JP2018522858A5 - - Google Patents
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- JP2018522858A5 JP2018522858A5 JP2017566338A JP2017566338A JP2018522858A5 JP 2018522858 A5 JP2018522858 A5 JP 2018522858A5 JP 2017566338 A JP2017566338 A JP 2017566338A JP 2017566338 A JP2017566338 A JP 2017566338A JP 2018522858 A5 JP2018522858 A5 JP 2018522858A5
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- Prior art keywords
- pharmaceutical composition
- cancer
- treating
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- pharmaceutically acceptable
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- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 102000004965 antibodies Human genes 0.000 claims 3
- 108090001123 antibodies Proteins 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 1
- 102100008614 IDO1 Human genes 0.000 claims 1
- 101710031171 IDO1 Proteins 0.000 claims 1
- 102100008615 IDO2 Human genes 0.000 claims 1
- 101710031174 IDO2 Proteins 0.000 claims 1
- 102100014437 TDO2 Human genes 0.000 claims 1
- 101710006302 TDO2 Proteins 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 1
- 229940121650 immune-checkpoint protein inhibitors Drugs 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229940121354 immunomodulators Drugs 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Claims (4)
- 請求項１〜１９のいずれか一項に記載の化合物、および薬学的に許容し得る担体または希釈剤を含む医薬組成物。
- 有効量の請求項１〜１９のいずれか一項に記載の化合物またはその薬学的に許容し得る塩を含む、がんを有する対象を治療するための医薬組成物。
- 有効量の請求項１〜１９のいずれか一項に記載の化合物またはその薬学的に許容し得る塩を含む、がんを有する対象を治療するための医薬組成物であって、該医薬組成物は、有効な第二の抗がん治療（例、化学療法剤、標的化治療剤、放射線または手術）と組み合わせて使用される、医薬組成物。
- 有効量の請求項１〜１９のいずれか一項に記載の化合物またはその薬学的に許容し得る塩を含む、がんを有する対象を治療するための医薬組成物であって、該医薬組成物は、有効量の、チェックポイント阻害剤（例、抗ＰＤ−１抗体、抗ＣＴＬＡ４抗体または抗ＰＤ−Ｌ１抗体）またはトリプトファン酸化阻害剤（例、ＩＤＯ１、ＩＤＯ２またはＴＤＯ２阻害剤）などの免疫調節剤と組み合わせて使用される、医薬組成物。
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021097834A JP7241810B2 (ja) | 2015-06-25 | 2021-06-11 | Ｈｐｋ１阻害剤およびそれを用いる方法 |
| JP2023034474A JP2023071911A (ja) | 2015-06-25 | 2023-03-07 | Ｈｐｋ１阻害剤およびそれを用いる方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562184348P | 2015-06-25 | 2015-06-25 | |
| US62/184,348 | 2015-06-25 | ||
| PCT/CA2016/050734 WO2016205942A1 (en) | 2015-06-25 | 2016-06-23 | Hpk1 inhibitors and methods of using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021097834A Division JP7241810B2 (ja) | 2015-06-25 | 2021-06-11 | Ｈｐｋ１阻害剤およびそれを用いる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522858A JP2018522858A (ja) | 2018-08-16 |
| JP2018522858A5 true JP2018522858A5 (ja) | 2019-07-25 |
| JP6898868B2 JP6898868B2 (ja) | 2021-07-07 |
Family
ID=57584335
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566338A Active JP6898868B2 (ja) | 2015-06-25 | 2016-06-23 | Ｈｐｋ１阻害剤およびそれを用いる方法 |
| JP2021097834A Active JP7241810B2 (ja) | 2015-06-25 | 2021-06-11 | Ｈｐｋ１阻害剤およびそれを用いる方法 |
| JP2023034474A Pending JP2023071911A (ja) | 2015-06-25 | 2023-03-07 | Ｈｐｋ１阻害剤およびそれを用いる方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021097834A Active JP7241810B2 (ja) | 2015-06-25 | 2021-06-11 | Ｈｐｋ１阻害剤およびそれを用いる方法 |
| JP2023034474A Pending JP2023071911A (ja) | 2015-06-25 | 2023-03-07 | Ｈｐｋ１阻害剤およびそれを用いる方法 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10501474B2 (ja) |
| EP (1) | EP3322711B1 (ja) |
| JP (3) | JP6898868B2 (ja) |
| KR (2) | KR102614872B1 (ja) |
| CN (2) | CN113214287B (ja) |
| AU (1) | AU2016282289B2 (ja) |
| BR (2) | BR122023006150B1 (ja) |
| CA (1) | CA2989684A1 (ja) |
| CY (1) | CY1124489T1 (ja) |
| DK (1) | DK3322711T3 (ja) |
| EA (1) | EA035421B1 (ja) |
| ES (1) | ES2872555T3 (ja) |
| HK (1) | HK1255833A1 (ja) |
| HR (1) | HRP20210895T1 (ja) |
| HU (1) | HUE054159T2 (ja) |
| IL (2) | IL283353B (ja) |
| LT (1) | LT3322711T (ja) |
| MA (1) | MA42456B1 (ja) |
| MD (1) | MD3322711T2 (ja) |
| MX (2) | MX2018000048A (ja) |
| PL (1) | PL3322711T3 (ja) |
| PT (1) | PT3322711T (ja) |
| RS (1) | RS61919B1 (ja) |
| SG (1) | SG10202105964RA (ja) |
| SI (1) | SI3322711T1 (ja) |
| TW (1) | TWI733679B (ja) |
| WO (1) | WO2016205942A1 (ja) |
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| US20180228786A1 (en) | 2017-02-15 | 2018-08-16 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
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| BR112019019555A2 (pt) * | 2017-03-30 | 2020-04-22 | Hoffmann La Roche | composto de fórmula i, composição farmacêutica, método de inibição de hpk1, método para melhorar uma resposta imune, método para tratar um distúrbio e uso do composto |
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| US8501750B2 (en) | 2007-05-21 | 2013-08-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| PT2262500T (pt) | 2008-04-11 | 2016-08-16 | Merck Patent Gmbh | Derivados de tienopiridona como ativadores da proteína quinase ativada por amp (ampk) |
| UA103617C2 (ru) | 2008-05-05 | 2013-11-11 | Мерк Патент Гмбх | Производные тиенопиридона как активаторы амр-активированной протеинкиназы (амрк) |
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2016
- 2016-06-23 HU HUE16813437A patent/HUE054159T2/hu unknown
- 2016-06-23 JP JP2017566338A patent/JP6898868B2/ja active Active
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- 2016-06-23 CN CN201680048058.0A patent/CN107922431B/zh active Active
- 2016-06-23 EP EP16813437.7A patent/EP3322711B1/en active Active
- 2016-06-23 KR KR1020187001327A patent/KR102614872B1/ko active IP Right Grant
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- 2016-06-23 PL PL16813437T patent/PL3322711T3/pl unknown
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- 2016-06-23 CA CA2989684A patent/CA2989684A1/en active Pending
- 2016-06-23 KR KR1020237042987A patent/KR20240000617A/ko not_active Application Discontinuation
- 2016-06-23 RS RS20210675A patent/RS61919B1/sr unknown
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