FR2831537B1 - Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation - Google Patents

Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation

Info

Publication number
FR2831537B1
FR2831537B1 FR0113868A FR0113868A FR2831537B1 FR 2831537 B1 FR2831537 B1 FR 2831537B1 FR 0113868 A FR0113868 A FR 0113868A FR 0113868 A FR0113868 A FR 0113868A FR 2831537 B1 FR2831537 B1 FR 2831537B1
Authority
FR
France
Prior art keywords
medicaments
preparation
pharmaceutical compositions
benzimidazole derivatives
novel benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0113868A
Other languages
English (en)
Other versions
FR2831537A1 (fr
Inventor
Fabienne Babin
Brun Alain Le
Lazo Laurence Gauzy
Herve Bouchard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0113868A priority Critical patent/FR2831537B1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to BR0213562-0A priority patent/BR0213562A/pt
Priority to AU2002334217A priority patent/AU2002334217B2/en
Priority to IL16157602A priority patent/IL161576A0/xx
Priority to EP02801954A priority patent/EP1441725A1/fr
Priority to PCT/GB2002/004763 priority patent/WO2003035065A1/fr
Priority to MXPA04003954A priority patent/MXPA04003954A/es
Priority to HN2002000311A priority patent/HN2002000311A/es
Priority to US10/279,834 priority patent/US6897208B2/en
Priority to CA2465247A priority patent/CA2465247C/fr
Priority to JP2003537632A priority patent/JP5039268B2/ja
Priority to GT200200219A priority patent/GT200200219A/es
Priority to SV2002001369A priority patent/SV2008001369A/es
Priority to UY27516A priority patent/UY27516A1/es
Priority to PA20028557101A priority patent/PA8557101A1/es
Priority to ARP020104061A priority patent/AR037032A1/es
Priority to PE2002001052A priority patent/PE20030612A1/es
Priority to JO2002108A priority patent/JO2339B1/en
Publication of FR2831537A1 publication Critical patent/FR2831537A1/fr
Priority to US11/029,064 priority patent/US8288425B2/en
Application granted granted Critical
Publication of FR2831537B1 publication Critical patent/FR2831537B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
FR0113868A 2001-10-26 2001-10-26 Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation Expired - Fee Related FR2831537B1 (fr)

Priority Applications (19)

Application Number Priority Date Filing Date Title
FR0113868A FR2831537B1 (fr) 2001-10-26 2001-10-26 Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation
IL16157602A IL161576A0 (en) 2001-10-26 2002-10-24 Benzimidazoles and analogues and their use as protein kinases inhibitors
AU2002334217A AU2002334217B2 (en) 2001-10-26 2002-10-24 Benzimidazoles and analogues and their use as protein kinases inhibitors
EP02801954A EP1441725A1 (fr) 2001-10-26 2002-10-24 Benzimidazoles et analogues et leur utilisation comme inhibiteurs de proteines kinases
PCT/GB2002/004763 WO2003035065A1 (fr) 2001-10-26 2002-10-24 Benzimidazoles et analogues et leur utilisation comme inhibiteurs de proteines kinases
MXPA04003954A MXPA04003954A (es) 2001-10-26 2002-10-24 Bencimidazoles.
HN2002000311A HN2002000311A (es) 2001-10-26 2002-10-24 Benzoimidazoles
US10/279,834 US6897208B2 (en) 2001-10-26 2002-10-24 Benzimidazoles
CA2465247A CA2465247C (fr) 2001-10-26 2002-10-24 Benzimidazoles et analogues et leur utilisation comme inhibiteurs de proteines kinases
JP2003537632A JP5039268B2 (ja) 2001-10-26 2002-10-24 ベンゾイミダゾールおよび類縁体および蛋白キナーゼ阻害剤としてのその使用
BR0213562-0A BR0213562A (pt) 2001-10-26 2002-10-24 Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna
PE2002001052A PE20030612A1 (es) 2001-10-26 2002-10-25 Benzoimidazoles
SV2002001369A SV2008001369A (es) 2001-10-26 2002-10-25 Benzimidazoles
UY27516A UY27516A1 (es) 2001-10-26 2002-10-25 Bencimidazoles
PA20028557101A PA8557101A1 (es) 2001-10-26 2002-10-25 Benzimidazoles
ARP020104061A AR037032A1 (es) 2001-10-26 2002-10-25 Benzoimidazoles
GT200200219A GT200200219A (es) 2001-10-26 2002-10-25 Bencimidazoles
JO2002108A JO2339B1 (en) 2001-10-26 2002-10-27 Benzamidazole compounds
US11/029,064 US8288425B2 (en) 2001-10-26 2005-01-04 Benzimidazoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0113868A FR2831537B1 (fr) 2001-10-26 2001-10-26 Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation

Publications (2)

Publication Number Publication Date
FR2831537A1 FR2831537A1 (fr) 2003-05-02
FR2831537B1 true FR2831537B1 (fr) 2008-02-29

Family

ID=8868756

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0113868A Expired - Fee Related FR2831537B1 (fr) 2001-10-26 2001-10-26 Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation

Country Status (2)

Country Link
FR (1) FR2831537B1 (fr)
GT (1) GT200200219A (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854159B1 (fr) * 2003-04-25 2008-01-11 Aventis Pharma Sa Nouveaux derives de l'indole, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de kdr
AR045037A1 (es) * 2003-07-10 2005-10-12 Aventis Pharma Sa Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion.
FR2857363B1 (fr) * 2003-07-10 2007-09-07 Aventis Pharma Sa 4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c] pyridines substituees compositions les contenant et utilisation
EP2641906B1 (fr) 2009-07-08 2015-04-22 Dermira (Canada), Inc. Analogues de tofa utiles dans le traitement de troubles ou états dermatologiques
CA2770195C (fr) * 2009-08-07 2015-10-13 Chugai Seiyaku Kabushiki Kaisha Derive d'aminopyrazole
DK3087986T3 (da) 2013-12-27 2019-12-02 Chugai Pharmaceutical Co Ltd Mutant fgfr-gatekeepergen og aktivt stof rettet mod samme
JP6762300B2 (ja) 2015-06-17 2020-09-30 中外製薬株式会社 アミノピラゾール誘導体
EP3296297A1 (fr) * 2016-09-15 2018-03-21 Centre National De La Recherche Scientifique Dérivés de benzimidazole pour le traitement d'infection par un filovirus

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2130030A1 (de) * 1971-06-18 1972-12-21 Bayer Ag Fungizide und bakterizide Mittel
DE2130029A1 (de) * 1971-06-18 1972-12-21 Bayer Ag Verfahren zur Herstellung von 2-[Pyrazolyl-(1)]-benzimidazolen
BE793501A (fr) * 1971-12-31 1973-06-29 Ciba Geigy Composes heterocycliques et produits phytopharmaceutiques qui en contiennent
JP4357004B2 (ja) * 1997-04-11 2009-11-04 あすか製薬株式会社 ピラゾール誘導体およびそれを含有するｃｏｘ阻害剤
RS50340B (sr) * 1999-06-23 2009-11-10 Sanofi-Aventis Deutschland Gmbh., Supstituisani benzimidazoli
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
YU54202A (sh) * 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije

Also Published As

Publication number Publication date
FR2831537A1 (fr) 2003-05-02
GT200200219A (es) 2003-07-11

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Effective date: 20160630