HU190236B - Process for preparing mitomycine analogues and pharmaceutical compositions containing such compounds as active substances - Google Patents
Process for preparing mitomycine analogues and pharmaceutical compositions containing such compounds as active substances Download PDFInfo
- Publication number
- HU190236B HU190236B HU84483A HU48384A HU190236B HU 190236 B HU190236 B HU 190236B HU 84483 A HU84483 A HU 84483A HU 48384 A HU48384 A HU 48384A HU 190236 B HU190236 B HU 190236B
- Authority
- HU
- Hungary
- Prior art keywords
- lower alkyl
- substituted
- nitro
- methoxy
- alkyl
- Prior art date
Links
- 0 CC(C*1C(C(C(*)=C2N=C)=O)=C(C3*)C2=O)*C13O Chemical compound CC(C*1C(C(C(*)=C2N=C)=O)=C(C3*)C2=O)*C13O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Beschrieben werden neue Verfahren zur Behandlung neoplastischer Krankheitszustaende bei Tieren, wobei eine therapeutisch wirksame Menge einer Verbindung der Formel III a, in der Y Wasserstoff oder ein niederes Alkyl bezeichnet und Z einen hydroxy-substituierten 1-Pyrrolidinyl-Rest, oder einen durch niederes Alkyl substituierten Piperidyl-Rest oder einen 1-Piperazinyl-Rest oder einen durch Acetamino, Acetyl-Carbamido, Cyano, Carboxy-nieder-alkyl-amino, Di-niederalkoxy, Nitro, Sulfamyl oder Niederalkyl substituierten Anilino-Rest oder einen Rest der Formel -R -N-R1bezeichnet, in der R fuer Wasserstoff oder niederes Alkyl und R1 fuer einen stickstoffhaltigen heterocyclischen Rest ausgewaehlt aus der aus amino-substituiertem Triazolyl, niederalkyl-substituiertem Isothiazolyl, Benzothiazolyl sowie nitro- und halogenosubstituierten Derivaten des Benzothiazolyls bestehenden Gruppe stehen oder R1 einen substituierten niederen Alkyl-Rest ausgewaehlt aus der aus Amino-Niederalkyl, Niederalkylamino-niederalkyl, Hydroxyniederalkylamino-niederalkyl, Hydroxyniederalkoxyniederalkyl, Imidazolyl-niederalkyl, nitrosubstituiertem Imidazolyl-niederalkyl, Mono- und Di-hydroxyphenyl-niederalkyl, nitrosubstituiertem Pyridylamino-niederalkyl, Piperazinyl-niederalkyl und Pyridylethyl bestehenden Gruppe, bezeichnet.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46461283A | 1983-02-07 | 1983-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU190236B true HU190236B (en) | 1986-08-28 |
Family
ID=23844605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU84483A HU190236B (en) | 1983-02-07 | 1984-02-06 | Process for preparing mitomycine analogues and pharmaceutical compositions containing such compounds as active substances |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPS59152384A (de) |
| KR (1) | KR900006854B1 (de) |
| AT (1) | AT385509B (de) |
| AU (1) | AU571193B2 (de) |
| BE (1) | BE898856A (de) |
| CA (1) | CA1252789A (de) |
| CH (1) | CH658658A5 (de) |
| DD (1) | DD233844A5 (de) |
| DE (1) | DE3403922A1 (de) |
| DK (1) | DK161890C (de) |
| ES (1) | ES8607305A1 (de) |
| FI (1) | FI80698C (de) |
| FR (1) | FR2540500B1 (de) |
| GB (1) | GB2134514B (de) |
| GR (1) | GR81455B (de) |
| HU (1) | HU190236B (de) |
| IE (1) | IE56814B1 (de) |
| IL (1) | IL70897A (de) |
| IT (1) | IT1178855B (de) |
| LU (1) | LU85199A1 (de) |
| NL (1) | NL8400338A (de) |
| NO (1) | NO161374C (de) |
| NZ (1) | NZ206932A (de) |
| OA (1) | OA07654A (de) |
| PH (1) | PH20249A (de) |
| PT (1) | PT78067B (de) |
| SE (1) | SE461982B (de) |
| YU (1) | YU44984B (de) |
| ZA (1) | ZA84788B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4487769A (en) * | 1982-06-04 | 1984-12-11 | Bristol-Myers Company | Amidines |
| CA1282069C (en) * | 1985-09-12 | 1991-03-26 | Damon L. Meyer | Antibody complexes of hapten-modified diagnostic or therapeutic agents |
| JPS63150282A (ja) * | 1986-12-13 | 1988-06-22 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体 |
| JPS63246379A (ja) * | 1987-03-31 | 1988-10-13 | Kyowa Hakko Kogyo Co Ltd | ７−ｎ，８−ｎ−エチレンマイトマイシン８−イミン類 |
| EP0485904B1 (de) * | 1990-11-13 | 1997-08-20 | Kyowa Hakko Kogyo Co., Ltd. | Mitomycinderivate |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3332944A (en) * | 1964-11-02 | 1967-07-25 | American Cyanamid Co | Antibiotic derivatives of mitomycins a, b, c and porfiromycin |
| JPS5439098A (en) * | 1977-08-31 | 1979-03-24 | Kyowa Hakko Kogyo Co Ltd | Mitomycin c derivatives |
| US4268676A (en) * | 1979-12-05 | 1981-05-19 | University Patents, Inc. | Mitomycin analogs |
| JPS5686184A (en) * | 1979-12-17 | 1981-07-13 | Kyowa Hakko Kogyo Co Ltd | Novel mitomycin c derivative |
| NZ199617A (en) * | 1981-05-15 | 1985-08-30 | University Patents Inc | Azirino(2',3',:3,4)pyrrolo(1,2-a)indole-4,7-dione derivatives and pharmaceutical compositions |
| US4487769A (en) * | 1982-06-04 | 1984-12-11 | Bristol-Myers Company | Amidines |
| US4642352A (en) * | 1983-12-23 | 1987-02-10 | Bristol-Myers Company | Acylamino mitosanes |
-
1984
- 1984-01-25 NZ NZ206932A patent/NZ206932A/en unknown
- 1984-01-27 GB GB08402233A patent/GB2134514B/en not_active Expired
- 1984-02-02 ZA ZA84788A patent/ZA84788B/xx unknown
- 1984-02-03 NL NL8400338A patent/NL8400338A/nl not_active Application Discontinuation
- 1984-02-03 AU AU24073/84A patent/AU571193B2/en not_active Ceased
- 1984-02-04 DE DE19843403922 patent/DE3403922A1/de not_active Withdrawn
- 1984-02-06 PT PT78067A patent/PT78067B/pt not_active IP Right Cessation
- 1984-02-06 NO NO840433A patent/NO161374C/no unknown
- 1984-02-06 ES ES529478A patent/ES8607305A1/es not_active Expired
- 1984-02-06 AT AT0037684A patent/AT385509B/de not_active IP Right Cessation
- 1984-02-06 IE IE272/84A patent/IE56814B1/en not_active IP Right Cessation
- 1984-02-06 DD DD84259885A patent/DD233844A5/de not_active IP Right Cessation
- 1984-02-06 PH PH30204A patent/PH20249A/en unknown
- 1984-02-06 HU HU84483A patent/HU190236B/hu not_active IP Right Cessation
- 1984-02-06 DK DK052484A patent/DK161890C/da active
- 1984-02-06 CH CH550/84A patent/CH658658A5/de not_active IP Right Cessation
- 1984-02-06 CA CA000446811A patent/CA1252789A/en not_active Expired
- 1984-02-06 GR GR73720A patent/GR81455B/el unknown
- 1984-02-07 FR FR8401845A patent/FR2540500B1/fr not_active Expired
- 1984-02-07 YU YU217/84A patent/YU44984B/xx unknown
- 1984-02-07 FI FI840502A patent/FI80698C/fi not_active IP Right Cessation
- 1984-02-07 OA OA58227A patent/OA07654A/xx unknown
- 1984-02-07 IL IL70897A patent/IL70897A/xx unknown
- 1984-02-07 IT IT67113/84A patent/IT1178855B/it active
- 1984-02-07 LU LU85199A patent/LU85199A1/fr unknown
- 1984-02-07 SE SE8400628A patent/SE461982B/sv not_active IP Right Cessation
- 1984-02-07 BE BE0/212351A patent/BE898856A/fr not_active IP Right Cessation
- 1984-02-07 KR KR1019840000574A patent/KR900006854B1/ko not_active IP Right Cessation
- 1984-02-07 JP JP59021505A patent/JPS59152384A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |