PT2635607T - Design de anticorpo heterodimérico estável com mutações no domínio do fc - Google Patents

Design de anticorpo heterodimérico estável com mutações no domínio do fc

Info

Publication number
PT2635607T
PT2635607T PT118373703T PT11837370T PT2635607T PT 2635607 T PT2635607 T PT 2635607T PT 118373703 T PT118373703 T PT 118373703T PT 11837370 T PT11837370 T PT 11837370T PT 2635607 T PT2635607 T PT 2635607T
Authority
PT
Portugal
Prior art keywords
mutations
domain
heterodimeric antibody
antibody design
stable heterodimeric
Prior art date
Application number
PT118373703T
Other languages
English (en)
Inventor
Escobar Cabrera Eric
Spreter Von Kreudenstein Thomas
Bhimarao Dixit Surjit
Irene Lario Paula
Kai Yuen Poon David
Edmondo Paolo D'ANGELO Igor
Original Assignee
Zymeworks Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymeworks Inc filed Critical Zymeworks Inc
Publication of PT2635607T publication Critical patent/PT2635607T/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/524CH2 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/526CH3 domain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PT118373703T 2010-11-05 2011-11-04 Design de anticorpo heterodimérico estável com mutações no domínio do fc PT2635607T (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US41074610P 2010-11-05 2010-11-05
US201061425375P 2010-12-21 2010-12-21
US201161439341P 2011-02-03 2011-02-03
US201161475614P 2011-04-14 2011-04-14
US201161491846P 2011-05-31 2011-05-31
US201161497861P 2011-06-16 2011-06-16

Publications (1)

Publication Number Publication Date
PT2635607T true PT2635607T (pt) 2019-12-11

Family

ID=46023901

Family Applications (1)

Application Number Title Priority Date Filing Date
PT118373703T PT2635607T (pt) 2010-11-05 2011-11-04 Design de anticorpo heterodimérico estável com mutações no domínio do fc

Country Status (19)

Country Link
US (3) US9562109B2 (pt)
EP (1) EP2635607B1 (pt)
JP (1) JP6167040B2 (pt)
KR (2) KR101973930B1 (pt)
CN (2) CN103429620B (pt)
AU (1) AU2011325833C1 (pt)
BR (1) BR112013011811A2 (pt)
CA (1) CA2815266C (pt)
CY (1) CY1122409T1 (pt)
DK (1) DK2635607T3 (pt)
ES (1) ES2758994T3 (pt)
HR (1) HRP20192045T1 (pt)
HU (1) HUE047228T2 (pt)
MX (1) MX352929B (pt)
PL (1) PL2635607T3 (pt)
PT (1) PT2635607T (pt)
RS (1) RS59589B1 (pt)
RU (1) RU2604490C2 (pt)
WO (1) WO2012058768A1 (pt)

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