BR112012018413A2 - 1h-pirazol[3,4-b]piridinas e usos terapêuticos dos mesmos. - Google Patents

1h-pirazol[3,4-b]piridinas e usos terapêuticos dos mesmos.

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Publication number
BR112012018413A2
BR112012018413A2 BR112012018413A BR112012018413A BR112012018413A2 BR 112012018413 A2 BR112012018413 A2 BR 112012018413A2 BR 112012018413 A BR112012018413 A BR 112012018413A BR 112012018413 A BR112012018413 A BR 112012018413A BR 112012018413 A2 BR112012018413 A2 BR 112012018413A2
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BR
Brazil
Prior art keywords
pyridines
pyrazol
therapeutic uses
breast cancer
cancers
Prior art date
Application number
BR112012018413A
Other languages
English (en)
Inventor
David Mark Wallace
John Hood
Sunil Kumar Kc
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of BR112012018413A2 publication Critical patent/BR112012018413A2/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

patente de invenção: 1h-pirazol[3,4-b]piridinas e usos terapêuticos dos mesmos. são aqui propostos compostos de acordo com a fórmula i e os sais farmaceuticamente aceitáveis dos mesmos, e a composições compreendendo esses compostos, para uso em variados métodos, incluindo o tratamento de cânceres, como câncer de cólon, ovariano, pancreático, câncer de mama, câncer de fígado, câncer de próstata e cânceres hematológicos.
BR112012018413A 2009-12-21 2010-12-15 1h-pirazol[3,4-b]piridinas e usos terapêuticos dos mesmos. BR112012018413A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28854409P 2009-12-21 2009-12-21
PCT/US2010/060514 WO2011084486A1 (en) 2009-12-21 2010-12-15 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
BR112012018413A2 true BR112012018413A2 (pt) 2016-08-09

Family

ID=44305706

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012018413A BR112012018413A2 (pt) 2009-12-21 2010-12-15 1h-pirazol[3,4-b]piridinas e usos terapêuticos dos mesmos.

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US (8) US8450340B2 (pt)
EP (3) EP3001903B1 (pt)
JP (3) JP5822844B2 (pt)
CN (2) CN102821607B (pt)
BR (1) BR112012018413A2 (pt)
CA (2) CA2986631C (pt)
CY (1) CY1119844T1 (pt)
DK (1) DK3001903T3 (pt)
ES (2) ES2550820T3 (pt)
HK (2) HK1223247A1 (pt)
HR (1) HRP20171893T1 (pt)
HU (1) HUE035612T2 (pt)
LT (1) LT3001903T (pt)
NO (1) NO3001903T3 (pt)
PL (1) PL3001903T3 (pt)
PT (1) PT3001903T (pt)
RS (1) RS56669B1 (pt)
SI (1) SI3001903T1 (pt)
WO (1) WO2011084486A1 (pt)

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