ES2116977T3 - Soportes solidos para ensayos de hibridacion de acidos nucleicos y metodos para inmovilizar oligonucleotidos de modo covalente. - Google Patents

Soportes solidos para ensayos de hibridacion de acidos nucleicos y metodos para inmovilizar oligonucleotidos de modo covalente.

Info

Publication number
ES2116977T3
ES2116977T3 ES90309671T ES90309671T ES2116977T3 ES 2116977 T3 ES2116977 T3 ES 2116977T3 ES 90309671 T ES90309671 T ES 90309671T ES 90309671 T ES90309671 T ES 90309671T ES 2116977 T3 ES2116977 T3 ES 2116977T3
Authority
ES
Spain
Prior art keywords
nucleic acid
acid hybridization
methods
solid supports
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90309671T
Other languages
English (en)
Inventor
Ness Jeffrey Van
John C Tabone
Charles E Petrie
Nicolaas M J Vermeulen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanogen Inc
Original Assignee
MicroProbe Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MicroProbe Corp filed Critical MicroProbe Corp
Application granted granted Critical
Publication of ES2116977T3 publication Critical patent/ES2116977T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE DESCRIBEN COMPOSICIONES Y METODOS PARA INMOVILIZAR COVALENTEMENTE UN OLIGONUCLEOTIDO EN UN LECHO REVESTIDO DE POLIMERO O UNA ESTRUCTURA SIMILAR. ESPECIFICAMENTE, EL LECHO CUBIERTO CON UN POLIMERO O UNA ESTRUCTURA SIMILAR, POSEE UN GRAN NUMERO DE MITADES ACTIVADAS, PREFERIBLEMENTE AMINAS PRIMARIAS Y SECUNDARIAS. UN OLIGONUCLEOTIDO ES ACTIVADO CON UN REAGENTE MONOFUNCIONAL O MULTIFUNCIONAL, PREFERIBLEMENTE EL REAGENTE HOMOTRIFUNCIONAL CLORURO DE CIANURO. LOS OLIGONUCLEOTIDOS INMOVILIZADOS COVALENTEMENTE RESULTANTES, EN LOS LECHOS O ESTRUCTURAS SIMILARES PUEDEN SERVIR COMO PRUEBAS DE ACIDO NUCLEICO EN SOPORTES SOLIDOS, Y ENSAYOS DE HIBRIDACION PUEDEN SER EFECTUADO DONDE ACIDOS NUCLEICOS DE BLANCO ESPECIFICO SON DETECTADOS EN MUESTRAS DE COMPLEJOS BIOLOGICOS. LAS GOTAS O ESTRUCTURAS SIMILARES PUEDEN SER EMPLEADAS LIBRES DE SOLUCION, TAL COMO EN UN FORMANTE DE POZO MICROTITO; EN UN FORMANTE A TRAVES DE FLUJO, TAL COMO EN UNA COLUMNA; O EN UN PALILLO DE HUNDIMIENTO, INCLUYENDO UNA TARJETA INDICADORA DE SITIOS MULTIPLES, DONDE SE PUEDEN ALINEAR MUY CERCA GOTAS MULTIPLES POSEYENDO OLIGONUCLEOTIDOS CON DIFERENTES SECUENCIAS O ESPECIFICACIONES Y SE PUEDEN DETECTAR UNA MULTIPLICIDAD DE PATOGENOS EN UNA SOLA MUESTRA BIOLOGICA. ADICIONALMENTE, SE INCLUYEN EN ESTA INVENCION OLIGONUCLEOTIDOS DICLOROTRIACINOS Y PROCESOS PARA ACTIVAR OLIGONUCLEOTIDOS MEDIANTE SU TRATAMIENTO CON CLORURO DE CIANURO.
ES90309671T 1990-05-11 1990-09-04 Soportes solidos para ensayos de hibridacion de acidos nucleicos y metodos para inmovilizar oligonucleotidos de modo covalente. Expired - Lifetime ES2116977T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52244290A 1990-05-11 1990-05-11

Publications (1)

Publication Number Publication Date
ES2116977T3 true ES2116977T3 (es) 1998-08-01

Family

ID=24080872

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90309671T Expired - Lifetime ES2116977T3 (es) 1990-05-11 1990-09-04 Soportes solidos para ensayos de hibridacion de acidos nucleicos y metodos para inmovilizar oligonucleotidos de modo covalente.

Country Status (7)

Country Link
US (1) US5514785A (es)
EP (2) EP0745689A3 (es)
JP (1) JPH0420300A (es)
AT (1) ATE167523T1 (es)
DE (1) DE69032425T2 (es)
DK (1) DK0455905T3 (es)
ES (1) ES2116977T3 (es)

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