PT2262500T - Derivados de tienopiridona como ativadores da proteína quinase ativada por amp (ampk) - Google Patents

Derivados de tienopiridona como ativadores da proteína quinase ativada por amp (ampk)

Info

Publication number
PT2262500T
PT2262500T PT97312656T PT09731265T PT2262500T PT 2262500 T PT2262500 T PT 2262500T PT 97312656 T PT97312656 T PT 97312656T PT 09731265 T PT09731265 T PT 09731265T PT 2262500 T PT2262500 T PT 2262500T
Authority
PT
Portugal
Prior art keywords
ampk
activators
protein kinase
activated protein
thienopyridone derivatives
Prior art date
Application number
PT97312656T
Other languages
English (en)
Inventor
Hallakou-Bozec Sophie
Charon Christine
Lepifre Franck
Cravo Daniel
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PT2262500T publication Critical patent/PT2262500T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
PT97312656T 2008-04-11 2009-03-17 Derivados de tienopiridona como ativadores da proteína quinase ativada por amp (ampk) PT2262500T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08290364 2008-04-11

Publications (1)

Publication Number Publication Date
PT2262500T true PT2262500T (pt) 2016-08-16

Family

ID=40671017

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97312656T PT2262500T (pt) 2008-04-11 2009-03-17 Derivados de tienopiridona como ativadores da proteína quinase ativada por amp (ampk)

Country Status (26)

Country Link
US (1) US8563729B2 (pt)
EP (1) EP2262500B1 (pt)
JP (1) JP5592348B2 (pt)
KR (1) KR101630466B1 (pt)
CN (1) CN101998853B (pt)
AU (1) AU2009235784B2 (pt)
BR (1) BRPI0910439B8 (pt)
CA (1) CA2721025C (pt)
CO (1) CO6300954A2 (pt)
DK (1) DK2262500T3 (pt)
EA (1) EA017756B1 (pt)
EC (1) ECSP10010599A (pt)
ES (1) ES2584278T3 (pt)
HK (1) HK1155955A1 (pt)
HR (1) HRP20160907T1 (pt)
HU (1) HUE027857T2 (pt)
IL (1) IL208067A (pt)
MX (1) MX2010011047A (pt)
MY (1) MY155836A (pt)
NZ (1) NZ589136A (pt)
PL (1) PL2262500T3 (pt)
PT (1) PT2262500T (pt)
SI (1) SI2262500T1 (pt)
UA (1) UA103321C2 (pt)
WO (1) WO2009124636A1 (pt)
ZA (1) ZA201008050B (pt)

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CA2723429C (en) * 2008-05-05 2016-10-11 Daniel Cravo Thienopyridone derivatives as amp-activated protein kinase (ampk) activators
WO2011080277A1 (en) * 2009-12-29 2011-07-07 Poxel Thieno [2,3-b] pyridinedione activators of ampk and therapeutic uses thereof
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011121109A1 (en) 2010-04-02 2011-10-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1)
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
JP5990170B2 (ja) * 2010-09-01 2016-09-07 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 除草活性を有するケトスルタム類及びジケトピリジン類
JP2014507452A (ja) * 2011-03-07 2014-03-27 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー キノリン誘導体
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2679591A1 (en) * 2012-06-29 2014-01-01 Poxel Thienopyridone derivatives useful as activators of AMPK
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ａｍｐｋを活性化させるインダゾール化合物
WO2015002818A1 (en) 2013-07-01 2015-01-08 Emory University Treating or preventing nephrogenic diabetes insipidus
US10143703B2 (en) 2014-01-02 2018-12-04 Massachusetts Eye And Ear Infirmary Treating ocular neovascularization
CN104945370A (zh) * 2015-06-23 2015-09-30 佛山市赛维斯医药科技有限公司 含卤代噻吩和硝苯六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN104945369A (zh) * 2015-06-23 2015-09-30 佛山市赛维斯医药科技有限公司 一种含六甲基苯环和硝基苯结构的黄原酸酯类化合物、其制备方法及用途
CN105037321A (zh) * 2015-06-23 2015-11-11 佛山市赛维斯医药科技有限公司 含六甲基苯环的黄原酸酯类的ampk激活剂、制备方法及用途
CN105037322A (zh) * 2015-06-23 2015-11-11 佛山市赛维斯医药科技有限公司 含六甲基苯环和烷氧苯结构的黄原酸酯类化合物、其制备方法及用途
CN104892569A (zh) * 2015-06-23 2015-09-09 佛山市赛维斯医药科技有限公司 末端取代的硝苯六甲苯黄原酸酯类的化合物、制备方法及用途
CN104892568A (zh) * 2015-06-23 2015-09-09 佛山市赛维斯医药科技有限公司 一种含六甲基苯环和腈基苯结构的黄原酸酯类化合物、其制备方法及用途
CN104926756A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 一类含腈基苯的双酰基苄胺类化合物、其制备方法及用途
CN105037296A (zh) * 2015-06-24 2015-11-11 佛山市赛维斯医药科技有限公司 一类卤代苯双酰基苄胺类的ampk激活剂、其制备方法及用途
CN104926755A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 硝苯双酰基苄胺类ampk激活剂、其制备方法及用途
CN105001194A (zh) * 2015-06-24 2015-10-28 佛山市赛维斯医药科技有限公司 一种含氨基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN104945371A (zh) * 2015-06-24 2015-09-30 佛山市赛维斯医药科技有限公司 一种含腈基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN104926757A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 含烷氧苯基的双酰基苄胺类ampk激活剂、其制备方法及用途
CN104945372A (zh) * 2015-06-24 2015-09-30 佛山市赛维斯医药科技有限公司 一种含二硝基以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN105001181A (zh) * 2015-06-24 2015-10-28 佛山市赛维斯医药科技有限公司 一类双酰基苄胺类的ampk激活剂、其制备方法及用途
CA2989684A1 (en) * 2015-06-25 2016-12-29 University Health Network Hpk1 inhibitors and methods of using same
EP3355876A2 (en) 2015-09-30 2018-08-08 Instituto de Medicina Molecular Methods for attenuating parasite virulence
WO2018002215A1 (en) 2016-06-30 2018-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cardiomyopathies
EP3880683B1 (en) * 2018-11-16 2023-11-01 Poxel Monohydrate potassium salt of a thienopyridone derivative and its preparation process
WO2020201263A1 (en) 2019-04-01 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling
CA3171453A1 (en) * 2020-03-26 2021-09-30 Sebastien Bolze Use of a thienopyridone derivative in the treatment of adrenoleukodystrophy or adrenomyeloneuropathy
IL296843A (en) 2020-04-02 2022-11-01 Poxel Use of a thianopyridone derivative in the treatment of autosomal dominant polycystic kidney disease (adpkd)
CN116323608A (zh) 2020-05-19 2023-06-23 卡尔优普公司 Ampk活化剂
JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ，インク． Ａｍｐｋアクチベーター
CN116322663A (zh) 2020-09-30 2023-06-23 比奥维拉迪维治疗股份有限公司 Ampk激活剂及其使用方法
WO2022106892A1 (en) 2020-11-17 2022-05-27 Instituto De Medicina Molecular Anti-malarial compounds

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AU626418B2 (en) 1989-05-16 1992-07-30 Merrell Pharmaceuticals Inc. Excitatory amino acid antagonists
DE4444815A1 (de) 1994-12-15 1996-06-20 Merck Patent Gmbh Thienopyridone
GB0214268D0 (en) 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
US7119205B2 (en) * 2003-05-16 2006-10-10 Abbott Laboratories Thienopyridones as AMPK activators for the treatment of diabetes and obesity
EP1754483A1 (en) * 2005-08-18 2007-02-21 Merck Sante Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them
US8273744B2 (en) 2008-02-04 2012-09-25 Mercury Therapeutics, Inc. AMPK modulators

Also Published As

Publication number Publication date
US8563729B2 (en) 2013-10-22
EP2262500B1 (en) 2016-04-27
SI2262500T1 (sl) 2016-09-30
ECSP10010599A (es) 2010-12-30
BRPI0910439B1 (pt) 2020-10-20
HK1155955A1 (en) 2012-06-01
CN101998853A (zh) 2011-03-30
BRPI0910439B8 (pt) 2021-05-25
EA201001585A1 (ru) 2011-06-30
CA2721025C (en) 2016-07-26
JP5592348B2 (ja) 2014-09-17
PL2262500T3 (pl) 2016-09-30
AU2009235784A1 (en) 2009-10-15
EP2262500A1 (en) 2010-12-22
KR101630466B1 (ko) 2016-06-14
EA017756B1 (ru) 2013-02-28
HRP20160907T1 (hr) 2016-09-23
IL208067A (en) 2015-05-31
ES2584278T3 (es) 2016-09-26
ZA201008050B (en) 2011-07-27
CN101998853B (zh) 2015-02-11
MY155836A (en) 2015-12-15
IL208067A0 (en) 2010-12-30
AU2009235784B2 (en) 2013-09-19
CA2721025A1 (en) 2009-10-15
HUE027857T2 (en) 2016-11-28
DK2262500T3 (en) 2016-08-15
BRPI0910439A2 (pt) 2015-09-29
US20110034505A1 (en) 2011-02-10
JP2011516510A (ja) 2011-05-26
UA103321C2 (ru) 2013-10-10
KR20100137563A (ko) 2010-12-30
MX2010011047A (es) 2010-10-26
CO6300954A2 (es) 2011-07-21
NZ589136A (en) 2012-06-29
WO2009124636A1 (en) 2009-10-15

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