EE04495B1 - Meetod antikolinergikum tiotroopiumbromiidi valmistamiseks - Google Patents
Meetod antikolinergikum tiotroopiumbromiidi valmistamiseksInfo
- Publication number
- EE04495B1 EE04495B1 EEP200300309A EEP200300309A EE04495B1 EE 04495 B1 EE04495 B1 EE 04495B1 EE P200300309 A EEP200300309 A EE P200300309A EE P200300309 A EEP200300309 A EE P200300309A EE 04495 B1 EE04495 B1 EE 04495B1
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- tiotropium bromide
- anticholinergic
- anticholinergic tiotropium
- bromide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catalysts (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10064816A DE10064816A1 (de) | 2000-12-22 | 2000-12-22 | Verfahren zur Herstellung eines Anticholinergikums |
PCT/EP2001/014566 WO2002051840A1 (de) | 2000-12-22 | 2001-12-12 | Verfahren zur herstellung des anticholinergikums tiotropiumbromid |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200300309A EE200300309A (et) | 2003-10-15 |
EE04495B1 true EE04495B1 (et) | 2005-06-15 |
Family
ID=7668836
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200300309A EE04495B1 (et) | 2000-12-22 | 2001-12-12 | Meetod antikolinergikum tiotroopiumbromiidi valmistamiseks |
Country Status (42)
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6908928B2 (en) | 2000-10-12 | 2005-06-21 | Bi Pharma Kg. | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
JP3870159B2 (ja) * | 2000-10-12 | 2007-01-17 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | チオトロピウムを含む新規吸入性粉剤 |
US6706726B2 (en) * | 2000-10-14 | 2004-03-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anticholinergics which may be used as medicaments as well as processes for preparing them |
US6852728B2 (en) * | 2000-10-14 | 2005-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them |
US20020151541A1 (en) * | 2000-10-31 | 2002-10-17 | Michel Pairet | Pharmaceutical compositions containing tiotropium salts and antihistamines and their use |
US20020111363A1 (en) * | 2000-10-31 | 2002-08-15 | Karin Drechsel | Inhalable formulation of a solution containing a tiotropium salt |
US20020137764A1 (en) | 2000-10-31 | 2002-09-26 | Karin Drechsel | Inhalable formulation of a solution containing a tiotropium salt |
US7776315B2 (en) * | 2000-10-31 | 2010-08-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and additional active ingredients |
US20020193392A1 (en) * | 2000-11-13 | 2002-12-19 | Christel Schmelzer | Pharmaceutical compositions based on tiotropium salts of salts of salmeterol |
US20100310477A1 (en) * | 2000-11-28 | 2010-12-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Pharmaceutical compositions based on anticholingerics and additional active ingredients |
US20030013675A1 (en) * | 2001-05-25 | 2003-01-16 | Boehringer Ingelheim Pharma Kg | Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases |
US20030070679A1 (en) * | 2001-06-01 | 2003-04-17 | Boehringer Ingelheim Pharma Kg | Capsules containing inhalable tiotropium |
US6608055B2 (en) | 2001-06-22 | 2003-08-19 | Boehringer Ingelheim Pharma Kg | Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition |
JP2005504015A (ja) * | 2001-06-22 | 2005-02-10 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 抗コリン作用薬、その製造方法及び医薬組成物を製造するためのその使用 |
US20030018019A1 (en) * | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
DE10141377A1 (de) * | 2001-08-23 | 2003-03-13 | Boehringer Ingelheim Pharma | Aufstreuverfahren zur Herstellung von Pulverformulierungen |
US6919325B2 (en) * | 2001-09-14 | 2005-07-19 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts |
DE10200943A1 (de) * | 2002-01-12 | 2003-07-24 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Scopinestern |
US7405224B2 (en) * | 2002-01-31 | 2008-07-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions |
US6790856B2 (en) * | 2002-01-31 | 2004-09-14 | Boehringer Ingelheim Pharma Kg | Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments |
US7309707B2 (en) * | 2002-03-20 | 2007-12-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament |
US7244415B2 (en) | 2002-03-28 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations of an anhydrate |
US7311894B2 (en) * | 2002-03-28 | 2007-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | HFA suspension formulations containing an anticholinergic |
RU2004132222A (ru) * | 2002-04-04 | 2005-10-10 | Берингер Ингельхайм Фарма Гмбх Унд Ко.Кг (De) | Порошковые композиции, пригодные для ингаляции |
US20030235538A1 (en) | 2002-04-09 | 2003-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for the administration of an anticholinergic by inhalation |
US7417051B2 (en) * | 2002-04-12 | 2008-08-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising betamimetics and a novel anticholinergic |
US7084153B2 (en) * | 2002-04-12 | 2006-08-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising steroids and a novel anticholinergic |
US7763280B2 (en) * | 2002-11-28 | 2010-07-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tiotropium containing powder formulation for inhalation |
DE10345065A1 (de) * | 2003-09-26 | 2005-04-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum |
WO2005042528A1 (de) * | 2003-11-03 | 2005-05-12 | Boehringer Ingelheim International Gmbh | Neue tiotropiumsalze, verfahren zu deren herstellung sowie diese enthaltende arzneimittelformulierungen |
PT2067779E (pt) * | 2003-11-03 | 2013-07-25 | Boehringer Ingelheim Int | Sais de tiotrópio, processo para a sua preparação e formulações de produtos farmacêuticos contendo os mesmos |
SE0303570L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
AU2006243239A1 (en) * | 2005-05-02 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Crystalline forms of tiotropium bromide |
WO2006117299A2 (en) * | 2005-05-02 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Novel crystalline forms of tiotropium bromide |
WO2006134021A2 (en) * | 2005-06-15 | 2006-12-21 | Boehringer Ingelheim International Gmbh | Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof |
DE102005035112A1 (de) * | 2005-07-27 | 2007-02-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen |
CN1316245C (zh) * | 2005-07-28 | 2007-05-16 | 山东齐都药业有限公司 | 托烷司琼合成中残留中间体托品醇的检测方法 |
TWI274641B (en) * | 2005-08-30 | 2007-03-01 | Rexon Ind Corp Ltd | Cutting machine |
DE102005059602A1 (de) | 2005-12-14 | 2007-06-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Mikronisierung |
PT1869035E (pt) | 2005-12-19 | 2013-01-10 | Sicor Inc | Novas formas de brometo de tiotrópio e processos para sua preparação |
RU2453547C2 (ru) * | 2005-12-19 | 2012-06-20 | Сикор Инк. | Новые формы тиотропия бромида и способы их получения |
US20070167480A1 (en) * | 2005-12-19 | 2007-07-19 | Sicor Inc. | Pure and stable tiotropium bromide |
KR20080079586A (ko) * | 2005-12-19 | 2008-09-01 | 시코르, 인크. | 순수하고 안정한 티오트로퓸 브로마이드 |
US9108962B2 (en) | 2005-12-19 | 2015-08-18 | Sicor, Inc. | Forms of tiotropium bromide and processes for preparation thereof |
CN100410254C (zh) * | 2006-03-07 | 2008-08-13 | 南昌弘益科技有限公司 | 噻托溴铵无水物制备方法 |
US20080051582A1 (en) | 2006-07-10 | 2008-02-28 | Sicor Inc. | Process for the preparation of tiotropium bromide |
EP1882691A1 (en) * | 2006-07-26 | 2008-01-30 | CHIESI FARMACEUTICI S.p.A. | Quinuclidine derivatives as M3 antagonists |
EP1950196A1 (de) * | 2007-01-29 | 2008-07-30 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von Ammoniumhexafluorophosphaten |
EP2036898A2 (de) * | 2007-09-13 | 2009-03-18 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von 1,3-Dioxolan-2Onen sowie von Carbonsäureestern durch Transacylierung unter Basischen Reaktionsbedingungen |
PL2240477T3 (pl) * | 2008-01-10 | 2015-03-31 | Generics Uk Ltd | Nowy sposób wytwarzania estrów skopiny |
WO2011015884A1 (en) | 2009-08-07 | 2011-02-10 | Generics [Uk] Limited | Process to prepare scopine esters |
NZ597920A (en) | 2009-08-07 | 2014-05-30 | Generics Uk Ltd | Anhydrate of tiotropium bromide |
CN101768158B (zh) * | 2010-01-04 | 2013-05-29 | 南昌弘益科技有限公司 | 噻托溴铵无水物及其制备方法 |
CN101863885B (zh) * | 2010-06-03 | 2012-05-30 | 南京金丹呈医药技术有限公司 | 一种噻托溴铵的制备方法 |
TR201007108A2 (tr) * | 2010-08-25 | 2012-03-21 | B�Lg�� Mahmut | Yeni tiotropyum bromür kristali ve üretim yöntemi.@ |
ITRM20110508A1 (it) | 2011-09-27 | 2013-03-28 | Lusochimica Spa | Processo per la preparazione degli esteri della scopina. |
RS55996B1 (sr) * | 2011-12-22 | 2017-09-29 | Cerbios-Pharma S A | Kontinuirani postupak za alkilaciju cikličnih tercijarnih amina |
PT106142B (pt) | 2012-02-10 | 2014-07-18 | Hovione Farmaci Ncia S A | Processo para a preparação de brometo de tiotrópio |
CZ305012B6 (cs) * | 2012-03-30 | 2015-03-25 | Zentiva, K.S. | Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu |
RU2015146871A (ru) | 2013-04-01 | 2017-05-10 | Пулматрикс, Инк. | Сухие порошки с тиотропием |
WO2018055642A1 (en) * | 2016-09-23 | 2018-03-29 | Gbr Laboratories Pvt. Ltd. | A process for preparing tiotropium bromide and intermediates thereof |
WO2019129801A1 (en) | 2017-12-28 | 2019-07-04 | Linnea S.A. | Process for the purification of methyl-2,2-dithienylglycolate |
CN113264929B (zh) * | 2021-05-02 | 2023-10-10 | 润生药业有限公司 | 一种噻托溴铵的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
US5610163A (en) * | 1989-09-16 | 1997-03-11 | Boehringer Ingelheim Gmbh | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
US5770738A (en) * | 1992-03-05 | 1998-06-23 | Boehringer Ingelheim Kg | Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions |
-
2000
- 2000-12-22 DE DE10064816A patent/DE10064816A1/de not_active Withdrawn
-
2001
- 2001-12-12 EP EP04005241A patent/EP1426373B1/de not_active Expired - Lifetime
- 2001-12-12 KR KR1020037008327A patent/KR100853109B1/ko active IP Right Grant
- 2001-12-12 HU HU0301457A patent/HU230320B1/hu unknown
- 2001-12-12 AU AU2002229650A patent/AU2002229650B2/en not_active Expired
- 2001-12-12 EG EG20011334A patent/EG23914A/xx active
- 2001-12-12 ME MEP-406/08A patent/MEP40608A/xx unknown
- 2001-12-12 AT AT04005241T patent/ATE337314T1/de active
- 2001-12-12 SK SK935-2003A patent/SK287318B6/sk not_active IP Right Cessation
- 2001-12-12 ES ES04005241T patent/ES2271722T3/es not_active Expired - Lifetime
- 2001-12-12 PT PT01990546T patent/PT1345936E/pt unknown
- 2001-12-12 IL IL15635101A patent/IL156351A0/xx active IP Right Grant
- 2001-12-12 CN CNB200610004553XA patent/CN100393719C/zh not_active Expired - Lifetime
- 2001-12-12 EE EEP200300309A patent/EE04495B1/xx not_active IP Right Cessation
- 2001-12-12 MX MXPA03005426A patent/MXPA03005426A/es active IP Right Grant
- 2001-12-12 BR BRPI0116444A patent/BRPI0116444B8/pt not_active IP Right Cessation
- 2001-12-12 CA CA002433518A patent/CA2433518C/en not_active Expired - Fee Related
- 2001-12-12 DE DE50110835T patent/DE50110835D1/de not_active Expired - Lifetime
- 2001-12-12 ES ES01990546T patent/ES2221658T3/es not_active Expired - Lifetime
- 2001-12-12 CN CNB018208851A patent/CN1244581C/zh not_active Expired - Lifetime
- 2001-12-12 EP EP01990546A patent/EP1345936B1/de not_active Expired - Lifetime
- 2001-12-12 TR TR2004/01127T patent/TR200401127T4/xx unknown
- 2001-12-12 EA EA200300666A patent/EA005533B1/ru not_active IP Right Cessation
- 2001-12-12 PT PT04005241T patent/PT1426373E/pt unknown
- 2001-12-12 UA UA2003076873A patent/UA74409C2/uk unknown
- 2001-12-12 CZ CZ20031685A patent/CZ294958B6/cs not_active IP Right Cessation
- 2001-12-12 AT AT01990546T patent/ATE266661T1/de active
- 2001-12-12 JP JP2002552935A patent/JP4198991B2/ja not_active Expired - Lifetime
- 2001-12-12 DE DE50102299T patent/DE50102299D1/de not_active Expired - Lifetime
- 2001-12-12 RS YU50903A patent/RS50271B/sr unknown
- 2001-12-12 DK DK01990546T patent/DK1345936T3/da active
- 2001-12-12 DK DK04005241T patent/DK1426373T3/da active
- 2001-12-12 SI SI200130096T patent/SI1345936T1/sl unknown
- 2001-12-12 NZ NZ527066A patent/NZ527066A/xx not_active IP Right Cessation
- 2001-12-12 PL PL361837A patent/PL202478B1/pl unknown
- 2001-12-12 WO PCT/EP2001/014566 patent/WO2002051840A1/de active IP Right Grant
- 2001-12-18 UY UY27079A patent/UY27079A1/es not_active Application Discontinuation
- 2001-12-19 US US10/025,425 patent/US6486321B2/en not_active Expired - Lifetime
- 2001-12-19 AR ARP010105885A patent/AR033599A1/es active Pending
- 2001-12-20 PE PE2001001285A patent/PE20020755A1/es not_active Application Discontinuation
- 2001-12-21 MY MYPI20015832A patent/MY129525A/en unknown
- 2001-12-21 TW TW090131874A patent/TWI234564B/zh not_active IP Right Cessation
- 2001-12-23 SA SA01220589A patent/SA01220589B1/ar unknown
-
2003
- 2003-06-09 IL IL156351A patent/IL156351A/en unknown
- 2003-06-12 EC EC2003004652A patent/ECSP034652A/es unknown
- 2003-06-13 BG BG107910A patent/BG66373B1/bg active Active
- 2003-06-18 ZA ZA200304707A patent/ZA200304707B/en unknown
- 2003-06-18 HR HR20030502A patent/HRP20030502B1/xx not_active IP Right Cessation
- 2003-06-20 NO NO20032827A patent/NO327739B1/no not_active IP Right Cessation
-
2004
- 2004-05-20 HK HK04103588A patent/HK1060570A1/xx not_active IP Right Cessation
-
2006
- 2006-08-30 CY CY20061101230T patent/CY1105210T1/el unknown
-
2007
- 2007-03-15 HK HK07102807A patent/HK1096683A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EE200300309A (et) | Meetod antikolinergikum tiotroopiumbromiidi valmistamiseks | |
AU2002229650A1 (en) | Method for producing the anticholinergic agent tiotropium bromide | |
DK1326862T3 (da) | Krystallinsk monohydrat af tiotropiumbromid, fremgangsmåde til fremstilling deraf og anvendelse deraf til fremstilling af et lægemiddel | |
EG24851A (en) | Crystalline anticholinergic process for the preparation thereof for preparing a medicament | |
EE200200656A (et) | Ravis kasutatavad tropaani derivaadid | |
EE05179B1 (et) | Ravimitena kasutatavad antikolinergikumid ning meetod nende valmistamiseks | |
EP1343481A4 (en) | PROCESS FOR THE PREPARATION OF A QUICKLY SOLUBLE DOSAGE FORM | |
NO20030012L (no) | Fremgangsmåte for fremstilling av substituerte oktanoylamider | |
NO20032518L (no) | Fremgangsmåte for fremstilling av amlodipinmaleat | |
NO20023950D0 (no) | Fremgangsmåte for fremstilling av en titanholdig zeolitt | |
DE60233709D1 (de) | Ausnehmmechanismus einer Hohlglasformmaschine | |
DK1808435T3 (da) | Teknisk fremstilling af tiotropiumbromid | |
NO20023973L (no) | Fremgangsmåte for fremstilling av en titanholdig zeolitt | |
DE60233549D1 (de) | Ausnehmmechanismus einer Hohlglasformmaschine | |
DE60218269D1 (de) | Ausnehmmechanismus einer Hohlglasformmaschine | |
HK1048112B (zh) | 3-乙烯基-頭孢化合物的製備方法 | |
NO20031911D0 (no) | Inhalasjonslösningsformulering med et tiotropiumsalt | |
FI20011034A (fi) | Menetelmä absorboivien aineiden valmistamiseksi | |
NO20024887L (no) | FremgangsmÕte for fremstilling av benzokondenserte heterosykliske forbindelser | |
NO324220B1 (no) | Fremgangsmate for fremstilling av en polymorf | |
EE200300204A (et) | Meetod distamütsiini derivaadi valmistamiseks | |
FI20010927A (fi) | Menetelmä terapeuttisesti aktiivisen yhdisteen valmistamiseksi | |
NO20023702D0 (no) | Fremgangsmåte for fremstilling av 5-arylnikotinaldehyder | |
NO20025385L (no) | Fremgangsmate for fremstilling av sulfonylbenzoylguanidiniumsalter | |
NO20032707D0 (no) | Ny fremgangsmåte for fremstilling av diaryl-4- aminopiperidinylforbindelser |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
|
MM4A | Lapsed by not paying the annual fees |
Effective date: 20141212 |