JOP20170091B1 - إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية - Google Patents

إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية

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Publication number
JOP20170091B1
JOP20170091B1 JOP/2017/0091A JOP20170091A JOP20170091B1 JO P20170091 B1 JOP20170091 B1 JO P20170091B1 JO P20170091 A JOP20170091 A JO P20170091A JO P20170091 B1 JOP20170091 B1 JO P20170091B1
Authority
JO
Jordan
Prior art keywords
treatment
myeloid leukemia
administration
bispecific construct
construct
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Application number
JOP/2017/0091A
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English (en)
Inventor
Gerhard Zugmaier
Peter Kufer
Roman Kischel
Marion Subklewe
Christina Krupka
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Amgen Res Munich Gmbh
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Publication of JOP20170091B1 publication Critical patent/JOP20170091B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Abstract

يوفر الاختراع الحالي تركيبة ثنائية النوعية تشتمل على نطاق ربط أول يرتبط نوعيًا بـ CD33 ونطاق ربط ثانٍ يرتبط نوعيًا بـ CD3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية، حيث يتم إعطاء التركيبة لمدة أقصها 14 يومًا يعقبها 14 يومًا على الأقل دون إعطاء التركيبة. علاوةً على ذلك، يوفر الاختراع طريقة لعلاج اللوكيميا النخاعية تشتمل على إعطاء كمية فعالة علاجيًا من تلك التركيبة ثنائية النوعية واستخدام تلك التركيبة ثنائية النوعية لتحضير تركيبة صيدلية لعلاج اللوكيميا النخاعية.
JOP/2017/0091A 2016-04-19 2017-04-16 إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية JOP20170091B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662324451P 2016-04-19 2016-04-19

Publications (1)

Publication Number Publication Date
JOP20170091B1 true JOP20170091B1 (ar) 2021-08-17

Family

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Family Applications (1)

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JOP/2017/0091A JOP20170091B1 (ar) 2016-04-19 2017-04-16 إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية

Country Status (18)

Country Link
US (1) US11053318B2 (ar)
EP (1) EP3445784B1 (ar)
JP (1) JP2019514871A (ar)
AU (1) AU2017253621A1 (ar)
BR (1) BR112018070946A2 (ar)
CA (1) CA3019740A1 (ar)
EA (1) EA038736B1 (ar)
IL (1) IL262423A (ar)
JO (1) JOP20170091B1 (ar)
MA (1) MA44726A (ar)
MX (1) MX2018012717A (ar)
MY (1) MY194062A (ar)
PH (1) PH12018502230A1 (ar)
SG (1) SG11201808656SA (ar)
TW (1) TWI752952B (ar)
UA (1) UA124732C2 (ar)
WO (1) WO2017182427A1 (ar)
ZA (1) ZA201806514B (ar)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
CN114652827A (zh) 2015-05-29 2022-06-24 安普希韦纳治疗公司 双特异性cd33和cd3结合蛋白质的使用方法
EP3165536A1 (en) * 2015-11-09 2017-05-10 Ludwig-Maximilians-Universität München Trispecific molecule combining specific tumor targeting and local immune checkpoint inhibition
JP2021532140A (ja) * 2018-07-30 2021-11-25 アムジェン リサーチ （ミュニック） ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｄ３３及びｃｄ３に結合する二重特異性抗体コンストラクトの長期投与
EP3863644A4 (en) * 2018-10-12 2022-10-05 Jeanmarie Guenot CD33×CD3-BINDING PROTEINS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS AND DISEASES
TW202034952A (zh) 2018-12-20 2020-10-01 荷蘭商美勒斯公司 用於治療疾病之CLEC12AxCD3雙特異性抗體及方法
EP3990022A4 (en) * 2019-06-26 2023-06-28 Memorial Sloan Kettering Cancer Center Anti-cd33 antibodies for treating cancer
TW202132340A (zh) * 2019-11-04 2021-09-01 美商安進公司 治療白血病之方法
WO2021138407A2 (en) * 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Multifunctional molecules that bind to cd33 and uses thereof

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AU2017253621A1 (en) 2018-10-18
BR112018070946A2 (pt) 2019-02-26
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MY194062A (en) 2022-11-10
MA44726A (fr) 2019-02-27
SG11201808656SA (en) 2018-10-30
TW201741339A (zh) 2017-12-01
WO2017182427A1 (en) 2017-10-26
UA124732C2 (uk) 2021-11-10
IL262423A (en) 2018-12-31
US11053318B2 (en) 2021-07-06
EP3445784A1 (en) 2019-02-27
EA038736B1 (ru) 2021-10-12
CA3019740A1 (en) 2017-10-26
EP3445784B1 (en) 2022-06-01
MX2018012717A (es) 2019-05-15
EA201892367A1 (ru) 2019-04-30
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TWI752952B (zh) 2022-01-21
PH12018502230A1 (en) 2019-07-08

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