ATE524196T1 - An das krebsassoziierte antigen cd46 bindende antikörper und verwendungsverfahren dafür - Google Patents
An das krebsassoziierte antigen cd46 bindende antikörper und verwendungsverfahren dafürInfo
- Publication number
- ATE524196T1 ATE524196T1 AT02801760T AT02801760T ATE524196T1 AT E524196 T1 ATE524196 T1 AT E524196T1 AT 02801760 T AT02801760 T AT 02801760T AT 02801760 T AT02801760 T AT 02801760T AT E524196 T1 ATE524196 T1 AT E524196T1
- Authority
- AT
- Austria
- Prior art keywords
- cancer
- associated antigen
- antibodies binding
- antigen
- mpa7
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32964401P | 2001-10-16 | 2001-10-16 | |
PCT/US2002/033116 WO2003032814A2 (en) | 2001-10-16 | 2002-10-16 | Antibodies that bind to cancer-associated antigen cd46 and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE524196T1 true ATE524196T1 (de) | 2011-09-15 |
Family
ID=23286361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02801760T ATE524196T1 (de) | 2001-10-16 | 2002-10-16 | An das krebsassoziierte antigen cd46 bindende antikörper und verwendungsverfahren dafür |
Country Status (7)
Country | Link |
---|---|
US (2) | US7148038B2 (de) |
EP (1) | EP1441766B1 (de) |
JP (1) | JP4347694B2 (de) |
AT (1) | ATE524196T1 (de) |
CA (1) | CA2463927A1 (de) |
HK (1) | HK1064621A1 (de) |
WO (1) | WO2003032814A2 (de) |
Families Citing this family (32)
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ATE524196T1 (de) | 2001-10-16 | 2011-09-15 | Macrogenics West Inc | An das krebsassoziierte antigen cd46 bindende antikörper und verwendungsverfahren dafür |
US7264800B2 (en) * | 2002-07-18 | 2007-09-04 | Helix Biopharma Corporation | Method and composition for inhibiting cancer cell growth |
SI1530482T1 (sl) * | 2002-07-18 | 2014-03-31 | Helix Biopharma Corp. | Uporaba ureaze za inhibiranje rasti rakavih celic |
US20050226873A1 (en) * | 2003-09-30 | 2005-10-13 | Del Priore Lucian V | Medical devices and methods for modulating cell adhesion |
PE20090046A1 (es) * | 2003-11-10 | 2009-01-26 | Schering Corp | Anticuerpo recombinante humanizado anti-interleuquina 10 |
US20080219981A1 (en) * | 2004-03-29 | 2008-09-11 | Hideki Shimada | Diagnostic Kit for Solid Cancer and Medicament for Solid Cancer Therapy |
GB0425972D0 (en) * | 2004-11-25 | 2004-12-29 | Celltech R&D Ltd | Biological products |
JP2010516259A (ja) | 2007-01-22 | 2010-05-20 | レイベン バイオテクノロジーズ | ヒトがん幹細胞 |
CA2699394C (en) | 2007-09-17 | 2020-03-24 | The Regents Of The University Of California | Internalizing human monoclonal antibodies targeting prostate cancer cells in situ |
CN106432503B (zh) | 2008-12-19 | 2020-03-06 | 宏观基因有限公司 | 共价双抗体及其用途 |
NZ602161A (en) | 2010-03-04 | 2014-12-24 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
JP5964300B2 (ja) | 2010-08-02 | 2016-08-03 | マクロジェニクス,インコーポレーテッド | 共有結合型ダイアボディおよびその使用 |
SG10201506959SA (en) * | 2010-09-03 | 2015-10-29 | Stemcentrx Inc | Novel modulators and methods of use |
EP2689787A1 (de) * | 2010-09-03 | 2014-01-29 | Stem Centrx, Inc. | Neue Modulatoren und deren Verwendung |
US9778264B2 (en) | 2010-09-03 | 2017-10-03 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
US8642951B2 (en) | 2011-05-04 | 2014-02-04 | Agilent Technologies, Inc. | Device, system, and method for reflecting ions |
NZ618016A (en) | 2011-05-21 | 2015-05-29 | Macrogenics Inc | Deimmunized serum-binding domains and their use for extending serum half-life |
US9567402B2 (en) * | 2013-03-14 | 2017-02-14 | The Regents Of The University Of California | Internalizing human monoclonal antibodies targeting prostate and other cancer cells |
WO2015007887A1 (en) * | 2013-07-19 | 2015-01-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination of a ligand of hvem and an immunotoxin for use in therapy |
WO2015085162A1 (en) | 2013-12-05 | 2015-06-11 | Rfemb Holdings, Llc | Cancer immunotherapy by radiofrequency electrical membrane breakdown (rf-emb) |
TWI707872B (zh) | 2014-05-29 | 2020-10-21 | 美商宏觀基因股份有限公司 | 特異性結合多種癌症抗原的三特異性結合分子和其使用方法 |
EP3191524A4 (de) | 2014-09-12 | 2018-05-30 | The Regents of The University of California | Makropinozytosierende menschliche anti-cd46-antikörper und zielgerichtete krebstherapeutika |
WO2016123608A2 (en) | 2015-01-30 | 2016-08-04 | Rfemb Holdings, Llc | Radio-frequency electrical membrane breakdown for the treatment of high risk and recurrent prostate cancer, unresectable pancreatic cancer, tumors of the breast, melanoma or other skin malignancies, sarcoma, soft tissue tumors, ductal carcinoma, neoplasia, and intra and extra luminal abnormal tissue |
IL297090A (en) | 2015-07-30 | 2022-12-01 | Macrogenics Inc | Molecules that bind pd-1 and methods of using them |
TWI758267B (zh) | 2015-12-14 | 2022-03-21 | 美商宏觀基因股份有限公司 | 對於pd-1和ctla-4具有免疫反應性的雙特異性分子及其使用方法 |
US11612426B2 (en) | 2016-01-15 | 2023-03-28 | Immunsys, Inc. | Immunologic treatment of cancer |
CN105462935B (zh) * | 2016-01-20 | 2017-08-04 | 潘世扬 | 抗卵巢癌单克隆抗体及其应用 |
US11434301B2 (en) | 2016-11-11 | 2022-09-06 | The Regents Of The University Of California | Anti-CD46 antibodies and methods of use |
US11459394B2 (en) | 2017-02-24 | 2022-10-04 | Macrogenics, Inc. | Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof |
BR112020011810A2 (pt) | 2017-12-12 | 2020-11-17 | Macrogenics, Inc. | molécula de ligação cd16 x antígeno de doença, composição farmacêutica, uso da composição farmacêutica, e método para o tratamento de uma doença |
JP7337079B2 (ja) | 2018-02-15 | 2023-09-01 | マクロジェニクス,インコーポレーテッド | 変異型cd3結合ドメイン、及び疾患の治療のための併用療法におけるその使用 |
JP2023534765A (ja) | 2020-08-07 | 2023-08-10 | フォーティス セラピューティクス,インク. | 免疫複合体を標的とするcd46およびその使用方法 |
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US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5807715A (en) * | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
US5496550A (en) * | 1986-08-14 | 1996-03-05 | Chilwalner | Method of reducing the output of Eimeria oocysts from a newborn chick |
DE10299017I2 (de) * | 1987-06-22 | 2005-05-25 | Medeva Holdings Bv | Hepatitis-B-Oberfl{chenantigen enthaltendes Peptid. |
US5677425A (en) * | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
US5514787A (en) * | 1989-07-21 | 1996-05-07 | Washington University | DNA sequences encoding human membrane cofactor protein (MCP) |
EP0483247A4 (en) * | 1989-07-21 | 1992-12-09 | Washington University | Recombinantly produced human membrane cofactor protein (mcp) |
GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US5846715A (en) * | 1990-05-11 | 1998-12-08 | The Austin Research Institute | CD46 variants |
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WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
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CA2078539C (en) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
US5714350A (en) * | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
JP3919830B2 (ja) * | 1992-11-28 | 2007-05-30 | 財団法人化学及血清療法研究所 | 抗ネコヘルペスウイルス−1組換え抗体および該抗体をコードする遺伝子断片 |
US6210671B1 (en) * | 1992-12-01 | 2001-04-03 | Protein Design Labs, Inc. | Humanized antibodies reactive with L-selectin |
WO1994015969A1 (en) * | 1993-01-14 | 1994-07-21 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Recombinant anti-hiv antibody and preparation thereof |
US6180377B1 (en) * | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
US5665570A (en) * | 1994-02-10 | 1997-09-09 | Takeda Chemical Industries, Ltd. | Antibody-encoding recombinant DNA and its use |
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US6110724A (en) * | 1996-10-18 | 2000-08-29 | The Research Foundation For Microbial Diseases Of Osaka University | Rotavirus antigen, vaccine and diagnostic agent for rotavirus infections, and a method for producing the antigen |
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US20030129677A1 (en) * | 2000-05-12 | 2003-07-10 | Martens Mark G. | Diagnostic method for screening complement regulatory protein levels |
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EP1184458A1 (de) * | 2000-08-28 | 2002-03-06 | U-BISys B.V. | Unterschiedlich exprimierte CD46 Epitope, proteinartige Moleküle die fähig sind daran zu binden, und deren Verwendungen |
US20020115065A1 (en) * | 2000-08-28 | 2002-08-22 | Ton Logtenberg | Differentially expressed epitopes and uses thereof |
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ATE524196T1 (de) * | 2001-10-16 | 2011-09-15 | Macrogenics West Inc | An das krebsassoziierte antigen cd46 bindende antikörper und verwendungsverfahren dafür |
KR20050004263A (ko) * | 2002-05-30 | 2005-01-12 | 레이븐 바이오테크놀로지스, 인코퍼레이티드 | 독물학 및 투여량 예측을 위한 동물 모델 |
AU2003304203A1 (en) * | 2002-10-29 | 2005-01-04 | Pharmacia Corporation | Differentially expressed genes involved in cancer, the polypeptides encoded thereby, and methods of using the same |
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-
2002
- 2002-10-16 AT AT02801760T patent/ATE524196T1/de not_active IP Right Cessation
- 2002-10-16 US US10/272,835 patent/US7148038B2/en not_active Expired - Fee Related
- 2002-10-16 JP JP2003535624A patent/JP4347694B2/ja not_active Expired - Fee Related
- 2002-10-16 WO PCT/US2002/033116 patent/WO2003032814A2/en active Application Filing
- 2002-10-16 CA CA002463927A patent/CA2463927A1/en not_active Abandoned
- 2002-10-16 EP EP02801760A patent/EP1441766B1/de not_active Expired - Lifetime
-
2004
- 2004-10-07 HK HK04107696.8A patent/HK1064621A1/xx not_active IP Right Cessation
-
2006
- 2006-09-19 US US11/524,344 patent/US7744878B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4347694B2 (ja) | 2009-10-21 |
HK1064621A1 (en) | 2005-02-04 |
US7148038B2 (en) | 2006-12-12 |
US7744878B2 (en) | 2010-06-29 |
US20030108966A1 (en) | 2003-06-12 |
EP1441766A2 (de) | 2004-08-04 |
EP1441766A4 (de) | 2006-03-08 |
EP1441766B1 (de) | 2011-09-14 |
CA2463927A1 (en) | 2003-04-24 |
US20070128202A1 (en) | 2007-06-07 |
WO2003032814A3 (en) | 2003-09-12 |
WO2003032814A2 (en) | 2003-04-24 |
JP2005511525A (ja) | 2005-04-28 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |