PE20171517A1 - Compuestos y composiciones de alfa-cinamida como inhibidores de hdac 8 - Google Patents
Compuestos y composiciones de alfa-cinamida como inhibidores de hdac 8Info
- Publication number
- PE20171517A1 PE20171517A1 PE2017001532A PE2017001532A PE20171517A1 PE 20171517 A1 PE20171517 A1 PE 20171517A1 PE 2017001532 A PE2017001532 A PE 2017001532A PE 2017001532 A PE2017001532 A PE 2017001532A PE 20171517 A1 PE20171517 A1 PE 20171517A1
- Authority
- PE
- Peru
- Prior art keywords
- compositions
- alpha
- alkyl
- cinamide
- phenyl
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract
Se refiere a compuestos de alfa-cinamida de formula (I), en donde: X1, X2, X3 y X4 son independientemente CH o N, donde no mas de dos son N y no son contiguos; Ra es H o alquilo; Rb es H, -(CH2)nRc, -C(O)Rc, entre otros o Ra y Rb estan combinados para formar un heterociclo; Rc es H, alquilo C1-C6, entre otros; A es H o fluorina; n es 0, 1, 2, 3 o 4 con la condicion de que: (1) ambos Ra y Rb no pueden ser simultaneamente H ni Me; o (2) cuando Ra es H y Rb es -C(O)Rc, Rc no puede ser fenilo, 1-naftilo, 2-naftilo, 4-bifenilo, 1-estirilo o alquilo con fenilo no sustituido. Un compuesto seleccionado es (E)-3-(2-((1H-benzo[d]imidazol-2-ilo)amino)fenilo)-N-hidroxiacrilamida; entre otros. Tambien se refiere a una composicion farmaceutica que lo comprende. Dichos compuestos son inhibidores de la histona desacetilasa 8 (HDAC8) siendo utiles en el tratamiento de cancer, enfermedades neurologicas, entre otras
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EA201792028A1 (ru) | 2015-03-13 | 2018-04-30 | Форма Терапьютикс, Инк. | Альфа-цинамидные соединения и композиции как ингибиторы hdac8 |
WO2017030892A1 (en) | 2015-08-14 | 2017-02-23 | Reaction Biology Corp. | Histone deacetylase inhibitors and methods for use thereof |
AR105911A1 (es) | 2015-09-03 | 2017-11-22 | Forma Therapeutics Inc | Inhibidores de hdac8 bicíclicos fusionados [6,6] |
TWI659949B (zh) | 2016-05-16 | 2019-05-21 | 臺北醫學大學 | 組蛋白去乙醯酶6抑制劑及其用途 |
US20180127386A1 (en) | 2016-10-20 | 2018-05-10 | Forma Therapeutics, Inc. | Methods using hdac11 inhibitors |
CN107056631A (zh) * | 2017-04-14 | 2017-08-18 | 六盘水师范学院 | 一种基于Heck反应的2‑烯基苯胺类化合物制备方法 |
US11230524B2 (en) * | 2017-08-17 | 2022-01-25 | Standard Llc | Myocyte enhancer factor 2 (MEF2) modulators |
US11535607B2 (en) | 2018-04-20 | 2022-12-27 | Valo Health, Inc. | Isoindolines as HDAC inhibitors |
MX2020011087A (es) * | 2018-04-20 | 2021-01-08 | Valo Early Discovery Inc | Isoindolinas como inhibidores de histonas desacetilasas (hdac). |
KR102055369B1 (ko) * | 2018-08-09 | 2019-12-12 | 충북대학교 산학협력단 | 신규한 3/4-((치환된 벤즈아미도페녹시)메틸)-n-히드록시 벤즈아미드/프로펜아미드 화합물 및 이의 용도 |
WO2020115683A1 (en) | 2018-12-06 | 2020-06-11 | Novartis Ag | 5-hydroxy-7-oxabicyclo[2.2.1]heptane-2-carboxamide derivatives for inducing chondrogenesis for treating joint damage |
CN113493407A (zh) * | 2020-04-03 | 2021-10-12 | 中国医学科学院药物研究所 | 一种吡啶类化合物及其制法和药物用途 |
CN111728961B (zh) * | 2020-08-05 | 2021-06-15 | 牡丹江医学院 | 一种用于治疗老年痴呆的药物组合物及其用途 |
CN114605304A (zh) * | 2020-12-04 | 2022-06-10 | 杭州中美华东制药有限公司 | 一种(±)-2-(4-(1-氧代异吲哚-2-基)苯基)丁酸乙酯的合成方法 |
CN113192633B (zh) * | 2021-05-24 | 2022-05-31 | 山西大学 | 基于注意力机制的胃癌细粒度分类方法 |
KR20230141506A (ko) | 2022-03-31 | 2023-10-10 | 재단법인 대구경북첨단의료산업진흥재단 | 3,4-다이하이드로퀴녹살린-2-카복사미드 유도체 화합물 및 이를 포함하는 암 질환 예방 또는 치료용 약학적 조성물 |
CN115417877A (zh) * | 2022-09-20 | 2022-12-02 | 杭州师范大学 | 组蛋白去乙酰化酶抑制剂及其制备和在制备抗癌症药物上的应用 |
Family Cites Families (213)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4834699B1 (es) | 1968-07-03 | 1973-10-23 | ||
GB8320702D0 (en) | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agents |
GB8531839D0 (en) | 1985-12-30 | 1986-02-05 | Wellcome Found | Aryl derivatives |
US4820828A (en) | 1987-03-04 | 1989-04-11 | Ortho Pharmaceutical Corporation | Cinnamohydroxamic acids |
GB8820185D0 (en) | 1988-08-25 | 1988-09-28 | Wellcome Found | New medical use |
US5466704A (en) | 1991-02-26 | 1995-11-14 | E. R. Squibb & Sons, Inc. | N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists |
KR100236806B1 (ko) | 1991-12-10 | 2000-01-15 | 시오노 요시히코 | 방향족 설폰아미드계 하이드록삼산 유도체 |
US5234923A (en) | 1991-12-16 | 1993-08-10 | E. R. Squibb & Sons, Inc. | Substitute indole and benzimidazole derivatives |
US5312820A (en) | 1992-07-17 | 1994-05-17 | Merck & Co., Inc. | Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines |
JPH08502484A (ja) | 1992-10-14 | 1996-03-19 | メルク エンド カンパニー インコーポレーテッド | フィブリノゲンリセプタ拮抗剤 |
JPH06130434A (ja) | 1992-10-19 | 1994-05-13 | Hoechst Japan Ltd | 有機非線形光学材料 |
US5262564A (en) | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
DE4238260A1 (de) | 1992-11-12 | 1994-05-19 | Basf Ag | Substituierte ortho-Ethenylphenylessigsäurederivate |
CN1073571A (zh) | 1992-11-28 | 1993-06-30 | 黄尊景 | 防止坡面被冲刷的施工法 |
EP0673247A4 (en) | 1992-12-01 | 1996-05-01 | Merck & Co Inc | FIBRINOGEN RECEPTOR ANTAGONISTS. |
US5814651A (en) | 1992-12-02 | 1998-09-29 | Pfizer Inc. | Catechol diethers as selective PDEIV inhibitors |
JP3203108B2 (ja) | 1993-08-26 | 2001-08-27 | 協和メデックス株式会社 | グルコース−6−リン酸デヒドロゲナーゼの安定化方法 |
WO1995013264A1 (fr) | 1993-11-08 | 1995-05-18 | Terumo Kabushiki Kaisha | Derive d'acide hydroxamique et preparation medicamenteuse contenant ledit derive |
US6872542B1 (en) | 1993-11-18 | 2005-03-29 | Siga Pharmaceuticals, Inc. | Treatment or prophylaxis of diseases caused by pilus-forming bacteria |
US5563143A (en) | 1994-09-21 | 1996-10-08 | Pfizer Inc. | Catechol diether compounds as inhibitors of TNF release |
WO1996011925A1 (en) | 1994-10-13 | 1996-04-25 | Pfizer Inc. | Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b4' (ltb4) antagonists |
CZ111797A3 (cs) | 1994-10-13 | 1998-07-15 | Pfizer Inc. | Benzopyranové a jiné sloučeniny s přikondenzovaným benzenovým kruhem a farmaceutické prostředky na jejich bázi |
CN1078279C (zh) | 1994-10-20 | 2002-01-23 | 诺沃奇梅兹有限公司 | 包括使用酚氧化酶、过氧化氢源和增强剂的漂白方法 |
EP0717143A1 (de) | 1994-12-16 | 1996-06-19 | Lignozym GmbH | Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung |
ES2175079T3 (es) | 1995-04-10 | 2002-11-16 | Fujisawa Pharmaceutical Co | Derivados de indol utiles como inhibidores de cgmp-pde. |
JP3964478B2 (ja) | 1995-06-30 | 2007-08-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬 |
CA2230106A1 (en) | 1995-09-18 | 1997-03-27 | Basf Aktiengesellschaft | Phenylacetic acids, their preparation, and compositions comprising them |
US5795890A (en) | 1995-09-27 | 1998-08-18 | Ono Pharmaceutical Co., Ltd. | Sulfonamide derivatives |
MY127641A (en) | 1995-10-12 | 2006-12-29 | Essential Therapeutics Inc | Cephalosporin antibiotics |
JPH09268125A (ja) | 1996-04-02 | 1997-10-14 | Terumo Corp | 腎炎治療薬 |
US5958957A (en) | 1996-04-19 | 1999-09-28 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
EP0845026A1 (de) | 1996-06-19 | 1998-06-03 | CALL, Hans-Peter Dr. | Mehrkomponentensystem zur verwendung mit waschaktiven substanzen |
WO1997049684A1 (en) | 1996-06-24 | 1997-12-31 | Novo Nordisk A/S | Factor vii-binding reagent |
AUPO721997A0 (en) | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
DE69841434D1 (de) | 1997-07-18 | 2010-02-25 | Novo Nordisk Healthcare Ag | VERWENDUNG VON FVIIa ODER FVIIAi ZUR BEHANDLUNG VON ENDOTHELIALER FEHLFUNKTION BZW ZUR INHIBIERUNG DER ANGIOGENESE |
US6355669B1 (en) | 1997-10-22 | 2002-03-12 | Eisai Co., Ltd. | Retinoic acid agonists as preventive and therapeutic agents for nephritis |
US20020128256A1 (en) | 1997-11-20 | 2002-09-12 | Carlo Brugnara | Methods for the treatment or prevention of inflammatory diseases characterized by abnormal cell proliferation |
IL128731A0 (en) | 1998-03-12 | 2000-01-31 | Pfizer Prod Inc | Method of preventing allograft rejection |
EP0963755A3 (en) | 1998-04-16 | 2001-03-14 | Pfizer Products Inc. | Use of benzopyranes for preventing allograft rejection |
IL140041A0 (en) | 1998-06-03 | 2002-02-10 | Guilford Pharm Inc | Multiple heteroatom containing heterocyclic ring compounds substituted with carboxylic acids and isosteres thereof |
US6211197B1 (en) | 1998-10-07 | 2001-04-03 | Merck Frosst Canada & Co. | Prostaglandin receptor ligands |
US6593322B1 (en) | 1999-03-17 | 2003-07-15 | Signal Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
AU766648B2 (en) | 1999-03-17 | 2003-10-23 | Axys Pharmaceuticals, Inc. | Compounds and methods for modulation of estrogen receptors |
KR100710100B1 (ko) | 1999-04-15 | 2007-04-23 | 브리스톨-마이어스스퀴브컴파니 | 환형 단백질 티로신 키나제 억제제 |
ATE296814T1 (de) | 1999-05-12 | 2005-06-15 | Neurosearch As | Ionenkanal modulierende mittel |
DE60029803T2 (de) | 1999-09-20 | 2007-09-20 | Nippon Soda Co. Ltd. | Verfahren für die herstellung von 4(5)-amino-5(4)-carboxamidoimidazolen und deren zwischenprodukte |
KR101026205B1 (ko) | 1999-11-23 | 2011-03-31 | 메틸진 인코포레이티드 | 히스톤 디아세틸라제의 억제제 |
EP1263754A1 (en) | 2000-02-01 | 2002-12-11 | Millennium Pharmaceuticals, Inc. | INDALONE AND BENZIMIDAZOLONE INHIBITORS OF FACTOR Xa |
CA2400649A1 (en) | 2000-02-28 | 2001-09-07 | Sugen, Inc. | 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors |
WO2001072708A2 (en) | 2000-03-24 | 2001-10-04 | Cor Therapeutics, Inc. | OXINDOLE INHIBITORS OF FACTOR Xa |
WO2001077091A2 (en) | 2000-04-05 | 2001-10-18 | Tularik Inc. | Ns5b hcv polymerase inhibitors |
PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
DE60138658D1 (de) | 2000-09-29 | 2009-06-18 | Topotarget Uk Ltd | Carbaminsäurederivate enthaltend eine Amidgruppe zur Behandlung von Malaria |
JP4975941B2 (ja) | 2000-09-29 | 2012-07-11 | トポターゲット ユーケー リミテッド | (e)−n−ヒドロキシ−3−(3−スルファモイル−フェニル)アクリルアミド化合物及びその治療用途 |
US20030152557A1 (en) | 2001-01-12 | 2003-08-14 | Besterman Jeffrey M. | Methods for inhibiting histone deacetylase-4 |
US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
US8026280B2 (en) | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US7842727B2 (en) | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
CN1511151A (zh) | 2001-05-24 | 2004-07-07 | ֮����ҩ��ʽ���� | 3-喹啉-2(1h)-亚基二氢吲哚-2-酮衍生物 |
WO2003000251A1 (en) | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Novel idolinones and uses thereof |
BR0213932A (pt) | 2001-11-06 | 2004-08-31 | Novartis Ag | Combinação do inibidor da ciclooxigenase-2/inibidor da desacetilase histona |
WO2003055877A1 (en) | 2001-12-21 | 2003-07-10 | Astrazeneca Ab | Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3 |
WO2003057184A2 (en) | 2001-12-28 | 2003-07-17 | Integriderm, Inc. | Hydroxamic acid and its derivatives as inhibitors of melanocyte tyrosinase for topical skin lighteners |
MXPA04009490A (es) | 2002-04-03 | 2005-06-08 | Topo Target Uk Ltd | Compuesto de acido carbamico que comprenden un enlace de piperazina como inhibidores de histona desacetilasa. |
US7615640B2 (en) | 2002-07-29 | 2009-11-10 | Mitsubishi PaperMillsLtd. | Organic dye, photoelectric conversion material, semiconductor electrode and photoelectric conversion device |
EP1527345A2 (en) | 2002-07-29 | 2005-05-04 | Axxima Pharmaceuticals AG | Method for isolating atp binding proteins by means of immobilized protein inhibitors |
JP2006505522A (ja) | 2002-08-08 | 2006-02-16 | スミスクライン ビーチャム コーポレーション | チオフェン化合物 |
AU2002951247A0 (en) | 2002-09-06 | 2002-09-19 | Alchemia Limited | Compounds that interact with kinases |
AU2003302665B2 (en) | 2002-11-15 | 2009-12-24 | Symphony Evolution, Inc. | Kinase modulators |
DE60312548T2 (de) | 2002-11-18 | 2007-12-13 | Galderma Research & Development, S.N.C. | Neue liganden, die antagonisten der rar-rezeptoren sind, herstellungsverfahren für diese liganden und verwendung dieser liganden in der humanmedizin und in der kosmetik |
GB0226855D0 (en) | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
TW200418806A (en) | 2003-01-13 | 2004-10-01 | Fujisawa Pharmaceutical Co | HDAC inhibitor |
US7084189B2 (en) | 2003-02-20 | 2006-08-01 | Xerox Corporation | Phase change inks with isocyanate-derived antioxidants and UV stabilizers |
KR20050122210A (ko) | 2003-03-17 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
SE0301699D0 (sv) | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
US20060235012A1 (en) | 2003-06-16 | 2006-10-19 | Chroma Therapeutics Limited | Carboline and betacarboline derivatives for use as hdac enzyme inhibitors |
US20060270730A1 (en) | 2003-08-07 | 2006-11-30 | Andreas Katopodis | Histone deacetylase inhibitors as immunosuppressants |
EP1664006A2 (en) | 2003-09-06 | 2006-06-07 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
US20060074124A1 (en) | 2003-09-12 | 2006-04-06 | Andrew Napper | Methods of treating a disorder |
WO2005025557A1 (en) | 2003-09-16 | 2005-03-24 | Monash University | An agent for plasminogen-activation and matrix metalloproteinase associated conditions and methods of use |
NZ545864A (en) | 2003-09-22 | 2009-12-24 | S Bio Pte Ltd | Benzimidazole derivates: preparation and pharmaceutical applications |
TW200524575A (en) | 2003-10-27 | 2005-08-01 | S Bio Pte Ltd | Biaryl linked hydroxamates: preparation and pharmaceutical applications |
JP2005145928A (ja) | 2003-11-19 | 2005-06-09 | Yamanouchi Pharmaceut Co Ltd | 3−キノリン−2(1h)−イリデンインドリン−2−オン誘導体を有効成分とする医薬組成物 |
WO2005066151A2 (en) | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
US20050159470A1 (en) | 2003-12-19 | 2005-07-21 | Syrrx, Inc. | Histone deacetylase inhibitors |
US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
JP2007535555A (ja) | 2004-04-28 | 2007-12-06 | イコス・コーポレイション | 炎症性疾患および免疫疾患の処置に有用なアリールフェニルアミノ−およびアリールフェニルエーテル−スルフィド誘導体、およびそれらを含む医薬組成物 |
DE102004021779A1 (de) | 2004-04-30 | 2005-11-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
US20050261327A1 (en) | 2004-05-20 | 2005-11-24 | Bock Mark G | 2-(Bicyclo)alkylamino-derivatives as mediatores of chronic pain and inflammation |
WO2005115990A1 (ja) | 2004-05-26 | 2005-12-08 | Eisai R & D Management Co., Ltd. | シンナミド化合物 |
CA2574035A1 (en) | 2004-07-19 | 2006-02-23 | Sandro Belvedere | Histone deacetylase inhibitors |
MX2007001550A (es) | 2004-08-09 | 2007-04-10 | Astellas Pharma Inc | Compuestos de hidroxiamida que tienen actividad como inhibidores de histona desacetilasa (hdac). |
RU2007109794A (ru) | 2004-08-19 | 2008-09-27 | Вертекс Фармасьютикалз, Инкорпорейтед (Us) | Модуляторы мускариновых рецепторов |
WO2006029575A1 (en) | 2004-09-17 | 2006-03-23 | Institute Of Mataria Medica, Chinese Academy Of Medical Sciences | NOVEL α-ALKYLOXY PROPIONIC ACIDS, THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USES |
US8242175B2 (en) | 2004-10-01 | 2012-08-14 | Dac S.R.L. | Class of histone deacetylase inhibitors |
FR2878247B1 (fr) | 2004-11-19 | 2008-10-03 | Galderma Res & Dev | Nouveaux composes modulateurs des recepteurs de type ppary et leur utilisation dans des compositions cosmetiques ou pharmaceutiques |
CA2589501A1 (en) | 2004-12-17 | 2006-06-22 | Boehringer Ingelheim International Gmbh | Indolinones and their use as antiproliferative agents |
JP2008528634A (ja) | 2005-01-31 | 2008-07-31 | セプション・セラピューティクス・インコーポレーテッド | 腫瘍壊死因子インヒビター |
CA2596015A1 (en) | 2005-02-14 | 2006-08-24 | Sampath K. Anandan | Fused heterocyclic compounds useful as inhibitors of histone deacetylase |
WO2006101456A1 (en) | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Bicyclic heterocycles hydroxamate compounds useful as histone deacetylase (hdac) inhibitors |
EP1869052A1 (en) | 2005-04-06 | 2007-12-26 | AstraZeneca AB | Substituted heterocycles and their use as chk1, pdk1 and pak inhibitors |
ZA200710313B (en) | 2005-05-13 | 2009-05-27 | Topotarget Uk Ltd | Pharmaceutical formulations of HDAC inhibitors |
GB0510204D0 (en) * | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
WO2006125784A1 (en) | 2005-05-24 | 2006-11-30 | Laboratoires Serono S.A. | Tricyclic spiro derivatives as crth2 modulators |
US7399786B2 (en) | 2005-06-30 | 2008-07-15 | Bexel Pharmaceuticals, Inc. | Derivatives of amino acids for treatment of obesity and related disorders |
US8003624B2 (en) | 2005-08-25 | 2011-08-23 | Schering Corporation | Functionally selective ALPHA2C adrenoreceptor agonists |
JP2007056213A (ja) | 2005-08-26 | 2007-03-08 | Fujifilm Corp | 焼結含油軸受油用組成物、並びにそれを用いた軸受け装置及び摺動部材 |
WO2007030455A2 (en) | 2005-09-07 | 2007-03-15 | Novartis Ag | Mutations and polymorphisms of hdac10 |
TW200745066A (en) | 2005-09-16 | 2007-12-16 | Torrent Pharmaceuticals Ltd | Novel PTP1B inhibitors |
AR057579A1 (es) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
AU2006330866A1 (en) | 2005-12-22 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
PE20071025A1 (es) | 2006-01-31 | 2007-10-17 | Mitsubishi Tanabe Pharma Corp | Compuesto amina trisustituido |
WO2007092213A2 (en) | 2006-02-02 | 2007-08-16 | Millennium Pharmaceuticals, Inc. | Inhibitors of e1 activating enzyme |
JP5441416B2 (ja) | 2006-02-14 | 2014-03-12 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 二官能性ヒストンデアセチラーゼインヒビター |
FI20065162A0 (fi) | 2006-03-13 | 2006-03-13 | Wallac Oy | Terminoivia DNA polymeraasisubstraatteja |
JPWO2007135970A1 (ja) | 2006-05-19 | 2009-10-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環系−シンナミド誘導体 |
WO2008021975A2 (en) | 2006-08-11 | 2008-02-21 | Allergan, Inc. | Therapeutic lactams |
JP2010502741A (ja) | 2006-09-11 | 2010-01-28 | キュリス,インコーポレイテッド | Ptkインヒビターとしての亜鉛結合部分を含む置換2−インドリノン |
GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
WO2008060721A1 (en) | 2006-11-14 | 2008-05-22 | Pharmacyclics, Inc. | Uses of selective inhibitors of hdac8 for treatment of t-cell proliferative disorders |
MY148893A (en) | 2006-12-04 | 2013-06-14 | Novartis Ag | Combination of an hdac inhibitor and an antimetabolite |
EP2099756A1 (en) | 2006-12-15 | 2009-09-16 | Astellas Pharma Inc. | N-hydroxyacrylamide compounds |
US8796330B2 (en) | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
CA2673410A1 (en) | 2006-12-21 | 2008-07-03 | Schering Corporation | Pyrrolo [3, 2-a] pyridine derivatives for inhibiting ksp kinesin activity |
EP2120952A4 (en) | 2007-01-15 | 2011-09-21 | Us Of America As Represented By The Secretary Of The Army On Behalf Of The U S Army Res Inst Of Infe | ANTIVIRAL COMPOUNDS AND METHOD FOR THEIR USE |
WO2008087514A2 (en) | 2007-01-17 | 2008-07-24 | Orchid Research Laboratories Limited | Hdac inhibitors |
ITRM20070038A1 (it) | 2007-01-26 | 2008-07-27 | Uni Degli Studi Di Roma La Sapienza | Forme solubili di complessi di inclusione di inibitori dell istone deacetilasi e ciclodestrine loro processi di preparazione e impieghi in campo farmaceutico |
US7985763B2 (en) | 2007-04-10 | 2011-07-26 | National Health Research Institutes | Hepatitis C virus inhibitors |
EP2152683A1 (en) | 2007-05-24 | 2010-02-17 | Basf Se | Substituted amino-thiourea compounds for combating animal pests |
US8207179B2 (en) | 2007-06-12 | 2012-06-26 | Boehringer Ingelheim International Gmbh | Substituted indolines as tyrosine kinase inhibitors |
JP4834699B2 (ja) | 2007-07-30 | 2011-12-14 | 田辺三菱製薬株式会社 | 医薬組成物 |
JP4846769B2 (ja) | 2007-07-30 | 2011-12-28 | 田辺三菱製薬株式会社 | 医薬組成物 |
KR101092397B1 (ko) | 2007-09-26 | 2011-12-09 | 제이에스알 가부시끼가이샤 | 액정 배향제, 액정 배향막과 그의 형성방법 및, 액정 표시 소자 |
JP2011501746A (ja) | 2007-10-10 | 2011-01-13 | オーキッド リサーチ ラボラトリーズ リミテッド | 新規ヒストンデアセチラーゼインヒビター |
EP2060565A1 (en) | 2007-11-16 | 2009-05-20 | 4Sc Ag | Novel bifunctional compounds which inhibit protein kinases and histone deacetylases |
WO2009089454A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
EP2257546B1 (en) | 2008-02-21 | 2012-08-15 | Merck Sharp & Dohme Corp. | Functionally selective alpha2c adrenoreceptor agonists |
JP5330498B2 (ja) * | 2008-03-26 | 2013-10-30 | ノバルティス アーゲー | 脱アセチル化酵素bのヒドロキサメートを基にした阻害剤 |
ES2336746B1 (es) | 2008-04-10 | 2011-01-25 | Universitat De Girona | Catalizadores de manganeso y su uso para la epoxidacion selectiva de olefinas. |
US8198284B2 (en) | 2008-04-30 | 2012-06-12 | National Health Research Institutes | Treatment of neurodegenerative disorders with thiourea compounds |
US8058427B2 (en) | 2008-06-12 | 2011-11-15 | National Health Research Institutes | Coumarin compounds and their use for treating cancer |
US20090312406A1 (en) | 2008-06-12 | 2009-12-17 | Hsing-Pang Hsieh | Coumarin compounds and their use for treating viral infection |
US20110224242A1 (en) | 2008-07-23 | 2011-09-15 | Bioalliance Pharma | Styrlyquinolines, their process of preparation and their therapeutic uses |
EP2149557A1 (en) | 2008-07-23 | 2010-02-03 | BioAlliance Pharma | Styrylquinolines, their process of preparation and their therapeutic uses |
KR20110046503A (ko) | 2008-07-24 | 2011-05-04 | 지멘스 메디컬 솔루션즈 유에스에이, 인크. | Ad 병인을 확인하기에 유용한 영상화제 |
WO2010017827A1 (en) | 2008-08-14 | 2010-02-18 | European Molecular Biology Laboratory | 6-substituted 1-sulfonyl-2, 3-dihydro-indole derivatives for the treatment of proliferative diseases |
JP2010077096A (ja) | 2008-09-29 | 2010-04-08 | Fujifilm Corp | 化合物、液晶性組成物、膜、及び位相差板 |
WO2010043000A1 (en) | 2008-10-17 | 2010-04-22 | Akaal Pharma Pty Ltd | S1p receptors modulators and their use thereof |
US8426428B2 (en) | 2008-12-05 | 2013-04-23 | Principia Biopharma, Inc. | EGFR kinase knockdown via electrophilically enhanced inhibitors |
WO2010068287A2 (en) | 2008-12-11 | 2010-06-17 | Angion Biomedica Corp. | Small molecule modulators of hepatocyte growth factor (scatter factor) activity |
WO2010077310A2 (en) | 2008-12-17 | 2010-07-08 | The Regents Of The University Of California | Amide derivatives of ethacrynic acid |
AR074760A1 (es) | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
US7897602B2 (en) | 2009-01-12 | 2011-03-01 | Development Center For Biotechnology | Indolinone compounds as kinase inhibitors |
ES2406131T3 (es) | 2009-01-28 | 2013-06-05 | Bayer Intellectual Property Gmbh | Derivados fungicidas de N-cicloalquil-N-biciclometileno-carboxamina |
AU2010212590B2 (en) | 2009-02-10 | 2013-01-10 | Astrazeneca Ab | Triazolo [4,3-b] pyridazine derivatives and their uses for prostate cancer |
GB0903480D0 (en) | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
US8927576B2 (en) | 2009-04-06 | 2015-01-06 | PTC Therpeutics, Inc. | HCV inhibitor and therapeutic agent combinations |
TW201039827A (en) | 2009-04-15 | 2010-11-16 | Daiichi Sankyo Co Ltd | Indoline compound |
EP2451790A4 (en) | 2009-07-07 | 2012-12-26 | Anthem Biosciences Private Ltd | INHIBITORS OF HISTONE DEACETYLASE |
KR101118587B1 (ko) | 2009-08-17 | 2012-06-12 | 포항공과대학교 산학협력단 | 감응성 고분자 캡슐 및 그 제조방법 |
US20110053925A1 (en) * | 2009-08-28 | 2011-03-03 | Novartis Ag | Hydroxamate-Based Inhibitors of Deacetylases |
EP2604619A3 (en) | 2009-12-14 | 2014-01-22 | University of Basel | Mannose derivatives as antagonists of bacterial adhesion |
WO2011084991A2 (en) | 2010-01-08 | 2011-07-14 | President And Fellows Of Harvard College | Fluorinated hdac inhibitors and uses thereof |
EP2536275A1 (en) | 2010-02-16 | 2012-12-26 | UWM Research Foundation, Inc. | Methods of reducing virulence in bacteria |
WO2011106650A2 (en) | 2010-02-27 | 2011-09-01 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Novel p53-mdm2/p53-mdm4 antagonists to treat proliferative disease |
TWI429628B (zh) | 2010-03-29 | 2014-03-11 | Univ Taipei Medical | 吲哚基或吲哚啉基羥肟酸化合物 |
CN107674073B (zh) | 2010-05-17 | 2021-09-10 | 印蔻真治疗公司 | 作为蛋白激酶调节剂的3,5-二取代-3h-咪唑(或[1,2,3]***)并[4,5-b] 吡啶化合物 |
US8299117B2 (en) | 2010-06-16 | 2012-10-30 | Metabolex Inc. | GPR120 receptor agonists and uses thereof |
ES2526124T3 (es) | 2010-06-16 | 2015-01-07 | Cymabay Therapeutics, Inc. | Agonistas del receptor GPR120 y sus usos |
US20130323269A1 (en) | 2010-07-30 | 2013-12-05 | Muthiah Manoharan | Methods and compositions for delivery of active agents |
US9000025B2 (en) | 2010-08-20 | 2015-04-07 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
WO2012069917A1 (en) | 2010-11-26 | 2012-05-31 | Lupin Limited | Bicyclic gpr119 modulators |
TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
US9708299B2 (en) | 2011-01-03 | 2017-07-18 | Genentech, Inc. | Hedgehog antagonists having zinc binding moieties |
EP2670733B1 (en) | 2011-02-01 | 2019-04-10 | The Board of Trustees of the University of Illionis | N-hydroxybenzamide derivatives as hdac inhibitors and therapeutic methods using the same |
US20120225846A1 (en) | 2011-03-02 | 2012-09-06 | Bioenergenix | Heterocyclic compounds for the inhibition of pask |
WO2012117421A1 (en) | 2011-03-02 | 2012-09-07 | Orchid Research Laboratories Ltd | Histone deacetylase inhibitors |
WO2012117021A2 (en) | 2011-03-03 | 2012-09-07 | Syngenta Participations Ag | Novel microbiocidal oxime ethers |
WO2012164074A1 (en) | 2011-06-03 | 2012-12-06 | University Of Basel | Mannose phosphate derivatives as antagonists of bacterial adhesion |
WO2013024427A1 (en) | 2011-08-16 | 2013-02-21 | Glenmark Pharmaceuticals S.A. | Novel urea derivatives as tec kinase inhibitors and uses thereof |
WO2013040527A1 (en) | 2011-09-16 | 2013-03-21 | Microbiotix, Inc. | Antimicrobial compounds |
CA2850757A1 (en) | 2011-10-03 | 2013-04-11 | The Trustees Of Columbia University In The City Of New York | Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1 |
WO2013092460A1 (en) | 2011-12-20 | 2013-06-27 | Syngenta Participations Ag | Cyclic bisoxime microbicides |
CN104136410A (zh) | 2011-12-29 | 2014-11-05 | 药品循环公司 | 作为组蛋白脱乙酰酶8抑制剂的肉桂酸羟基酰胺 |
AR092790A1 (es) | 2012-02-01 | 2015-05-06 | Euro Celtique Sa | Derivados bencimidazolicos del acido hidroxamico |
JP5885140B2 (ja) | 2012-02-28 | 2016-03-15 | 国立大学法人 岡山大学 | Rxrパーシャルアゴニスト |
WO2013134079A1 (en) | 2012-03-05 | 2013-09-12 | Amgen Inc. | Oxazolidinone compounds and derivatives thereof |
CN103374021B (zh) | 2012-04-21 | 2015-10-28 | 通化济达医药有限公司 | 含有锌结合基的吡啶并嘧啶类HDAC和mTOR抑制剂 |
CN103373997B (zh) | 2012-04-21 | 2015-07-15 | 通化济达医药有限公司 | 含有锌结合基的吡啶并萘啶类HDAC和mTOR抑制剂 |
EP2852439A1 (en) | 2012-05-23 | 2015-04-01 | Stemergie Biotechnology SA | Inhibitors of the activity of complex (iii) of the mitochondrial electron transport chain and use thereof |
TR201807207T4 (tr) | 2012-06-11 | 2018-06-21 | Ucb Biopharma Sprl | Tnf-alfa modüle edici benzimidazol bileşikleri. |
CN103739482B (zh) | 2012-06-29 | 2015-08-26 | 常州大学 | 酰基苯氧乙酸类化合物及其制备方法 |
CN103524372B (zh) | 2012-07-03 | 2015-06-10 | 南京圣和药业股份有限公司 | 一种组蛋白去乙酰化酶抑制剂 |
CN104780764A (zh) | 2012-09-05 | 2015-07-15 | 拜尔农作物科学股份公司 | 取代的2-酰氨基苯并咪唑、2-酰氨基苯并噁唑和2-酰氨基苯并噻唑或其盐作为活性物质对抗非生物植物胁迫的用途 |
WO2014046544A1 (en) | 2012-09-21 | 2014-03-27 | Aapa B.V. | Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators |
US9718760B2 (en) | 2012-10-31 | 2017-08-01 | The Regents Of The University Of Michigan | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof |
CN103755595A (zh) | 2012-12-25 | 2014-04-30 | 中南大学 | 异羟肟酸类衍生物及其应用 |
KR101988930B1 (ko) | 2012-12-31 | 2019-06-13 | 동우 화인켐 주식회사 | 감광성 수지 조성물 및 이로부터 제조되는 절연막 |
WO2014124651A1 (en) | 2013-02-15 | 2014-08-21 | Københavns Universitet | Pyrrolidine-2-carboxylic acid derivatives as iglur antagonists |
DK2961741T3 (en) | 2013-03-01 | 2017-07-03 | Fund Para La Investig Medica Aplicada | Novel compounds as dual inhibitors of phosphodiesterases and histone deacetylases |
US9227962B2 (en) | 2013-03-13 | 2016-01-05 | Boston Biomedical, Inc. | Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative |
RU2015144103A (ru) | 2013-03-15 | 2017-04-28 | Зингента Партисипейшнс Аг | Микробиоцидно-активные имидазопиридиновые производные |
WO2014200882A1 (en) | 2013-06-11 | 2014-12-18 | Janssen Pharmaceutica Nv | PDE10a INHIBITORS FOR THE TREATMENT OF TYPE II DIABETES |
EP3035924A4 (en) * | 2013-08-20 | 2017-04-19 | City of Hope | Hdac8 inhibitors for treating cancer |
WO2015157504A1 (en) | 2014-04-11 | 2015-10-15 | Taipei Medical University | Histone deacetylase inhibitors |
CN103936752A (zh) | 2014-05-05 | 2014-07-23 | 潍坊博创国际生物医药研究院 | 靛红类组蛋白去乙酰化酶抑制剂及其制备方法和应用 |
CA2990165C (en) | 2015-02-02 | 2023-12-12 | Forma Therapeutics, Inc. | 3-aryl-4-amido-bicyclic [4,5,0]hydroxamic acids as hdac inhibitors |
US10183934B2 (en) | 2015-02-02 | 2019-01-22 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
EA201792028A1 (ru) | 2015-03-13 | 2018-04-30 | Форма Терапьютикс, Инк. | Альфа-цинамидные соединения и композиции как ингибиторы hdac8 |
US9637453B2 (en) | 2015-04-17 | 2017-05-02 | Forma Therapeutics, Inc. | 3-spirocyclic-6-hydroxamic acid tetralins as HDAC inhibitors |
AR105911A1 (es) | 2015-09-03 | 2017-11-22 | Forma Therapeutics Inc | Inhibidores de hdac8 bicíclicos fusionados [6,6] |
EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
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US10266487B2 (en) | 2019-04-23 |
US20200331847A1 (en) | 2020-10-22 |
EA201792028A1 (ru) | 2018-04-30 |
US20160264518A1 (en) | 2016-09-15 |
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US10988441B2 (en) | 2021-04-27 |
HK1249104A1 (zh) | 2018-10-26 |
CO2017009298A2 (es) | 2018-01-31 |
MX2017011778A (es) | 2017-12-04 |
EP3268358A1 (en) | 2018-01-17 |
MA41677A (fr) | 2021-06-02 |
BR112017019453A2 (pt) | 2018-05-15 |
JP2018531213A (ja) | 2018-10-25 |
SG11201707418WA (en) | 2017-10-30 |
CA2979391A1 (en) | 2016-09-22 |
CA2979391C (en) | 2023-10-17 |
WO2016149099A1 (en) | 2016-09-22 |
TW201639811A (zh) | 2016-11-16 |
CN107531660A (zh) | 2018-01-02 |
AU2016233568A1 (en) | 2017-10-05 |
EP3932914A1 (en) | 2022-01-05 |
US11919839B2 (en) | 2024-03-05 |
US20220073452A1 (en) | 2022-03-10 |
US10508077B2 (en) | 2019-12-17 |
CR20170420A (es) | 2017-10-03 |
IL254383A0 (en) | 2017-11-30 |
KR20170124602A (ko) | 2017-11-10 |
PH12017501669A1 (en) | 2018-03-19 |
US20190241506A1 (en) | 2019-08-08 |
US9745253B2 (en) | 2017-08-29 |
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