MX343008B - Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6). - Google Patents

Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).

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Publication number
MX343008B
MX343008B MX2013011177A MX2013011177A MX343008B MX 343008 B MX343008 B MX 343008B MX 2013011177 A MX2013011177 A MX 2013011177A MX 2013011177 A MX2013011177 A MX 2013011177A MX 343008 B MX343008 B MX 343008B
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MX
Mexico
Prior art keywords
compositions
methods
inhibiting expression
tmprss6 gene
tmprss6
Prior art date
Application number
MX2013011177A
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English (en)
Other versions
MX2013011177A (es
Inventor
Bumcrot David
Bettencourt Brian
Toudjarska Ivanka
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2013011177A publication Critical patent/MX2013011177A/es
Publication of MX343008B publication Critical patent/MX343008B/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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Abstract

La presente invención se refiere a composiciones de ácido ribonucleico de doble hebra (ARNdh) que se dirigen al gen TMPRSS6, y a métodos de uso de las composiciones de ARNdh para inhibir la expresión de TMPRSS6.
MX2013011177A 2011-03-29 2012-03-28 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6). MX343008B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161468830P 2011-03-29 2011-03-29
US201161568942P 2011-12-09 2011-12-09
PCT/US2012/030786 WO2012135246A2 (en) 2011-03-29 2012-03-28 Compositions and methods for inhibiting expression of tmprss6 gene

Publications (2)

Publication Number Publication Date
MX2013011177A MX2013011177A (es) 2013-12-06
MX343008B true MX343008B (es) 2016-10-21

Family

ID=46932295

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2013011177A MX343008B (es) 2011-03-29 2012-03-28 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).
MX2016013802A MX360349B (es) 2011-03-29 2012-03-28 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).
MX2018013216A MX2018013216A (es) 2011-03-29 2013-09-27 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2016013802A MX360349B (es) 2011-03-29 2012-03-28 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).
MX2018013216A MX2018013216A (es) 2011-03-29 2013-09-27 Composiciones y metodos para inhibir la expresion del gen de proteasa transmembrana, serina 6 (tmprss6).

Country Status (13)

Country Link
US (4) US9175290B2 (es)
EP (2) EP3674409A1 (es)
JP (6) JP6108628B2 (es)
KR (4) KR102271245B1 (es)
CN (2) CN113736782A (es)
AU (4) AU2012236700B2 (es)
BR (1) BR112013025006B1 (es)
CA (2) CA3217805A1 (es)
MX (3) MX343008B (es)
PH (1) PH12017501501A1 (es)
RU (1) RU2702501C2 (es)
SG (2) SG10201602369PA (es)
WO (1) WO2012135246A2 (es)

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US10745702B2 (en) 2015-04-08 2020-08-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the LECT2 gene
CA3043768A1 (en) 2016-11-29 2018-06-07 PureTech Health LLC Exosomes for delivery of therapeutic agents
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CN110997917B (zh) 2017-12-01 2024-04-09 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
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CN110959011B (zh) 2017-12-29 2023-03-28 苏州瑞博生物技术股份有限公司 缀合物及其制备方法和用途
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JP2021533800A (ja) 2018-08-21 2021-12-09 スーチョウ リボ ライフ サイエンス カンパニー、リミテッドSuzhou Ribo Life Science Co., Ltd. 核酸、当該核酸を含む薬物組成物及び複合体ならびにその使用
JP7376952B2 (ja) 2018-09-30 2023-11-09 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド ｓｉＲＮＡ複合体及びその調製方法と使用
CN111973619B (zh) * 2019-05-23 2024-01-30 苏州瑞博生物技术股份有限公司 核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途
KR20240001207A (ko) * 2021-04-26 2024-01-03 알닐람 파마슈티칼스 인코포레이티드 막관통 프로테아제, 세린 6(TMPRSS6) iRNA 조성물 및 이의 사용 방법
MX2023012834A (es) 2021-04-27 2023-11-08 Silence Therapeutics Gmbh Inhibidor de la matriptasa-2 para el tratamiento de trastornos mieloproliferativos.
TW202400193A (zh) 2022-06-24 2024-01-01 丹麥商諾佛 儂迪克股份有限公司 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法
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