HRP20020675A2 (ru)
HU (1) HUP0203965A3 (ru)
IL (1) IL150730A0 (ru)
IS (1) IS6474A (ru)
MA (1) MA27589A1 (ru)
MX (1) MXPA02007058A (ru)
MY (1) MY136604A (ru)
NO (1) NO20022117L (ru)
NZ (1) NZ518531A (ru)
OA (1) OA12160A (ru)
PA (1) PA8509901A1 (ru)
PE (1) PE20011334A1 (ru)
PL (1) PL357590A1 (ru)
SK (1) SK10052002A3 (ru)
SV (1) SV2002000293A (ru)
UA (1) UA75880C2 (ru)
WO (1) WO2001053268A2 (ru)
YU (1) YU54202A (ru)
ZA (1) ZA200203040B (ru)

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RU2770613C2 (ru) * 2016-10-21 2022-04-19 СЭМЬЮМЕД, ЭлЭлСи Способы применения индазол-3-карбоксамидов и их применение в качестве ингибиторов сигнального пути wnt/в-катенина
US11446288B2 (en) 2016-11-07 2022-09-20 Biosplice Therapeutics, Inc. Single-dose, ready-to-use injectable formulations
US11560378B2 (en) 2015-11-06 2023-01-24 Biosplice Therapeutics, Inc. Treatment of osteoarthritis

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US11560378B2 (en) 2015-11-06 2023-01-24 Biosplice Therapeutics, Inc. Treatment of osteoarthritis
US11667632B2 (en) 2015-11-06 2023-06-06 Biosplice Therapeutics, Inc. 2-(1H-indazol-3-yl)-3H-imidazo[4,5-C]pyridines and their anti-inflammatory uses thereof
RU2770613C2 (ru) * 2016-10-21 2022-04-19 СЭМЬЮМЕД, ЭлЭлСи Способы применения индазол-3-карбоксамидов и их применение в качестве ингибиторов сигнального пути wnt/в-катенина
US11684615B2 (en) 2016-10-21 2023-06-27 Biosplice Therapeutics, Inc. Methods of using indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors
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US11819499B2 (en) 2016-11-07 2023-11-21 Biosplice Therapeutics, Inc. Single-dose, ready-to-use injectable formulations

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