FI2155783T4 - Lajien välisesti spesifinen cd3-epsilon-sitoutumisdomeeni - Google Patents

Lajien välisesti spesifinen cd3-epsilon-sitoutumisdomeeni Download PDF

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FI2155783T4
FI2155783T4 FIEP08735001.3T FI08735001T FI2155783T4 FI 2155783 T4 FI2155783 T4 FI 2155783T4 FI 08735001 T FI08735001 T FI 08735001T FI 2155783 T4 FI2155783 T4 FI 2155783T4
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Matthias Klinger
Tobias Raum
Doris Rau
Susanne Mangold
Roman Kischel
Ralf LUTTERBÜSE
Patrick Hoffmann
Peter Kufer
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Claims (14)

PATENTTIVAATIMUKSET
1. Polypeptidi, joka käsittää sitoutumisdomeenin, joka on sellainen vasta-aine, joka kykenee sitoutumaan ihmisen ja Callithrix jacchus-, Saguinus oedipus- tai Saimiri sciureus -lajin CD3e-ketjun epitooppiin, jolloin kyseinen epitooppi on osa sellaista aminohapposek- venssiä, joka koostuu ryhmästä, joka koostuu sekvensseistä SEO ID NO: 2, 4, 6 ja 8, ja kä- sittää vähintään aminohapposekvenssin Gln-Asp-Gly-Asn-Glu, jolloin polypeptidi käsittää lisäksi toisen sitoutumisdomeenin, joka kykenee sitoutumaan solun pinnan antigeeniin, jo- ka on tuumoriantigeeni, jossa ensimmäinen sitoutumisdomeeni käsittää VL-alueen, joka käsittää CDR-L1:n, CDR-L2:n ja CDR-L3:n, jotka valitaan seuraavien joukosta: (a) —sekvenssin SEO ID NO: 27 esittämä CDR-L1, sekvenssin SEO ID NO: 28 esittämä CDR-L2 ja sekvenssin SEO ID NO: 29 esittämä CDR-L3; (b) sekvenssin SEO ID NO: 117 esittämä CDR-L1, sekvenssin SEO ID NO: 118 esittämä CDR-L2 ja sekvenssin SEO ID NO: 119 esittämä CDR-L3 ja (c) —sekvenssin SEO ID NO: 153 esittämä CDR-L1, sekvenssin SEO ID NO: 154 esittämä CDR-L2 ja sekvenssin SEO ID NO: 155 esittämä CDR-L3; ja käsittää VH-alueen, joka käsittää CDR-H1:n, CDR-H2:n ja CDR-H3:n, jotka valitaan seu- raavien joukosta: (a) —sekvenssin SEQ ID NO: 12 esittämä CDR-HI, sekvenssin SEO ID NO: 13 esittämä CDR-H2 ja sekvenssin SEO ID NO: 14 esittämä CDR-H3; (b) sekvenssin SEO ID NO: 30 esittämä CDR-H1, sekvenssin SEQ ID NO: 31 esittämä CDR-H2 ja sekvenssin SEO ID NO: 32 esittämä CDR-H3; (c) —sekvenssin SEQ ID NO: 48 esittämä CDR-HI, sekvenssin SEO ID NO: 49 — esittämä CDR-H2 ja sekvenssin SEO ID NO: 50 esittämä CDR-B3; (d) sekvenssin SEQ ID NO: 66 esittämä CDR-HI, sekvenssin SEO ID NO: 67 esittämä CDR-H2 ja sekvenssin SEO ID NO: 68 esittämä CDR-H3;
(e) sekvenssin SEQ ID NO: 84 esittämä CDR-HI, sekvenssin SEQ ID NO: 85 esittämä CDR-H2 ja sekvenssin SEQ ID NO: 86 esittämä CDR-H3; (f) —sekvenssin SEQ ID NO: 102 esittämä CDR-HI, sekvenssin SEQ ID NO: 103 esittämä CDR-H2 ja sekvenssin SEQ ID NO: 104 esittämä CDR-H3; (g) sekvenssin SEQ ID NO: 120 esittämä CDR-HI, sekvenssin SEQ ID NO: 121 esittämä CDR-H2 ja sekvenssin SEQ ID NO: 122 esittämä CDR-H3; (h) —sekvenssin SEQ ID NO: 138 esittämä CDR-HI, sekvenssin SEQ ID NO: 139 esittämä CDR-H2 ja sekvenssin SEO ID NO: 140 esittämä CDR-H3; (1) — sekvenssin SEQ ID NO: 156 esittämä CDR-HI, sekvenssin SEQ ID NO: 157 esittämä CDR-H2 ja sekvenssin SEQ ID NO: 158 esittämä CDR-H3; ja (J) — sekvenssin SEO ID NO: 174 esittämä CDR-HI, sekvenssin SEQ ID NO: 175 esittämä CDR-H2 ja sekvenssin SEO ID NO: 176 esittämä CDR-H3.
2. Patenttivaatimuksen 1 mukainen polypeptidi, jossa epitooppi on osa aminohep- posekvenssiä, jonka käsittää ryhmä, joka koostuu seuraavista: SEO ID NO 2, 4, 6 ja 8, ja — käsittää vähintään aminohapposekvenssin Gln-Asp-Gly-Asn-Glu.
3. Patenttivaatimuksen 1 tai 2 mukainen polypeptidi, jossa ensimmäinen sitoutumis- domeeni käsittää VL-alueen, joka valitaan ryhmästä, joka koostuu sekvenssien SEO ID NO: 35, 39, 125, 129, 161 ja 165 esittämistä VL-alueista.
4. Jonkin patenttivaatimuksen 1-3 mukainen polypeptidi, jossa ensimmäinen sitou- — tumisdomeeni käsittää VH-alueen, joka valitaan ryhmästä, joka koostuu sekvenssien SEO ID NO: 15, 19, 33, 37, 51, 55, 69, 73, 87, 91, 105, 109, 123, 127, 141, 145, 159, 163, 177 ja 181 esittämistä VH-alueista.
5. Jonkin patenttivaatimuksen 1-4 mukainen polypeptidi, jossa ensimmäinen sitou- tuminen käsittää VL-alueen ja VH-alueen, jotka valitaan ryhmästä, joka koostuu seuraavis- ta: (a) —sekvenssin SEO ID NO: 17 tai 21 esittämä VL-alue ja sekvenssin SEQ ID NO: 15 tai 19 esittämä VH-alue;
(b) —sekvenssin SEQ ID NO: 35 tai 39 esittämä VL-alue ja sekvenssin SEQ ID NO: 33 tai 37 esittämä VH-alue; (c) —sekvenssin SEO ID NO: 53 tai 57 esittämä VL-alue ja sekvenssin SEO ID NO: 51 tai 55 esittämä VH-alue; (d) sekvenssin SEO ID NO: 71 tai 75 esittämä VL-alue ja sekvenssin SEO ID NO: 69 tai 73 esittämä VH-alue; (e) —sekvenssin SEQ ID NO: 89 tai 93 esittämä VL-alue ja sekvenssin SEQ ID NO: 87 tai 91 esittämä VH-alue; (f) —sekvenssin SEO ID NO: 107 tai 111 esittämä VL-alue ja sekvenssin SEO ID NO: 105 tai 109 esittämä VH-alue; (g) sekvenssin SEO ID NO: 125 tai 129 esittämä VL-alue ja sekvenssin SEO ID NO: 123 tai 127 esittämä VH-alue; (h) —sekvenssin SEQ ID NO: 143 tai 147 esittämä VL-alue ja sekvenssin SEO ID NO: 141 tai 145 esittämä VH-alue; (1) — sekvenssin SEO ID NO: 161 tai 165 esittämä VL-alue ja sekvenssin SEO ID NO: 159 tai 163 esittämä VH-alue ja (j) sekvenssin SEO ID NO: 179 tai 183 esittämä VL-alue ja sekvenssin SEO ID NO: 177 tai 181 esittämä VH-alue.
6. Patenttivaatimuksen 5 mukainen polypeptidi, jossa ensimmäinen sitoutumisdo- — meeni käsittää aminohapposekvenssin, joka valitaan ryhmästä, joka koostuu sekvensseistä SEO ID NO: 23, 25, 41, 43, 59, 61, 77, 79, 95, 97, 113, 115, 131, 133, 149, 151, 167, 169, 185 ja 187.
7. Jonkin patenttivaatimuksen 1-6 mukainen polypeptidi, joka mainittu polypeptidi on bispesifinen yksiketjuinen vasta-ainemolekyyli.
8. Nukleiinihapposekvenssi, joka koodaa jonkin patenttivaatimuksen 1-7 mukaista polypeptidiä.
9. Vektori, joka käsittää patenttivaatimuksen 8 mukaisen nukleiinihapposekvenssin.
10. Isäntäsolu, joka on transformoitu tai transfektoitu patenttivaatimuksen 9 mukaisel- la vektorilla.
11. Menetelmä jonkin patenttivaatimuksen 1-7 mukaisen polypeptidin valmista- miseksi, joka kyseinen menetelmä käsittää vaiheet, joissa patenttivaatimuksen 10 mukaista isäntäsolua viljellään olosuhteissa, jotka mahdollistavat jonkin patenttivaatimuksen 1-7 mukaisen polypeptidin ilmentämisen, sekä kerätään tuotettu polypeptidi talteen viljelmästä.
12. Lääkekoostumus, joka käsittää jonkin patenttivaatimuksen 1-7 mukaista polypep- tidiä tai joka on valmistettu patenttivaatimuksen 11 mukaisella menetelmällä.
13. Jonkin patenttivaatimuksen 1-7 mukainen polypeptidi tai polypeptidi, joka on — valmistettu patenttivaatimuksen 11 mukaisella menetelmällä, käytettäväksi sellaisen sai- rauden estämisessä, hoidossa tai lievittämisessä, joka valitaan proliferaatiosairauden, kas- vainsairauden ja immunologisen häiriön joukosta.
14. Kitti, joka käsittää jonkin patenttivaatimuksen 1-7 mukaista polypeptidiä, patent- tivaatimuksen 8 mukaista nukleiinihappomolekyyliä, jonkin patenttivaatimuksen 9 mukais- ta vektoria tai patenttivaatimuksen 10 mukaista isäntäsolua.
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