MX2016004230A - Composiciones y metodos para inhibir la expresion del gen lect2. - Google Patents

Composiciones y metodos para inhibir la expresion del gen lect2.

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Publication number
MX2016004230A
MX2016004230A MX2016004230A MX2016004230A MX2016004230A MX 2016004230 A MX2016004230 A MX 2016004230A MX 2016004230 A MX2016004230 A MX 2016004230A MX 2016004230 A MX2016004230 A MX 2016004230A MX 2016004230 A MX2016004230 A MX 2016004230A
Authority
MX
Mexico
Prior art keywords
compositions
methods
inhibiting expression
lect2 gene
lect2
Prior art date
Application number
MX2016004230A
Other languages
English (en)
Inventor
Fitzgerald Kevin
Hinkle Gregory
Bettencourt Brian
Sehgal Alfica
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2016004230A publication Critical patent/MX2016004230A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
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  • Molecular Biology (AREA)
  • Biotechnology (AREA)
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  • Plant Pathology (AREA)
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  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La invención se refiere a composiciones de ácido ribonucleico bicatenario (ARNbc) que tienen como diana el gen LECT2 y a métodos para utilizar tales composiciones de ARNbc con el fin de alterar (por ejemplo, inhibir) la expresión de LECT2.
MX2016004230A 2013-10-02 2014-10-01 Composiciones y metodos para inhibir la expresion del gen lect2. MX2016004230A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361885693P 2013-10-02 2013-10-02
US201462035819P 2014-08-11 2014-08-11
PCT/US2014/058624 WO2015050990A1 (en) 2013-10-02 2014-10-01 Compositions and methods for inhibiting expression of the lect2 gene

Publications (1)

Publication Number Publication Date
MX2016004230A true MX2016004230A (es) 2016-10-21

Family

ID=51795760

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016004230A MX2016004230A (es) 2013-10-02 2014-10-01 Composiciones y metodos para inhibir la expresion del gen lect2.
MX2021010716A MX2021010716A (es) 2013-10-02 2016-04-01 Composiciones y metodos para inhibir la expresion del gen lect2.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021010716A MX2021010716A (es) 2013-10-02 2016-04-01 Composiciones y metodos para inhibir la expresion del gen lect2.

Country Status (7)

Country Link
US (3) US10077444B2 (es)
EP (1) EP3052626A1 (es)
CN (2) CN109536493A (es)
CA (1) CA2925107A1 (es)
MX (2) MX2016004230A (es)
TW (2) TWI669393B (es)
WO (1) WO2015050990A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109536493A (zh) 2013-10-02 2019-03-29 阿尔尼拉姆医药品有限公司 用于抑制lect2基因表达的组合物和方法
EA201790420A1 (ru) 2014-08-20 2017-07-31 Элнилэм Фармасьютикалз, Инк. Средства, представляющие собой модифицированную двухнитевую рнк
US10745702B2 (en) 2015-04-08 2020-08-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the LECT2 gene
CA2996701C (en) * 2015-08-25 2024-05-28 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating a proprotein convertase subtilisin kexin (pcsk9) gene-associated disorder
MX2020004507A (es) 2017-11-09 2020-08-13 Alnylam Pharmaceuticals Inc Ensayos y métodos para determinar la expresión del gen de quimiotaxina 2 derivada de leucocitos (lect2).
CN111971063A (zh) * 2018-04-06 2020-11-20 4阵营疗法公司 通过靶向调节基因信号传导网络治疗疾病
AR115960A1 (es) * 2018-08-16 2021-03-17 Alnylam Pharmaceuticals Inc Composiciones y métodos para inhibir la expresión del gen lect2
CN110592030B (zh) * 2019-06-05 2022-03-22 浙江大学 特异性抑制肝内lect2表达的腺相关病毒、构建及应用
CN110646615B (zh) * 2019-08-27 2021-07-13 南方医科大学 肝纤维化的生物学标志物、治疗靶点及其用途
AU2020343255A1 (en) * 2019-09-03 2022-03-24 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the LECT2 gene

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