PE20240111A1 - Moleculas de union a pd-1 y metodos de uso de las mismas - Google Patents

Moleculas de union a pd-1 y metodos de uso de las mismas

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Publication number
PE20240111A1
PE20240111A1 PE2023001374A PE2023001374A PE20240111A1 PE 20240111 A1 PE20240111 A1 PE 20240111A1 PE 2023001374 A PE2023001374 A PE 2023001374A PE 2023001374 A PE2023001374 A PE 2023001374A PE 20240111 A1 PE20240111 A1 PE 20240111A1
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PE
Peru
Prior art keywords
antibodies
cancer
amino acid
acid sequence
methods
Prior art date
Application number
PE2023001374A
Other languages
English (en)
Inventor
Kalpana Shah
Douglas H Smith
Motte-Mohs Ross La
Leslie S Johnson
Paul A Moore
Ezio Bonvini
Scott Koenig
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of PE20240111A1 publication Critical patent/PE20240111A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Abstract

Refiere a anticuerpos monoclonales monoespecificos de union a PD-1 humanizados o quimericos, que comprenden un dominio de cadena pesada variable con la secuencia de aminoacidos SEQ ID NO: 147, un dominio de cadena ligera variable con la secuencia de aminoacidos SEQ ID NO: 153, una region Fc variante y un dominio bisagra del isotipo IgG4 que presenta una mutacion estabilizadora. Dichos anticuerpos se combinan con una o mas moleculas adicionales, como los anticuerpos anti-LAG-3 o anti-PD-L1, para unirse especificamente a un antigeno del cancer como VEGF-A y/o VEGFR2 y estimular una respuesta humanitaria. Asimismo, los presentes anticuerpos se utilizan para el tratamiento de cancer de cuello uterino, cancer metastasico renal y/o cancer de pulmon de celulas no pequenas. Tambien, la presente reivindica metodos para estimular respuestas inmunes con dichos anticuerpos y para la deteccion de PD-1.
PE2023001374A 2015-07-30 2016-07-28 Moleculas de union a pd-1 y metodos de uso de las mismas PE20240111A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562198867P 2015-07-30 2015-07-30
US201562239559P 2015-10-09 2015-10-09
US201562255140P 2015-11-13 2015-11-13
US201662322974P 2016-04-15 2016-04-15
PCT/US2016/044430 WO2017019846A1 (en) 2015-07-30 2016-07-28 Pd-1-binding molecules and methods use thereof

Publications (1)

Publication Number Publication Date
PE20240111A1 true PE20240111A1 (es) 2024-01-22

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ID=57884977

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2018000138A PE20181151A1 (es) 2015-07-30 2016-07-28 Moleculas de union a pd-1 y metodos de uso de las mismas
PE2023001374A PE20240111A1 (es) 2015-07-30 2016-07-28 Moleculas de union a pd-1 y metodos de uso de las mismas
PE2023001364A PE20231958A1 (es) 2015-07-30 2016-07-28 Moleculas de union a pd-1 y metodos de uso de las mismas

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PE2018000138A PE20181151A1 (es) 2015-07-30 2016-07-28 Moleculas de union a pd-1 y metodos de uso de las mismas

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PE2023001364A PE20231958A1 (es) 2015-07-30 2016-07-28 Moleculas de union a pd-1 y metodos de uso de las mismas

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US (3) US10577422B2 (es)
EP (3) EP3328419B1 (es)
JP (4) JP6959907B2 (es)
KR (2) KR20180093127A (es)
CN (4) CN116333138A (es)
AU (4) AU2016298227B9 (es)
CA (1) CA2993948A1 (es)
CL (1) CL2018000254A1 (es)
CO (1) CO2018000867A2 (es)
CR (3) CR20200423A (es)
CY (2) CY1124634T1 (es)
DK (2) DK3328419T3 (es)
EA (1) EA201890296A1 (es)
EC (1) ECSP18006831A (es)
ES (2) ES2898511T3 (es)
GE (3) GEP20227438B (es)
HK (1) HK1248106A1 (es)
HR (2) HRP20211645T1 (es)
HU (2) HUE056201T2 (es)
IL (4) IL287916B2 (es)
JO (2) JO3736B1 (es)
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MA (1) MA42542B1 (es)
MD (2) MD3456346T2 (es)
MX (3) MX2018001227A (es)
PE (3) PE20181151A1 (es)
PH (1) PH12018500232A1 (es)
PL (2) PL3328419T3 (es)
PT (2) PT3328419T (es)
RS (2) RS62374B1 (es)
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SI (2) SI3456346T1 (es)
TW (3) TWI691509B (es)
UA (1) UA127372C2 (es)
WO (1) WO2017019846A1 (es)
ZA (2) ZA201800500B (es)

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CR20220194A (es) 2022-06-16
GEP20227419B (en) 2022-10-10
EA201890296A1 (ru) 2018-08-31
AU2016298227A2 (en) 2018-09-13
CN108976300B (zh) 2023-04-14
HUE056201T2 (hu) 2022-02-28
ES2898511T3 (es) 2022-03-07
IL290571B2 (en) 2023-03-01
CN107847574B (zh) 2023-05-23
CN116333138A (zh) 2023-06-27
TWI762879B (zh) 2022-05-01
JP6959897B2 (ja) 2021-11-05
IL297090A (en) 2022-12-01
JOP20200213A1 (ar) 2022-10-30
CY1124634T1 (el) 2022-07-22
MD3328419T2 (ro) 2022-01-31
CN114773475A (zh) 2022-07-22
MD3456346T2 (ro) 2021-11-30
CR20200423A (es) 2021-01-20
DK3328419T3 (da) 2021-10-11
TW202028234A (zh) 2020-08-01
CN108976300A (zh) 2018-12-11
HRP20211333T1 (hr) 2021-11-26
PE20181151A1 (es) 2018-07-17

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