HK1137938A1 - Quinoline derivatives as pi3 kinase inhibitors - Google Patents

Quinoline derivatives as pi3 kinase inhibitors

Info

Publication number
HK1137938A1
HK1137938A1 HK10104231.9A HK10104231A HK1137938A1 HK 1137938 A1 HK1137938 A1 HK 1137938A1 HK 10104231 A HK10104231 A HK 10104231A HK 1137938 A1 HK1137938 A1 HK 1137938A1
Authority
HK
Hong Kong
Prior art keywords
kinase inhibitors
quinoline derivatives
quinoline
derivatives
kinase
Prior art date
Application number
HK10104231.9A
Other languages
English (en)
Inventor
Nicholas D Adams
Joelle Lorraine Burgess
Michael Gerard Darcy
Carla A Donatelli
Steven David Knight
Kenneth Allen Newlander
Lance Ridgers
Martha Sarpong
Stanley J Schmidt
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of HK1137938A1 publication Critical patent/HK1137938A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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HK10104231.9A 2007-05-18 2010-04-29 Quinoline derivatives as pi3 kinase inhibitors HK1137938A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93876107P 2007-05-18 2007-05-18
PCT/US2008/063819 WO2008144463A1 (en) 2007-05-18 2008-05-16 Quinoline derivatives as pi3 kinase inhibitors

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HK1137938A1 true HK1137938A1 (en) 2010-08-13

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KR (1) KR101458660B1 (es)
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AR (1) AR066614A1 (es)
AU (1) AU2008254915B2 (es)
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CA (1) CA2686016C (es)
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CY (1) CY1114070T1 (es)
DK (1) DK2162131T3 (es)
EA (1) EA019540B1 (es)
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HK (1) HK1137938A1 (es)
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PE (1) PE20090717A1 (es)
PL (1) PL2162131T3 (es)
PT (1) PT2162131E (es)
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UA (1) UA104408C2 (es)
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Families Citing this family (231)

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