UY27487A1 - Derivados de pirimidina, medicamentos que contienen estos compuestos, su empleo y procedimiento para su preparación - Google Patents

Derivados de pirimidina, medicamentos que contienen estos compuestos, su empleo y procedimiento para su preparación

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Publication number
UY27487A1
UY27487A1 UY27487A UY27487A UY27487A1 UY 27487 A1 UY27487 A1 UY 27487A1 UY 27487 A UY27487 A UY 27487A UY 27487 A UY27487 A UY 27487A UY 27487 A1 UY27487 A1 UY 27487A1
Authority
UY
Uruguay
Prior art keywords
substituted
alkyl
optionally substituted
inhibitor
kinase
Prior art date
Application number
UY27487A
Other languages
English (en)
Inventor
G Dahmann
F Himmelsbach
K Bernd
M Lenter
A Pautsch
G Schnapp
M Steegmaier
H Wittneben
A Prokopowicz
Walter Spevak
Andreaas Schoop
Steffen Steurer
Original Assignee
Boehringer Ingelheim Pharma
Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma, Co Kg filed Critical Boehringer Ingelheim Pharma
Publication of UY27487A1 publication Critical patent/UY27487A1/es

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D487/10—Spiro-condensed systems

Abstract

La presente invención se refiere a pirimidinas trisustituidas de la fórmula (I), en donde Ra a Re están definidas como en la reivindicación 1, las cuales son adecuadas para el tratamiento de enfermedades que están caracterizadas por una proliferación celular excesiva o anormal, a su empleo para la preparación de un medicamento con las propiedades precedentemente mencionadas, y a un procedimiento para su preparación.
UY27487A 2001-10-17 2002-10-14 Derivados de pirimidina, medicamentos que contienen estos compuestos, su empleo y procedimiento para su preparación UY27487A1 (es)

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US33014501P 2001-10-17 2001-10-17

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UY27487A1 true UY27487A1 (es) 2003-05-30

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US (3) US7173028B2 (es)
EP (3) EP2332924A1 (es)
JP (1) JP4460292B2 (es)
AT (1) ATE407678T1 (es)
CA (1) CA2463989C (es)
CY (1) CY1110442T1 (es)
DE (1) DE50212771D1 (es)
DK (1) DK1438053T3 (es)
ES (1) ES2314106T3 (es)
PT (1) PT1438053E (es)
UY (1) UY27487A1 (es)
WO (1) WO2003032997A1 (es)

Families Citing this family (132)

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Publication number Priority date Publication date Assignee Title
MXPA03010810A (es) * 2001-05-29 2004-03-22 Schering Ag Pirimidinas inhibidoras de cdk, su obtencion y su uso como medicamentos.
WO2003002544A1 (en) * 2001-06-26 2003-01-09 Bristol-Myers Squibb Company N-heterocyclic inhibitors of tnf-alpha expression
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CY1110442T1 (el) 2015-04-29
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EP2090571A1 (de) 2009-08-19
ES2314106T3 (es) 2009-03-16
US20030171359A1 (en) 2003-09-11
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US7709480B2 (en) 2010-05-04
DK1438053T3 (da) 2008-12-08
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ATE407678T1 (de) 2008-09-15
PT1438053E (pt) 2008-09-25
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