AR108325A1 - Isoquinolin-3-il carboxamidas y preparación y uso de las mismas - Google Patents
Isoquinolin-3-il carboxamidas y preparación y uso de las mismasInfo
- Publication number
- AR108325A1 AR108325A1 ARP170101055A ARP170101055A AR108325A1 AR 108325 A1 AR108325 A1 AR 108325A1 AR P170101055 A ARP170101055 A AR P170101055A AR P170101055 A ARP170101055 A AR P170101055A AR 108325 A1 AR108325 A1 AR 108325A1
- Authority
- AR
- Argentina
- Prior art keywords
- unsubstituted
- alkylene
- optionally substituted
- group
- haloalkyl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Abstract
Se divulgan compuestos isoquinolina para tratar diversas enfermedades y patologías. Más específicamente, se refiere al uso de un compuesto isoquinolina o a análogos del mismo, en el tratamiento de trastornos caracterizados por la activación de la señalización de la vía de Wnt (por ejemplo, cáncer, proliferación celular anormal, angiogénesis, trastornos fibróticos, enfermedades óseas y de los cartílagos y osteoartritis), la modulación de eventos celulares mediados por la señalización de la vía de Wnt, así como enfermedades genéticas y condiciones / trastornos / enfermedades neurológicas debido a mutaciones o la desregulación de la vía de Wnt y/o de uno o más componentes de la señalización de Wnt. También se proveen métodos para tratar estados de enfermedad relacionados con Wnt. Reivindicación 1: Un compuesto o una sal farmacéuticamente aceptable del mismo, de la fórmula (1), en donde: R¹, R², R⁴ y R⁵ se seleccionan independientemente del grupo que consiste en H, haluro, amino, -(haloalquilo C₁₋₃) no sustituido y -(alquilo C₁₋₃) no sustituido; R³ es un heteroarilo de 5 miembros opcionalmente sustituido con 1 - 4 R⁴⁵; R⁶ se selecciona del grupo que consiste en -fenilo sustituido con 1 - 5 R³⁶, -(alquileno C₁₋₃)ₚ-piridinilo opcionalmente sustituido con 1 - 6 R³⁷ y un heteroarilo de 6 - 10 miembros opcionalmente sustituido con 1 - 6 R³⁷; en donde el carbonilo de la fórmula (1) está unido a un anillo aromático del heteroarilo; en donde el -(alquileno C₁₋₃) se sustituye opcionalmente con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R³⁶ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₉) no sustituido, -(alquenilo C₂₋₉) no sustituido, -(alquinilo C₂₋₉) no sustituido, -(haloalquilo C₁₋₉) no sustituido, -XR⁴², -C(=O)N(R⁴⁷)₂, -(alquileno C₁₋₄)ₚ-N(R⁵⁰)₂, -(alquileno C₁₋₄)ₚ-heterociclilo opcionalmente sustituido con 1 - 10 R⁴³ y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R³⁷ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₉) no sustituido, -(alquenilo C₂₋₉) no sustituido, -(alquinilo C₂₋₉) no sustituido, -(haloalquilo C₁₋₉) no sustituido, -XR⁴², -C(=O)N(R⁴⁷)₂, -(alquileno C₁₋₄)ₚ-N(R⁵⁰)₂, -(alquileno C₁₋₄)ₚ-heterociclilo opcionalmente sustituido con 1 - 10 R⁴³ y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R³⁸ se selecciona independientemente del grupo que consisto en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido, -CN y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R³⁹ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido, -CN y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R⁴⁰ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido, -CN y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R⁴¹ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido y -CN; cada R⁴² se selecciona independientemente del grupo que consiste en H, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido, -(alquileno C₁₋₄)N(R⁴⁸)₂, -(alquileno C₁₋₄)ₚ-arilo opcionalmente sustituido con 1 - 10 R⁴⁶, -(alquileno C₁₋₄)ₚ-heterociclilo opcionalmente sustituido con 1 - 12 R⁴³ y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R⁴³ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido, -CN, -OH, -C(=O)R⁵¹, -N(R⁵⁰)₂ y -(alquileno C₁₋₄)ₚ-carbociclilo opcionalmente sustituido con 1 - 12 R⁴⁴; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R⁴⁴ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido y -CN; cada R⁴⁵ se selecciona independientemente del grupo que consiste en haluro, -(alquilo C₁₋₉) no sustituido, -(alquenilo C₂₋₉) no sustituido, -(alquinilo C₂₋₉) no sustituido, -(haloalquilo C₁₋₉) no sustituido, -(alquileno C₁₋₄)ₚ-N(R⁴⁸)₂, -(alquileno C₁₋₄)ₚ-OR⁴⁹, -C(=O)N(R⁴⁸)₂, -(alquileno C₁₋₄)ₚ-heterociclilo opcionalmente sustituido con 1 - 10 R³⁸, -carbociclilo opcionalmente sustituido con 1 - 12 R³⁹; en donde cada -(alquileno C₁₋₄) se sustituye opcionalmente, en forma independiente, con uno o más sustituyentes definidos en cualquier lugar de la presente; alternativamente, dos R⁴⁵ adyacentes tomados juntos forman un anillo que se selecciona del grupo que consiste en -heterociclilo opcionalmente sustituido con 1 - 10 R⁴⁰ y -carbociclilo opcionalmente sustituido con 1 - 12 R⁴¹; cada R⁴⁶ se selecciona independientemente del grupo que consiste en -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido y -CN; cada R⁴⁷ se selecciona independientemente del grupo que consiste en H, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido y -(haloalquilo C₁₋₅) no sustituido; cada R⁴⁸ se selecciona del grupo que consiste en H, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido; cada R⁴⁹ se selecciona independientemente del grupo que consiste en H, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido y -(haloalquilo C₁₋₅) no sustituido; cada R⁵⁰ se selecciona independientemente del grupo que consiste en H, -(alquilo C₁₋₅) no sustituido, -(alquenilo C₂₋₅) no sustituido, -(alquinilo C₂₋₅) no sustituido, -(haloalquilo C₁₋₅) no sustituido y -(alquileno C₁₋₄)N(R⁴⁸)₂; en donde el -(alquileno C₁₋₄) se sustituye opcionalmente con uno o más sustituyentes definidos en cualquier lugar de la presente; cada R⁵¹ es un heteroarilo opcionalmente sustituido con 1 - 6 R⁵²; cada R⁵² es un -heterociclilo opcionalmente sustituido con 1 - 10 R⁴⁶; cada X se selecciona del grupo que consiste en O, S y NR⁴⁸; y cada p es independientemente 0 ó 1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201662328255P | 2016-04-27 | 2016-04-27 |
Publications (1)
Publication Number | Publication Date |
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AR108325A1 true AR108325A1 (es) | 2018-08-08 |
Family
ID=60157337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP170101055A AR108325A1 (es) | 2016-04-27 | 2017-04-26 | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
Country Status (28)
Country | Link |
---|---|
US (7) | US10106527B2 (es) |
EP (2) | EP3448386B1 (es) |
JP (1) | JP6993985B2 (es) |
KR (1) | KR102374844B1 (es) |
CN (1) | CN109310690B (es) |
AR (1) | AR108325A1 (es) |
AU (1) | AU2017258193B2 (es) |
CA (1) | CA3022002A1 (es) |
CL (2) | CL2018003065A1 (es) |
CO (1) | CO2018012299A2 (es) |
CY (1) | CY1124302T1 (es) |
DK (1) | DK3448386T3 (es) |
ES (1) | ES2865374T3 (es) |
HR (1) | HRP20210607T1 (es) |
HU (1) | HUE054103T2 (es) |
IL (1) | IL262470B (es) |
LT (1) | LT3448386T (es) |
MA (1) | MA43619B1 (es) |
MD (1) | MD3448386T2 (es) |
MX (1) | MX2018013174A (es) |
PE (1) | PE20190326A1 (es) |
PH (1) | PH12018502258A1 (es) |
PL (1) | PL3448386T3 (es) |
PT (1) | PT3448386T (es) |
RS (1) | RS61879B1 (es) |
SG (2) | SG10201914054SA (es) |
SI (1) | SI3448386T1 (es) |
WO (1) | WO2017189829A1 (es) |
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PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
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CN113750101A (zh) | 2015-12-10 | 2021-12-07 | Ptc医疗公司 | 用于治疗亨廷顿病的方法 |
AR108326A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為RORγT調節劑之6-胺基吡啶-3-基噻唑 |
AR108325A1 (es) * | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
TW201843139A (zh) | 2017-03-30 | 2018-12-16 | 瑞士商赫孚孟拉羅股份公司 | 作為hpk1之抑制劑的異喹啉 |
SG11201911615WA (en) | 2017-06-05 | 2020-01-30 | Ptc Therapeutics Inc | Compounds for treating huntington's disease |
MX2019015578A (es) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
CA3067592A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methods for treating huntington's disease |
US10604514B2 (en) | 2017-10-19 | 2020-03-31 | Samumed, Llc | 6-(5-membered heteroaryl)isoquinolin-3-yl carboxamides and preparation and use thereof |
WO2019084496A1 (en) | 2017-10-27 | 2019-05-02 | Samumed, Llc | 6- (HETEROARYL 5-CHAIN) ISOQUINOLIN-3-YL- (HETEROARYL 5-CHAIN) CARBOXAMIDES, PREPARATION AND USE |
WO2019084497A1 (en) | 2017-10-27 | 2019-05-02 | Samumed, Llc | 6- (HETEROARYL AND ARYL WITH 6 CHAINS) ISOQUINOLIN-3-YL CARBOXAMIDES, THEIR PREPARATION AND THEIR USE |
WO2019089835A1 (en) * | 2017-10-31 | 2019-05-09 | Samumed, Llc | Diazanaphthalen-3-yl carboxamides and preparation and use thereof |
MX2020009957A (es) | 2018-03-27 | 2021-01-15 | Ptc Therapeutics Inc | Compuestos para el tratamiento de enfermedad de hungtinton. |
ES2929140T3 (es) | 2018-06-18 | 2022-11-25 | Janssen Pharmaceutica Nv | Imidazoles sustituidos con fenilo y piridinilo como moduladores de RORgammat |
ES2925473T3 (es) | 2018-06-18 | 2022-10-18 | Janssen Pharmaceutica Nv | Pirazoles de piridinilo como moduladores de RORyt |
CN112566901A (zh) | 2018-06-18 | 2021-03-26 | 詹森药业有限公司 | 作为RORγt的调节剂的苯基取代的吡唑类 |
EP3806958B1 (en) | 2018-06-18 | 2022-09-07 | Janssen Pharmaceutica NV | 6-aminopyridin-3-yl pyrazoles as modulators of roryt |
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