WO2005018629A1 - Treatment for acne vulgaris and method of use - Google Patents
Treatment for acne vulgaris and method of use Download PDFInfo
- Publication number
- WO2005018629A1 WO2005018629A1 PCT/US2003/025207 US0325207W WO2005018629A1 WO 2005018629 A1 WO2005018629 A1 WO 2005018629A1 US 0325207 W US0325207 W US 0325207W WO 2005018629 A1 WO2005018629 A1 WO 2005018629A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- acne vulgaris
- ethoxylate
- composition
- exchanged
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 58
- 206010000496 acne Diseases 0.000 title claims abstract description 51
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title claims abstract description 26
- 239000000203 mixture Substances 0.000 claims abstract description 33
- -1 polyethylene Polymers 0.000 claims abstract description 12
- 239000004698 Polyethylene Substances 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 10
- 229920000573 polyethylene Polymers 0.000 claims abstract description 10
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000011324 bead Substances 0.000 claims abstract description 7
- 108700004121 sarkosyl Proteins 0.000 claims abstract description 7
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims abstract description 7
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000004166 Lanolin Substances 0.000 claims abstract description 6
- 239000006260 foam Substances 0.000 claims abstract description 6
- 229940039717 lanolin Drugs 0.000 claims abstract description 6
- 235000019388 lanolin Nutrition 0.000 claims abstract description 6
- 238000005201 scrubbing Methods 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000003381 stabilizer Substances 0.000 claims abstract description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 2
- 229940071089 sarcosinate Drugs 0.000 claims 3
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 3
- 229910052708 sodium Inorganic materials 0.000 claims 3
- 239000011734 sodium Substances 0.000 claims 3
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 239000012749 thinning agent Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 5
- 230000000699 topical effect Effects 0.000 abstract description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 6
- 125000000524 functional group Chemical group 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 206010033733 Papule Diseases 0.000 description 4
- 230000002757 inflammatory effect Effects 0.000 description 4
- 230000003902 lesion Effects 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 238000007720 emulsion polymerization reaction Methods 0.000 description 2
- 238000005755 formation reaction Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000003860 topical agent Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- IEORSVTYLWZQJQ-UHFFFAOYSA-N 2-(2-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=CC=C1OCCO IEORSVTYLWZQJQ-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241001635598 Enicostema Species 0.000 description 1
- 206010027626 Milia Diseases 0.000 description 1
- 206010054107 Nodule Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000004130 lipolysis Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920000847 nonoxynol Polymers 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Definitions
- the present invention relates to a composition including surfactants for the treatment of acne vulgaris. Methods of use are also included ⁇ . BACKGROUND OF THE INVENTION AND PRIOR ART Acne vulgaris (or "acne") is a disorder of the sebaceous glands. It is characterized by lesions that are either non-inflammatory or inflammatory papules and nodules. Non-inflammatory papules may be open, commonly referred to as “blackheads", or closed, commonly referred to as “whiteheads”. As a group, non- inflammatory papules are called comedones.
- a topical treatment for acne 5 vulgaris a topical treatment for acne 5 vulgaris.
- a method is provided for applying a composition of 6 substances to the infected area, working the composition into the infected area, and 7 removing the composition from the infected area.
- the composition comprises at least 8 one ethoxylate in combination with Sodium Lauroyl Sarcosinate (or "SLS").
- SLS Sodium Lauroyl Sarcosinate
- An inert 9 scrubbing agent such as polyethylene beads, can also be included to the formula.
- Acetylated lanolin alcohol, a second ethoxylate, EDTA, a foam stabilizer, and water can 11 also be added to the composition without effecting performance.
- Other formulas that keep the polarity similar to that of the inventive formula will 13 also work. To keep the polarity similar, it is necessary for the compound to have similar 14 characteristics, such as Carbon chains, carbonyl groups, Nitrogen bound to Carbon, 15 Aromatic ring(s), Oxylate groups, and appropriate functional groups at the ends of the 16 individual molecules.
- the ideal substitute chemicals would have all of the characteristics 17 mentioned above, but it is not necessary to have every one of those as listed.
- the cutting agent must be added only in 2 sufficient amount that it promotes flow but does not effect the action of the composition. 3
- an sufficient amount of the composition is used to cover the infected area, 4 the composition is applied to an infected area and worked over the area by a scrubbing 5 motion. After sufficient time has elapsed to ensure that the infected area has been 6 adequately exposed to the composition such that they area feels clean, approximately ten 7 to thirty seconds for the typical person, the area is rinsed cleaned.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003264053A AU2003264053A1 (en) | 2003-08-12 | 2003-08-12 | Treatment for acne vulgaris and method of use |
JP2005508238A JP2007521234A (en) | 2003-08-12 | 2003-08-12 | Therapeutic agent and method of use for acne vulgaris |
PCT/US2003/025207 WO2005018629A1 (en) | 2003-08-12 | 2003-08-12 | Treatment for acne vulgaris and method of use |
EP03818329A EP1656128A4 (en) | 2003-08-12 | 2003-08-12 | Treatment for acne vulgaris and method of use |
CA002535550A CA2535550A1 (en) | 2003-08-12 | 2003-08-12 | Treatment for acne vulgaris and method of use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2003/025207 WO2005018629A1 (en) | 2003-08-12 | 2003-08-12 | Treatment for acne vulgaris and method of use |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005018629A1 true WO2005018629A1 (en) | 2005-03-03 |
Family
ID=34215304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/025207 WO2005018629A1 (en) | 2003-08-12 | 2003-08-12 | Treatment for acne vulgaris and method of use |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1656128A4 (en) |
JP (1) | JP2007521234A (en) |
AU (1) | AU2003264053A1 (en) |
CA (1) | CA2535550A1 (en) |
WO (1) | WO2005018629A1 (en) |
Cited By (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009060083A2 (en) * | 2007-11-08 | 2009-05-14 | L'oreal | Use of an n-acylated sarcosinate as an agent against microbial adhesion |
WO2009138519A1 (en) | 2008-05-16 | 2009-11-19 | Ablynx Nv | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
WO2010100135A1 (en) | 2009-03-05 | 2010-09-10 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
WO2011003622A1 (en) | 2009-07-10 | 2011-01-13 | Ablynx N.V. | Method for the production of variable domains |
DE112009000507T5 (en) | 2008-03-05 | 2011-02-10 | Ablynx Nv | Novel antigen-binding dimer complexes, process for their preparation and their use |
WO2011026945A1 (en) | 2009-09-03 | 2011-03-10 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
WO2011064382A1 (en) | 2009-11-30 | 2011-06-03 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
WO2011073180A1 (en) | 2009-12-14 | 2011-06-23 | Ablynx N.V. | Single variable domain antibodies against ox40l, constructs and therapeutic use |
WO2011083140A1 (en) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 |
WO2011098520A1 (en) | 2010-02-10 | 2011-08-18 | Novartis Ag | Agonist dr5 binding polypeptides |
WO2011098552A2 (en) | 2010-02-11 | 2011-08-18 | Ablynx Nv | Methods and compositions for the preparation of aerosols |
WO2011144749A1 (en) | 2010-05-20 | 2011-11-24 | Ablynx Nv | Biological materials related to her3 |
WO2011161263A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Pharmaceutical compositions for cutaneous administration |
WO2012056000A1 (en) | 2010-10-29 | 2012-05-03 | Ablynx Nv | Method for the production of immunoglobulin single variable domains |
WO2012062713A1 (en) | 2010-11-08 | 2012-05-18 | Novartis Ag | Cxcr2 binding polypeptides |
WO2012130872A1 (en) | 2011-03-28 | 2012-10-04 | Ablynx Nv | Method for producing solid formulations comprising immunoglobulin single variable domains |
EP2514767A1 (en) | 2006-12-19 | 2012-10-24 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders |
WO2012152823A1 (en) | 2011-05-09 | 2012-11-15 | Ablynx Nv | Method for the production of immunoglobulin single variable domains |
WO2012156219A1 (en) | 2011-05-05 | 2012-11-22 | Ablynx Nv | Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same |
WO2012163887A1 (en) | 2011-05-27 | 2012-12-06 | Ablynx Nv | Inhibition of bone resorption with rankl binding peptides |
WO2012175740A1 (en) | 2011-06-23 | 2012-12-27 | Ablynx Nv | Immunoglobulin single variable domains directed against ige |
EP2557090A2 (en) | 2006-12-19 | 2013-02-13 | Ablynx N.V. | Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
EP2650311A2 (en) | 2007-11-27 | 2013-10-16 | Ablynx N.V. | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same |
WO2013166594A1 (en) | 2012-05-10 | 2013-11-14 | Zymeworks Inc. | Heteromultimer constructs of immunoglobulin heavy chains with mutations in the fc domain |
US8858940B2 (en) | 2008-12-10 | 2014-10-14 | Ablynx N.V. | Amino acid sequences directed against the Angiopoietin/Tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
US8937164B2 (en) | 2010-03-26 | 2015-01-20 | Ablynx N.V. | Biological materials related to CXCR7 |
US9005963B2 (en) | 2008-10-14 | 2015-04-14 | Ablynx N.V. | Amino acid sequences directed against cellular receptors for viruses and bacteria |
EP2883883A1 (en) | 2013-12-16 | 2015-06-17 | Cardio3 Biosciences S.A. | Therapeutic targets and agents useful in treating ischemia reperfusion injury |
EP2947097A1 (en) | 2008-04-07 | 2015-11-25 | Ablynx N.V. | Amino acid sequences directed against the Notch pathways and uses thereof |
WO2015193452A1 (en) | 2014-06-18 | 2015-12-23 | Ablynx Nv | Kv1.3 binding immunoglobulins |
EP2982690A1 (en) | 2009-04-30 | 2016-02-10 | Ablynx N.V. | Method for the production of domain antibodies |
WO2016097313A1 (en) | 2014-12-19 | 2016-06-23 | Ablynx N.V. | Cysteine linked nanobody dimers |
US9499634B2 (en) | 2012-06-25 | 2016-11-22 | Zymeworks Inc. | Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells |
US9512236B2 (en) | 2006-12-19 | 2016-12-06 | Ablynx N.V. | Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
US9562109B2 (en) | 2010-11-05 | 2017-02-07 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
US9574010B2 (en) | 2011-11-04 | 2017-02-21 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
EP3205670A1 (en) | 2009-06-05 | 2017-08-16 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
WO2017200476A1 (en) | 2016-05-19 | 2017-11-23 | Biocool Ab | New use of product for skin treatment |
WO2018007442A1 (en) | 2016-07-06 | 2018-01-11 | Ablynx N.V. | Treatment of il-6r related diseases |
WO2018029182A1 (en) | 2016-08-08 | 2018-02-15 | Ablynx N.V. | Il-6r single variable domain antibodies for treatment of il-6r related diseases |
US9914785B2 (en) | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
WO2018050833A1 (en) | 2016-09-15 | 2018-03-22 | Ablynx Nv | Immunoglobulin single variable domains directed against macrophage migration inhibitory factor |
US9949915B2 (en) | 2016-06-10 | 2018-04-24 | Clarity Cosmetics Inc. | Non-comedogenic and non-acnegenic hair and scalp care formulations and method for use |
EP3311837A1 (en) | 2011-09-23 | 2018-04-25 | Ablynx NV | Prolonged inhibition of interleukin-6 mediated signaling |
WO2018091606A1 (en) | 2016-11-16 | 2018-05-24 | Ablynx Nv | T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta |
WO2018099968A1 (en) | 2016-11-29 | 2018-06-07 | Ablynx N.V. | Treatment of infection by respiratory syncytial virus (rsv) |
US9994639B2 (en) | 2011-03-28 | 2018-06-12 | Ablynx N.V. | Biological materials related to CXCR7 |
EP3335724A1 (en) | 2014-06-16 | 2018-06-20 | Ablynx NV | Immunoglobulin single variable domains for use in methods of treating ttp |
WO2018158335A1 (en) | 2017-02-28 | 2018-09-07 | Vib Vzw | Means and methods for oral protein delivery |
WO2018206734A1 (en) | 2017-05-11 | 2018-11-15 | Vib Vzw | Glycosylation of variable immunoglobulin domains |
WO2018220235A1 (en) | 2017-06-02 | 2018-12-06 | Merck Patent Gmbh | Mmp13 binding immunoglobulins |
WO2018220225A1 (en) | 2017-06-02 | 2018-12-06 | Ablynx Nv | Aggrecan binding immunoglobulins |
WO2018220234A1 (en) | 2017-06-02 | 2018-12-06 | Merck Patent Gmbh | Adamts binding immunoglobulins |
WO2018220236A1 (en) | 2017-06-02 | 2018-12-06 | Merck Patent Gmbh | Polypeptides binding adamts5, mmp13 and aggrecan |
EP3424526A1 (en) | 2008-06-05 | 2019-01-09 | Ablynx NV | Immunoglobulin single variable domains binding to the g envelope protein of rabies virus and uses thereof for the treatment and prevention of rabies |
WO2019016237A1 (en) | 2017-07-19 | 2019-01-24 | Vib Vzw | Serum albumin binding agents |
EP3461844A2 (en) | 2009-04-10 | 2019-04-03 | Ablynx N.V. | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders |
WO2019086548A1 (en) | 2017-10-31 | 2019-05-09 | Vib Vzw | Novel antigen-binding chimeric proteins and methods and uses thereof |
WO2019154867A1 (en) | 2018-02-06 | 2019-08-15 | Ablynx Nv | Methods of treating initial episode of ttp with immunoglobulin single variable domains |
WO2019166622A1 (en) | 2018-03-01 | 2019-09-06 | Vrije Universiteit Brussel | Human pd-l1-binding immunoglobulins |
WO2019180204A1 (en) | 2018-03-23 | 2019-09-26 | Université Libre de Bruxelles | Wnt signaling agonist molecules |
US10512739B2 (en) | 2014-10-10 | 2019-12-24 | Vectura Gmbh | Inhalation device for use in aerosol therapy of respiratory diseases |
US10561805B2 (en) | 2014-10-10 | 2020-02-18 | Ablynx N.V. | Methods of treating RSV infections |
WO2020185069A1 (en) | 2019-03-08 | 2020-09-17 | Linxis B.V. | Internalizing binding molecules targeting receptors involved in cell proliferation or cell differentiation |
WO2020239934A1 (en) | 2019-05-28 | 2020-12-03 | Vib Vzw | Cd8+ t-cells lacking plexins and their application in cancer treatment |
WO2020239945A1 (en) | 2019-05-28 | 2020-12-03 | Vib Vzw | Cancer treatment by targeting plexins in the immune compartment |
WO2021116252A1 (en) | 2019-12-12 | 2021-06-17 | Vib Vzw | Glycosylated single chain immunoglobulin domains |
WO2021213435A1 (en) | 2020-04-22 | 2021-10-28 | 迈威(上海)生物科技股份有限公司 | Single variable domain antibody targeting human programmed death ligand 1 (pd-l1) and derivative thereof |
WO2021229104A1 (en) | 2020-05-15 | 2021-11-18 | Université de Liège | Anti-cd38 single-domain antibodies in disease monitoring and treatment |
EP3932945A1 (en) | 2015-11-27 | 2022-01-05 | Ablynx NV | Polypeptides inhibiting cd40l |
WO2022060223A1 (en) | 2020-09-16 | 2022-03-24 | Linxis B.V. | Internalizing binding molecules |
WO2022063947A1 (en) | 2020-09-24 | 2022-03-31 | Vib Vzw | Combination of p2y6 inhibitors and immune checkpoint inhibitors |
WO2022063957A1 (en) | 2020-09-24 | 2022-03-31 | Vib Vzw | Biomarker for anti-tumor therapy |
WO2022120388A2 (en) | 2020-12-04 | 2022-06-09 | Tidal Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof |
WO2022178255A2 (en) | 2021-02-19 | 2022-08-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies that neutralize sars-cov-2 |
WO2022175392A1 (en) | 2021-02-17 | 2022-08-25 | Vib Vzw | Inhibition of slc4a4 in the treatment of cancer |
WO2022242892A1 (en) | 2021-05-17 | 2022-11-24 | Université de Liège | Anti-cd38 single-domain antibodies in disease monitoring and treatment |
WO2023281120A1 (en) | 2021-07-09 | 2023-01-12 | Luxembourg Institute Of Health (Lih) | Dimeric protein complexes and uses thereof |
EP4119662A1 (en) | 2013-05-10 | 2023-01-18 | Whitehead Institute For Biomedical Research | Protein modification of living cells using sortase |
WO2023240156A1 (en) | 2022-06-08 | 2023-12-14 | Tidal Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof |
WO2024008755A1 (en) | 2022-07-04 | 2024-01-11 | Vib Vzw | Blood-cerebrospinal fluid barrier crossing antibodies |
WO2024008274A1 (en) | 2022-07-04 | 2024-01-11 | Universiteit Antwerpen | T regulatory cell modification |
WO2024083843A1 (en) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1539031A (en) * | 1975-02-22 | 1979-01-24 | Beecham Group Ltd | Pharmaceutical compositions |
WO2000003686A2 (en) * | 1998-07-20 | 2000-01-27 | Sarlo Peter V | Acne treatment compositions |
US6423746B1 (en) * | 1999-07-03 | 2002-07-23 | The William M. Yarbrough Foundation | Urushiol induced contact dermatitis and method of use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4147782A (en) * | 1976-06-24 | 1979-04-03 | William H. Rorer, Inc. | Pharmaceutical detergent composition |
US7008963B2 (en) * | 1999-07-03 | 2006-03-07 | The William M. Yarbrough Foundation | Urushiol induced contact dermatitis solution |
-
2003
- 2003-08-12 JP JP2005508238A patent/JP2007521234A/en not_active Abandoned
- 2003-08-12 CA CA002535550A patent/CA2535550A1/en not_active Abandoned
- 2003-08-12 EP EP03818329A patent/EP1656128A4/en not_active Withdrawn
- 2003-08-12 AU AU2003264053A patent/AU2003264053A1/en not_active Abandoned
- 2003-08-12 WO PCT/US2003/025207 patent/WO2005018629A1/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1539031A (en) * | 1975-02-22 | 1979-01-24 | Beecham Group Ltd | Pharmaceutical compositions |
WO2000003686A2 (en) * | 1998-07-20 | 2000-01-27 | Sarlo Peter V | Acne treatment compositions |
US6423746B1 (en) * | 1999-07-03 | 2002-07-23 | The William M. Yarbrough Foundation | Urushiol induced contact dermatitis and method of use |
Non-Patent Citations (1)
Title |
---|
See also references of EP1656128A4 * |
Cited By (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2557090A2 (en) | 2006-12-19 | 2013-02-13 | Ablynx N.V. | Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
EP2514767A1 (en) | 2006-12-19 | 2012-10-24 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders |
US9512236B2 (en) | 2006-12-19 | 2016-12-06 | Ablynx N.V. | Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
WO2009060083A2 (en) * | 2007-11-08 | 2009-05-14 | L'oreal | Use of an n-acylated sarcosinate as an agent against microbial adhesion |
FR2923383A1 (en) * | 2007-11-08 | 2009-05-15 | Oreal | USE OF AN N-ACYLATED SARCOSINATE AS A MICROBIAL ANTI-ADHESION AGENT. |
WO2009060083A3 (en) * | 2007-11-08 | 2010-12-23 | L'oreal | Use of an n-acylated sarcosinate as an agent against microbial adhesion |
EP2650311A2 (en) | 2007-11-27 | 2013-10-16 | Ablynx N.V. | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same |
US8975382B2 (en) | 2007-11-27 | 2015-03-10 | Ablynx N.V. | Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers and/or tumors |
US9969805B2 (en) | 2007-11-27 | 2018-05-15 | Ablynx N.V. | Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers and/or tumors |
DE112009000507T5 (en) | 2008-03-05 | 2011-02-10 | Ablynx Nv | Novel antigen-binding dimer complexes, process for their preparation and their use |
EP2947097A1 (en) | 2008-04-07 | 2015-11-25 | Ablynx N.V. | Amino acid sequences directed against the Notch pathways and uses thereof |
US9212226B2 (en) | 2008-05-16 | 2015-12-15 | Ablynx N.V. | Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same |
WO2009138519A1 (en) | 2008-05-16 | 2009-11-19 | Ablynx Nv | AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME |
EP3424526A1 (en) | 2008-06-05 | 2019-01-09 | Ablynx NV | Immunoglobulin single variable domains binding to the g envelope protein of rabies virus and uses thereof for the treatment and prevention of rabies |
US9005963B2 (en) | 2008-10-14 | 2015-04-14 | Ablynx N.V. | Amino acid sequences directed against cellular receptors for viruses and bacteria |
US9803018B2 (en) | 2008-10-14 | 2017-10-31 | Ablynx N.V. | Amino acid sequences directed against cellular receptors for viruses and bacteria |
US9382333B2 (en) | 2008-12-10 | 2016-07-05 | Ablynx N.V. | Amino acid sequences directed against the Angiopoietin/Tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
US8858940B2 (en) | 2008-12-10 | 2014-10-14 | Ablynx N.V. | Amino acid sequences directed against the Angiopoietin/Tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
US9822175B2 (en) | 2008-12-10 | 2017-11-21 | Ablynx N.V. | Amino acid sequences directed against the angiopoietin/tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
WO2010100135A1 (en) | 2009-03-05 | 2010-09-10 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
EP3461844A2 (en) | 2009-04-10 | 2019-04-03 | Ablynx N.V. | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders |
EP2982690A1 (en) | 2009-04-30 | 2016-02-10 | Ablynx N.V. | Method for the production of domain antibodies |
EP3828201A1 (en) | 2009-04-30 | 2021-06-02 | Ablynx N.V. | Method for the production of domain antibodies |
EP3205670A1 (en) | 2009-06-05 | 2017-08-16 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
WO2011003622A1 (en) | 2009-07-10 | 2011-01-13 | Ablynx N.V. | Method for the production of variable domains |
EP3438126A1 (en) | 2009-09-03 | 2019-02-06 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
WO2011026945A1 (en) | 2009-09-03 | 2011-03-10 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
EP2805731A2 (en) | 2009-09-03 | 2014-11-26 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
EP3725330A1 (en) | 2009-09-03 | 2020-10-21 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
WO2011026948A1 (en) | 2009-09-03 | 2011-03-10 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
WO2011064382A1 (en) | 2009-11-30 | 2011-06-03 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
WO2011073180A1 (en) | 2009-12-14 | 2011-06-23 | Ablynx N.V. | Single variable domain antibodies against ox40l, constructs and therapeutic use |
EP3309176A1 (en) | 2009-12-14 | 2018-04-18 | Ablynx N.V. | Immunoglobulin single variable domain antibodies against ox40l, constructs and therapeutic use |
WO2011083140A1 (en) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 |
WO2011098520A1 (en) | 2010-02-10 | 2011-08-18 | Novartis Ag | Agonist dr5 binding polypeptides |
WO2011098552A2 (en) | 2010-02-11 | 2011-08-18 | Ablynx Nv | Methods and compositions for the preparation of aerosols |
EP3501499A1 (en) | 2010-02-11 | 2019-06-26 | Ablynx NV | Methods and compositions for the preparation of aerosols |
US9758584B2 (en) | 2010-03-26 | 2017-09-12 | Ablynx N.V. | Biological materials related to CXCR7 |
US8937164B2 (en) | 2010-03-26 | 2015-01-20 | Ablynx N.V. | Biological materials related to CXCR7 |
WO2011144749A1 (en) | 2010-05-20 | 2011-11-24 | Ablynx Nv | Biological materials related to her3 |
EP3546483A1 (en) | 2010-05-20 | 2019-10-02 | Ablynx N.V. | Biological materials related to her3 |
WO2011161263A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Pharmaceutical compositions for cutaneous administration |
WO2012056000A1 (en) | 2010-10-29 | 2012-05-03 | Ablynx Nv | Method for the production of immunoglobulin single variable domains |
EP3279214A1 (en) | 2010-10-29 | 2018-02-07 | Ablynx NV | Method for the production of immunoglobulin single variable domains |
US10875931B2 (en) | 2010-11-05 | 2020-12-29 | Zymeworks, Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
US9562109B2 (en) | 2010-11-05 | 2017-02-07 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
EP3578568A2 (en) | 2010-11-08 | 2019-12-11 | Ablynx N.V. | Cxcr2 binding polypeptides |
EP3575321A1 (en) | 2010-11-08 | 2019-12-04 | Ablynx N.V. | Cxcr2 binding polypeptides |
WO2012062713A1 (en) | 2010-11-08 | 2012-05-18 | Novartis Ag | Cxcr2 binding polypeptides |
US9994639B2 (en) | 2011-03-28 | 2018-06-12 | Ablynx N.V. | Biological materials related to CXCR7 |
WO2012130872A1 (en) | 2011-03-28 | 2012-10-04 | Ablynx Nv | Method for producing solid formulations comprising immunoglobulin single variable domains |
EP4105231A1 (en) | 2011-05-05 | 2022-12-21 | Merck Patent GmbH | Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same |
WO2012156219A1 (en) | 2011-05-05 | 2012-11-22 | Ablynx Nv | Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same |
EP3363815A1 (en) | 2011-05-05 | 2018-08-22 | Merck Patent GmbH | Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same |
EP3590950A1 (en) | 2011-05-09 | 2020-01-08 | Ablynx NV | Method for the production of immunoglobulin single varible domains |
WO2012152823A1 (en) | 2011-05-09 | 2012-11-15 | Ablynx Nv | Method for the production of immunoglobulin single variable domains |
WO2012163887A1 (en) | 2011-05-27 | 2012-12-06 | Ablynx Nv | Inhibition of bone resorption with rankl binding peptides |
WO2012175740A1 (en) | 2011-06-23 | 2012-12-27 | Ablynx Nv | Immunoglobulin single variable domains directed against ige |
EP3311837A1 (en) | 2011-09-23 | 2018-04-25 | Ablynx NV | Prolonged inhibition of interleukin-6 mediated signaling |
US9988460B2 (en) | 2011-11-04 | 2018-06-05 | Zymeworks Inc. | Crystal structures of heterodimeric Fc domains |
US9574010B2 (en) | 2011-11-04 | 2017-02-21 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
US9732155B2 (en) | 2011-11-04 | 2017-08-15 | Zymeworks Inc. | Crystal structures of heterodimeric Fc domains |
US10457742B2 (en) | 2011-11-04 | 2019-10-29 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
WO2013166594A1 (en) | 2012-05-10 | 2013-11-14 | Zymeworks Inc. | Heteromultimer constructs of immunoglobulin heavy chains with mutations in the fc domain |
US9499634B2 (en) | 2012-06-25 | 2016-11-22 | Zymeworks Inc. | Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells |
US10508154B2 (en) | 2012-06-25 | 2019-12-17 | Zymeworks Inc. | Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells |
US9914785B2 (en) | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
US11078296B2 (en) | 2012-11-28 | 2021-08-03 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
EP4119662A1 (en) | 2013-05-10 | 2023-01-18 | Whitehead Institute For Biomedical Research | Protein modification of living cells using sortase |
EP2883883A1 (en) | 2013-12-16 | 2015-06-17 | Cardio3 Biosciences S.A. | Therapeutic targets and agents useful in treating ischemia reperfusion injury |
EP3335724A1 (en) | 2014-06-16 | 2018-06-20 | Ablynx NV | Immunoglobulin single variable domains for use in methods of treating ttp |
EP3366305A1 (en) | 2014-06-16 | 2018-08-29 | Ablynx NV | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
EP3335723A1 (en) | 2014-06-16 | 2018-06-20 | Ablynx NV | Immunoglobulin single variable domains for use in methods of treating ttp |
EP4059513A1 (en) | 2014-06-16 | 2022-09-21 | Ablynx NV | Methods of treating ttp with immunoglobulin single variable domains and uses thereof |
WO2015193452A1 (en) | 2014-06-18 | 2015-12-23 | Ablynx Nv | Kv1.3 binding immunoglobulins |
US10512739B2 (en) | 2014-10-10 | 2019-12-24 | Vectura Gmbh | Inhalation device for use in aerosol therapy of respiratory diseases |
US10561805B2 (en) | 2014-10-10 | 2020-02-18 | Ablynx N.V. | Methods of treating RSV infections |
WO2016097313A1 (en) | 2014-12-19 | 2016-06-23 | Ablynx N.V. | Cysteine linked nanobody dimers |
EP3932945A1 (en) | 2015-11-27 | 2022-01-05 | Ablynx NV | Polypeptides inhibiting cd40l |
WO2017200476A1 (en) | 2016-05-19 | 2017-11-23 | Biocool Ab | New use of product for skin treatment |
US10159637B2 (en) | 2016-06-10 | 2018-12-25 | Clarity Cosmetics Inc. | Non-comedogenic and non-acnegenic hair and scalp care formulations and method for use |
US10813872B2 (en) | 2016-06-10 | 2020-10-27 | Clarity Cosmetics Inc. | Hair and scalp formulations |
US11160746B2 (en) | 2016-06-10 | 2021-11-02 | Clarity Cosmetics Inc. | Non-comedogenic and non-acnegenic hair and scalp care formulations and method for use |
US9949915B2 (en) | 2016-06-10 | 2018-04-24 | Clarity Cosmetics Inc. | Non-comedogenic and non-acnegenic hair and scalp care formulations and method for use |
WO2018007442A1 (en) | 2016-07-06 | 2018-01-11 | Ablynx N.V. | Treatment of il-6r related diseases |
WO2018029182A1 (en) | 2016-08-08 | 2018-02-15 | Ablynx N.V. | Il-6r single variable domain antibodies for treatment of il-6r related diseases |
WO2018050833A1 (en) | 2016-09-15 | 2018-03-22 | Ablynx Nv | Immunoglobulin single variable domains directed against macrophage migration inhibitory factor |
WO2018091606A1 (en) | 2016-11-16 | 2018-05-24 | Ablynx Nv | T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta |
WO2018099968A1 (en) | 2016-11-29 | 2018-06-07 | Ablynx N.V. | Treatment of infection by respiratory syncytial virus (rsv) |
WO2018158335A1 (en) | 2017-02-28 | 2018-09-07 | Vib Vzw | Means and methods for oral protein delivery |
WO2018206734A1 (en) | 2017-05-11 | 2018-11-15 | Vib Vzw | Glycosylation of variable immunoglobulin domains |
WO2018220236A1 (en) | 2017-06-02 | 2018-12-06 | Merck Patent Gmbh | Polypeptides binding adamts5, mmp13 and aggrecan |
EP4272822A2 (en) | 2017-06-02 | 2023-11-08 | Merck Patent GmbH | Adamts binding immunoglobulins |
WO2018220234A1 (en) | 2017-06-02 | 2018-12-06 | Merck Patent Gmbh | Adamts binding immunoglobulins |
WO2018220225A1 (en) | 2017-06-02 | 2018-12-06 | Ablynx Nv | Aggrecan binding immunoglobulins |
WO2018220235A1 (en) | 2017-06-02 | 2018-12-06 | Merck Patent Gmbh | Mmp13 binding immunoglobulins |
WO2019016237A1 (en) | 2017-07-19 | 2019-01-24 | Vib Vzw | Serum albumin binding agents |
WO2019086548A1 (en) | 2017-10-31 | 2019-05-09 | Vib Vzw | Novel antigen-binding chimeric proteins and methods and uses thereof |
WO2019154867A1 (en) | 2018-02-06 | 2019-08-15 | Ablynx Nv | Methods of treating initial episode of ttp with immunoglobulin single variable domains |
WO2019166622A1 (en) | 2018-03-01 | 2019-09-06 | Vrije Universiteit Brussel | Human pd-l1-binding immunoglobulins |
US11858960B2 (en) | 2018-03-01 | 2024-01-02 | Vrije Universiteit Brussel | Human PD-L1-binding immunoglobulins |
EP4163295A1 (en) | 2018-03-23 | 2023-04-12 | Université Libre de Bruxelles | Wnt signaling agonist molecules |
WO2019180204A1 (en) | 2018-03-23 | 2019-09-26 | Université Libre de Bruxelles | Wnt signaling agonist molecules |
WO2020185069A1 (en) | 2019-03-08 | 2020-09-17 | Linxis B.V. | Internalizing binding molecules targeting receptors involved in cell proliferation or cell differentiation |
EP4378485A2 (en) | 2019-03-08 | 2024-06-05 | LinXis B.V. | Internalizing binding molecules targeting receptors involved in cell proliferation or cell differentiation |
WO2020239945A1 (en) | 2019-05-28 | 2020-12-03 | Vib Vzw | Cancer treatment by targeting plexins in the immune compartment |
WO2020239934A1 (en) | 2019-05-28 | 2020-12-03 | Vib Vzw | Cd8+ t-cells lacking plexins and their application in cancer treatment |
WO2021116252A1 (en) | 2019-12-12 | 2021-06-17 | Vib Vzw | Glycosylated single chain immunoglobulin domains |
WO2021213435A1 (en) | 2020-04-22 | 2021-10-28 | 迈威(上海)生物科技股份有限公司 | Single variable domain antibody targeting human programmed death ligand 1 (pd-l1) and derivative thereof |
WO2021229104A1 (en) | 2020-05-15 | 2021-11-18 | Université de Liège | Anti-cd38 single-domain antibodies in disease monitoring and treatment |
WO2022060223A1 (en) | 2020-09-16 | 2022-03-24 | Linxis B.V. | Internalizing binding molecules |
WO2022063957A1 (en) | 2020-09-24 | 2022-03-31 | Vib Vzw | Biomarker for anti-tumor therapy |
WO2022063947A1 (en) | 2020-09-24 | 2022-03-31 | Vib Vzw | Combination of p2y6 inhibitors and immune checkpoint inhibitors |
WO2022120388A2 (en) | 2020-12-04 | 2022-06-09 | Tidal Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof |
WO2022175392A1 (en) | 2021-02-17 | 2022-08-25 | Vib Vzw | Inhibition of slc4a4 in the treatment of cancer |
WO2022178255A2 (en) | 2021-02-19 | 2022-08-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Single domain antibodies that neutralize sars-cov-2 |
WO2022242892A1 (en) | 2021-05-17 | 2022-11-24 | Université de Liège | Anti-cd38 single-domain antibodies in disease monitoring and treatment |
WO2023281120A1 (en) | 2021-07-09 | 2023-01-12 | Luxembourg Institute Of Health (Lih) | Dimeric protein complexes and uses thereof |
WO2023240156A1 (en) | 2022-06-08 | 2023-12-14 | Tidal Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof |
WO2024008755A1 (en) | 2022-07-04 | 2024-01-11 | Vib Vzw | Blood-cerebrospinal fluid barrier crossing antibodies |
WO2024008274A1 (en) | 2022-07-04 | 2024-01-11 | Universiteit Antwerpen | T regulatory cell modification |
WO2024083843A1 (en) | 2022-10-18 | 2024-04-25 | Confo Therapeutics N.V. | Amino acid sequences directed against the melanocortin 4 receptor and polypeptides comprising the same for the treatment of mc4r-related diseases and disorders |
Also Published As
Publication number | Publication date |
---|---|
CA2535550A1 (en) | 2005-03-03 |
EP1656128A1 (en) | 2006-05-17 |
JP2007521234A (en) | 2007-08-02 |
EP1656128A4 (en) | 2007-02-28 |
AU2003264053A1 (en) | 2005-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1656128A1 (en) | Treatment for acne vulgaris and method of use | |
US6423746B1 (en) | Urushiol induced contact dermatitis and method of use | |
CA2256960C (en) | High glycerin containing anti-microbial cleansers | |
US4395398A (en) | Dental hemostatic composition | |
US9730870B2 (en) | Sodium hypochlorite-based body wash compositions | |
JP3434435B2 (en) | Hair cosmetic composition having dandruff inhibitory effect | |
US10561626B2 (en) | Method for treating urushiol induced contact dermatitis | |
US20080075776A1 (en) | Topical Pharmaceutical Compositions Containing An Antiacne Compound And Antibiotic Compound | |
CN108066164B (en) | Transparent composite cleaning composition and preparation method thereof | |
JP2008533037A (en) | Benzoyl peroxide composition and method of use | |
EP1933840B1 (en) | Use of delmopinol in the treatment of acne | |
JP2007238607A (en) | Chlorine remover | |
JP2001504153A (en) | Germicidal soap bar | |
JP2668853B2 (en) | Kitchen detergent | |
WO2000069403A1 (en) | Alpha amino acid composition and method for the treatment of skin | |
JP2001079568A (en) | Dechlorinating agent | |
WO2004052358A1 (en) | Urushiol induced contact dermatitis treatment and method of use | |
CA1220426A (en) | Method of treating acne vulgaris and composition containing carbamide peroxide | |
JP2007502289A (en) | Compositions for the treatment of biting and invasive organisms, parasites and urticaria, and methods of use | |
EP1982694B1 (en) | Anti-oedema composition | |
US20050037039A1 (en) | Composition for treatment of tinea pedis and method of use | |
JP2000143440A (en) | Bactericidal agent comprising string-shaped giant micelle | |
TH17177A (en) | Topical formulation containing water | |
CN85106029A (en) | A kind ofly can remove pigmented spots, freckle, promote the pure white cosmetics materials of skin | |
PL194902B1 (en) | Method of obtaining a gel-type antiacneic preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AU BR CA CN CR HU IL IN JP KR MX NO NZ PH PL SC SG US ZA |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
ENP | Entry into the national phase |
Ref document number: 2535550 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2006/001668 Country of ref document: MX Ref document number: 2003818329 Country of ref document: EP Ref document number: 2005508238 Country of ref document: JP |
|
WWP | Wipo information: published in national office |
Ref document number: 2003818329 Country of ref document: EP |