RU2007137489A - Способы и композиции для модуляции целостности сосудов - Google Patents

Способы и композиции для модуляции целостности сосудов Download PDF

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RU2007137489A
RU2007137489A RU2007137489/04A RU2007137489A RU2007137489A RU 2007137489 A RU2007137489 A RU 2007137489A RU 2007137489/04 A RU2007137489/04 A RU 2007137489/04A RU 2007137489 A RU2007137489 A RU 2007137489A RU 2007137489 A RU2007137489 A RU 2007137489A
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dscr1
modulator
nucleic acid
modulator according
activity
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Ханс-Петер ГЕРБЕР (US)
Ханс-Петер Гербер
Борис А. ХЕССЕР (US)
Борис А. ХЕССЕР
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Дженентек, Инк. (Us)
Дженентек, Инк.
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Abstract

1. Модулятор DSCR1, который модулирует активность DSCR1 в эндотелиальных клетках. ! 2. Модулятор DSCR1 по п.1, где модулятор модулирует активность DSCR1, индуцированную сигнальным путем, опосредованным рецептором VEGF 2 (VEGFR-2). ! 3. Модулятор DSCR1 по любому из предшествующих пунктов, где модулятор модулирует путь DSCR1-кальциневрин A (CnA). ! 4. Модулятор DSCR1 по п.1, где модулятор модулирует клеточное событие, связанное с активностью NFAT. ! 5. Модулятор DSCR1 по п.4, где клеточное событие представляет собой фосфорилирование NFAT, транслокацию NFAT в ядро или транскрипционную активность NFAT. ! 6. Модулятор DSCR1 по п.1, где модулятор включат в себя нуклеиновую кислоту, которая кодирует полипептид, способный препятствовать экспрессии генов, индуцированной CnA. ! 7. Модулятор DSCR1 по п.6, где полипептид включает в себя пептид, содержащий по меньшей мере часть DSCR1, где пептид способен взаимодействовать с CnA. ! 8. Модулятор DSCR1 по п.6 или 7, где полипептид содержит аминокислоты приблизительно в положениях 96-125 или приблизительно в положениях 108-122 человеческого DSCR1. ! 9. Модулятор DSCR1 по п.1 или 2, где модулятор способен препятствовать функционированию DSCR1. ! 10. Модулятор DSCR1 по п.9, где модулятор включает в себя нуклеиновую кислоту, которая в случае присутствия в эндотелиальной клетке ингибирует активность DSCR1 в клетке. ! 11. Модулятор DSCR1 по п.10, где нуклеиновая кислота включает в себя антисмысловой олигонуклеотид. ! 12. Модулятор DSCR1 по п.10, где нуклеиновая кислота включает в себя ингибирующую/интерферирующую РНК. ! 13. Модулятор DSCR1 по п.12, где ингибирующая/интерферирующая РНК представляет собой малую ингибирующую/интерферирующую РНК (siРНК). ! 14. Модулятор DSCR1 по п.12, где нуклеиновая кисло�

Claims (35)

1. Модулятор DSCR1, который модулирует активность DSCR1 в эндотелиальных клетках.
2. Модулятор DSCR1 по п.1, где модулятор модулирует активность DSCR1, индуцированную сигнальным путем, опосредованным рецептором VEGF 2 (VEGFR-2).
3. Модулятор DSCR1 по любому из предшествующих пунктов, где модулятор модулирует путь DSCR1-кальциневрин A (CnA).
4. Модулятор DSCR1 по п.1, где модулятор модулирует клеточное событие, связанное с активностью NFAT.
5. Модулятор DSCR1 по п.4, где клеточное событие представляет собой фосфорилирование NFAT, транслокацию NFAT в ядро или транскрипционную активность NFAT.
6. Модулятор DSCR1 по п.1, где модулятор включат в себя нуклеиновую кислоту, которая кодирует полипептид, способный препятствовать экспрессии генов, индуцированной CnA.
7. Модулятор DSCR1 по п.6, где полипептид включает в себя пептид, содержащий по меньшей мере часть DSCR1, где пептид способен взаимодействовать с CnA.
8. Модулятор DSCR1 по п.6 или 7, где полипептид содержит аминокислоты приблизительно в положениях 96-125 или приблизительно в положениях 108-122 человеческого DSCR1.
9. Модулятор DSCR1 по п.1 или 2, где модулятор способен препятствовать функционированию DSCR1.
10. Модулятор DSCR1 по п.9, где модулятор включает в себя нуклеиновую кислоту, которая в случае присутствия в эндотелиальной клетке ингибирует активность DSCR1 в клетке.
11. Модулятор DSCR1 по п.10, где нуклеиновая кислота включает в себя антисмысловой олигонуклеотид.
12. Модулятор DSCR1 по п.10, где нуклеиновая кислота включает в себя ингибирующую/интерферирующую РНК.
13. Модулятор DSCR1 по п.12, где ингибирующая/интерферирующая РНК представляет собой малую ингибирующую/интерферирующую РНК (siРНК).
14. Модулятор DSCR1 по п.12, где нуклеиновая кислота содержит одну или несколько последовательностей, выбранных из группы, состоящей из GCUCAGACCUUACACAUAG, GGACAUCACCUUUCAGUAU, GAAAGAAUGAGGAGACCUA, GACAUCACCUUUCAGUAUU, AACGUAUGACAAGGACAUCAC, AAGGACAUCACCUUUCAGUAU, AAGUUAUAUUUUGCUCAGACC и AAGAUGCGACCCCAGUCAUAA.
15. Модулятор DSCR1 по п.10, где нуклеиновая кислота включает в себя аптамер.
16. Способ лечения нарушения, ассоциированного с аномальным воспалением сосудов, где указанный способ лечения включает в себя введение субъекту эффективного количества модулятора DSCR1 по любому из пп.1-15.
17. Способ по п.16, где модулятор усиливает воспаление, ассоциированное с сосудистой сетью.
18. Способ по п.16, где модулятор ингибирует воспаление, ассоциированное с сосудистой сетью.
19. Способ лечения иммунологического нарушения, ассоциированного с аномальным воспалением сосудов, где указанный способ лечения включает в себя введение субъекту эффективного количества модулятора DSCR1 по любому из пп.1-15.
20. Способ по п.19, где модулятор усиливает воспаление, ассоциированное с сосудистой сетью.
21. Способ по п.20, где модулятор ингибирует воспаление, ассоциированное с сосудистой сетью.
22. Способ лечения состояния, ассоциированного с нарушением целостности сосудов, где указанный способ лечения включает в себя введение субъекту эффективного количества модулятора DSCR1 по любому из пп.1-15.
23. Способ по п.22, где нарушение целостности сосудов ассоциировано с воспалением, связанным с сосудистыми/эндотелиальными клетками.
24. Способ по п.23, где модулятор усиливает воспаление, ассоциированное с сосудистой сетью.
25. Способ по п.23, где модулятор ингибирует воспаление, ассоциированное с сосудистой сетью.
26. Способ уменьшения побочных эффектов, ассоциированных с противовоспалительной терапией, который включает в себя введение субъекту модулятора DSCR1 по любому из пп.1-15 в сочетании с противовоспалительной терапией, в результате которой происходит снижение побочных эффектов.
27. Способ по п.26, где модулятор DSCR1 ингибирует активность DSCR1 в эндотелиальной клетке.
28. Способ по п.26 или 27, где противовоспалительная терапия включает в себя средство, подавляющее воспаление.
29. Способ по п.26, где указанный модулятор усиливает воспаление, ассоциированное с сосудистой сетью.
30. Способ по п.26, где модулятор ингибирует воспаление, ассоциированное с сосудистой сетью.
31. Способ лечения нарушения, ассоциированного с нежелательным ангиогенезом, включающий в себя введение субъекту, страдающему указанным нарушением, антиангиогенного средства и модулятора DSCR1 по любому из пп.1-15.
32. Способ ингибирования опухолевого роста или роста злокачественных клеток, включающий в себя введение в опухоль или злокачественную клетку эффективного количества противоракового средства и эффективного количества модулятора DSCR1 по любому из пп.1-15, где комбинированное эффективное количество ингибирует рост опухоли или рост раковых клеток.
33. Способ по п.32, где противораковое средство включает в себя антиангиогенное средство.
34. Способ по п.33, где антиангиогенное средство включает в себя антагонист VEGF.
35. Способ по п.34, где антагонист VEGF представляет собой антитело против VEGF.
RU2007137489/04A 2005-03-10 2006-03-09 Способы и композиции для модуляции целостности сосудов RU2007137489A (ru)

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CN108384787B (zh) * 2018-03-09 2020-05-19 山东大学深圳研究院 一种RCAN1适配子RCAN1-s14
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