US6040138A
(en)
*
|
1995-09-15 |
2000-03-21 |
Affymetrix, Inc. |
Expression monitoring by hybridization to high density oligonucleotide arrays
|
DE69132905T2
(de)
*
|
1990-12-06 |
2002-08-01 |
Affymetrix Inc N D Ges D Staat |
Detektion von Nukleinsäuresequenzen
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
US5747244A
(en)
*
|
1991-12-23 |
1998-05-05 |
Chiron Corporation |
Nucleic acid probes immobilized on polystyrene surfaces
|
AU679903B2
(en)
*
|
1991-12-24 |
1997-07-17 |
Tepnel Medical Limited |
Manipulating nucleic acid sequences
|
US6207651B1
(en)
*
|
1996-08-02 |
2001-03-27 |
Metabolite Laboratories |
Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6
|
AU675251B2
(en)
*
|
1993-01-04 |
1997-01-30 |
Becton Dickinson & Company |
Flow-through hybridization assay for oligonucleotide sequences
|
US6194144B1
(en)
|
1993-01-07 |
2001-02-27 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry
|
US5679510A
(en)
*
|
1993-04-27 |
1997-10-21 |
Hybridon, Inc. |
Quantitative detection of specific nucleic acid sequences using lambdoid bacteriophages linked by oligonucleotides to solid support
|
JP3484197B2
(ja)
|
1993-09-03 |
2004-01-06 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
アミン誘導化ヌクレオシドおよびオリゴヌクレオシド
|
DE4409436A1
(de)
*
|
1994-03-19 |
1995-09-21 |
Boehringer Mannheim Gmbh |
Verfahren zur Bearbeitung von Nukleinsäuren
|
JPH10500862A
(ja)
*
|
1994-05-28 |
1998-01-27 |
テプネル・メディカル・リミテッド |
核酸のコピーの産生
|
US7323298B1
(en)
|
1994-06-17 |
2008-01-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Microarray for determining the relative abundances of polynuceotide sequences
|
US5807522A
(en)
*
|
1994-06-17 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for fabricating microarrays of biological samples
|
US7378236B1
(en)
|
1994-06-17 |
2008-05-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method for analyzing gene expression patterns
|
US5578446A
(en)
*
|
1994-07-08 |
1996-11-26 |
Becton Dickinson And Company |
Analytical dipstick for improved mixing and reduced reagent volume
|
US8236493B2
(en)
*
|
1994-10-21 |
2012-08-07 |
Affymetrix, Inc. |
Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
|
US6428955B1
(en)
|
1995-03-17 |
2002-08-06 |
Sequenom, Inc. |
DNA diagnostics based on mass spectrometry
|
US7803529B1
(en)
|
1995-04-11 |
2010-09-28 |
Sequenom, Inc. |
Solid phase sequencing of biopolymers
|
US6420549B1
(en)
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
JP3517031B2
(ja)
*
|
1995-06-09 |
2004-04-05 |
日清紡績株式会社 |
生物学的活性物質の分析法
|
EP0910570A4
(de)
*
|
1995-11-14 |
2002-01-16 |
Baylor College Medicine |
Integrierte nukleinsaure-hybridisierung-vorrichtung auf der basis von aktiver-oberflachenchemie
|
US5854033A
(en)
|
1995-11-21 |
1998-12-29 |
Yale University |
Rolling circle replication reporter systems
|
EP0880598A4
(de)
|
1996-01-23 |
2005-02-23 |
Affymetrix Inc |
Verfahren zur analyse von nukleinsäure
|
EP0907889B1
(de)
*
|
1996-04-25 |
2007-07-04 |
BioArray Solutions Ltd. |
Licht-regulierte, elektrokinetische zusammensetzung von partikeln an oberflächen
|
US20030044941A1
(en)
|
1996-06-06 |
2003-03-06 |
Crooke Stanley T. |
Human RNase III and compositions and uses thereof
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US7875733B2
(en)
*
|
2003-09-18 |
2011-01-25 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation
|
US5898031A
(en)
*
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US20070275921A1
(en)
*
|
1996-06-06 |
2007-11-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric Compounds That Facilitate Risc Loading
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
DE69737598T2
(de)
*
|
1996-07-29 |
2007-12-27 |
Nanosphere Inc., Skokie |
Nanopartikel mit daran angehefteten oligonukleotiden sowie deren verwendungen
|
US5900481A
(en)
*
|
1996-11-06 |
1999-05-04 |
Sequenom, Inc. |
Bead linkers for immobilizing nucleic acids to solid supports
|
AU2002300406B9
(en)
*
|
1996-11-06 |
2005-11-03 |
Sequenom, Inc. |
Compositions and Methods for Immobilizing Nucleic Acids to Solid Supports
|
DE19782096T1
(de)
|
1996-11-06 |
2000-03-23 |
Sequenom Inc |
Immobiliserung von Nucleinsäuren in hoher Dichte
|
JP2008298785A
(ja)
*
|
1996-11-06 |
2008-12-11 |
Sequenom Inc |
固体支持体に核酸を固定化するための組成物および方法
|
US6140053A
(en)
|
1996-11-06 |
2000-10-31 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry via exonuclease degradation
|
DE69706187T2
(de)
*
|
1996-11-06 |
2002-04-11 |
Sequenom Inc |
Zusammensetzungen und verfahren zur immobilisierung von nukleinsäure auf festträgern
|
US6133436A
(en)
|
1996-11-06 |
2000-10-17 |
Sequenom, Inc. |
Beads bound to a solid support and to nucleic acids
|
AU745126B2
(en)
*
|
1997-04-16 |
2002-03-14 |
Applied Biosystems, Llc |
Nucleic acid archiving
|
US6887906B1
(en)
|
1997-07-01 |
2005-05-03 |
Isispharmaceuticals, Inc. |
Compositions and methods for the delivery of oligonucleotides via the alimentary canal
|
WO1999005308A2
(en)
|
1997-07-22 |
1999-02-04 |
Rapigene, Inc. |
Apparatus and methods for arraying solution onto a solid support
|
US6268131B1
(en)
|
1997-12-15 |
2001-07-31 |
Sequenom, Inc. |
Mass spectrometric methods for sequencing nucleic acids
|
CA2321100A1
(en)
*
|
1998-02-19 |
1999-08-26 |
Edvotek |
Articles of manufacture and methods for staining biomolecules
|
US6013789A
(en)
*
|
1998-02-20 |
2000-01-11 |
Beckman Coulter, Inc. |
Covalent attachment of biomolecules to derivatized polypropylene supports
|
EP1058832A1
(de)
|
1998-02-21 |
2000-12-13 |
Basf Aktiengesellschaft |
Verwendung von fluoreszenzfarbstoffen zur oberflächenuntersuchung
|
US7321828B2
(en)
*
|
1998-04-13 |
2008-01-22 |
Isis Pharmaceuticals, Inc. |
System of components for preparing oligonucleotides
|
US20040186071A1
(en)
*
|
1998-04-13 |
2004-09-23 |
Bennett C. Frank |
Antisense modulation of CD40 expression
|
US6048695A
(en)
*
|
1998-05-04 |
2000-04-11 |
Baylor College Of Medicine |
Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
|
US6979728B2
(en)
*
|
1998-05-04 |
2005-12-27 |
Baylor College Of Medicine |
Articles of manufacture and methods for array based analysis of biological molecules
|
US6723564B2
(en)
|
1998-05-07 |
2004-04-20 |
Sequenom, Inc. |
IR MALDI mass spectrometry of nucleic acids using liquid matrices
|
EP1080226A4
(de)
*
|
1998-05-21 |
2004-04-21 |
Isis Pharmaceuticals Inc |
Zusammensetzungen und methoden zur topischen verabreichung von oligonukleotiden
|
EP1080103A4
(de)
*
|
1998-05-21 |
2003-07-02 |
Isis Pharmaceuticals Inc |
Zubereitungen und verfahren zur nicht-parenteralen verabreichung von oligonukleotiden
|
US6335439B1
(en)
|
1998-06-11 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Method of preparing phosphoramidites
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
US6225293B1
(en)
|
1998-09-02 |
2001-05-01 |
Isis Pharmaceuticals, Inc. |
Methods and compounds for tracking the biodistribution of macromolecule-carrier combinations
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
US6667176B1
(en)
|
2000-01-11 |
2003-12-23 |
Geron Corporation |
cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
|
BE1012275A3
(fr)
*
|
1998-11-12 |
2000-08-01 |
Univ Bruxelles |
Fixation covalente d'oligonucleotides a la surface du nylon.
|
CA2351616A1
(en)
*
|
1998-11-23 |
2000-06-02 |
Usamriid |
Purification method and apparatus
|
US6638760B1
(en)
*
|
1998-11-25 |
2003-10-28 |
Pe Corporation (Ny) |
Method and apparatus for flow-through hybridization
|
US6300320B1
(en)
|
1999-01-05 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Modulation of c-jun using inhibitors of protein kinase C
|
US6127124A
(en)
*
|
1999-01-20 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
Fluorescence based nuclease assay
|
DE19903576C2
(de)
|
1999-01-29 |
2001-02-22 |
Bodenseewerk Perkin Elmer Co |
Quantitative Bestimmung von Analyten in einem heterogenen System
|
CA2359901A1
(en)
*
|
1999-02-16 |
2000-08-24 |
Pe Corporation (Ny) |
Bead dispensing system
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
US6268141B1
(en)
*
|
1999-05-12 |
2001-07-31 |
Beckman Coulter, Inc. |
Immobilization of unmodified biopolymers to acyl fluoride activated substrates
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
US6339147B1
(en)
|
1999-07-29 |
2002-01-15 |
Epoch Biosciences, Inc. |
Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
US6617442B1
(en)
|
1999-09-30 |
2003-09-09 |
Isis Pharmaceuticals, Inc. |
Human Rnase H1 and oligonucleotide compositions thereof
|
US7668658B2
(en)
|
1999-10-13 |
2010-02-23 |
Sequenom, Inc. |
Methods for generating databases and databases for identifying polymorphic genetic markers
|
CA2389769A1
(en)
*
|
1999-11-02 |
2001-05-10 |
Celine Hu |
Molecular microarrays and methods for production and use thereof
|
US7109024B2
(en)
*
|
1999-11-15 |
2006-09-19 |
Dr. Chip Biotechnology Inc. |
Biomolecule-bound substrates
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
AU2000225808A1
(en)
*
|
2000-02-09 |
2001-08-20 |
Resq Lab B.V. |
Packing materials for separation of biomolecules
|
US20030176385A1
(en)
*
|
2000-02-15 |
2003-09-18 |
Jingfang Ju |
Antisense modulation of protein expression
|
US6911535B2
(en)
*
|
2000-03-22 |
2005-06-28 |
Solvlink Biosciences |
Biomolecule/polymer conjugates
|
US6413722B1
(en)
*
|
2000-03-22 |
2002-07-02 |
Incyte Genomics, Inc. |
Polymer coated surfaces for microarray applications
|
EP2202241A3
(de)
*
|
2000-04-13 |
2010-07-28 |
Thomas N. Wight |
Therapeutische Verbindungen und Verfahren zur V3-Modulation, einer Versican-Isoform
|
US6458589B1
(en)
|
2000-04-27 |
2002-10-01 |
Geron Corporation |
Hepatocyte lineage cells derived from pluripotent stem cells
|
US6680172B1
(en)
|
2000-05-16 |
2004-01-20 |
Regents Of The University Of Michigan |
Treatments and markers for cancers of the central nervous system
|
CA2410879A1
(en)
*
|
2000-06-07 |
2001-12-13 |
Baylor College Of Medicine |
Novel compositions and methods for array-based nucleic acid hybridization
|
US20060166227A1
(en)
*
|
2000-06-20 |
2006-07-27 |
Stephen Kingsmore |
Protein expression profiling
|
US9709559B2
(en)
|
2000-06-21 |
2017-07-18 |
Bioarray Solutions, Ltd. |
Multianalyte molecular analysis using application-specific random particle arrays
|
US7892854B2
(en)
|
2000-06-21 |
2011-02-22 |
Bioarray Solutions, Ltd. |
Multianalyte molecular analysis using application-specific random particle arrays
|
US6323009B1
(en)
*
|
2000-06-28 |
2001-11-27 |
Molecular Staging, Inc. |
Multiply-primed amplification of nucleic acid sequences
|
US6958214B2
(en)
|
2000-07-10 |
2005-10-25 |
Sequenom, Inc. |
Polymorphic kinase anchor proteins and nucleic acids encoding the same
|
US8568766B2
(en)
|
2000-08-24 |
2013-10-29 |
Gattadahalli M. Anantharamaiah |
Peptides and peptide mimetics to treat pathologies associated with eye disease
|
AU9684601A
(en)
|
2000-10-12 |
2002-04-22 |
Univ Rochester |
Compositions that inhibit proliferation of cancer cells
|
US20030045005A1
(en)
*
|
2000-10-17 |
2003-03-06 |
Michael Seul |
Light-controlled electrokinetic assembly of particles near surfaces
|
US7767802B2
(en)
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
WO2002061146A1
(en)
*
|
2001-02-01 |
2002-08-08 |
The Trustees Of Columbia University In The City Of New York |
Use of electrical fields to control interactions between proteins and nucleic acid constructions immobilized on solid supports
|
JP2004533815A
(ja)
|
2001-03-14 |
2004-11-11 |
ミリアド・ジェネティックス・インコーポレイテッド |
Tsg101−gag相互作用およびその使用
|
US7803915B2
(en)
*
|
2001-06-20 |
2010-09-28 |
Genentech, Inc. |
Antibody compositions for the diagnosis and treatment of tumor
|
CA2451239A1
(en)
|
2001-06-20 |
2003-01-03 |
Genentech, Inc. |
Antibodies against tumor-associated antigenic taget (tat) polypeptides
|
US20050107595A1
(en)
*
|
2001-06-20 |
2005-05-19 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
US7262063B2
(en)
|
2001-06-21 |
2007-08-28 |
Bio Array Solutions, Ltd. |
Directed assembly of functional heterostructures
|
EP2270024B1
(de)
|
2001-06-21 |
2018-10-24 |
Ionis Pharmaceuticals, Inc. |
Antisense-Modulation von Superoxid-Dismutase 1, Expression in Lösung
|
US7297553B2
(en)
*
|
2002-05-28 |
2007-11-20 |
Nanosphere, Inc. |
Method for attachment of silylated molecules to glass surfaces
|
US7687437B2
(en)
|
2001-07-13 |
2010-03-30 |
Nanosphere, Inc. |
Method for immobilizing molecules onto surfaces
|
US20050287560A1
(en)
*
|
2001-07-13 |
2005-12-29 |
Nanosphere, Inc. |
Method for preparing substrates having immobilized molecules and substrates
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
NZ531674A
(en)
|
2001-09-18 |
2009-03-31 |
Genentech Inc |
Compositions and methods for the diagnosis and treatment of tumor
|
DE60204158T2
(de)
|
2001-10-05 |
2006-02-02 |
SurModics, Inc., Eden Prairie |
Beschichtungen mit immobilisierten partikeln sowie verwendungen derselben
|
US7195913B2
(en)
|
2001-10-05 |
2007-03-27 |
Surmodics, Inc. |
Randomly ordered arrays and methods of making and using
|
NZ566396A
(en)
|
2001-10-09 |
2009-07-31 |
Isis Pharmaceuticals Inc |
Antisense modulation of insulin-like growth factor binding protein 5 expressions
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
US7439346B2
(en)
*
|
2001-10-12 |
2008-10-21 |
Perkinelmer Las Inc. |
Nucleic acids arrays and methods of use therefor
|
WO2003091426A1
(en)
*
|
2001-10-12 |
2003-11-06 |
Spectral Genomics, Inc. |
Compilations of nucleic acids and arrays and methods of using them
|
WO2003034029A2
(en)
|
2001-10-15 |
2003-04-24 |
Bioarray Solutions, Ltd. |
Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
|
WO2003054143A2
(en)
*
|
2001-10-25 |
2003-07-03 |
Neurogenetics, Inc. |
Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
|
US20030170678A1
(en)
*
|
2001-10-25 |
2003-09-11 |
Neurogenetics, Inc. |
Genetic markers for Alzheimer's disease and methods using the same
|
US20030224380A1
(en)
*
|
2001-10-25 |
2003-12-04 |
The General Hospital Corporation |
Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases
|
DE10154291B4
(de)
*
|
2001-11-05 |
2005-05-19 |
Hain Lifescience Gmbh |
Verfahren zum Nachweis von Nukleinsäuren in Form eines Trockenschnelltestes
|
WO2003042697A1
(en)
*
|
2001-11-14 |
2003-05-22 |
Genospectra, Inc. |
Biochemical analysis system with combinatorial chemistry applications
|
US6927029B2
(en)
|
2001-12-03 |
2005-08-09 |
Agilent Technologies, Inc. |
Surface with tethered polymeric species for binding biomolecules
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
US8367013B2
(en)
*
|
2001-12-24 |
2013-02-05 |
Kimberly-Clark Worldwide, Inc. |
Reading device, method, and system for conducting lateral flow assays
|
US20030119203A1
(en)
|
2001-12-24 |
2003-06-26 |
Kimberly-Clark Worldwide, Inc. |
Lateral flow assay devices and methods for conducting assays
|
JP3634307B2
(ja)
*
|
2001-12-27 |
2005-03-30 |
三菱電機株式会社 |
チャット管理システム
|
US20030124542A1
(en)
*
|
2001-12-28 |
2003-07-03 |
Spectral Genomics, Inc. |
Methods for mapping the chromosomal loci of genes expressed by a cell
|
KR100623128B1
(ko)
|
2002-01-02 |
2006-09-14 |
제넨테크, 인크. |
종양의 진단 및 치료 방법 및 이를 위한 조성물
|
WO2003064679A2
(en)
*
|
2002-01-30 |
2003-08-07 |
Id Biomedical Corporation |
Methods for detecting vancomycin-resistant microorganisms and compositions therefor
|
CA2474530A1
(en)
*
|
2002-02-07 |
2003-08-14 |
Eastern Virginia Medical School Of The Medical College Of Hampton Roads |
Diagnostic microarray and method of use thereof
|
US7553619B2
(en)
*
|
2002-02-08 |
2009-06-30 |
Qiagen Gmbh |
Detection method using dissociated rolling circle amplification
|
AU2003228348A1
(en)
*
|
2002-03-20 |
2003-10-08 |
John T. Fassett |
Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors
|
US20030180712A1
(en)
|
2002-03-20 |
2003-09-25 |
Biostratum Ab |
Inhibition of the beta3 subunit of L-type Ca2+ channels
|
US7169916B2
(en)
*
|
2002-04-01 |
2007-01-30 |
Isis Pharmaceuticals, Inc. |
Chloral-free DCA in oligonucleotide synthesis
|
MXPA04010092A
(es)
|
2002-04-16 |
2004-12-13 |
Genentech Inc |
Composiciones y metodos para el diagnostico y tratamiento de tumores.
|
AU2003228809A1
(en)
*
|
2002-05-03 |
2003-11-17 |
Sequenom, Inc. |
Kinase anchor protein muteins, peptides thereof, and related methods
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
AU2003276131A1
(en)
*
|
2002-06-18 |
2003-12-31 |
Epigenesis Pharmaceuticals, Inc. |
A dry powder oligonucleotide formulation, preparation and its uses
|
JP2004097173A
(ja)
*
|
2002-07-17 |
2004-04-02 |
Toyo Kohan Co Ltd |
静電層を有する固体支持体及びその用途
|
US20040019000A1
(en)
*
|
2002-07-19 |
2004-01-29 |
Muthiah Manoharan |
Polyalkyleneamine-containing oligomers
|
US20050287648A1
(en)
|
2002-08-05 |
2005-12-29 |
University Of Rochester |
Protein Transducing Domain/Deaminase Chimeric Proteins, Related Compounds, and Uses Thereof
|
US6878805B2
(en)
*
|
2002-08-16 |
2005-04-12 |
Isis Pharmaceuticals, Inc. |
Peptide-conjugated oligomeric compounds
|
US7508608B2
(en)
|
2004-11-17 |
2009-03-24 |
Illumina, Inc. |
Lithographically fabricated holographic optical identification element
|
US7923260B2
(en)
|
2002-08-20 |
2011-04-12 |
Illumina, Inc. |
Method of reading encoded particles
|
US7164533B2
(en)
|
2003-01-22 |
2007-01-16 |
Cyvera Corporation |
Hybrid random bead/chip based microarray
|
JP4485949B2
(ja)
*
|
2002-08-20 |
2010-06-23 |
シヴェラ コーポレイション |
マルチプレックス実験用の回折格子ベースのコード化マイクロパーティクル
|
US7900836B2
(en)
|
2002-08-20 |
2011-03-08 |
Illumina, Inc. |
Optical reader system for substrates having an optically readable code
|
US7901630B2
(en)
|
2002-08-20 |
2011-03-08 |
Illumina, Inc. |
Diffraction grating-based encoded microparticle assay stick
|
US7872804B2
(en)
|
2002-08-20 |
2011-01-18 |
Illumina, Inc. |
Encoded particle having a grating with variations in the refractive index
|
AU2003265583C1
(en)
*
|
2002-08-20 |
2009-05-21 |
Cyvera Corporation |
Diffraction grating-based optical identification element
|
US7285424B2
(en)
|
2002-08-27 |
2007-10-23 |
Kimberly-Clark Worldwide, Inc. |
Membrane-based assay devices
|
US7314763B2
(en)
*
|
2002-08-27 |
2008-01-01 |
Kimberly-Clark Worldwide, Inc. |
Fluidics-based assay devices
|
EP1540591A1
(de)
*
|
2002-09-12 |
2005-06-15 |
Cyvera Corporation |
Mit hilfe eines beugungsgitters kodierte mikropartikeln für multiplex-experimente
|
US20100255603A9
(en)
|
2002-09-12 |
2010-10-07 |
Putnam Martin A |
Method and apparatus for aligning microbeads in order to interrogate the same
|
CA2498916A1
(en)
*
|
2002-09-12 |
2004-03-25 |
Cyvera Corporation |
Chemical synthesis using diffraction grating-based encoded optical elements
|
CA2499037A1
(en)
*
|
2002-09-12 |
2004-03-25 |
Cyvera Corporation |
Method and apparatus for labelling using diffraction grating-based encoded optical identification elements
|
EP1575707A1
(de)
*
|
2002-09-12 |
2005-09-21 |
Cyvera Corporation |
Verfahren und vorrichtung zur ausrichtung von länglichen mikroperlen zu deren untersuchung
|
US7092160B2
(en)
|
2002-09-12 |
2006-08-15 |
Illumina, Inc. |
Method of manufacturing of diffraction grating-based optical identification element
|
AU2003270655A1
(en)
*
|
2002-09-12 |
2004-04-30 |
Cyvera Corporation |
Assay stick comprising coded microbeads
|
WO2004024919A1
(en)
|
2002-09-13 |
2004-03-25 |
Replicor, Inc. |
Non-sequence complementary antiviral oligonucleotides
|
EP2233494A3
(de)
*
|
2002-09-20 |
2013-05-29 |
Yale University |
Riboswitches, Verfahren für deren Anwendung, Zusammensetzungen damit
|
JP4694201B2
(ja)
*
|
2002-09-20 |
2011-06-08 |
インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド |
アントラキノン消光色素、それらの製造方法及び使用
|
US7229976B2
(en)
|
2002-09-26 |
2007-06-12 |
Isis Pharmaceuticals, Inc. |
Modulation of forkhead box O1A expression
|
EP1560597A4
(de)
*
|
2002-10-29 |
2007-06-27 |
Pharmacia Corp |
Differentiell ausgedrückte krebsgene, dabei kodierte polypeptide und verfahren zu ihrer verwendung
|
US9150605B2
(en)
*
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
AU2003290596B2
(en)
|
2002-11-05 |
2011-05-12 |
Isis Pharmaceuticals, Inc. |
Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
US9150606B2
(en)
*
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
WO2004044138A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
CA2504694C
(en)
|
2002-11-05 |
2013-10-01 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
DK2336318T3
(da)
|
2002-11-13 |
2013-07-15 |
Genzyme Corp |
Antisense-modulering af apolipoprotein b-ekspression
|
JP4986109B2
(ja)
|
2002-11-13 |
2012-07-25 |
ジェンザイム・コーポレーション |
アポリポタンパク質b発現のアンチセンス調節
|
AU2003295576B2
(en)
|
2002-11-15 |
2011-03-17 |
Eisai, Inc. |
Methods of generating high-production of antibodies from hybridomas created by in vitro immunization
|
WO2004047007A1
(en)
|
2002-11-15 |
2004-06-03 |
Bioarray Solutions, Ltd. |
Analysis, secure access to, and transmission of array images
|
AU2003298650B2
(en)
|
2002-11-15 |
2010-03-11 |
Musc Foundation For Research Development |
Complement receptor 2 targeted complement modulators
|
EP1624753B1
(de)
|
2002-11-21 |
2012-01-25 |
The University of Utah Research Foundation |
Purinerge geruchsmodulation
|
US7781172B2
(en)
*
|
2003-11-21 |
2010-08-24 |
Kimberly-Clark Worldwide, Inc. |
Method for extending the dynamic detection range of assay devices
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
US7247500B2
(en)
*
|
2002-12-19 |
2007-07-24 |
Kimberly-Clark Worldwide, Inc. |
Reduction of the hook effect in membrane-based assay devices
|
US20040121334A1
(en)
*
|
2002-12-19 |
2004-06-24 |
Kimberly-Clark Worldwide, Inc. |
Self-calibrated flow-through assay devices
|
US20040121339A1
(en)
*
|
2002-12-19 |
2004-06-24 |
Jizhong Zhou |
Special film-coated substrate for bio-microarray fabrication and use thereof
|
US9487823B2
(en)
|
2002-12-20 |
2016-11-08 |
Qiagen Gmbh |
Nucleic acid amplification
|
EP2261371B1
(de)
|
2002-12-20 |
2015-07-22 |
QIAGEN GmbH |
Nukleinsäureamplifikation
|
US6977153B2
(en)
*
|
2002-12-31 |
2005-12-20 |
Qiagen Gmbh |
Rolling circle amplification of RNA
|
NZ541637A
(en)
|
2003-02-11 |
2008-07-31 |
Antisense Therapeutics Pty Ltd |
Modulation of insulin like growth factor I receptor
|
US7002006B2
(en)
*
|
2003-02-12 |
2006-02-21 |
Isis Pharmaceuticals, Inc. |
Protection of nucleosides
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
US20070141570A1
(en)
*
|
2003-03-07 |
2007-06-21 |
Sequenom, Inc. |
Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
US8043834B2
(en)
|
2003-03-31 |
2011-10-25 |
Qiagen Gmbh |
Universal reagents for rolling circle amplification and methods of use
|
US7851209B2
(en)
*
|
2003-04-03 |
2010-12-14 |
Kimberly-Clark Worldwide, Inc. |
Reduction of the hook effect in assay devices
|
US20040197819A1
(en)
*
|
2003-04-03 |
2004-10-07 |
Kimberly-Clark Worldwide, Inc. |
Assay devices that utilize hollow particles
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
WO2004108081A2
(en)
*
|
2003-06-02 |
2004-12-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide synthesis with alternative solvents
|
EP1633307A4
(de)
|
2003-06-03 |
2009-06-24 |
Isis Pharmaceuticals Inc |
Modulation der survivin-expression
|
US7786290B2
(en)
|
2003-06-13 |
2010-08-31 |
Alnylam Pharmaceuticals, Inc. |
Double-stranded ribonucleic acid with increased effectiveness in an organism
|
EP1644475A4
(de)
*
|
2003-06-20 |
2009-06-03 |
Isis Pharmaceuticals Inc |
Doppelstrang-zusammensetzungen mit einem 3'-endo-modifizierten strang zur verwendung bei der genmodulation
|
EP2530157B1
(de)
|
2003-07-31 |
2016-09-28 |
Regulus Therapeutics Inc. |
Oligomerverbindungen und Zusammensetzungen zur Verwendung bei der Modulation von miRNAs
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
US20050053981A1
(en)
*
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
US20070123480A1
(en)
*
|
2003-09-11 |
2007-05-31 |
Replicor Inc. |
Oligonucleotides targeting prion diseases
|
US7425544B2
(en)
|
2003-09-18 |
2008-09-16 |
Eli Lilly And Company |
Modulation of eIF4E expression
|
WO2005029705A2
(en)
|
2003-09-18 |
2005-03-31 |
Bioarray Solutions, Ltd. |
Number coding for identification of subtypes of coded types of solid phase carriers
|
NZ546072A
(en)
|
2003-09-22 |
2009-08-28 |
Bioarray Solutions Ltd |
Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
|
JP2007507430A
(ja)
|
2003-10-10 |
2007-03-29 |
メディテック リサーチ リミテッド |
疾患の治療におけるヒアルロナン合成および分解の調節法
|
AU2004286252A1
(en)
|
2003-10-28 |
2005-05-12 |
Bioarray Solutions Ltd. |
Optimization of gene expression analysis using immobilized capture probes
|
AU2004287069B2
(en)
|
2003-10-29 |
2009-07-16 |
Bioarray Solutions, Ltd. |
Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
US7439341B2
(en)
*
|
2003-11-14 |
2008-10-21 |
Integrated Dna Technologies, Inc. |
Fluorescence quenching azo dyes, their methods of preparation and use
|
NZ596981A
(en)
|
2003-11-17 |
2013-10-25 |
Genentech Inc |
Compositions and methods for the treatment of tumor of hematopoietic origin
|
US7713748B2
(en)
*
|
2003-11-21 |
2010-05-11 |
Kimberly-Clark Worldwide, Inc. |
Method of reducing the sensitivity of assay devices
|
US7943395B2
(en)
*
|
2003-11-21 |
2011-05-17 |
Kimberly-Clark Worldwide, Inc. |
Extension of the dynamic detection range of assay devices
|
US20050112703A1
(en)
|
2003-11-21 |
2005-05-26 |
Kimberly-Clark Worldwide, Inc. |
Membrane-based lateral flow assay devices that utilize phosphorescent detection
|
US20050136550A1
(en)
*
|
2003-12-19 |
2005-06-23 |
Kimberly-Clark Worldwide, Inc. |
Flow control of electrochemical-based assay devices
|
US7943089B2
(en)
*
|
2003-12-19 |
2011-05-17 |
Kimberly-Clark Worldwide, Inc. |
Laminated assay devices
|
US20050136500A1
(en)
*
|
2003-12-19 |
2005-06-23 |
Kimberly-Clark Worldwide; Inc. |
Flow-through assay devices
|
EP2363480A3
(de)
|
2004-01-20 |
2015-10-07 |
Isis Pharmaceuticals, Inc. |
Modulierung der Glukokortikoid-Rezeptor-Expression
|
US7468431B2
(en)
*
|
2004-01-22 |
2008-12-23 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP2 expression
|
US8778900B2
(en)
*
|
2004-01-22 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP1 expression
|
US7433123B2
(en)
|
2004-02-19 |
2008-10-07 |
Illumina, Inc. |
Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
|
US20050191704A1
(en)
*
|
2004-03-01 |
2005-09-01 |
Kimberly-Clark Worldwide, Inc. |
Assay devices utilizing chemichromic dyes
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
EP1730309B1
(de)
|
2004-03-15 |
2016-05-04 |
Ionis Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur optimierung der spaltung von rna durch rnase h
|
US20050244869A1
(en)
*
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
US20050267300A1
(en)
|
2004-04-05 |
2005-12-01 |
Muthiah Manoharan |
Processes and reagents for oligonucleotide synthesis and purification
|
US20050260755A1
(en)
*
|
2004-04-06 |
2005-11-24 |
Isis Pharmaceuticals, Inc. |
Sequential delivery of oligomeric compounds
|
US20050260652A1
(en)
*
|
2004-04-15 |
2005-11-24 |
The General Hospital Corporation |
Compositions and methods that modulate RNA interference
|
JP4584987B2
(ja)
|
2004-04-30 |
2010-11-24 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
C5修飾ピリミジンを含むオリゴヌクレオチド
|
EP1773872B1
(de)
|
2004-05-21 |
2017-03-15 |
The Uab Research Foundation |
Variable lymphozytenrezeptoren, verwandte polypeptide und nukleinsäuren sowie verwendung dafür
|
WO2005121372A2
(en)
*
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
US20080261904A1
(en)
*
|
2004-06-03 |
2008-10-23 |
Balkrishen Bhat |
Chimeric Gapped Oligomeric Compounds
|
US7906276B2
(en)
*
|
2004-06-30 |
2011-03-15 |
Kimberly-Clark Worldwide, Inc. |
Enzymatic detection techniques
|
US7094528B2
(en)
*
|
2004-06-30 |
2006-08-22 |
Kimberly-Clark Worldwide, Inc. |
Magnetic enzyme detection techniques
|
WO2006020363A2
(en)
|
2004-07-21 |
2006-02-23 |
Illumina, Inc. |
Method and apparatus for drug product tracking using encoded optical identification elements
|
US7848889B2
(en)
|
2004-08-02 |
2010-12-07 |
Bioarray Solutions, Ltd. |
Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
|
WO2006023880A2
(en)
*
|
2004-08-23 |
2006-03-02 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for the characterization of oligonucleotides
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
EP1809303B1
(de)
|
2004-09-23 |
2019-03-06 |
ARC Medical Devices, Inc. |
Pharmazeutische zusammensetzungen und verfahren zur hemmung von fibröser adhäsion oder entzündungserkrankung mit niedermolekularen sulfat-fucanen
|
JP2008516991A
(ja)
|
2004-10-20 |
2008-05-22 |
アンチセンス セラピューティクス リミテッド |
インテグリンα4発現のアンチセンス調節
|
EP2194485B1
(de)
|
2004-11-16 |
2012-10-17 |
Illumina, Inc. |
Verfahren und Vorrichtung zum Auslesen kodierter Mikroperlen
|
WO2006063031A2
(en)
|
2004-12-06 |
2006-06-15 |
Haplomics |
Allelic variants of human factor viii
|
BRPI0607985A2
(pt)
|
2005-03-10 |
2009-10-27 |
Genentech Inc |
modulador da dscr1, métodos de tratamento, método de melhoria de efeitos colaterais e método de inibição do crescimento de tumores
|
US7476733B2
(en)
*
|
2005-03-25 |
2009-01-13 |
The United States Of America As Represented By The Department Of Health And Human Services |
Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease
|
US8309303B2
(en)
|
2005-04-01 |
2012-11-13 |
Qiagen Gmbh |
Reverse transcription and amplification of RNA with simultaneous degradation of DNA
|
WO2006125124A2
(en)
*
|
2005-05-18 |
2006-11-23 |
Nanosphere, Inc. |
Substrate functionalization method for high sensitivity applications
|
US7476735B2
(en)
*
|
2005-05-20 |
2009-01-13 |
Integrated Dna Technologies, Inc. |
Compounds and methods for labeling oligonucleotides
|
EP1891141B1
(de)
|
2005-05-31 |
2016-11-16 |
Ecole Polytechnique Fédérale de Lausanne (EPFL) |
Triblockcopolymere zur zytoplasmatischen zuführung von arzneistoffen auf genbasis
|
US8486629B2
(en)
|
2005-06-01 |
2013-07-16 |
Bioarray Solutions, Ltd. |
Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
|
EP1904111A4
(de)
|
2005-06-03 |
2009-08-19 |
Univ Johns Hopkins |
Zusammensetzungen und verfahren zur verringerung der microrna-expression zur behandlung von neoplasien
|
WO2006138145A1
(en)
|
2005-06-14 |
2006-12-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
CA2618665C
(en)
|
2005-08-11 |
2012-11-13 |
J. Craig Venter Institute |
Method for in vitro recombination
|
CA2617693A1
(en)
|
2005-08-17 |
2007-02-22 |
Medexis S.A. |
Composition and method for determination of ck19 expression
|
DK1931780T3
(en)
|
2005-08-29 |
2016-01-25 |
Regulus Therapeutics Inc |
Antisense-forbindelser med forøget anti-microrna-aktivitet
|
ATE494372T1
(de)
|
2005-08-29 |
2011-01-15 |
Regulus Therapeutics Inc |
Verfahren für mir-122a-modulation
|
EP1762627A1
(de)
|
2005-09-09 |
2007-03-14 |
Qiagen GmbH |
Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
|
EP2392647A1
(de)
|
2005-10-14 |
2011-12-07 |
MUSC Foundation For Research Development |
Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie
|
US8080534B2
(en)
*
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
CA2627025A1
(en)
*
|
2005-10-28 |
2007-05-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of huntingtin gene
|
US7582745B2
(en)
*
|
2005-11-04 |
2009-09-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of Nav1.8 gene
|
AU2006311730B2
(en)
|
2005-11-09 |
2010-12-02 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of Factor V Leiden mutant gene
|
CA2630602A1
(en)
|
2005-11-21 |
2007-05-31 |
Isis Pharmaceuticals, Inc. |
Modulation of eif4e-bp2 expression
|
EP1974052A2
(de)
*
|
2005-12-21 |
2008-10-01 |
Yale University |
Verfahren und zusammensetzungen in verbindung mit der modulation von riboschaltern
|
CN103301475B
(zh)
|
2005-12-28 |
2016-08-03 |
斯克里普斯研究所 |
药物组合物和表达载体以及调节基因表达的方法和核酸分子的应用
|
SI2161038T1
(sl)
|
2006-01-26 |
2014-05-30 |
Isis Pharmaceuticals, Inc. |
Sestavki in njihove uporabe, usmerjeni proti huntingtinu
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
DK1984381T3
(da)
|
2006-01-27 |
2010-11-01 |
Isis Pharmaceuticals Inc |
6-modificerede bicycliske nukleinsyreanaloger
|
EP2388328A1
(de)
|
2006-01-27 |
2011-11-23 |
Isis Pharmaceuticals, Inc. |
Oligomerverbindungen und Zusammensetzungen zur Verwendung bei der Modulation von microRNAs
|
KR101462874B1
(ko)
|
2006-03-31 |
2014-11-18 |
알닐람 파마슈티칼스 인코포레이티드 |
Eg5 유전자의 발현을 억제하는 이본쇄 리보핵산
|
WO2007114518A1
(en)
*
|
2006-03-31 |
2007-10-11 |
Canon Kabushiki Kaisha |
Probe, probe set, probe-immobilized carrier, and genetic testing method
|
US7830575B2
(en)
|
2006-04-10 |
2010-11-09 |
Illumina, Inc. |
Optical scanner with improved scan time
|
US20070258862A1
(en)
*
|
2006-05-02 |
2007-11-08 |
Applera Corporation |
Variable volume dispenser and method
|
CA2651031A1
(en)
*
|
2006-05-03 |
2007-11-08 |
Baltic Technology Development, Ltd. |
Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease
|
WO2007143315A2
(en)
*
|
2006-05-05 |
2007-12-13 |
Isis Pharmaceutical, Inc. |
Compounds and methods for modulating expression of pcsk9
|
EP2505648A1
(de)
|
2006-05-05 |
2012-10-03 |
Isis Pharmaceuticals, Inc. |
Verbindungen und Verfahren zur Modulation der Expression von PTP1B
|
US7666854B2
(en)
*
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
CA2651453C
(en)
*
|
2006-05-11 |
2014-10-14 |
Isis Pharmaceuticals, Inc. |
5'-modified bicyclic nucleic acid analogs
|
BRPI0712034A2
(pt)
|
2006-05-19 |
2012-01-10 |
Alnylam Pharmaceuticals Inc |
modulação de rnai de aha e usos terapêuticos do mesmo
|
EP2584051B1
(de)
|
2006-05-22 |
2014-07-16 |
Alnylam Pharmaceuticals Inc. |
Zusammensetzungen und Verfahren zur Hemmung von IKK-B-Genexpressionen
|
EP2023938A4
(de)
*
|
2006-05-23 |
2010-11-10 |
Isis Pharmaceuticals Inc |
Modulation von chrebp-expression
|
WO2008097328A2
(en)
*
|
2006-06-23 |
2008-08-14 |
Northwestern University |
Asymmetric functionalized nanoparticles and methods of use
|
US8198253B2
(en)
|
2006-07-19 |
2012-06-12 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to HBXIP
|
AU2007281082A1
(en)
*
|
2006-08-04 |
2008-02-07 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the modulation of JNK proteins
|
WO2008105814A2
(en)
*
|
2006-08-22 |
2008-09-04 |
Los Alamos National Security, Llc |
Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids
|
WO2008033866A2
(en)
*
|
2006-09-11 |
2008-03-20 |
Yale University |
Methods and compositions for the use of lysine riboswitches
|
KR101556798B1
(ko)
|
2006-10-05 |
2015-10-01 |
메사츄세츠 인스티튜트 어브 테크놀로지 |
고성능 분석을 위한 다중기능성 인코딩된 입자
|
JP5665317B2
(ja)
|
2006-10-18 |
2015-02-04 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
アンチセンス化合物
|
EP2104516B1
(de)
|
2006-11-01 |
2015-01-07 |
University of Rochester |
Verfahren und zusammensetzungen in zusammenhang mit der struktur und funktion von apobec3g
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
CA2670563A1
(en)
*
|
2006-11-27 |
2008-06-05 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
BRPI0720038A2
(pt)
|
2006-12-11 |
2013-12-24 |
Univ Utah Res Found |
Métodos para inibir a permeabilidade vascular em tecido, para triar ou avaliar um agente que inibe a permeabilidade vascular, para tratar ou prevenir a síndrome da angústia respiratória, a retinopatia de prematuridade, a retinopatia diabética e a degeneração macular úmida em um indivíduo, para tratar indivíduos com sugestões repulsivas ou miméticos e para promover a angiogênese em um tecido, polipeptídeo isolado, ácido nucleico isolado, e, vetor
|
WO2008094370A2
(en)
|
2006-12-22 |
2008-08-07 |
University Of Utah Research Foundation |
Method of detecting ocular diseases and pathologic conditions and treatment of same
|
US8507200B2
(en)
*
|
2007-02-09 |
2013-08-13 |
Northwestern University |
Particles for detecting intracellular targets
|
EP2129803A4
(de)
*
|
2007-02-27 |
2010-11-03 |
Univ Northwestern |
Anbringung von molekülen an nanopartikeln
|
EP2471925A1
(de)
|
2007-03-22 |
2012-07-04 |
Yale University |
Verfahren und Zusammensetzungen für Riboswitches, die das alternative Spleissen kontrollieren
|
EP2905336A1
(de)
|
2007-03-29 |
2015-08-12 |
Alnylam Pharmaceuticals Inc. |
Zusammensetzungen und Verfahren zur Hemmung der Expression eines Gens von Ebola
|
CA2690281A1
(en)
|
2007-05-11 |
2008-11-20 |
The Johns Hopkins University |
Biomarkers for melanoma
|
KR20100017905A
(ko)
|
2007-05-29 |
2010-02-16 |
예일 유니버시티 |
리보스위치, 리보스위치의 사용 방법 및 리보스위치를 함유하는 조성물
|
KR20100017893A
(ko)
*
|
2007-05-29 |
2010-02-16 |
예일 유니버시티 |
택일적 스플라이싱 및 rna 프로세싱을 조절하는 리보스위치와 관련된 방법 및 조성물
|
US8278425B2
(en)
|
2007-05-30 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
WO2008151049A2
(en)
*
|
2007-05-30 |
2008-12-11 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
US7807372B2
(en)
*
|
2007-06-04 |
2010-10-05 |
Northwestern University |
Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay
|
DK2173760T4
(en)
|
2007-06-08 |
2016-02-08 |
Isis Pharmaceuticals Inc |
Carbocyclic bicyclic nukleinsyreanaloge
|
US8278283B2
(en)
*
|
2007-07-05 |
2012-10-02 |
Isis Pharmaceuticals, Inc. |
6-disubstituted or unsaturated bicyclic nucleic acid analogs
|
AU2008286771B2
(en)
*
|
2007-08-15 |
2013-08-15 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
CA2697957A1
(en)
|
2007-08-28 |
2009-03-12 |
Uab Research Foundation |
Synthetic apolipoprotein e mimicking polypeptides and methods of use
|
US9422363B2
(en)
|
2007-08-28 |
2016-08-23 |
Uab Research Foundation |
Synthetic apolipoprotein E mimicking polypeptides and methods of use
|
US8445217B2
(en)
|
2007-09-20 |
2013-05-21 |
Vanderbilt University |
Free solution measurement of molecular interactions by backscattering interferometry
|
WO2009039442A1
(en)
*
|
2007-09-21 |
2009-03-26 |
California Institute Of Technology |
Nfia in glial fate determination, glioma therapy and astrocytoma treatment
|
CA2700953A1
(en)
|
2007-10-02 |
2009-04-09 |
Amgen Inc. |
Increasing erythropoietin using nucleic acids hybridizable to micro-rna and precursors thereof
|
JP2011502502A
(ja)
*
|
2007-11-05 |
2011-01-27 |
バルティック テクロノジー デヴェロプメント,リミテッド |
核酸のハイブリッド形成における修飾塩基を含むオリゴヌクレオチドの使用
|
USRE47320E1
(en)
|
2007-11-20 |
2019-03-26 |
Ionis Pharmaceuticals, Inc. |
Modulation of CD40 expression
|
US7871985B2
(en)
|
2007-12-10 |
2011-01-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of factor VII gene
|
JP5749494B2
(ja)
|
2008-01-02 |
2015-07-15 |
テクミラ ファーマシューティカルズ コーポレイション |
核酸の送達のための改善された組成物および方法
|
WO2009100320A2
(en)
*
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
US20090215050A1
(en)
|
2008-02-22 |
2009-08-27 |
Robert Delmar Jenison |
Systems and methods for point-of-care amplification and detection of polynucleotides
|
KR101397407B1
(ko)
|
2008-03-05 |
2014-06-19 |
알닐람 파마슈티칼스 인코포레이티드 |
Eg5 및 VEGF 유전자의 발현을 억제하기 위한 조성물 및 방법
|
EP2282744B1
(de)
|
2008-03-21 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
Oligomere verbindungen mit trizyklischen nukleosiden und anwendungsverfahren dafür
|
EP2105145A1
(de)
*
|
2008-03-27 |
2009-09-30 |
ETH Zürich |
Verfahren zur muskelspezifischen Abgabe lipidkonjugierter Oligonukleotide
|
US8846639B2
(en)
*
|
2008-04-04 |
2014-09-30 |
Isis Pharmaceutical, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
DK2285819T3
(da)
*
|
2008-04-04 |
2013-12-02 |
Isis Pharmaceuticals Inc |
Oligomere forbindelser omfattende neutralt bundne, terminale bicykliske nukleosider
|
WO2009126933A2
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
DK2281042T3
(en)
|
2008-04-18 |
2015-11-09 |
Baxter Int |
Microsphere-based composition for preventing and / or deletion of starting autoimmune diabetes
|
CA2722668A1
(en)
*
|
2008-04-29 |
2009-11-05 |
Wyeth Llc |
Methods for treating inflammation
|
US8324366B2
(en)
|
2008-04-29 |
2012-12-04 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for delivering RNAI using lipoproteins
|
WO2009137059A1
(en)
|
2008-05-05 |
2009-11-12 |
Los Alamos National Security, Llc |
Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control
|
WO2009149182A1
(en)
|
2008-06-04 |
2009-12-10 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small rna targeting of gene promoters
|
JP2011529686A
(ja)
|
2008-07-29 |
2011-12-15 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
ポリグルタミンタンパク質発現の選択的阻害
|
US20110237646A1
(en)
*
|
2008-08-07 |
2011-09-29 |
Isis Pharmaceuticals, Inc. |
Modulation of transthyretin expression for the treatment of cns related disorders
|
AU2009275387B2
(en)
|
2008-08-25 |
2010-07-08 |
Excaliard Pharmaceuticals, Inc. |
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
|
WO2010027832A1
(en)
|
2008-08-25 |
2010-03-11 |
Excaliard Pharmaceuticals, Inc. |
Method for reducing scarring during wound healing using antisense compounds directed to ctgf
|
EP2690175B1
(de)
|
2008-09-02 |
2016-12-28 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und Verfahren zur kombinierten Hemmung der Expression eines mutierenden EGFR-Gens und IL-6
|
US8962580B2
(en)
|
2008-09-23 |
2015-02-24 |
Alnylam Pharmaceuticals, Inc. |
Chemical modifications of monomers and oligonucleotides with cycloaddition
|
US8501805B2
(en)
*
|
2008-09-24 |
2013-08-06 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-L-bicyclic nucleosides
|
DK2361256T3
(da)
*
|
2008-09-24 |
2013-07-01 |
Isis Pharmaceuticals Inc |
Cyclohexenyl-nukleinsyreanaloger
|
CA2739170A1
(en)
|
2008-09-25 |
2010-04-01 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of serum amyloid a gene
|
CA2740000C
(en)
|
2008-10-09 |
2017-12-12 |
Tekmira Pharmaceuticals Corporation |
Improved amino lipids and methods for the delivery of nucleic acids
|
ES2657679T3
(es)
|
2008-10-15 |
2018-03-06 |
Ionis Pharmaceuticals, Inc. |
Modulación del factor de expresión 11
|
LT2937418T
(lt)
|
2008-10-20 |
2018-02-12 |
Alnylam Pharmaceuticals, Inc. |
Kompozicijos ir būdas transtiretino raiškos slopinimui
|
EP2358398A2
(de)
|
2008-10-24 |
2011-08-24 |
Isis Pharmaceuticals, Inc. |
Oligomere verbindungen und verfahren
|
EP2358397B1
(de)
|
2008-10-24 |
2020-01-01 |
Ionis Pharmaceuticals, Inc. |
5 - und 2 -bis-substituierte nukleoside und daraus hergestellte oligomere verbindungen
|
EP2355851B1
(de)
|
2008-11-10 |
2018-04-04 |
Arbutus Biopharma Corporation |
Neue lipide und zusammensetzungen für die zuführung von therapeutika
|
KR101692880B1
(ko)
|
2008-11-24 |
2017-01-04 |
노오쓰웨스턴 유니버시티 |
다가 rna-나노입자 구조체
|
RU2620970C2
(ru)
|
2008-12-04 |
2017-05-30 |
КьюРНА,Инк., |
Лечение связанных с эритропоэтином (еро) заболеваний путем ингибирования природного антисмыслового транскрипта к еро
|
CN102361985B
(zh)
|
2008-12-04 |
2017-06-20 |
库尔纳公司 |
通过抑制肿瘤抑制基因的天然反义转录物***抑制基因相关性疾病
|
US20110237649A1
(en)
|
2008-12-04 |
2011-09-29 |
Opko Curna, Llc |
Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirtuin 1
|
US8324368B2
(en)
|
2008-12-10 |
2012-12-04 |
Alnylam Pharmaceuticals, Inc. |
GNAQ targeted dsRNA compositions and methods for inhibiting expression
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
MX2011007350A
(es)
*
|
2009-01-08 |
2011-09-06 |
Univ Northwestern |
Inhibicion de produccion de proteina bacteriana por conjugados de nanoparticulas modificadas por oligonucleotidos polivalentes.
|
KR101546673B1
(ko)
*
|
2009-01-15 |
2015-08-25 |
삼성전자주식회사 |
전자 사진용 토너 및 그의 제조방법
|
EP2391343B1
(de)
|
2009-01-29 |
2017-03-01 |
Arbutus Biopharma Corporation |
Verbesserte lipidformulierung zur verabreichung von nukleinsaueren
|
EP2393825A2
(de)
|
2009-02-06 |
2011-12-14 |
Isis Pharmaceuticals, Inc. |
Oligomere verbindungen und verfahren
|
US8536320B2
(en)
|
2009-02-06 |
2013-09-17 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
ES2560107T3
(es)
|
2009-02-12 |
2016-02-17 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de cerebro (BDNF) por inhibición de transcrito antisentido natural para BDNF
|
ES2658626T3
(es)
|
2009-02-12 |
2018-03-12 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado de células gliales (GDNF) por inhibición de transcrito antisentido natural a GDNF
|
US20120041051A1
(en)
|
2009-02-26 |
2012-02-16 |
Kevin Fitzgerald |
Compositions And Methods For Inhibiting Expression Of MIG-12 Gene
|
US8975389B2
(en)
|
2009-03-02 |
2015-03-10 |
Alnylam Pharmaceuticals, Inc. |
Nucleic acid chemical modifications
|
EP2963116B1
(de)
|
2009-03-04 |
2020-11-11 |
CuRNA, Inc. |
Behandlung von sirtuin 1 (sirt1)-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen sirt 1
|
WO2010105209A1
(en)
|
2009-03-12 |
2010-09-16 |
Alnylam Pharmaceuticals, Inc. |
LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES
|
CA2755409C
(en)
|
2009-03-16 |
2019-04-30 |
Joseph Collard |
Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2
|
CA2755404C
(en)
|
2009-03-17 |
2020-03-24 |
Joseph Collard |
Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1
|
CA2757694C
(en)
|
2009-04-15 |
2020-10-06 |
Northwestern University |
Delivery of oligonucleotide-functionalized nanoparticles
|
EP3248618A1
(de)
|
2009-04-22 |
2017-11-29 |
Massachusetts Institute Of Technology |
Angeborene immununterdrückung mit ermöglichung der wiederholten verabreichung von langen rna-molekülen
|
WO2010124231A2
(en)
|
2009-04-24 |
2010-10-28 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression using oligomers that target gene regions downstream of 3' untranslated regions
|
NO2424987T3
(de)
|
2009-05-01 |
2018-04-14 |
|
|
CA3045126A1
(en)
|
2009-05-05 |
2010-11-11 |
Arbutus Biopharma Corporation |
Methods of delivering oligonucleotides to immune cells
|
US8883202B2
(en)
|
2009-05-05 |
2014-11-11 |
Tekmira Pharmaceuticals Corporation |
Lipid compositions
|
US20120046236A1
(en)
|
2009-05-06 |
2012-02-23 |
Opko Curna Llc |
Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp
|
CN106237345A
(zh)
|
2009-05-06 |
2016-12-21 |
库尔纳公司 |
通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
|
EP2430161A1
(de)
|
2009-05-15 |
2012-03-21 |
Yale University |
Gemm-riboswitches, strukturbasierte verbindungskonstruktion mit gemm-riboswitches sowie verfahren und zusammensetzungen zur verwendung von und mit gemm-riboswitches
|
CA2762369C
(en)
|
2009-05-18 |
2021-12-28 |
Joseph Collard |
Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
|
WO2010135695A2
(en)
|
2009-05-22 |
2010-11-25 |
Curna, Inc. |
TREATMENT OF TRANSCRIPTION FACTOR E3 (TFE3) and INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO TFE3
|
ES2618576T3
(es)
|
2009-05-28 |
2017-06-21 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con un gen antivírico mediante la inhibición de una transcripción antisentido natural a un gen antivírico
|
TR201811076T4
(tr)
|
2009-06-10 |
2018-08-27 |
Arbutus Biopharma Corp |
Geliştirilmiş lipit formulasyonu.
|
EP2443237B1
(de)
|
2009-06-16 |
2017-02-22 |
CuRNA, Inc. |
Behandlung von krankheiten im zusammenhang mit dem kollagengen durch hemmung des natürlichen antisense-transkripts zu einem kollagengens
|
CN102612560B
(zh)
|
2009-06-16 |
2017-10-17 |
库尔纳公司 |
通过抑制针对对氧磷酶1(pon1)的天然反义转录物来治疗pon1相关的疾病
|
LT3449926T
(lt)
|
2009-06-17 |
2020-01-27 |
Biogen Ma Inc. |
Kompozicijos ir smn2 splaisingo subjekte moduliavimo būdai
|
US8859515B2
(en)
|
2009-06-24 |
2014-10-14 |
Curna, Inc. |
Treatment of tumor necrosis factor receptor 2 (TNFR2) related diseases by inhibition of natural antisense transcript to TNFR2
|
CN102482672B
(zh)
|
2009-06-26 |
2016-11-09 |
库尔纳公司 |
通过抑制唐氏综合征基因的天然反义转录物治疗唐氏综合征基因相关疾病
|
CA2769665A1
(en)
|
2009-08-05 |
2011-02-10 |
Opko Curna, Llc |
Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)
|
EP2462153B1
(de)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclische cyclohexosenukleinsäureanaloga
|
EP2810643A3
(de)
|
2009-08-14 |
2015-03-11 |
Alnylam Pharmaceuticals Inc. |
Zusammensetzungen aus Lipidformulierung und Verfahren zur Hemmung der Expression eines Gens aus dem Ebola-Virus
|
US20120157324A1
(en)
|
2009-08-17 |
2012-06-21 |
Yale University |
Methylation biomarkers and methods of use
|
JP5964232B2
(ja)
|
2009-08-25 |
2016-08-03 |
カッパーアールエヌエー,インコーポレイテッド |
‘iqモチーフ含有gtpアーゼ活性化タンパク質’(iqgap)に対する天然アンチセンス転写産物の阻害によるiqgap関連疾患の治療
|
AU2010289400B2
(en)
|
2009-09-02 |
2014-10-23 |
Curis, Inc. |
Mutant smoothened and methods of using the same
|
JP5819308B2
(ja)
|
2009-10-22 |
2015-11-24 |
ジェネンテック, インコーポレイテッド |
マクロファージ刺激タンパク質のヘプシン活性化を調節するための方法及び組成物
|
US20110129832A1
(en)
|
2009-10-27 |
2011-06-02 |
Swift Biosciences, Inc. |
Polynucleotide Primers and Probes
|
KR20120136345A
(ko)
|
2009-10-30 |
2012-12-18 |
노오쓰웨스턴 유니버시티 |
주형화된 나노컨쥬게이트
|
WO2011053994A1
(en)
|
2009-11-02 |
2011-05-05 |
Alnylam Pharmaceuticals, Inc. |
Modulation of ldl receptor gene expression with double-stranded rnas targeting the ldl receptor gene promoter
|
EP2496716A1
(de)
|
2009-11-03 |
2012-09-12 |
University Of Virginia Patent Foundation |
Vielseitiges sichtbares verfahren für den nachweis von polymeranalyten
|
JP2013511285A
(ja)
|
2009-11-23 |
2013-04-04 |
スイフト・バイオサイエンシズ・インコーポレイテツド |
一本鎖標的分子を伸長させるデバイス
|
MX338694B
(es)
|
2009-11-30 |
2016-04-27 |
Genentech Inc |
Composiciones y metodos para el diagnostico y el tratamiento de tumores.
|
CA3044884A1
(en)
|
2009-12-07 |
2011-06-16 |
Arbutus Biopharma Corporation |
Compositions for nucleic acid delivery
|
KR101823702B1
(ko)
|
2009-12-16 |
2018-01-30 |
큐알엔에이, 인크. |
막 결합 전사 인자 펩티다제, 부위 1(mbtps1)에 대한 천연 안티센스 전사체의 억제에 의한 mbtps1 관련 질환의 치료
|
WO2011075656A1
(en)
|
2009-12-18 |
2011-06-23 |
The University Of British Columbia |
Methods and compositions for delivery of nucleic acids
|
KR101793753B1
(ko)
|
2009-12-23 |
2017-11-03 |
큐알엔에이, 인크. |
커플링방지 단백질 2(ucp2)에 대한 천연 안티센스 전사체의 저해에 의한 ucp2 관련 질환의 치료
|
RU2609631C2
(ru)
|
2009-12-23 |
2017-02-02 |
Курна, Инк. |
Лечение заболеваний, связанных с фактором роста гепатоцитов (фрг), посредством ингибирования природного антисмыслового транскрипта к фрг
|
US8921334B2
(en)
|
2009-12-29 |
2014-12-30 |
Curna, Inc. |
Treatment of nuclear respiratory factor 1 (NRF1) related diseases by inhibition of natural antisense transcript to NRF1
|
RU2611186C2
(ru)
|
2009-12-29 |
2017-02-21 |
Курна, Инк. |
ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С ОПУХОЛЕВЫМ БЕЛКОМ 63 (р63), ПУТЕМ ИНГИБИРОВАНИЯ ПРИРОДНОГО АНТИСМЫСЛОВОГО ТРАНСКРИПТА К р63
|
JP5886757B2
(ja)
|
2010-01-04 |
2016-03-16 |
カッパーアールエヌエー,インコーポレイテッド |
インターフェロン調節因子8(irf8)に対する天然アンチセンス転写物の阻害によるインターフェロン調節因子8(irf8)関連疾患の治療
|
RU2612161C2
(ru)
|
2010-01-06 |
2017-03-02 |
Курна, Инк. |
Лечение заболеваний, связанных с геном развития поджелудочной железы, путем ингибирования природного антисмыслового транскрипта к гену развития поджелудочной железы
|
WO2011085102A1
(en)
|
2010-01-11 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
KR101854926B1
(ko)
|
2010-01-11 |
2018-05-04 |
큐알엔에이, 인크. |
성 호르몬 결합 글로불린 (shbg)에 대한 자연 안티센스 전사체의 저해에 의한 성 호르몬 결합 글로불린 (shbg) 관련된 질환의 치료
|
SG182365A1
(en)
|
2010-01-12 |
2012-08-30 |
Univ Yale |
Structured rna motifs and compounds and methods for their use
|
BR112012017483A2
(pt)
*
|
2010-01-14 |
2019-09-24 |
Haplomics Inc |
previsão e redução de aloimunogenicidade de terapêuticos de proteína
|
CA2786568A1
(en)
|
2010-01-25 |
2011-07-28 |
Curna, Inc. |
Treatment of rnase h1 related diseases by inhibition of natural antisense transcript to rnase h1
|
WO2011094580A2
(en)
|
2010-01-28 |
2011-08-04 |
Alnylam Pharmaceuticals, Inc. |
Chelated copper for use in the preparation of conjugated oligonucleotides
|
WO2011100131A2
(en)
|
2010-01-28 |
2011-08-18 |
Alnylam Pharmacuticals, Inc. |
Monomers and oligonucleotides comprising cycloaddition adduct(s)
|
WO2011097388A1
(en)
|
2010-02-03 |
2011-08-11 |
Alnylam Pharmaceuticals, Inc. |
Selective inhibition of polyglutamine protein expression
|
US20130028889A1
(en)
|
2010-02-04 |
2013-01-31 |
Ico Therapeutics Inc. |
Dosing regimens for treating and preventing ocular disorders using c-raf antisense
|
CA2790506A1
(en)
|
2010-02-22 |
2011-08-25 |
Curna, Inc. |
Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1
|
WO2011105902A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-beta (c8-beta) and uses thereof
|
WO2011105900A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
|
WO2011105901A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 9 (c9) and uses thereof
|
CN102985113B
(zh)
|
2010-02-23 |
2015-05-20 |
霍夫曼-拉罗奇有限公司 |
用于肿瘤诊断和治疗的组合物和方法
|
WO2011112516A1
(en)
|
2010-03-08 |
2011-09-15 |
Ico Therapeutics Inc. |
Treating and preventing hepatitis c virus infection using c-raf kinase antisense oligonucleotides
|
US20130101512A1
(en)
|
2010-03-12 |
2013-04-25 |
Chad A. Mirkin |
Crosslinked polynucleotide structure
|
ES2743600T3
(es)
|
2010-03-12 |
2020-02-20 |
Brigham & Womens Hospital Inc |
Métodos de tratamiento de los trastornos inflamatorios vasculares
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US9506057B2
(en)
|
2010-03-26 |
2016-11-29 |
Integrated Dna Technologies, Inc. |
Modifications for antisense compounds
|
US8916345B2
(en)
*
|
2010-03-26 |
2014-12-23 |
Integrated Dna Technologies, Inc. |
Methods for enhancing nucleic acid hybridization
|
WO2011120046A2
(en)
|
2010-03-26 |
2011-09-29 |
Swift Biosciences, Inc. |
Methods and compositions for isolating polynucleotides
|
CA2792291A1
(en)
|
2010-03-29 |
2011-10-06 |
Kumamoto University |
Sirna therapy for transthyretin (ttr) related ocular amyloidosis
|
WO2011123621A2
(en)
|
2010-04-01 |
2011-10-06 |
Alnylam Pharmaceuticals Inc. |
2' and 5' modified monomers and oligonucleotides
|
US8507663B2
(en)
|
2010-04-06 |
2013-08-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of CD274/PD-L1 gene
|
WO2011127337A2
(en)
|
2010-04-09 |
2011-10-13 |
Opko Curna Llc |
Treatment of fibroblast growth factor 21 (fgf21) related diseases by inhibition of natural antisense transcript to fgf21
|
WO2011133695A2
(en)
|
2010-04-20 |
2011-10-27 |
Swift Biosciences, Inc. |
Materials and methods for nucleic acid fractionation by solid phase entrapment and enzyme-mediated detachment
|
WO2011133868A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Conformationally restricted dinucleotide monomers and oligonucleotides
|
US10913767B2
(en)
|
2010-04-22 |
2021-02-09 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
US9725479B2
(en)
|
2010-04-22 |
2017-08-08 |
Ionis Pharmaceuticals, Inc. |
5′-end derivatives
|
EP2625186B1
(de)
|
2010-04-28 |
2016-07-27 |
Ionis Pharmaceuticals, Inc. |
5'-modifizierte nukleoside und daraus hergestellte oligomere verbindungen
|
CN103154014B
(zh)
|
2010-04-28 |
2015-03-25 |
Isis制药公司 |
修饰核苷、其类似物以及由它们制备的寡聚化合物
|
EP2606057B1
(de)
|
2010-04-28 |
2016-06-15 |
Ionis Pharmaceuticals, Inc. |
Modifizierte 5' diphosphat-nukleoside und daraus hergestellte oligomere verbindungen
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
PT2563920T
(pt)
|
2010-04-29 |
2017-05-26 |
Ionis Pharmaceuticals Inc |
Modulação da expressão de transtirretina
|
KR20130079384A
(ko)
|
2010-05-03 |
2013-07-10 |
제넨테크, 인크. |
종양의 진단 및 치료를 위한 조성물 및 방법
|
JP2013525483A
(ja)
|
2010-05-03 |
2013-06-20 |
カッパーアールエヌエー,インコーポレイテッド |
サーチュイン(sirt)に対する天然アンチセンス転写物の阻害によるサーチュイン(sirt)関連疾患の治療
|
TWI586356B
(zh)
|
2010-05-14 |
2017-06-11 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
US20130203045A1
(en)
|
2010-05-26 |
2013-08-08 |
University Of Virginia Patent Foundation |
Method for detecting nucleic acids based on aggregate formation
|
EP2576783B1
(de)
|
2010-05-26 |
2017-11-29 |
CuRNA, Inc. |
Behandlung von durch atonal homolog 1 (atoh1) vermittelten erkrankungen durch hemmung des natürlichen antisense-transkripts für atoh1
|
EP2576579B1
(de)
|
2010-06-02 |
2018-08-08 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur behandlung von leberfibrose
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
CA2802059C
(en)
|
2010-06-07 |
2020-05-12 |
Firefly Bioworks, Inc. |
Nucleic acid detection and quantification by post-hybridization labeling and universal encoding
|
US8846637B2
(en)
|
2010-06-08 |
2014-09-30 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011156713A1
(en)
|
2010-06-11 |
2011-12-15 |
Vanderbilt University |
Multiplexed interferometric detection system and method
|
WO2011163121A1
(en)
|
2010-06-21 |
2011-12-29 |
Alnylam Pharmaceuticals, Inc. |
Multifunctional copolymers for nucleic acid delivery
|
WO2011163466A1
(en)
|
2010-06-23 |
2011-12-29 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Regulation of skin pigmentation by neuregulin-1 (nrg-1)
|
RU2611190C2
(ru)
|
2010-07-14 |
2017-02-21 |
Курна, Инк. |
Лечение заболеваний, связанных с геном dlg, путем ингибирования природного антисмыслового транскрипта гена dlg
|
CN106434648A
(zh)
|
2010-07-19 |
2017-02-22 |
F·C·贝内特 |
肌强直性营养障碍蛋白激酶(dmpk)表达的调节
|
WO2012016184A2
(en)
|
2010-07-30 |
2012-02-02 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
US20130202652A1
(en)
|
2010-07-30 |
2013-08-08 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for delivery of active agents
|
US20130143955A1
(en)
|
2010-08-09 |
2013-06-06 |
Yale University |
Cyclic di-GMP-II Riboswitches, Motifs, and Compounds, and Methods for Their Use
|
EP2614149B1
(de)
|
2010-09-07 |
2015-04-08 |
Integrated Dna Technologies, Inc. |
Modifizierungen für antisense-verbindungen
|
SG188666A1
(en)
|
2010-09-30 |
2013-05-31 |
Agency Science Tech & Res |
Methods and reagents for detection and treatment of esophageal metaplasia
|
AU2011312205B2
(en)
|
2010-10-05 |
2015-08-13 |
Curis, Inc. |
Mutant smoothened and methods of using the same
|
EP2625274B1
(de)
|
2010-10-06 |
2017-07-19 |
CuRNA, Inc. |
Behandlung sialidase-4-(neu4)-vermittelter erkrankungen durch hemmung des natürlichen antisense-transkripts gegen neu4
|
US20140031250A1
(en)
|
2010-10-07 |
2014-01-30 |
David Tsai Ting |
Biomarkers of Cancer
|
EP2630241B1
(de)
|
2010-10-22 |
2018-10-17 |
CuRNA, Inc. |
Behandlung von alpha-l-iduronidase (idua)-bedingten erkrankungen mittels hemmung des natürlichen antisense-transkripts gegen idua
|
WO2012058268A2
(en)
|
2010-10-27 |
2012-05-03 |
Opko Curna Llc |
Treatment of interferon-related developmental regulator 1 (ifrd1) related diseases by inhibition of natural antisense transcript to ifrd1
|
CN110123830A
(zh)
|
2010-11-09 |
2019-08-16 |
阿尔尼拉姆医药品有限公司 |
用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法
|
AU2011325956B2
(en)
|
2010-11-12 |
2016-07-14 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
WO2012068405A2
(en)
|
2010-11-17 |
2012-05-24 |
Isis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
WO2012071238A2
(en)
|
2010-11-23 |
2012-05-31 |
Opko Curna Llc |
Treatment of nanog related diseases by inhibition of natural antisense transcript to nanog
|
US9150926B2
(en)
|
2010-12-06 |
2015-10-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Diagnosis and treatment of adrenocortical tumors using human microRNA-483
|
EP2648763A4
(de)
|
2010-12-10 |
2014-05-14 |
Alnylam Pharmaceuticals Inc |
Zusammensetzungen und verfahren zur expressionshemmung der gene klf-1 und bcl11a
|
WO2012078967A2
(en)
|
2010-12-10 |
2012-06-14 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for increasing erythropoietin (epo) production
|
EP2663548B1
(de)
|
2011-01-11 |
2017-04-05 |
Alnylam Pharmaceuticals, Inc. |
Pegylierte lipide und ihre verwendung zur wirkstofffreisetzung
|
WO2012097261A2
(en)
|
2011-01-14 |
2012-07-19 |
The General Hospital Corporation |
Methods targeting mir-128 for regulating cholesterol/lipid metabolism
|
EP2670411B1
(de)
|
2011-02-02 |
2019-04-10 |
Excaliard Pharmaceuticals, Inc. |
Auf dem bindegewebe-wachstumsfaktor (ctgf) gerichtete antisense-verbindungen zur verwendung in einem verfahren zur behandlung von keloiden oder hypertrophischen narben
|
US20130338178A1
(en)
|
2011-02-02 |
2013-12-19 |
The Trustees Of Princeton University |
Sirtuin modulators as inhibitors of cytomegalovirus
|
MX2013008944A
(es)
|
2011-02-03 |
2014-01-08 |
Mirna Therapeutics Inc |
Mimeticos sinteticos de mir-124.
|
US8586727B2
(en)
|
2011-02-03 |
2013-11-19 |
Mirna Therapeutics, Inc. |
Synthetic mimics of miR-34
|
EP3467109A1
(de)
|
2011-02-08 |
2019-04-10 |
Ionis Pharmaceuticals, Inc. |
Oligomere verbindungen mit bicyclischen nukleotiden und verwendungen davon
|
US20140044644A1
(en)
|
2011-02-21 |
2014-02-13 |
University Of Zurich |
Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders
|
US9562853B2
(en)
|
2011-02-22 |
2017-02-07 |
Vanderbilt University |
Nonaqueous backscattering interferometric methods
|
WO2012135246A2
(en)
|
2011-03-29 |
2012-10-04 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of tmprss6 gene
|
EP2694660B1
(de)
|
2011-04-03 |
2018-08-08 |
The General Hospital Corporation |
Effiziente in-vivo-proteinexpression mittels modifizierter rna (mod-rna)
|
EP2699700B8
(de)
|
2011-04-20 |
2016-08-24 |
Mesa Biotech, Inc. |
Integrierte vorrichtung zur nukleinsäuredetektion und -identifizierung
|
US20140186844A1
(en)
|
2011-04-26 |
2014-07-03 |
Swift Biosciences, Inc. |
Polynucleotide primers and probes
|
WO2012151268A1
(en)
|
2011-05-02 |
2012-11-08 |
University Of Virginia Patent Foundation |
Method and system for high throughput optical and label free detection of analytes
|
WO2012151289A2
(en)
|
2011-05-02 |
2012-11-08 |
University Of Virginia Patent Foundation |
Method and system to detect aggregate formation on a substrate
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
CA2838588C
(en)
|
2011-06-09 |
2021-09-14 |
Curna, Inc. |
Treatment of frataxin (fxn) related diseases by inhibition of natural antisense transcript to fxn
|
EP3320922A1
(de)
|
2011-06-10 |
2018-05-16 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur modulierung der kallikrein (klkb1)-expression
|
US9068184B2
(en)
|
2011-06-21 |
2015-06-30 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibition of expression of protein C (PROC) genes
|
AU2012272970A1
(en)
|
2011-06-21 |
2014-02-06 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
|
EP2723756B1
(de)
|
2011-06-21 |
2020-03-11 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur hemmung der expression von apolipoprotein-c-iii (apoc3)-genen
|
US20140235693A1
(en)
|
2011-06-23 |
2014-08-21 |
Alnylam Pharmaceuticals, Inc. |
Serpina1 sirnas: compositions of matter and methods of treatment
|
US9322021B2
(en)
|
2011-06-29 |
2016-04-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating kallikrein (KLKB1) expression
|
EP2739735A2
(de)
|
2011-08-01 |
2014-06-11 |
Alnylam Pharmaceuticals, Inc. |
Verfahren zur verbesserung der erfolgsquote von hämatopoetischen stammzellentransplantaten
|
WO2013022966A1
(en)
|
2011-08-11 |
2013-02-14 |
Isis Pharmaceuticals, Inc. |
Linkage modified gapped oligomeric compounds and uses thereof
|
CA2847698C
(en)
|
2011-09-14 |
2020-09-01 |
Northwestern University |
Nanoconjugates able to cross the blood-brain barrier
|
WO2013040429A1
(en)
|
2011-09-14 |
2013-03-21 |
Rana Therapeutics Inc. |
Multimeric oligonucleotide compounds
|
WO2013040548A2
(en)
|
2011-09-17 |
2013-03-21 |
Yale University |
Fluoride-responsive riboswitchs, fluoride transporters, and methods of use
|
EP2760477B1
(de)
|
2011-09-27 |
2018-08-08 |
Alnylam Pharmaceuticals, Inc. |
Substituierte di-aliphatic pegylierte lipide
|
AU2012322788B2
(en)
|
2011-10-11 |
2018-01-04 |
The Brigham And Women's Hospital, Inc. |
Micrornas in neurodegenerative disorders
|
AU2012322618A1
(en)
|
2011-10-14 |
2014-05-29 |
Genentech, Inc. |
Anti-HtrA1 antibodies and methods of use
|
JP2015502365A
(ja)
|
2011-12-12 |
2015-01-22 |
オンコイミューニン,インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
RS63244B1
(sr)
|
2011-12-16 |
2022-06-30 |
Modernatx Inc |
Kompozicije modifikovane mrna
|
WO2013096837A1
(en)
|
2011-12-22 |
2013-06-27 |
Isis Pharmaceuticals, Inc. |
Methods for modulating metastasis-associated-in-lung-adenocarcinoma-transcript-1(malat-1) expression
|
WO2013120003A1
(en)
|
2012-02-08 |
2013-08-15 |
Isis Pharmaceuticals, Inc. |
Modulation of rna by repeat targeting
|
WO2013138536A1
(en)
|
2012-03-13 |
2013-09-19 |
Swift Biosciences, Inc. |
Methods and compositions for size-controlled homopolymer tailing of substrate polynucleotides by a nucleic acid polymerase
|
US20150031750A1
(en)
|
2012-03-15 |
2015-01-29 |
The Scripps Research Institute |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
US9610362B2
(en)
|
2012-03-16 |
2017-04-04 |
Valerion Therapeutics, Llc |
Antisense conjugates for decreasing expression of DMPK
|
US9340784B2
(en)
|
2012-03-19 |
2016-05-17 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for modulating alpha-1-antitrypsin expression
|
CA2868391A1
(en)
|
2012-04-02 |
2013-10-10 |
Stephane Bancel |
Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same
|
US20140010861A1
(en)
|
2012-04-02 |
2014-01-09 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins associated with human disease
|
US9221864B2
(en)
|
2012-04-09 |
2015-12-29 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
US9133461B2
(en)
|
2012-04-10 |
2015-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
WO2013159108A2
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
CN104704122A
(zh)
|
2012-04-20 |
2015-06-10 |
艾珀特玛治疗公司 |
产热的miRNA调节剂
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
EP3597741A1
(de)
|
2012-04-27 |
2020-01-22 |
Duke University |
Genetische korrektur mutierter gene
|
US9273949B2
(en)
|
2012-05-11 |
2016-03-01 |
Vanderbilt University |
Backscattering interferometric methods
|
CA2873809A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating gene expression
|
JP2015523854A
(ja)
|
2012-05-16 |
2015-08-20 |
ラナ セラピューティクス インコーポレイテッド |
Smn遺伝子ファミリー発現を調節するための組成物及び方法
|
WO2013177248A2
(en)
|
2012-05-22 |
2013-11-28 |
Isis Pharmaceuticals, Inc. |
Modulation of enhancer rna mediated gene expression
|
DK3461895T3
(da)
|
2012-06-25 |
2020-07-20 |
Ionis Pharmaceuticals Inc |
Modulation af ube3a-ats-ekspression
|
US20140038182A1
(en)
|
2012-07-17 |
2014-02-06 |
Dna Logix, Inc. |
Cooperative primers, probes, and applications thereof
|
US20150297629A1
(en)
|
2012-07-27 |
2015-10-22 |
Isis Pharmaceuticals, Inc. |
Modulation of renin-angiotensin system (ras) related diseases by angiotensinogen
|
CA2880833A1
(en)
|
2012-08-03 |
2014-02-06 |
Aptamir Therapeutics, Inc. |
Cell-specific delivery of mirna modulators for the treatment of obesity and related disorders
|
EP2885312A4
(de)
|
2012-08-15 |
2016-01-20 |
Isis Pharmaceuticals Inc |
Verfahren zur herstellung oligomerer verbindungen unter verwendung von modifizierten kappungsprotokollen
|
EP2897633B1
(de)
|
2012-09-18 |
2020-01-01 |
UTI Limited Partnership |
Behandlung von schmerzen durch hemmung von usp5-deubiquitinase
|
EP4052709A1
(de)
|
2012-10-11 |
2022-09-07 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur behandlung der kennedy-krankheit
|
WO2014059353A2
(en)
|
2012-10-11 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and uses thereof
|
US9175291B2
(en)
|
2012-10-11 |
2015-11-03 |
Isis Pharmaceuticals Inc. |
Modulation of androgen receptor expression
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
CA2887702C
(en)
|
2012-10-26 |
2023-08-01 |
Geron Corporation |
C-myc antisense oligonucleotides and methods for using the same to treat cell-proliferative disorders
|
WO2014071358A2
(en)
|
2012-11-05 |
2014-05-08 |
Foundation Medicine, Inc. |
Novel ntrk1 fusion molecules and uses thereof
|
LT2922554T
(lt)
|
2012-11-26 |
2022-06-27 |
Modernatx, Inc. |
Terminaliai modifikuota rnr
|
WO2014089541A2
(en)
|
2012-12-07 |
2014-06-12 |
Haplomics, Inc. |
Factor viii mutation repair and tolerance induction
|
AU2013374345A1
(en)
|
2013-01-17 |
2015-08-06 |
Moderna Therapeutics, Inc. |
Signal-sensor polynucleotides for the alteration of cellular phenotypes
|
EP2945652B1
(de)
|
2013-01-18 |
2021-07-07 |
Foundation Medicine, Inc. |
Verfahren zur behandlung cholangiokarzinom
|
US9701708B2
(en)
|
2013-01-31 |
2017-07-11 |
Ionis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified coupling protocols
|
US9593333B2
(en)
|
2013-02-14 |
2017-03-14 |
Ionis Pharmaceuticals, Inc. |
Modulation of apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations
|
US20150366890A1
(en)
|
2013-02-25 |
2015-12-24 |
Trustees Of Boston University |
Compositions and methods for treating fungal infections
|
CN105143470B
(zh)
|
2013-02-28 |
2020-06-09 |
德克萨斯大学***董事会 |
用于将癌症分类为易感于tmepai定向疗法以及治疗所述癌症的方法
|
WO2014159813A1
(en)
|
2013-03-13 |
2014-10-02 |
Moderna Therapeutics, Inc. |
Long-lived polynucleotide molecules
|
US10258698B2
(en)
|
2013-03-14 |
2019-04-16 |
Modernatx, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
CA2904654C
(en)
|
2013-03-14 |
2023-12-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
WO2014160871A2
(en)
|
2013-03-27 |
2014-10-02 |
The General Hospital Corporation |
Methods and agents for treating alzheimer's disease
|
CN105518146B
(zh)
|
2013-04-04 |
2022-07-15 |
哈佛学院校长同事会 |
利用CRISPR/Cas***的基因组编辑的治疗性用途
|
WO2014172698A1
(en)
|
2013-04-19 |
2014-10-23 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation nucleic acids through nonsense mediated decay
|
JP6995478B2
(ja)
|
2013-05-01 |
2022-01-14 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Hbvおよびttr発現を調節するための組成物および方法
|
RU2015154721A
(ru)
|
2013-05-22 |
2017-06-27 |
Элнилэм Фармасьютикалз, Инк. |
КОМПОЗИЦИИ НА ОСНОВЕ RNAi SERPINA1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
WO2014190157A1
(en)
|
2013-05-22 |
2014-11-27 |
Alnylam Pharmaceuticals, Inc. |
Tmprss6 compositions and methods of use thereof
|
US20160113911A1
(en)
|
2013-06-06 |
2016-04-28 |
The General Hospital Corporation |
Methods and compositions for the treatment of cancer
|
CA2918787A1
(en)
|
2013-06-13 |
2014-12-18 |
George Tachas |
Combination therapy
|
WO2014205449A2
(en)
|
2013-06-21 |
2014-12-24 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating apolipoprotein c-iii expression for improving a diabetic profile
|
WO2015002971A2
(en)
|
2013-07-02 |
2015-01-08 |
Isis Pharmaceuticals, Inc. |
Modulators of growth hormone receptor
|
PT3019619T
(pt)
|
2013-07-11 |
2021-11-11 |
Modernatx Inc |
Composições que compreendem polinucleótidos sintéticos que codificam proteínas relacionadas com crispr e sgarn sintéticos e métodos de utilização
|
WO2015017694A1
(en)
*
|
2013-07-31 |
2015-02-05 |
Regents Of The University Of California |
Dna double-write/double binding identity
|
AU2014306271A1
(en)
|
2013-08-08 |
2016-03-24 |
The Scripps Research Institute |
A method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
ES2790574T3
(es)
|
2013-08-28 |
2020-10-28 |
Ionis Pharmaceuticals Inc |
Modulación de expresión de prekallikrein (PKK)
|
JP2016530294A
(ja)
|
2013-09-03 |
2016-09-29 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
キメラポリヌクレオチド
|
WO2015034925A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
DK3043827T3
(da)
|
2013-09-13 |
2019-08-26 |
Ionis Pharmaceuticals Inc |
Modulatorer af komplement faktor b
|
TWI669393B
(zh)
|
2013-10-02 |
2019-08-21 |
艾爾妮蘭製藥公司 |
抑制lect2基因表現之組合物及方法
|
KR20160067219A
(ko)
|
2013-10-03 |
2016-06-13 |
모더나 세라퓨틱스, 인코포레이티드 |
저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
|
CA2925357C
(en)
|
2013-10-04 |
2024-02-27 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the alas1 gene
|
WO2015054451A1
(en)
|
2013-10-09 |
2015-04-16 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services |
Detection of hepatitis delta virus (hdv) for the diagnosis and treatment of sjögren's syndrome and lymphoma
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
EP3683321B1
(de)
|
2013-10-21 |
2021-12-08 |
The General Hospital Corporation |
Verfahren im zusammenhang mit zirkulierenden tumorzellclustern und mit der behandlung von krebs
|
WO2015061246A1
(en)
|
2013-10-21 |
2015-04-30 |
Isis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
US10301622B2
(en)
|
2013-11-04 |
2019-05-28 |
Northwestern University |
Quantification and spatio-temporal tracking of a target using a spherical nucleic acid (SNA)
|
CN107075515B
(zh)
|
2013-11-22 |
2020-10-30 |
米纳治疗有限公司 |
C/EBPα组合物和使用方法
|
CA2932122C
(en)
|
2013-12-03 |
2022-04-19 |
Northwestern University |
Liposomal particles, methods of making same and uses thereof
|
US10385388B2
(en)
|
2013-12-06 |
2019-08-20 |
Swift Biosciences, Inc. |
Cleavable competitor polynucleotides
|
CA2844640A1
(en)
|
2013-12-06 |
2015-06-06 |
The University Of British Columbia |
Method for treatment of castration-resistant prostate cancer
|
KR20210158880A
(ko)
|
2013-12-12 |
2021-12-31 |
알닐람 파마슈티칼스 인코포레이티드 |
보체 성분 iRNA 조성물 및 이의 이용 방법
|
EP3082840B1
(de)
|
2013-12-20 |
2021-03-24 |
The General Hospital Corporation |
Verfahren und tests im zusammenhang mit zirkulierenden tumorzellen
|
CN111440795A
(zh)
|
2013-12-24 |
2020-07-24 |
Ionis制药公司 |
促血管生成素样3表达的调节
|
CA2937539A1
(en)
|
2014-02-04 |
2015-08-13 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
EA201691587A1
(ru)
|
2014-02-11 |
2017-01-30 |
Элнилэм Фармасьютикалз, Инк. |
КОМПОЗИЦИИ НА ОСНОВЕ iRNA ДЛЯ КЕТОГЕКСОКИНАЗЫ (KHK) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
US10036019B2
(en)
|
2014-03-17 |
2018-07-31 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
RS62526B1
(sr)
|
2014-03-19 |
2021-11-30 |
Ionis Pharmaceuticals Inc |
Kompozicije za modulaciju ekspresije ataksina 2
|
WO2015143245A1
(en)
|
2014-03-19 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating ataxin 2 expression
|
EP3126499B1
(de)
|
2014-04-01 |
2020-06-24 |
Biogen MA Inc. |
Zusammensetzungen zur modulierung der sod-1 -expression
|
EP3943607A1
(de)
|
2014-04-09 |
2022-01-26 |
The Scripps Research Institute |
Import von unnatürlichen oder modifizierten nukleosid-triphosphaten in zellen mittels nukleinsäure-triphosphattransportern
|
EP3797780B1
(de)
|
2014-04-17 |
2022-09-14 |
Biogen MA Inc. |
Zusammensetzungen und verfahren zur modulation der smn2-aufspaltung in einem patienten
|
WO2015164693A1
(en)
|
2014-04-24 |
2015-10-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
ES2849600T3
(es)
|
2014-05-01 |
2021-08-19 |
Ionis Pharmaceuticals Inc |
Conjugados de oligonucleótidos antisentido modificados y su uso para modular la expresión de PKK
|
CA2942570A1
(en)
|
2014-05-01 |
2015-11-05 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating growth hormone receptor expression
|
US10098959B2
(en)
|
2014-05-01 |
2018-10-16 |
Ionis Pharmaceuticals, Inc. |
Method for synthesis of reactive conjugate clusters
|
SG11201608502TA
(en)
|
2014-05-01 |
2016-11-29 |
Ionis Pharmaceuticals Inc |
Compositions and methods for modulating complement factor b expression
|
BR112016024850B1
(pt)
|
2014-05-01 |
2021-07-06 |
Ionis Pharmaceuticals, Inc |
compostos e composições para modulação da expressão de angptl3 e seus usos
|
WO2015171918A2
(en)
|
2014-05-07 |
2015-11-12 |
Louisiana State University And Agricultural And Mechanical College |
Compositions and uses for treatment thereof
|
WO2015175510A1
(en)
|
2014-05-12 |
2015-11-19 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating a serpinc1-associated disorder
|
CA3215908A1
(en)
|
2014-05-22 |
2015-11-26 |
Alnylam Pharmaceuticals, Inc. |
Angiotensinogen (agt) irna compositions and methods of use thereof
|
EP3148564B1
(de)
|
2014-06-02 |
2020-01-08 |
Children's Medical Center Corporation |
Verfahren und zusammensetzungen zur immunmodulation
|
AU2015272128B2
(en)
|
2014-06-10 |
2021-10-28 |
Erasmus University Medical Center Rotterdam |
Antisense oligonucleotides useful in treatment of Pompe disease
|
US10301624B2
(en)
|
2014-06-25 |
2019-05-28 |
The General Hospital Corporation |
Targeting human satellite II (HSATII)
|
CA2955250A1
(en)
|
2014-07-16 |
2016-01-21 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
US9951327B1
(en)
|
2014-07-17 |
2018-04-24 |
Integrated Dna Technologies, Inc. |
Efficient and rapid method for assembling and cloning double-stranded DNA fragments
|
EP3171895A1
(de)
|
2014-07-23 |
2017-05-31 |
Modernatx, Inc. |
Modifizierte polynukleotide zur herstellung von intrabodys
|
CN107074923B
(zh)
|
2014-07-31 |
2021-08-03 |
Uab研究基金会 |
Apoe模拟肽及对清除血浆胆固醇的较高效力
|
CN113069551A
(zh)
|
2014-08-19 |
2021-07-06 |
西北大学 |
蛋白质/寡核苷酸核-壳纳米颗粒治疗剂
|
CA2959386C
(en)
|
2014-08-29 |
2024-06-04 |
Lee Adam Wheeler |
Methods and compositions for the treatment of cancer
|
US10060921B2
(en)
|
2014-08-29 |
2018-08-28 |
Alnylam Pharmaceuticals, Inc. |
Methods of treating transthyretin (TTR) mediated amyloidosis
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
US10436802B2
(en)
|
2014-09-12 |
2019-10-08 |
Biogen Ma Inc. |
Methods for treating spinal muscular atrophy
|
WO2016040589A1
(en)
|
2014-09-12 |
2016-03-17 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
WO2016041058A1
(en)
|
2014-09-18 |
2016-03-24 |
The University Of British Columbia |
Allele-specific therapy for huntington disease haplotypes
|
US10556020B2
(en)
|
2014-09-26 |
2020-02-11 |
University Of Massachusetts |
RNA-modulating agents
|
JOP20200115A1
(ar)
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
|
EP3207138B1
(de)
|
2014-10-17 |
2020-07-15 |
Alnylam Pharmaceuticals, Inc. |
Gegen aminolävulinsäuresynthase-1 (alas1) gerichtete polynukleotidmittel und verwendungen davon
|
WO2016069694A2
(en)
|
2014-10-30 |
2016-05-06 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
AU2015344741A1
(en)
|
2014-11-10 |
2017-05-25 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Combination long acting compositions and methods for hepatitis C
|
AU2015344739A1
(en)
|
2014-11-10 |
2017-05-25 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Long acting pharmaceutical compositions for hepatitis C
|
AU2015350120B2
(en)
|
2014-11-17 |
2021-05-27 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof
|
JP2017537619A
(ja)
|
2014-11-21 |
2017-12-21 |
ノースウェスタン ユニバーシティ |
球状核酸ナノ粒子複合体の配列特異的細胞内取込
|
WO2016086104A1
(en)
|
2014-11-25 |
2016-06-02 |
Ionis Pharmaceuticals, Inc. |
Modulation of ube3a-ats expression
|
EP3229842B1
(de)
|
2014-12-08 |
2022-07-06 |
The Board of Regents of The University of Texas System |
Lipokationische polymere und verwendungen davon
|
AU2015364508A1
(en)
|
2014-12-18 |
2017-07-06 |
Alnylam Pharmaceuticals, Inc. |
ReversirTM compounds
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
EP3247988A4
(de)
|
2015-01-23 |
2018-12-19 |
Vanderbilt University |
Robustes interferometer und verfahren zur verwendung davon
|
JP6929791B2
(ja)
|
2015-02-09 |
2021-09-01 |
デューク ユニバーシティ |
エピゲノム編集のための組成物および方法
|
CA2976445A1
(en)
|
2015-02-13 |
2016-08-18 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
EP3262181B1
(de)
|
2015-02-23 |
2024-04-10 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur flüssigphasendetritylierung von oligomeren verbindungen
|
US20180200387A1
(en)
|
2015-02-23 |
2018-07-19 |
Crispr Therapeutics Ag |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
WO2016138353A1
(en)
|
2015-02-26 |
2016-09-01 |
Ionis Pharmaceuticals, Inc. |
Allele specific modulators of p23h rhodopsin
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
CA2984237A1
(en)
|
2015-03-27 |
2016-10-06 |
President And Fellows Of Harvard College |
Modified t cells and methods of making and using the same
|
WO2016164463A1
(en)
|
2015-04-07 |
2016-10-13 |
The General Hospital Corporation |
Methods for reactivating genes on the inactive x chromosome
|
US10745702B2
(en)
|
2015-04-08 |
2020-08-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the LECT2 gene
|
SG10202001856WA
(en)
|
2015-04-16 |
2020-04-29 |
Ionis Pharmaceuticals Inc |
Compositions for modulating c9orf72 expression
|
WO2016167780A1
(en)
|
2015-04-16 |
2016-10-20 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
WO2016201301A1
(en)
|
2015-06-12 |
2016-12-15 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
WO2016205323A1
(en)
|
2015-06-18 |
2016-12-22 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
AU2016282986A1
(en)
|
2015-06-26 |
2018-02-01 |
Beth Israel Deaconess Medical Center, Inc. |
Cancer therapy targeting tetraspanin 33 (tspan33) in myeloid derived suppressor cells
|
CA2991045A1
(en)
|
2015-06-29 |
2017-01-05 |
Caris Science, Inc. |
Therapeutic oligonucleotides binding c1q
|
WO2017011286A1
(en)
|
2015-07-10 |
2017-01-19 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
|
WO2017015109A1
(en)
|
2015-07-17 |
2017-01-26 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
AU2016298317B2
(en)
|
2015-07-28 |
2021-02-18 |
Caris Science, Inc. |
Targeted oligonucleotides
|
WO2017021961A1
(en)
|
2015-08-04 |
2017-02-09 |
Yeda Research And Development Co. Ltd. |
Methods of screening for riboswitches and attenuators
|
CN108368507B
(zh)
|
2015-09-02 |
2022-03-22 |
阿尔尼拉姆医药品有限公司 |
程序性细胞死亡1配体1(PD-L1)的iRNA组合物及其使用方法
|
JP7041616B2
(ja)
|
2015-09-14 |
2022-03-24 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
リポカチオン性デンドリマーおよびその使用
|
US20190048340A1
(en)
|
2015-09-24 |
2019-02-14 |
Crispr Therapeutics Ag |
Novel family of rna-programmable endonucleases and their uses in genome editing and other applications
|
WO2017053781A1
(en)
|
2015-09-25 |
2017-03-30 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating ataxin 3 expression
|
CN113817735A
(zh)
|
2015-10-08 |
2021-12-21 |
Ionis制药公司 |
用于调节血管紧张素原表达的化合物和方法
|
US11970710B2
(en)
|
2015-10-13 |
2024-04-30 |
Duke University |
Genome engineering with Type I CRISPR systems in eukaryotic cells
|
JP2019507579A
(ja)
|
2015-10-28 |
2019-03-22 |
クリスパー セラピューティクス アーゲー |
デュシェンヌ型筋ジストロフィーの処置のための材料および方法
|
US10421821B2
(en)
|
2015-10-30 |
2019-09-24 |
Genentech, Inc. |
Anti-HtrA1 antibodies and methods of use thereof
|
ES2938883T3
(es)
|
2015-11-05 |
2023-04-17 |
Los Angeles Childrens Hospital |
Oligo antisentido para su uso en el tratamiento de la leucemia mieloide aguda
|
WO2017077386A1
(en)
|
2015-11-06 |
2017-05-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of glycogen storage disease type 1a
|
PE20181180A1
(es)
|
2015-11-06 |
2018-07-20 |
Ionis Pharmaceuticals Inc |
MODULAR LA EXPRESION DE APOLIPOPROTEINA (a)
|
AU2016355178B9
(en)
|
2015-11-19 |
2019-05-30 |
Massachusetts Institute Of Technology |
Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
|
EP3967758A1
(de)
|
2015-12-01 |
2022-03-16 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von alpha-1-antitrypsin-defizienz
|
EP3389670A4
(de)
|
2015-12-04 |
2020-01-08 |
Ionis Pharmaceuticals, Inc. |
Verfahren zur behandlung von brustkrebs
|
AU2015416656B2
(en)
|
2015-12-07 |
2023-02-23 |
Erasmus University Medical Center Rotterdam |
Enzymatic replacement therapy and antisense therapy for Pompe disease
|
WO2017106767A1
(en)
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
EP3394260B1
(de)
|
2015-12-23 |
2021-02-17 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von amyothrophischer lateraler sklerose und/oder frontotemporaler demenz
|
US10907160B2
(en)
|
2016-01-05 |
2021-02-02 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing LRRK2 expression
|
WO2017132483A1
(en)
|
2016-01-29 |
2017-08-03 |
Vanderbilt University |
Free-solution response function interferometry
|
EP3411078A1
(de)
|
2016-02-02 |
2018-12-12 |
Crispr Therapeutics AG |
Materialien und verfahren zur behandlung von schwerer kombinierter immundefizienz (scid) oder omenn-syndrom
|
JP2019509721A
(ja)
|
2016-02-04 |
2019-04-11 |
キュリス,インコーポレイテッド |
突然変異体スムースンド及びその使用方法
|
US20190112353A1
(en)
|
2016-02-18 |
2019-04-18 |
Crispr Therapeutics Ag |
Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome
|
US11234996B2
(en)
|
2016-02-25 |
2022-02-01 |
The Brigham And Women's Hospital, Inc. |
Treatment methods for fibrosis targeting SMOC2
|
WO2017158422A1
(en)
|
2016-03-16 |
2017-09-21 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hereditary haemochromatosis
|
CA3013799A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating keap1
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
US10731166B2
(en)
|
2016-03-18 |
2020-08-04 |
Caris Science, Inc. |
Oligonucleotide probes and uses thereof
|
EP3445388B1
(de)
|
2016-04-18 |
2024-04-17 |
Vertex Pharmaceuticals Incorporated |
Materialien und verfahren zur behandlung von hämoglobinopathien
|
MA45295A
(fr)
|
2016-04-19 |
2019-02-27 |
Alnylam Pharmaceuticals Inc |
Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
|
WO2017191503A1
(en)
|
2016-05-05 |
2017-11-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
CA3024129A1
(en)
|
2016-05-16 |
2017-11-23 |
The Board Of Regents Of The University Of Texas System |
Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids
|
IL306052A
(en)
|
2016-05-25 |
2023-11-01 |
Caris Science Inc |
Oligonucleotide probes and their uses
|
US20190256845A1
(en)
|
2016-06-10 |
2019-08-22 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
EP3471781A4
(de)
|
2016-06-17 |
2020-05-06 |
Ionis Pharmaceuticals, Inc. |
Modulierung der gys1-expression
|
ES2929047T3
(es)
|
2016-06-24 |
2022-11-24 |
Scripps Research Inst |
Transportador de nucleósido trifosfato novedoso y usos del mismo
|
US11174469B2
(en)
|
2016-06-29 |
2021-11-16 |
Crispr Therapeutics Ag |
Materials and methods for treatment of Amyotrophic Lateral Sclerosis (ALS) and other related disorders
|
US11427838B2
(en)
|
2016-06-29 |
2022-08-30 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
|
WO2018002783A1
(en)
|
2016-06-29 |
2018-01-04 |
Crispr Therapeutics Ag |
Materials and methods for treatment of friedreich ataxia and other related disorders
|
CN109843914B
(zh)
|
2016-07-06 |
2024-03-15 |
沃泰克斯药物股份有限公司 |
用于治疗疼痛相关病症的材料和方法
|
WO2018007976A1
(en)
|
2016-07-06 |
2018-01-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of pain related disorders
|
WO2018007871A1
(en)
|
2016-07-08 |
2018-01-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of transthyretin amyloidosis
|
WO2018013525A1
(en)
|
2016-07-11 |
2018-01-18 |
Translate Bio Ma, Inc. |
Nucleic acid conjugates and uses thereof
|
CN109844103A
(zh)
|
2016-07-21 |
2019-06-04 |
美克斯细胞有限公司 |
用于修饰基因组dna的方法和组合物
|
WO2018020323A2
(en)
|
2016-07-25 |
2018-02-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of fatty acid disorders
|
NL2017295B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Antisense oligomeric compound for Pompe disease
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
WO2018039629A2
(en)
|
2016-08-25 |
2018-03-01 |
Northwestern University |
Micellar spherical nucleic acids from thermoresponsive, traceless templates
|
WO2018055577A1
(en)
|
2016-09-23 |
2018-03-29 |
Synthena Ag |
Mixed tricyclo-dna, 2'-modified rna oligonucleotide compositions and uses thereof
|
CN109661233A
(zh)
|
2016-10-06 |
2019-04-19 |
Ionis 制药公司 |
缀合低聚化合物的方法
|
US11459568B2
(en)
|
2016-10-31 |
2022-10-04 |
University Of Massachusetts |
Targeting microRNA-101-3p in cancer therapy
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
TWI788312B
(zh)
|
2016-11-23 |
2023-01-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
WO2018102745A1
(en)
|
2016-12-02 |
2018-06-07 |
Cold Spring Harbor Laboratory |
Modulation of lnc05 expression
|
CN110191955B
(zh)
|
2016-12-13 |
2024-05-31 |
西雅图儿童医院(Dba西雅图儿童研究所) |
在体外和体内对工程化的细胞中表达的化学物质诱导的信号传导复合物进行外源性药物激活的方法
|
KR20190098181A
(ko)
|
2016-12-16 |
2019-08-21 |
알닐람 파마슈티칼스 인코포레이티드 |
트랜스티레틴(TTR) iRNA 조성물을 사용하여 TTR-관련 질병을 치료하거나 예방하는 방법
|
BR112019014841A2
(pt)
|
2017-01-23 |
2020-04-28 |
Regeneron Pharma |
rna guia, uso do rna guia, rna antissentido, sirna ou shrna, uso do rna antissentido, do sirna ou do shrna, ácido nucleico isolado, vetor, composição, célula, e, métodos para modificar um gene hsd17b13 em uma célula, para diminuir a expressão de um gene hsd17b13 em uma célula, para modificar uma célula e para tratar um indivíduo que não é portador da variante de hsd17b13
|
EP3585898A1
(de)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von spinozerebellärer ataxie typ 1 (sca1) und anderen mit dem gen des proteins von spinozerebellärer ataxie typ 1 (atxn1) assoziierten erkrankungen oder störungen
|
JP2020508056A
(ja)
|
2017-02-22 |
2020-03-19 |
クリスパー・セラピューティクス・アクチェンゲゼルシャフトCRISPR Therapeutics AG |
遺伝子編集のための組成物および方法
|
US20200040061A1
(en)
|
2017-02-22 |
2020-02-06 |
Crispr Therapeutics Ag |
Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders
|
EP3585899A1
(de)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von primärer hyperoxalurie typ 1 (ph1) und anderen mit dem alanin-glyoxylataminotransferase (agxt)-gen assoziierten erkrankungen oder störungen
|
EP3585900B1
(de)
|
2017-02-22 |
2022-12-21 |
CRISPR Therapeutics AG |
Materialien und methoden zur behandlung von spinocerebellar ataxia typ 2 (sca2) und anderen spinocerebellar ataxia typ 2 protein (atxn2) gen verwandten erkrankungen oder störungen
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
WO2018183969A1
(en)
|
2017-03-30 |
2018-10-04 |
California Institute Of Technology |
Barcoded rapid assay platform for efficient analysis of candidate molecules and methods of making and using the platform
|
CA3059446A1
(en)
|
2017-04-18 |
2018-10-25 |
Alnylam Pharmaceuticals, Inc. |
Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
|
WO2018193428A1
(en)
|
2017-04-20 |
2018-10-25 |
Synthena Ag |
Modified oligomeric compounds comprising tricyclo-dna nucleosides and uses thereof
|
CA3059321A1
(en)
|
2017-04-20 |
2018-10-25 |
Synthena Ag |
Modified oligomeric compounds comprising tricyclo-dna nucleosides and uses thereof
|
US20200384115A1
(en)
|
2017-04-21 |
2020-12-10 |
The Broad Institute , Inc. |
Targeted delivery to beta cells
|
US20180325955A1
(en)
|
2017-05-12 |
2018-11-15 |
Crispr Therapeutics Ag |
Materials and methods for engineering cells and uses thereof in immuno-oncology
|
AR112756A1
(es)
|
2017-07-11 |
2019-12-11 |
Synthorx Inc |
Incorporación de nucleótidos no naturales, y su método
|
EP3652186A4
(de)
|
2017-07-13 |
2021-03-31 |
Northwestern University |
Allgemeines und direktes verfahren zur herstellung von oligonukleotidfunktionalisierten metallorganischen gerüstnanopartikeln
|
CA3069868A1
(en)
|
2017-07-13 |
2019-01-17 |
Alnylam Pharmaceuticals Inc. |
Lactate dehydrogenase a (ldha) irna compositions and methods of use thereof
|
KR20200035092A
(ko)
|
2017-08-03 |
2020-04-01 |
신톡스, 인크. |
자가면역 질환의 치료를 위한 사이토카인 접합체
|
AU2018318231A1
(en)
|
2017-08-18 |
2020-02-13 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
EP3679138B1
(de)
|
2017-09-08 |
2023-03-22 |
MiNA Therapeutics Limited |
Hnf4a-sarna-zusammensetzungen und verfahren zur verwendung
|
US20200208152A1
(en)
|
2017-09-08 |
2020-07-02 |
Mina Therapeutics Limited |
Stabilized sarna compositions and methods of use
|
WO2019051173A1
(en)
|
2017-09-08 |
2019-03-14 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF SMAD7 EXPRESSION
|
US11999953B2
(en)
|
2017-09-13 |
2024-06-04 |
The Children's Medical Center Corporation |
Compositions and methods for treating transposon associated diseases
|
AU2018336806A1
(en)
|
2017-09-19 |
2020-05-07 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating transthyretin (TTR) mediated amyloidosis
|
BR112020007502A2
(pt)
|
2017-10-17 |
2020-10-06 |
Crispr Therapeutics Ag |
composições e métodos para edição gênica para hemofilia a
|
EP3701029A1
(de)
|
2017-10-26 |
2020-09-02 |
Vertex Pharmaceuticals Incorporated |
Materialien und verfahren zur behandlung von hämoglobinopathien
|
SG11202002940QA
(en)
|
2017-11-01 |
2020-04-29 |
Alnylam Pharmaceuticals Inc |
Complement component c3 irna compositions and methods of use thereof
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
EP3707256A1
(de)
|
2017-11-09 |
2020-09-16 |
CRISPR Therapeutics AG |
Selbstinaktivierende (sin) crispr/cas- oder crispr/cpf1-systeme und verwendungen davon
|
US20200385719A1
(en)
|
2017-11-16 |
2020-12-10 |
Alnylam Pharmaceuticals, Inc. |
Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
|
EP3714054A1
(de)
|
2017-11-20 |
2020-09-30 |
Alnylam Pharmaceuticals, Inc. |
Serum-amyloid p-komponente (apcs) irna zusammensetzungen und verfahren zu deren verwendung
|
EP3714055A1
(de)
|
2017-11-21 |
2020-09-30 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung von autosomal-dominanter retinitis pigmentosa
|
KR20200106159A
(ko)
|
2017-12-05 |
2020-09-11 |
버텍스 파마슈티칼스 인코포레이티드 |
크리스퍼-cas9 변형된 cd34+ 인간 조혈 줄기 및 전구 세포 및 그의 용도
|
JP2021506251A
(ja)
|
2017-12-14 |
2021-02-22 |
クリスパー セラピューティクス アーゲー |
新規rnaプログラム可能エンドヌクレアーゼ系、ならびにゲノム編集および他の適用におけるその使用
|
CN111727252A
(zh)
|
2017-12-18 |
2020-09-29 |
阿尔尼拉姆医药品有限公司 |
高速泳动族盒-1(HMGB1)iRNA组合物及其使用方法
|
EP3728594A1
(de)
|
2017-12-21 |
2020-10-28 |
CRISPR Therapeutics AG |
Materialien und verfahren zur behandlung des usher-syndroms typ 2a
|
WO2019123430A1
(en)
|
2017-12-21 |
2019-06-27 |
Casebia Therapeutics Llp |
Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp)
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
MA51637A
(fr)
|
2018-01-12 |
2020-11-18 |
Bayer Healthcare Llc |
Compositions et méthodes pour l'édition génique par ciblage de la transferrine
|
JP2021511072A
(ja)
|
2018-01-15 |
2021-05-06 |
アイオニス・ファーマシューティカルズ・インコーポレイテッドIonis Pharmaceuticals,Inc. |
Dnm2発現のモジュレーター
|
WO2019147743A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
WO2019150196A1
(en)
|
2018-02-05 |
2019-08-08 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
MA51788A
(fr)
|
2018-02-05 |
2020-12-16 |
Vertex Pharma |
Substances et méthodes pour traiter des hémoglobinopathies
|
EP3752616A1
(de)
|
2018-02-16 |
2020-12-23 |
CRISPR Therapeutics AG |
Zusammensetzungen und verfahren zur geneditierung durch targeting von fibrinogen-alpha
|
BR112020017016A2
(pt)
|
2018-02-26 |
2020-12-29 |
Synthorx, Inc. |
Conjugados da il-15 e usos dos mesmos
|
EP3759127A4
(de)
|
2018-03-02 |
2022-03-30 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur modulation des amyloid-beta-vorläuferproteins
|
CN111886011B
(zh)
|
2018-03-02 |
2024-03-08 |
Ionis制药公司 |
Irf4表达的调节剂
|
WO2019183150A1
(en)
|
2018-03-19 |
2019-09-26 |
Casebia Therapeutics Limited Liability Partnership |
Novel rna-programmable endonuclease systems and uses thereof
|
US11661601B2
(en)
|
2018-03-22 |
2023-05-30 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating FMR1 expression
|
EP4051799A2
(de)
|
2018-03-30 |
2022-09-07 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Aptamere zur gezielten aktivierung von t-zellvermittelter immunität
|
JP2021520781A
(ja)
|
2018-04-06 |
2021-08-26 |
チルドレンズ メディカル センター コーポレーションChildren’S Medical Center Corporation |
体細胞リプログラミングおよびインプリンティングのモジュレートのための組成物および方法
|
EP3775204A4
(de)
|
2018-04-11 |
2021-12-29 |
Ionis Pharmaceuticals, Inc. |
Modulatoren der ezh2-expression
|
WO2019197845A1
(en)
|
2018-04-12 |
2019-10-17 |
Mina Therapeutics Limited |
Sirt1-sarna compositions and methods of use
|
WO2019204668A1
(en)
|
2018-04-18 |
2019-10-24 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for knockdown of apo(a) by gene editing for treatment of cardiovascular disease
|
AU2019260687B2
(en)
|
2018-04-27 |
2022-09-22 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Rapamycin resistant cells
|
US20220125823A1
(en)
|
2018-05-07 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Extrahepatic delivery
|
EP3799604A4
(de)
|
2018-05-09 |
2022-09-07 |
Ionis Pharmaceuticals, Inc. |
Verbindungen und verfahren zur verminderung der fxi-expression
|
CA3098144A1
(en)
|
2018-05-09 |
2019-11-14 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing atxn3 expression
|
TW202016304A
(zh)
|
2018-05-14 |
2020-05-01 |
美商阿尼拉製藥公司 |
血管收縮素原(AGT)iRNA組成物及其使用方法
|
WO2019241648A1
(en)
|
2018-06-14 |
2019-12-19 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for increasing stmn2 expression
|
TWI833770B
(zh)
|
2018-06-27 |
2024-03-01 |
美商Ionis製藥公司 |
用於減少 lrrk2 表現之化合物及方法
|
JP7411632B2
(ja)
|
2018-07-25 |
2024-01-11 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Atxn2発現を低減するための化合物及び方法
|
CA3106701A1
(en)
|
2018-08-13 |
2020-02-20 |
Alnylam Pharmaceuticals, Inc. |
Hepatitis b virus (hbv) dsrna agent compositions and methods of use thereof
|
TW202020157A
(zh)
|
2018-08-16 |
2020-06-01 |
美商艾爾妮蘭製藥公司 |
用於抑制lect2基因表現之組合物及方法
|
EP3843845A4
(de)
|
2018-08-29 |
2022-05-11 |
University Of Massachusetts |
Hemmung von proteinkinasen zur behandlung von friedreich-ataxie
|
EP3849584A4
(de)
|
2018-09-14 |
2022-06-22 |
Northwestern University |
Programmierung von proteinpolymerisation mit dna
|
US20210332367A1
(en)
|
2018-09-18 |
2021-10-28 |
Alnylam Pharmaceuticals, Inc. |
KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
TW202028465A
(zh)
|
2018-09-28 |
2020-08-01 |
美商阿尼拉製藥公司 |
甲狀腺素運載蛋白(TTR)iRNA組成物及其治療或預防TTR相關眼部疾病之使用方法
|
WO2020081843A1
(en)
|
2018-10-17 |
2020-04-23 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for delivering transgenes
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
EA202191342A1
(ru)
|
2018-11-15 |
2021-08-10 |
Айонис Фармасьютикалз, Инк. |
Модуляторы экспрессии irf5
|
US20210332495A1
(en)
|
2018-12-06 |
2021-10-28 |
Northwestern University |
Protein Crystal Engineering Through DNA Hybridization Interactions
|
AU2019405961A1
(en)
|
2018-12-20 |
2021-07-22 |
Humabs Biomed Sa |
Combination HBV therapy
|
CA3123617A1
(en)
|
2018-12-20 |
2020-06-25 |
Praxis Precision Medicines, Inc. |
Compositions and methods for the treatment of kcnt1 related disorders
|
BR112021013956A2
(pt)
|
2019-01-16 |
2021-09-21 |
Genzyme Corporation |
Composições de irna de serpinc1 e métodos de uso das mesmas
|
SG11202107399WA
(en)
|
2019-01-31 |
2021-08-30 |
Ionis Pharmaceuticals Inc |
Modulators of yap1 expression
|
TW202045208A
(zh)
|
2019-02-06 |
2020-12-16 |
美商欣爍克斯公司 |
Il-2結合物及其使用方法
|
SG11202108357PA
(en)
|
2019-02-15 |
2021-08-30 |
Crispr Therapeutics Ag |
Gene editing for hemophilia a with improved factor viii expression
|
WO2020171889A1
(en)
|
2019-02-19 |
2020-08-27 |
University Of Rochester |
Blocking lipid accumulation or inflammation in thyroid eye disease
|
US11279932B2
(en)
|
2019-02-27 |
2022-03-22 |
Ionis Pharmaceuticals, Inc. |
Modulators of MALAT1 expression
|
AU2020239225A1
(en)
|
2019-03-12 |
2021-09-30 |
Bayer Healthcare Llc |
Novel high fidelity RNA-programmable endonuclease systems and uses thereof
|
EP3941483A4
(de)
|
2019-03-21 |
2023-10-18 |
Arnay Sciences, Llc |
Antisense-oligonukleotide zur allelspezifität
|
CA3135579A1
(en)
|
2019-03-29 |
2020-10-08 |
Mitsubishi Tanabe Pharma Corporation |
Compound, method and pharmaceutical composition for modulating expression of dux4
|
KR20210144822A
(ko)
|
2019-03-29 |
2021-11-30 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Ube3a-ats를 조절하기 위한 화합물 및 방법
|
EP3953473A1
(de)
|
2019-04-12 |
2022-02-16 |
MiNA Therapeutics Limited |
Sirt1-sarna-zusammensetzungen und verfahren zur verwendung
|
BR112021022806A2
(pt)
|
2019-05-13 |
2022-01-25 |
Vir Biotechnology Inc |
Método para tratar a infecção crônica por hbv, sirna, usos de um sirna, e de um sirna e peg-ifna e de um sirna, peg-ifna e um nrti, método, composição para uso ou uso e kit
|
US20220211743A1
(en)
|
2019-05-17 |
2022-07-07 |
Alnylam Pharmaceuticals, Inc. |
Oral delivery of oligonucleotides
|
AU2020291535A1
(en)
|
2019-06-14 |
2022-01-20 |
The Scripps Research Institute |
Reagents and methods for replication, transcription, and translation in semi-synthetic organisms
|
WO2021021673A1
(en)
|
2019-07-26 |
2021-02-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating gfap
|
WO2021022108A2
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
EP4007812A1
(de)
|
2019-08-01 |
2022-06-08 |
Alnylam Pharmaceuticals, Inc. |
Irna-zusammensetzungen der serpinfamilie f element 2 (serpinf2) und verfahren zu deren verwendung
|
EP4013870A1
(de)
|
2019-08-13 |
2022-06-22 |
Alnylam Pharmaceuticals, Inc. |
Irna-wirkstoffzusammensetzungen der kleinen ribosomalen proteinuntereinheit 25 (rps25) und verfahren zu ihrer verwendung
|
TW202120128A
(zh)
|
2019-08-15 |
2021-06-01 |
美商欣爍克斯公司 |
使用il-2接合物之免疫腫瘤學組合療法
|
CN114555621A
(zh)
|
2019-08-15 |
2022-05-27 |
Ionis制药公司 |
键修饰的寡聚化合物及其用途
|
JP2022545101A
(ja)
|
2019-08-19 |
2022-10-25 |
ミナ セラピューティクス リミテッド |
オリゴヌクレオチドコンジュゲート組成物および使用方法
|
TW202122401A
(zh)
|
2019-08-23 |
2021-06-16 |
美商欣爍克斯公司 |
新穎之il-15接合物及其用途
|
MX2022002689A
(es)
|
2019-09-03 |
2022-04-07 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para inhibir la expresion del gen de quimiotaxina derivada de celulas de leucocitos 2 (lect2).
|
BR112022003335A2
(pt)
|
2019-09-10 |
2022-05-24 |
Synthorx Inc |
Conjugados de il-2 e métodos de uso para tratar doenças autoimunes
|
US20220389429A1
(en)
|
2019-10-04 |
2022-12-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing ugt1a1 gene expression
|
EP4045652A1
(de)
|
2019-10-18 |
2022-08-24 |
Alnylam Pharmaceuticals, Inc. |
Irna-zusammensetzungen eines elements der solute-carrier-familie und verwendungsverfahren dafür
|
CA3158320A1
(en)
|
2019-10-22 |
2021-04-29 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof
|
JP2023500661A
(ja)
|
2019-11-01 |
2023-01-10 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ハンチンチン(HTT)iRNA剤組成物およびその使用方法
|
US20230040920A1
(en)
|
2019-11-01 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajb1-prkaca fusion gene expression
|
TW202131952A
(zh)
|
2019-11-04 |
2021-09-01 |
美商欣爍克斯公司 |
介白素10接合物及其用途
|
CA3160329A1
(en)
|
2019-11-06 |
2021-05-14 |
Alnylam Pharmaceuticals, Inc. |
Extrahepatic delivery
|
WO2021092145A1
(en)
|
2019-11-06 |
2021-05-14 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna composition and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
PE20230179A1
(es)
|
2019-11-13 |
2023-02-01 |
Alnylam Pharmaceuticals Inc |
Metodos y composiciones para el tratamiento de un trastorno asociado con angiotensinogeno (agt)
|
US20230056569A1
(en)
|
2019-11-22 |
2023-02-23 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
TW202140509A
(zh)
|
2019-12-13 |
2021-11-01 |
美商阿尼拉製藥公司 |
人類染色體9開讀框72(C9ORF72)iRNA劑組成物及其使用方法
|
WO2021126734A1
(en)
|
2019-12-16 |
2021-06-24 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
EP4077674A1
(de)
|
2019-12-18 |
2022-10-26 |
Alia Therapeutics S.R.L. |
Zusammensetzungen und verfahren zur behandlung von retinitis pigmentosa
|
WO2021154705A1
(en)
|
2020-01-27 |
2021-08-05 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Rab13 and net1 antisense oligonucleotides to treat metastatic cancer
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
KR20220140593A
(ko)
|
2020-02-10 |
2022-10-18 |
알닐람 파마슈티칼스 인코포레이티드 |
Vegf-a 발현을 사일런싱하기 위한 조성물 및 방법
|
EP4107265A1
(de)
|
2020-02-18 |
2022-12-28 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein-c3 (apoc3)-irna-zusammensetzungen und verfahren zur verwendung davon
|
KR20220148230A
(ko)
|
2020-02-28 |
2022-11-04 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Smn2를 조절하기 위한 화합물 및 방법
|
EP4114947A1
(de)
|
2020-03-05 |
2023-01-11 |
Alnylam Pharmaceuticals, Inc. |
Komplementkomponenten-c3-irna-zusammensetzungen und verfahren zur verwendung davon zur behandlung oder prävention von mit komplementkomponenten-c3-assoziierten erkrankungen
|
AU2021232029A1
(en)
|
2020-03-06 |
2022-10-06 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of transthyretin (TTR)
|
CN115485383A
(zh)
|
2020-03-06 |
2022-12-16 |
阿尔尼拉姆医药品有限公司 |
己酮糖激酶(KHK)iRNA组合物及其使用方法
|
WO2021188611A1
(en)
|
2020-03-18 |
2021-09-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
|
CN116209759A
(zh)
|
2020-03-26 |
2023-06-02 |
阿尔尼拉姆医药品有限公司 |
冠状病毒iRNA组合物及其使用方法
|
EP4127171A2
(de)
|
2020-03-30 |
2023-02-08 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur ausschaltung der dnajc15-genexpression
|
JP2023520582A
(ja)
|
2020-04-06 |
2023-05-17 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Myoc発現をサイレンシングするための組成物および方法
|
WO2021206917A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
TW202204617A
(zh)
|
2020-04-07 |
2022-02-01 |
美商艾爾妮蘭製藥公司 |
用於靜默scn9a表現之組合物及方法
|
WO2021206922A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
|
CN115955972A
(zh)
|
2020-04-27 |
2023-04-11 |
阿尔尼拉姆医药品有限公司 |
载脂蛋白E(APOE)iRNA剂组合物及其使用方法
|
IL297680A
(en)
|
2020-04-30 |
2022-12-01 |
Alnylam Pharmaceuticals Inc |
IRNA compounds complement factor b (cfb) and methods of using them
|
WO2021222768A2
(en)
|
2020-05-01 |
2021-11-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating atxn1
|
US20230227824A1
(en)
|
2020-05-12 |
2023-07-20 |
Mitsubishi Tanabe Pharma Corporation |
Compound, method and pharmaceutical composition for regulating expression of ataxin 3
|
WO2021231692A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
EP4150086A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von leucinreicher repeat-kinase 2 (lrrk2)
|
EP4150088A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von argininosuccinat-synthetase (ass1)
|
EP4150078A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten editierung von argininosuccinat-lyase (asl)
|
EP4150089A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von retinosin 1 (rs1)
|
WO2021231685A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
EP4150076A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung von methyl-cpg-bindendem protein 2 (mecp2)
|
EP4150087A1
(de)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen zur adar-vermittelten bearbeitung des gap-junction-proteins beta 2 (gjb2)
|
WO2021237097A1
(en)
|
2020-05-21 |
2021-11-25 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting marc1 gene expression
|
AU2021274944A1
(en)
|
2020-05-22 |
2022-12-15 |
Wave Life Sciences Ltd. |
Double stranded oligonucleotide compositions and methods relating thereto
|
AR122534A1
(es)
|
2020-06-03 |
2022-09-21 |
Triplet Therapeutics Inc |
Métodos para el tratamiento de los trastornos de expansión por repetición de nucleótidos asociados con la actividad de msh3
|
EP4161552A1
(de)
|
2020-06-05 |
2023-04-12 |
The Broad Institute, Inc. |
Zusammensetzungen und verfahren zur behandlung von neoplasien
|
EP4162050A1
(de)
|
2020-06-09 |
2023-04-12 |
Alnylam Pharmaceuticals, Inc. |
Rnai-zusammensetzungen und verfahren zur verwendung davon zur verabreichung durch inhalation
|
KR20230026455A
(ko)
|
2020-06-18 |
2023-02-24 |
알닐람 파마슈티칼스 인코포레이티드 |
크산틴 데하이드로게나제 (XDH) iRNA 조성물 및 이의 사용 방법
|
JP2023531520A
(ja)
|
2020-06-24 |
2023-07-24 |
ヴィア・バイオテクノロジー・インコーポレイテッド |
操作されたb型肝炎ウイルス中和抗体およびその使用
|
CA3183834A1
(en)
|
2020-06-25 |
2021-12-30 |
Giovanni Abbadessa |
Immuno oncology combination therapy with il-2 conjugates and anti-egfr antibodies
|
CA3185749A1
(en)
|
2020-06-29 |
2022-01-06 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating plp1
|
WO2022011262A1
(en)
|
2020-07-10 |
2022-01-13 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods and compositions for treating epilepsy
|
WO2022011214A1
(en)
|
2020-07-10 |
2022-01-13 |
Alnylam Pharmaceuticals, Inc. |
Circular sirnas
|
EP4217489A1
(de)
|
2020-09-24 |
2023-08-02 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidylpeptidase 4 (dpp4)-irna-zusammensetzungen und verfahren zur verwendung davon
|
US20220290136A1
(en)
|
2020-09-30 |
2022-09-15 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis
|
EP3978608A1
(de)
|
2020-10-05 |
2022-04-06 |
SQY Therapeutics |
Oligomere verbindung zur dystrophinrettung in dmd-patienten während des skipping exon-51
|
JP2023544413A
(ja)
|
2020-10-05 |
2023-10-23 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Gタンパク質共役受容体75(GPR75)iRNA組成物およびその使用方法
|
CA3194880A1
(en)
|
2020-10-09 |
2022-04-14 |
Carolina E. CAFFARO |
Immuno oncology therapies with il-2 conjugates
|
EP4225376A1
(de)
|
2020-10-09 |
2023-08-16 |
Synthorx, Inc. |
Immunonkologische kombinationstherapie mit il-2-konjugaten und pembrolizumab
|
CA3198823A1
(en)
|
2020-10-21 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating primary hyperoxaluria
|
WO2022087329A1
(en)
|
2020-10-23 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Mucin 5b (muc5b) irna compositions and methods of use thereof
|
TW202237841A
(zh)
|
2020-11-13 |
2022-10-01 |
美商艾拉倫製藥股份有限公司 |
凝血因子V(F5)iRNA組成物及其使用方法
|
TW202227101A
(zh)
|
2020-11-18 |
2022-07-16 |
美商Ionis製藥公司 |
用於調節血管收縮素原表現之化合物及方法
|
CA3201452A1
(en)
|
2020-12-01 |
2022-06-09 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
|
WO2022125490A1
(en)
|
2020-12-08 |
2022-06-16 |
Alnylam Pharmaceuticals, Inc. |
Coagulation factor x (f10) irna compositions and methods of use thereof
|
JP2023554346A
(ja)
|
2020-12-18 |
2023-12-27 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
第xii因子を調節するための化合物及び方法
|
MX2023007630A
(es)
|
2020-12-23 |
2023-08-25 |
Flagship Pioneering Innovations Vi Llc |
Composiciones de trem modificadas y usos de las mismas.
|
WO2022147223A2
(en)
|
2020-12-31 |
2022-07-07 |
Alnylam Pharmaceuticals, Inc. |
2'-modified nucleoside based oligonucleotide prodrugs
|
JP2024501857A
(ja)
|
2020-12-31 |
2024-01-16 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
環状ジスルフィド修飾リン酸ベースのオリゴヌクレオチドプロドラッグ
|
WO2022150260A1
(en)
|
2021-01-05 |
2022-07-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
IL304880A
(en)
|
2021-02-12 |
2023-10-01 |
Alnylam Pharmaceuticals Inc |
Superoxide dismutase 1 (SOD1) IRNA compositions and methods of using them to treat or prevent superoxide dismutase 1- (SOD1-) associated neurodegenerative diseases
|
WO2022174102A1
(en)
|
2021-02-12 |
2022-08-18 |
Synthorx, Inc. |
Lung cancer combination therapy with il-2 conjugates and an anti-pd-1 antibody or antigen-binding fragment thereof
|
TW202245843A
(zh)
|
2021-02-12 |
2022-12-01 |
美商欣爍克斯公司 |
Il-2接合物及西米普利單抗(cemiplimab)之皮膚癌組合療法
|
WO2022182864A1
(en)
|
2021-02-25 |
2022-09-01 |
Alnylam Pharmaceuticals, Inc. |
Prion protein (prnp) irna compositions and methods and methods of use thereof
|
KR20230150844A
(ko)
|
2021-02-26 |
2023-10-31 |
알닐람 파마슈티칼스 인코포레이티드 |
케토헥소키나아제(KHK) iRNA 조성물 및 이의 사용 방법
|
IL305442A
(en)
|
2021-03-04 |
2023-10-01 |
Alnylam Pharmaceuticals Inc |
Angiopoietin-like 3 (ANGPTL3) IRNA compositions and methods of using them
|
WO2022192038A1
(en)
|
2021-03-12 |
2022-09-15 |
Northwestern University |
Antiviral vaccines using spherical nucleic acids
|
WO2022192519A1
(en)
|
2021-03-12 |
2022-09-15 |
Alnylam Pharmaceuticals, Inc. |
Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
|
CA3214137A1
(en)
|
2021-03-26 |
2022-09-29 |
Mina Therapeutics Limited |
Tmem173 sarna compositions and methods of use
|
KR20230162024A
(ko)
|
2021-03-29 |
2023-11-28 |
알닐람 파마슈티칼스 인코포레이티드 |
헌팅틴(HTT) iRNA 제제 조성물 및 이의 사용 방법
|
EP4314016A1
(de)
|
2021-03-31 |
2024-02-07 |
Entrada Therapeutics, Inc. |
Zyklische zellen penetrierende peptide
|
EP4314293A1
(de)
|
2021-04-01 |
2024-02-07 |
Alnylam Pharmaceuticals, Inc. |
Prolindehydrogenase 2 (prodh2)-irna-zusammensetzungen und verfahren zur verwendung davon
|
CA3214540A1
(en)
|
2021-04-22 |
2022-10-27 |
Pasi A. Janne |
Compositions and methods for treating cancer
|
TW202309280A
(zh)
|
2021-04-26 |
2023-03-01 |
美商艾拉倫製藥股份有限公司 |
跨膜絲胺酸蛋白酶6(TMPRSS6)iRNA組成物及其使用方法
|
WO2022232343A1
(en)
|
2021-04-29 |
2022-11-03 |
Alnylam Pharmaceuticals, Inc. |
Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
|
EP4334448A1
(de)
|
2021-05-03 |
2024-03-13 |
Alnylam Pharmaceuticals, Inc. |
Zusammensetzungen und verfahren zur behandlung von transthyretin(ttr)-vermittelter amyloidose
|
WO2022240721A1
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
KR20240012425A
(ko)
|
2021-05-10 |
2024-01-29 |
엔트라다 테라퓨틱스, 인크. |
세포내 치료제를 위한 조성물 및 방법
|
EP4337261A2
(de)
|
2021-05-10 |
2024-03-20 |
Entrada Therapeutics, Inc. |
Zusammensetzungen und verfahren zur modulation des spleissens von mrna
|
WO2022245583A1
(en)
|
2021-05-18 |
2022-11-24 |
Alnylam Pharmaceuticals, Inc. |
Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
|
WO2022246023A1
(en)
|
2021-05-20 |
2022-11-24 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
EP4347823A1
(de)
|
2021-06-02 |
2024-04-10 |
Alnylam Pharmaceuticals, Inc. |
Patin-ähnliche phospholipasedomäne mit 3 (pnpla3)-irna-zusammensetzungen und verfahren zur verwendung davon
|
WO2022256534A1
(en)
|
2021-06-03 |
2022-12-08 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
|
JP2024521907A
(ja)
|
2021-06-04 |
2024-06-04 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ヒト9番染色体オープンリーディングフレーム72(C9ORF72)iRNA剤組成物及びその使用方法
|
AR126070A1
(es)
|
2021-06-08 |
2023-09-06 |
Alnylam Pharmaceuticals Inc |
Composiciones y métodos para tratar o prevenir la enfermedad de stargardt y/o trastornos asociados con la proteína transportadora de retinol 4 (rbp4)
|
EP4101928A1
(de)
|
2021-06-11 |
2022-12-14 |
Bayer AG |
Programmierbare typ-v-rna-endonukleasesysteme
|
KR20240021218A
(ko)
|
2021-06-11 |
2024-02-16 |
바이엘 악티엔게젤샤프트 |
신규 유형 v rna 프로그래밍가능 엔도뉴클레아제 시스템
|
WO2022266414A1
(en)
|
2021-06-18 |
2022-12-22 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing ifnar1 expression
|
KR20240038967A
(ko)
|
2021-06-23 |
2024-03-26 |
엔트라다 테라퓨틱스, 인크. |
Cug 반복을 표적화하기 위한 안티센스 화합물 및 방법
|
EP4363574A1
(de)
|
2021-06-29 |
2024-05-08 |
Korro Bio, Inc. |
Verfahren und zusammensetzungen für adar-vermittelte bearbeitung
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
WO2023278576A1
(en)
|
2021-06-30 |
2023-01-05 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
|
EP4367237A2
(de)
|
2021-07-09 |
2024-05-15 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai-verbindungen zur zns-verabreichung
|
WO2023285431A1
(en)
|
2021-07-12 |
2023-01-19 |
Alia Therapeutics Srl |
Compositions and methods for allele specific treatment of retinitis pigmentosa
|
EP4373934A1
(de)
|
2021-07-19 |
2024-05-29 |
Alnylam Pharmaceuticals, Inc. |
Verfahren und zusammensetzungen zur behandlung von patienten mit oder mit einem risiko zur entwicklung einer nichtprimären hyperoxalurieerkrankung oder -störung
|
CA3226887A1
(en)
|
2021-07-21 |
2023-01-26 |
Alnylam Pharmaceuticals, Inc. |
Metabolic disorder-associated target gene irna compositions and methods of use thereof
|
CA3226878A1
(en)
|
2021-07-23 |
2023-01-26 |
Alnylam Pharmaceuticals, Inc. |
Beta-catenin (ctnnb1) irna compositions and methods of use thereof
|
EP4377458A1
(de)
|
2021-07-29 |
2024-06-05 |
Alnylam Pharmaceuticals, Inc. |
3-hydroxy-3-methylglutaryl-coa-reduktase (hmgcr)-irna-zusammensetzungen und verfahren zur verwendung davon
|
IL310244A
(en)
|
2021-08-03 |
2024-03-01 |
Alnylam Pharmaceuticals Inc |
Transthyretin (TTR) IRNA compositions and methods of using them
|
IL310295A
(en)
|
2021-08-04 |
2024-03-01 |
Alnylam Pharmaceuticals Inc |
iRNA compositions and methods for silencing angiotensinogen (AGT)
|
BR112024001923A2
(pt)
|
2021-08-13 |
2024-04-30 |
Alnylam Pharmaceuticals Inc |
Composições de irna de fator xii (f12) e métodos de usos das mesmas
|
AU2022339769A1
(en)
|
2021-09-01 |
2024-03-28 |
Entrada Therapeutics, Inc. |
Compounds and methods for skipping exon 44 in duchenne muscular dystrophy
|
EP4144841A1
(de)
|
2021-09-07 |
2023-03-08 |
Bayer AG |
Neue programmierbare rna-endonuklease-systeme mit verbesserter pam-spezifität und deren verwendung
|
WO2023044370A2
(en)
|
2021-09-17 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Irna compositions and methods for silencing complement component 3 (c3)
|
IL311454A
(en)
|
2021-09-20 |
2024-05-01 |
Alnylam Pharmaceuticals Inc |
Inhibin subunit E (INHBE) modulator compositions and methods of using them
|
IL311864A
(en)
|
2021-10-15 |
2024-06-01 |
Alnylam Pharmaceuticals Inc |
IRNA compositions for extrahepatic administration and methods of using them
|
CA3234835A1
(en)
|
2021-10-22 |
2023-04-27 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
CA3234636A1
(en)
|
2021-10-29 |
2023-05-04 |
Alnylam Pharmaceuticals, Inc. |
Complement factor b (cfb) irna compositions and methods of use thereof
|
WO2023076450A2
(en)
|
2021-10-29 |
2023-05-04 |
Alnylam Pharmaceuticals, Inc. |
HUNTINGTIN (HTT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF
|
US20240200078A1
(en)
|
2021-11-18 |
2024-06-20 |
Cornell University |
Microrna-dependent mrna switches for tissue-specific mrna-based therapies
|
WO2023099884A1
(en)
|
2021-12-01 |
2023-06-08 |
Mina Therapeutics Limited |
Pax6 sarna compositions and methods of use
|
WO2023122573A1
(en)
|
2021-12-20 |
2023-06-29 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
|
WO2023118349A1
(en)
|
2021-12-21 |
2023-06-29 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
WO2023118068A1
(en)
|
2021-12-23 |
2023-06-29 |
Bayer Aktiengesellschaft |
Novel small type v rna programmable endonuclease systems
|
WO2023122750A1
(en)
|
2021-12-23 |
2023-06-29 |
Synthorx, Inc. |
Cancer combination therapy with il-2 conjugates and cetuximab
|
WO2023141314A2
(en)
|
2022-01-24 |
2023-07-27 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
WO2023170435A1
(en)
|
2022-03-07 |
2023-09-14 |
Mina Therapeutics Limited |
Il10 sarna compositions and methods of use
|
WO2023194359A1
(en)
|
2022-04-04 |
2023-10-12 |
Alia Therapeutics Srl |
Compositions and methods for treatment of usher syndrome type 2a
|
WO2023220744A2
(en)
|
2022-05-13 |
2023-11-16 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
WO2023237587A1
(en)
|
2022-06-10 |
2023-12-14 |
Bayer Aktiengesellschaft |
Novel small type v rna programmable endonuclease systems
|
WO2024006999A2
(en)
|
2022-06-30 |
2024-01-04 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
WO2024039776A2
(en)
|
2022-08-18 |
2024-02-22 |
Alnylam Pharmaceuticals, Inc. |
Universal non-targeting sirna compositions and methods of use thereof
|
WO2024059165A1
(en)
|
2022-09-15 |
2024-03-21 |
Alnylam Pharmaceuticals, Inc. |
17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof
|
WO2024056880A2
(en)
|
2022-09-16 |
2024-03-21 |
Alia Therapeutics Srl |
Enqp type ii cas proteins and applications thereof
|
WO2024073732A1
(en)
|
2022-09-30 |
2024-04-04 |
Alnylam Pharmaceuticals, Inc. |
Modified double-stranded rna agents
|
WO2024105162A1
(en)
|
2022-11-16 |
2024-05-23 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
WO2024129743A2
(en)
|
2022-12-13 |
2024-06-20 |
Bluerock Therapeutics Lp |
Engineered type v rna programmable endonucleases and their uses
|