HRP20030502B1 - Method for producing the anticholinergic agent tiotropium bromide - Google Patents

Method for producing the anticholinergic agent tiotropium bromide

Info

Publication number: HRP20030502B1
Authority: HR; Croatia
Prior art keywords: tiotropium bromide; producing; anticholinergic agent; agent tiotropium; formula
Prior art date: 2000-12-22

Application number

HR20030502A

Other languages

English (en)

Croatian (hr)

Inventor

Banholzer Rolf

Graulich Manfred

Luettke Sven

Mathes Andreas

Meissner Helmut

Specht Peter

Broeder Wolfgang

Original Assignee

Boehringer Ingelheim Pharma Gmbh & Co. Kg.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-22

Filing date

2003-06-18

Publication date

2011-09-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7668836&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20030502(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-06-18 Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg. filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg.

2005-04-30 Publication of HRP20030502A2 publication Critical patent/HRP20030502A2/hr

2011-09-30 Publication of HRP20030502B1 publication Critical patent/HRP20030502B1/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Catalysts (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)

HR20030502A 2000-12-22 2003-06-18 Method for producing the anticholinergic agent tiotropium bromide HRP20030502B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10064816A DE10064816A1 (de)	2000-12-22	2000-12-22	Verfahren zur Herstellung eines Anticholinergikums
PCT/EP2001/014566 WO2002051840A1 (de)	2000-12-22	2001-12-12	Verfahren zur herstellung des anticholinergikums tiotropiumbromid

Publications (2)

Publication Number	Publication Date
HRP20030502A2 HRP20030502A2 (en)	2005-04-30
HRP20030502B1 true HRP20030502B1 (en)	2011-09-30

Family

ID=7668836

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20030502A HRP20030502B1 (en)	2000-12-22	2003-06-18	Method for producing the anticholinergic agent tiotropium bromide

Country Status (42)

Country	Link
US (1)	US6486321B2 (xx)
EP (2)	EP1426373B1 (xx)
JP (1)	JP4198991B2 (xx)
KR (1)	KR100853109B1 (xx)
CN (2)	CN1244581C (xx)
AR (1)	AR033599A1 (xx)
AT (2)	ATE337314T1 (xx)
AU (1)	AU2002229650B2 (xx)
BG (1)	BG66373B1 (xx)
BR (1)	BRPI0116444B8 (xx)
CA (1)	CA2433518C (xx)
CY (1)	CY1105210T1 (xx)
CZ (1)	CZ294958B6 (xx)
DE (3)	DE10064816A1 (xx)
DK (2)	DK1426373T3 (xx)
EA (1)	EA005533B1 (xx)
EC (1)	ECSP034652A (xx)
EE (1)	EE04495B1 (xx)
EG (1)	EG23914A (xx)
ES (2)	ES2271722T3 (xx)
HK (2)	HK1060570A1 (xx)
HR (1)	HRP20030502B1 (xx)
HU (1)	HU230320B1 (xx)
IL (2)	IL156351A0 (xx)
ME (1)	MEP40608A (xx)
MX (1)	MXPA03005426A (xx)
MY (1)	MY129525A (xx)
NO (1)	NO327739B1 (xx)
NZ (1)	NZ527066A (xx)
PE (1)	PE20020755A1 (xx)
PL (1)	PL202478B1 (xx)
PT (2)	PT1345936E (xx)
RS (1)	RS50271B (xx)
SA (1)	SA01220589B1 (xx)
SI (1)	SI1345936T1 (xx)
SK (1)	SK287318B6 (xx)
TR (1)	TR200401127T4 (xx)
TW (1)	TWI234564B (xx)
UA (1)	UA74409C2 (xx)
UY (1)	UY27079A1 (xx)
WO (1)	WO2002051840A1 (xx)
ZA (1)	ZA200304707B (xx)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DZ3477A1 (xx) *	2000-10-12	2002-04-18
US6908928B2 (en)	2000-10-12	2005-06-21	Bi Pharma Kg.	Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
US6852728B2 (en)	2000-10-14	2005-02-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US6706726B2 (en) *	2000-10-14	2004-03-16	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Anticholinergics which may be used as medicaments as well as processes for preparing them
US7776315B2 (en) *	2000-10-31	2010-08-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20020137764A1 (en) *	2000-10-31	2002-09-26	Karin Drechsel	Inhalable formulation of a solution containing a tiotropium salt
US20020111363A1 (en) *	2000-10-31	2002-08-15	Karin Drechsel	Inhalable formulation of a solution containing a tiotropium salt
US20020151541A1 (en) *	2000-10-31	2002-10-17	Michel Pairet	Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020193392A1 (en) *	2000-11-13	2002-12-19	Christel Schmelzer	Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) *	2000-11-28	2010-12-09	Boehringer Ingelheim Pharma Gmbh & Co. Kg.	Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) *	2001-05-25	2003-01-16	Boehringer Ingelheim Pharma Kg	Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) *	2001-06-01	2003-04-17	Boehringer Ingelheim Pharma Kg	Capsules containing inhalable tiotropium
IL159238A0 (en) *	2001-06-22	2004-06-01	Boehringer Ingelheim Pharma	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
US6608055B2 (en)	2001-06-22	2003-08-19	Boehringer Ingelheim Pharma Kg	Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US20030018019A1 (en) *	2001-06-23	2003-01-23	Boehringer Ingelheim Pharma Kg	Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10141377A1 (de) *	2001-08-23	2003-03-13	Boehringer Ingelheim Pharma	Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) *	2001-09-14	2005-07-19	Boehringer Ingelheim Pharma Kg	Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) *	2002-01-12	2003-07-24	Boehringer Ingelheim Pharma	Verfahren zur Herstellung von Scopinestern
US6790856B2 (en) *	2002-01-31	2004-09-14	Boehringer Ingelheim Pharma Kg	Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US7405224B2 (en) *	2002-01-31	2008-07-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
US7309707B2 (en) *	2002-03-20	2007-12-18	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7244415B2 (en)	2002-03-28	2007-07-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations of an anhydrate
US7311894B2 (en) *	2002-03-28	2007-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations containing an anticholinergic
WO2003084509A1 (en) *	2002-04-04	2003-10-16	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Powder formulations suitable for inhalation
US20030235538A1 (en) *	2002-04-09	2003-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Method for the administration of an anticholinergic by inhalation
US7084153B2 (en) *	2002-04-12	2006-08-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments comprising steroids and a novel anticholinergic
US7417051B2 (en) *	2002-04-12	2008-08-26	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments comprising betamimetics and a novel anticholinergic
US7763280B2 (en) *	2002-11-28	2010-07-27	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) *	2003-09-26	2005-04-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
RS20060293A (xx) *	2003-11-03	2008-08-07	Boehringer Ingelheim International Gmbh.,	Nove soli tiotropijuma, postupci za njihovo dobijanje, kao i farmaceutske formulacije koje ih sadrže
SI2067779T1 (sl) *	2003-11-03	2013-08-30	Boehringer Ingelheim International Gmbh	Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo
SE0303570L (sv) *	2003-12-03	2005-06-04	Microdrug Ag	Fukt-känslig medicinsk produkt
RU2007144531A (ru) *	2005-05-02	2009-06-10	БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE)	Новые кристаллические формы тиотропийбромида
DK1881980T3 (da)	2005-05-02	2012-10-01	Boehringer Ingelheim Int	Nye krystalline former af tiotropiumbromid
WO2006134021A2 (en) *	2005-06-15	2006-12-21	Boehringer Ingelheim International Gmbh	Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) *	2005-07-27	2007-02-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
CN1316245C (zh) *	2005-07-28	2007-05-16	山东齐都药业有限公司	托烷司琼合成中残留中间体托品醇的检测方法
TWI274641B (en) *	2005-08-30	2007-03-01	Rexon Ind Corp Ltd	Cutting machine
DE102005059602A1 (de)	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Mikronisierung
US20070167480A1 (en) *	2005-12-19	2007-07-19	Sicor Inc.	Pure and stable tiotropium bromide
RU2453547C2 (ru) *	2005-12-19	2012-06-20	Сикор Инк.	Новые формы тиотропия бромида и способы их получения
US9108962B2 (en)	2005-12-19	2015-08-18	Sicor, Inc.	Forms of tiotropium bromide and processes for preparation thereof
EP2123650B1 (en) *	2005-12-19	2012-04-04	Sicor, Inc.	Novel form of tiotropium bromide and process for preparation thereof
TW200734333A (en) *	2005-12-19	2007-09-16	Sicor Inc	Pure and stable tiotropium bromide
CN100410254C (zh) *	2006-03-07	2008-08-13	南昌弘益科技有限公司	噻托溴铵无水物制备方法
US20080051582A1 (en)	2006-07-10	2008-02-28	Sicor Inc.	Process for the preparation of tiotropium bromide
EP1882691A1 (en) *	2006-07-26	2008-01-30	CHIESI FARMACEUTICI S.p.A.	Quinuclidine derivatives as M3 antagonists
EP1950196A1 (de) *	2007-01-29	2008-07-30	Boehringer Ingelheim Pharma GmbH & Co. KG	Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
EP2036898A2 (de) *	2007-09-13	2009-03-18	Boehringer Ingelheim Pharma GmbH & Co. KG	Verfahren zur Herstellung von 1,3-Dioxolan-2Onen sowie von Carbonsäureestern durch Transacylierung unter Basischen Reaktionsbedingungen
CN105601628A (zh) *	2008-01-10	2016-05-25	基因里克斯(英国)有限公司	用于制备东莨菪醇酯的方法
WO2011015884A1 (en)	2009-08-07	2011-02-10	Generics [Uk] Limited	Process to prepare scopine esters
NZ597920A (en)	2009-08-07	2014-05-30	Generics Uk Ltd	Anhydrate of tiotropium bromide
CN101768158B (zh) *	2010-01-04	2013-05-29	南昌弘益科技有限公司	噻托溴铵无水物及其制备方法
CN101863885B (zh) *	2010-06-03	2012-05-30	南京金丹呈医药技术有限公司	一种噻托溴铵的制备方法
TR201007108A2 (tr) *	2010-08-25	2012-03-21	B�Lg�� Mahmut	Yeni tiotropyum bromür kristali ve üretim yöntemi.@
ITRM20110508A1 (it)	2011-09-27	2013-03-28	Lusochimica Spa	Processo per la preparazione degli esteri della scopina.
PT2607351T (pt) *	2011-12-22	2017-05-26	Cerbios-Pharma S A	Processo contínuo para a alquilação de aminas terciárias cíclicas
PT106142B (pt)	2012-02-10	2014-07-18	Hovione Farmaci Ncia S A	Processo para a preparação de brometo de tiotrópio
CZ305012B6 (cs) *	2012-03-30	2015-03-25	Zentiva, K.S.	Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
CA2907566C (en)	2013-04-01	2023-08-22	Pulmatrix, Inc.	Tiotropium dry powders
WO2018055642A1 (en) *	2016-09-23	2018-03-29	Gbr Laboratories Pvt. Ltd.	A process for preparing tiotropium bromide and intermediates thereof
WO2019129801A1 (en)	2017-12-28	2019-07-04	Linnea S.A.	Process for the purification of methyl-2,2-dithienylglycolate
CN113264929B (zh) *	2021-05-02	2023-10-10	润生药业有限公司	一种噻托溴铵的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0418716A1 (de) *	1989-09-16	1991-03-27	Boehringer Ingelheim Kg	Neue Thienylcarbonsäureester von Aminoalkoholen, ihre Quaternierungsprodukte sowie die Herstellung und Verwendung dieser Verbindungen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5610163A (en) *	1989-09-16	1997-03-11	Boehringer Ingelheim Gmbh	Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
US5770738A (en) *	1992-03-05	1998-06-23	Boehringer Ingelheim Kg	Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions

2000
- 2000-12-22 DE DE10064816A patent/DE10064816A1/de not_active Withdrawn
2001
- 2001-12-12 SI SI200130096T patent/SI1345936T1/xx unknown
- 2001-12-12 BR BRPI0116444A patent/BRPI0116444B8/pt not_active IP Right Cessation
- 2001-12-12 SK SK935-2003A patent/SK287318B6/sk not_active IP Right Cessation
- 2001-12-12 RS YU50903A patent/RS50271B/sr unknown
- 2001-12-12 WO PCT/EP2001/014566 patent/WO2002051840A1/de active IP Right Grant
- 2001-12-12 JP JP2002552935A patent/JP4198991B2/ja not_active Expired - Lifetime
- 2001-12-12 ES ES04005241T patent/ES2271722T3/es not_active Expired - Lifetime
- 2001-12-12 AU AU2002229650A patent/AU2002229650B2/en not_active Expired
- 2001-12-12 ES ES01990546T patent/ES2221658T3/es not_active Expired - Lifetime
- 2001-12-12 CA CA002433518A patent/CA2433518C/en not_active Expired - Fee Related
- 2001-12-12 DE DE50102299T patent/DE50102299D1/de not_active Expired - Lifetime
- 2001-12-12 ME MEP-406/08A patent/MEP40608A/xx unknown
- 2001-12-12 EP EP04005241A patent/EP1426373B1/de not_active Expired - Lifetime
- 2001-12-12 AT AT04005241T patent/ATE337314T1/de active
- 2001-12-12 PL PL361837A patent/PL202478B1/pl unknown
- 2001-12-12 EA EA200300666A patent/EA005533B1/ru not_active IP Right Cessation
- 2001-12-12 EE EEP200300309A patent/EE04495B1/xx not_active IP Right Cessation
- 2001-12-12 CN CNB018208851A patent/CN1244581C/zh not_active Expired - Lifetime
- 2001-12-12 PT PT01990546T patent/PT1345936E/pt unknown
- 2001-12-12 NZ NZ527066A patent/NZ527066A/xx not_active IP Right Cessation
- 2001-12-12 AT AT01990546T patent/ATE266661T1/de active
- 2001-12-12 EG EG20011334A patent/EG23914A/xx active
- 2001-12-12 TR TR2004/01127T patent/TR200401127T4/xx unknown
- 2001-12-12 HU HU0301457A patent/HU230320B1/hu unknown
- 2001-12-12 UA UA2003076873A patent/UA74409C2/uk unknown
- 2001-12-12 MX MXPA03005426A patent/MXPA03005426A/es active IP Right Grant
- 2001-12-12 KR KR1020037008327A patent/KR100853109B1/ko active IP Right Grant
- 2001-12-12 IL IL15635101A patent/IL156351A0/xx active IP Right Grant
- 2001-12-12 DK DK04005241T patent/DK1426373T3/da active
- 2001-12-12 CN CNB200610004553XA patent/CN100393719C/zh not_active Expired - Lifetime
- 2001-12-12 CZ CZ20031685A patent/CZ294958B6/cs not_active IP Right Cessation
- 2001-12-12 EP EP01990546A patent/EP1345936B1/de not_active Expired - Lifetime
- 2001-12-12 DK DK01990546T patent/DK1345936T3/da active
- 2001-12-12 DE DE50110835T patent/DE50110835D1/de not_active Expired - Lifetime
- 2001-12-12 PT PT04005241T patent/PT1426373E/pt unknown
- 2001-12-18 UY UY27079A patent/UY27079A1/es not_active Application Discontinuation
- 2001-12-19 AR ARP010105885A patent/AR033599A1/es active Pending
- 2001-12-19 US US10/025,425 patent/US6486321B2/en not_active Expired - Lifetime
- 2001-12-20 PE PE2001001285A patent/PE20020755A1/es not_active Application Discontinuation
- 2001-12-21 TW TW090131874A patent/TWI234564B/zh not_active IP Right Cessation
- 2001-12-21 MY MYPI20015832A patent/MY129525A/en unknown
- 2001-12-23 SA SA01220589A patent/SA01220589B1/ar unknown
2003
- 2003-06-09 IL IL156351A patent/IL156351A/en unknown
- 2003-06-12 EC EC2003004652A patent/ECSP034652A/es unknown
- 2003-06-13 BG BG107910A patent/BG66373B1/bg active Active
- 2003-06-18 HR HR20030502A patent/HRP20030502B1/xx not_active IP Right Cessation
- 2003-06-18 ZA ZA200304707A patent/ZA200304707B/en unknown
- 2003-06-20 NO NO20032827A patent/NO327739B1/no not_active IP Right Cessation
2004
- 2004-05-20 HK HK04103588A patent/HK1060570A1/xx not_active IP Right Cessation
2006
- 2006-08-30 CY CY20061101230T patent/CY1105210T1/el unknown
2007
- 2007-03-15 HK HK07102807A patent/HK1096683A1/xx not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0418716A1 (de) *	1989-09-16	1991-03-27	Boehringer Ingelheim Kg	Neue Thienylcarbonsäureester von Aminoalkoholen, ihre Quaternierungsprodukte sowie die Herstellung und Verwendung dieser Verbindungen

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Publication	Publication Date	Title
HRP20030502B1 (en)	2011-09-30	Method for producing the anticholinergic agent tiotropium bromide
MEP40008A (en)	2011-02-10	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament
DK0405864T3 (da)	1995-07-03	Phospholipase A2-inhibitor, mikroorganismer der producerer inhibitoren og fremgangsmåder til den fremstilling
RS49531B (sr)	2006-12-15	Estrogen agonisti/antagonisti
NO20030012D0 (no)	2003-01-02	Fremgangsmåte for fremstilling av substituerte oktanoylamider
IS5300A (is)	1999-12-14	Aðferð til framleiðslu á sítalóprami
DK0443606T3 (da)	1995-07-10	4-(4-Alkoxyphenyl)-2-butylaminderivat og fremstilling deraf
DK0452392T3 (da)	1995-07-03	Heterocycliske chelatiseringsmidler
EG20085A (en)	1997-05-31	Process for preparing of imidazopyridine PAF/H2 antagonists
ATE255103T1 (de)	2003-12-15	Verfahren zur herstellung von pyridinmethanol- verbindungen
ATE100097T1 (de)	1994-01-15	Benzoxepin-derivate.
BR0015411A (pt)	2002-06-25	Método de preparo de cefpodoxima proxetil altamente pura
ATE406359T1 (de)	2008-09-15	Verfahren zum herstellen von isocoumarinen und zwischenprodukte hierfür
CA2434408A1 (en)	2002-08-01	Process for the preparation of heterocyclic indene analogs
HRP960369B1 (en)	2009-05-31	Process for the preparation of epoxide
EP1086948A4 (en)	2004-03-10	PYRIDONE DERIVATIVES AND THEIR MANUFACTURING PROCESS
NO20025323L (no)	2002-11-06	Nye polysykliske indanylimidazoler med alfa2-adrenerg aktivitet
MX9800705A (es)	1998-10-31	Compuestos heterociclicos, composiciones para tratar isquemia de miocardio que los contiene, y procedimiento para su preparacion.
MXPA02009203A (es)	2004-04-02	Proceso para producir camptotecina.
ES2062568T3 (es)	1994-12-16	Nuevos derivados de benzo (b) fenantrolinas-1,7 su preparacion y su aplicacion en terapeutica.
MY105057A (en)	1994-07-30	A process for preparing naphthalene derivatives
PL367981A1 (en)	2005-03-21	A process for the preparation of the 14beta-hydroxy-baccatin iii-1,14-carbonate
GR3025451T3 (en)	1998-02-27	Benzimidazole derivative, production thereof, antiemetic containing same as active ingredient, and intermediate for producing same.
ATE63544T1 (de)	1991-06-15	4-cyanopiperidine-derivate, herstellung und anwendung.
FR2428631A1 (fr)	1980-01-11	Procede de preparation de n-(1-benzylpiperid-4-yl) benzamides