JOP20190222A1 - الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3 - Google Patents

الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3

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Publication number
JOP20190222A1
JOP20190222A1 JOP/2019/0222A JOP20190222A JOP20190222A1 JO P20190222 A1 JOP20190222 A1 JO P20190222A1 JO P20190222 A JOP20190222 A JO P20190222A JO P20190222 A1 JOP20190222 A1 JO P20190222A1
Authority
JO
Jordan
Prior art keywords
tim
bispecific antibodies
antibodies
human
heterodimeric
Prior art date
Application number
JOP/2019/0222A
Other languages
English (en)
Inventor
Yi Zhang
Dale Lincoln Ludwig
Igor Edmondo Paolo D'angelo
Yang Shen
Yiwen Li
Original Assignee
Zymeworks Inc
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymeworks Inc, Lilly Co Eli filed Critical Zymeworks Inc
Publication of JOP20190222A1 publication Critical patent/JOP20190222A1/ar

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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    • C12P21/005—Glycopeptides, glycoproteins
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Abstract

يتعلق الاختراع الحالي بالأجسام المضادة التي تعد غير متجانسة دايمريًا وتربط PD-L1 البشري وTIM-3 البشري، ويمكن أن تكون مفيدة لعلاج السرطان بمفردها وفي توليفة مع العلاج الكيميائي والعوامل العلاجية الأخرى للسرطان.
JOP/2019/0222A 2017-04-11 2017-06-16 الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3 JOP20190222A1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762484025P 2017-04-11 2017-04-11

Publications (1)

Publication Number Publication Date
JOP20190222A1 true JOP20190222A1 (ar) 2019-09-24

Family

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JOP/2019/0222A JOP20190222A1 (ar) 2017-04-11 2017-06-16 الأجسام المضادة ثنائية النوعية المضادة لـ pd-l1 والمضادة لـ tim-3

Country Status (27)

Country Link
US (2) US10279034B2 (ar)
EP (1) EP3609920B1 (ar)
JP (1) JP6527644B1 (ar)
KR (1) KR102261582B1 (ar)
CN (1) CN110546165B (ar)
AR (1) AR111193A1 (ar)
AU (1) AU2018250793B2 (ar)
BR (1) BR112019020812A2 (ar)
CA (1) CA3057834A1 (ar)
CL (1) CL2019002802A1 (ar)
CO (1) CO2019010024A2 (ar)
CR (1) CR20190409A (ar)
DO (1) DOP2019000235A (ar)
EA (1) EA201992145A1 (ar)
EC (1) ECSP19073314A (ar)
ES (1) ES2957940T3 (ar)
IL (1) IL269577B (ar)
JO (1) JOP20190222A1 (ar)
MA (1) MA50222A (ar)
MX (1) MX2019012222A (ar)
NZ (1) NZ756581A (ar)
PE (1) PE20191743A1 (ar)
PH (1) PH12019502313A1 (ar)
SG (1) SG11201907755PA (ar)
TW (1) TWI677503B (ar)
WO (1) WO2018191074A1 (ar)
ZA (1) ZA201905711B (ar)

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JOP20190013A1 (ar) 2016-08-25 2019-01-31 Lilly Co Eli أجسام مضادة لـ (تي آي ام -3)

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MA50222A (fr) 2020-07-22
AR111193A1 (es) 2019-06-12
US10279034B2 (en) 2019-05-07
AU2018250793B2 (en) 2021-03-04
JP6527644B1 (ja) 2019-06-05
ECSP19073314A (es) 2019-10-31
PE20191743A1 (es) 2019-12-12
ZA201905711B (en) 2021-05-26
PH12019502313A1 (en) 2020-12-07
KR20190127791A (ko) 2019-11-13
EP3609920A1 (en) 2020-02-19
IL269577B (en) 2022-06-01
CL2019002802A1 (es) 2020-03-06
US11351251B2 (en) 2022-06-07
MX2019012222A (es) 2019-12-09
US20190247497A1 (en) 2019-08-15
CN110546165A (zh) 2019-12-06
EA201992145A1 (ru) 2020-02-12
CR20190409A (es) 2019-11-06
KR102261582B1 (ko) 2021-06-08
CA3057834A1 (en) 2018-10-18
BR112019020812A2 (pt) 2020-04-28
TWI677503B (zh) 2019-11-21
CO2019010024A2 (es) 2020-01-17
AU2018250793A1 (en) 2019-09-19
EP3609920B1 (en) 2023-07-12
NZ756581A (en) 2022-09-30
US20180289803A1 (en) 2018-10-11
SG11201907755PA (en) 2019-09-27
CN110546165B (zh) 2023-12-05
ES2957940T3 (es) 2024-01-30
JP2019522624A (ja) 2019-08-15
IL269577A (en) 2019-11-28
DOP2019000235A (es) 2020-02-28
WO2018191074A1 (en) 2018-10-18
TW201902923A (zh) 2019-01-16

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