BRPI0509580A - combinações de inibidores de transdução de sinal - Google Patents

combinações de inibidores de transdução de sinal

Info

Publication number
BRPI0509580A
BRPI0509580A BRPI0509580-8A BRPI0509580A BRPI0509580A BR PI0509580 A BRPI0509580 A BR PI0509580A BR PI0509580 A BRPI0509580 A BR PI0509580A BR PI0509580 A BRPI0509580 A BR PI0509580A
Authority
BR
Brazil
Prior art keywords
combinations
inhibitors
signal transduction
combination
specifically
Prior art date
Application number
BRPI0509580-8A
Other languages
English (en)
Inventor
Stephen Louis Eck
Daniel William Fry
Judith Ann Salsbery Leopold
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0509580A publication Critical patent/BRPI0509580A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

Abstract

COMBINAçõES DE INIBIDORES DE TRANSDUçãO DE SINAL. A presente invenção refere-se aos métodos para tratamento de câncer compreendendo emprego de uma combinação de inibidores de transdução de sinal. Mais especificamente, a presente invenção se refere às combinações dos assim chamados inibidores do ciclo celular com inibidores de transdução de sinal de cinase estimulados por mitogênio, mais especificamente combinações de inibidores de CDK com inibidores de transdução de sinal de cinase estimulados por mitogênio, mais preferivelmente inibidores de MEK. Outras concretizações da invenção se referem às combinações adicionais das combinações mencionadas anteriormente com agentes anticâncer padrão tais como, agentes citotóxicos, paliativos e antiangiogênicos. Mais especificamente essa invenção se refere às combinações de 6-acetil-8-ciclopentil-5-metil-2-(5-piperazin-1-il-piridin-2-ilamino)-8H-pir ido¢2,3-d! pirimidin-7-ona incluindo formas de sal, que é um inibidor seletivo de cina-se ciclina dependente(CDK4), em combinação com um ou mais inibidores de MEK, mais preferivelmente N-¢(R)-2,3-dihidróxi-propóxi!-3,4-diflúor-2-(2-flúor-4-iodo-fenilamino)-b enzamida. As combinações mencionadas anteriormente são úteis para tratamento de inflamação e doenças proliferativas celulares tais como, câncer e restenoses.
BRPI0509580-8A 2004-03-30 2005-03-18 combinações de inibidores de transdução de sinal BRPI0509580A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55762304P 2004-03-30 2004-03-30
PCT/IB2005/000720 WO2005094830A1 (en) 2004-03-30 2005-03-18 Combinations of signal transduction inhibitors

Publications (1)

Publication Number Publication Date
BRPI0509580A true BRPI0509580A (pt) 2007-11-27

Family

ID=34962238

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509580-8A BRPI0509580A (pt) 2004-03-30 2005-03-18 combinações de inibidores de transdução de sinal

Country Status (6)

Country Link
US (1) US20050222163A1 (pt)
EP (1) EP1740184A1 (pt)
JP (1) JP2007530654A (pt)
BR (1) BRPI0509580A (pt)
CA (1) CA2561516A1 (pt)
WO (1) WO2005094830A1 (pt)

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JP2007530654A (ja) 2007-11-01
CA2561516A1 (en) 2005-10-13
WO2005094830A1 (en) 2005-10-13
US20050222163A1 (en) 2005-10-06
EP1740184A1 (en) 2007-01-10

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