BRPI0116444B8 - processo para a preparação de brometo de tiotrópio anticolinérgico, bem como uso de éster de tropenol como material de partida - Google Patents

processo para a preparação de brometo de tiotrópio anticolinérgico, bem como uso de éster de tropenol como material de partida

Info

Publication number
BRPI0116444B8
BRPI0116444B8 BRPI0116444A BR0116444A BRPI0116444B8 BR PI0116444 B8 BRPI0116444 B8 BR PI0116444B8 BR PI0116444 A BRPI0116444 A BR PI0116444A BR 0116444 A BR0116444 A BR 0116444A BR PI0116444 B8 BRPI0116444 B8 BR PI0116444B8
Authority
BR
Brazil
Prior art keywords
preparation
well
starting material
tiotropium bromide
tropenol ester
Prior art date
Application number
BRPI0116444A
Other languages
English (en)
Other versions
BRPI0116444B1 (pt
BR0116444A (pt
Inventor
Mathes Andreas
Meissner Helmut
Graulich Manfred
Specht Peter
Bahnholzer Rolf
Luettke Sven
Broeder Wolfgang
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7668836&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0116444(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of BR0116444A publication Critical patent/BR0116444A/pt
Publication of BRPI0116444B1 publication Critical patent/BRPI0116444B1/pt
Publication of BRPI0116444B8 publication Critical patent/BRPI0116444B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)

Abstract

"processo para a preparação de brometo de tiotrópio anticolinérgico". a invenção refere-se a um novo processo para a preparação de brometo de (l<244>2, <225>,4 <225>,a7 <225>,7-[hidroxidl-2-tienilacetil)óxi]-9,9-dimetil-3-oxa9-azoniatricicio[3.3.1 .0^ 2,4^ ]nonano.
BRPI0116444A 2000-12-22 2001-12-12 processo para a preparação de brometo de tiotrópio anticolinérgico, bem como uso de éster de tropenol como material de partida BRPI0116444B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064816A DE10064816A1 (de) 2000-12-22 2000-12-22 Verfahren zur Herstellung eines Anticholinergikums
PCT/EP2001/014566 WO2002051840A1 (de) 2000-12-22 2001-12-12 Verfahren zur herstellung des anticholinergikums tiotropiumbromid

Publications (3)

Publication Number Publication Date
BR0116444A BR0116444A (pt) 2003-12-23
BRPI0116444B1 BRPI0116444B1 (pt) 2015-09-01
BRPI0116444B8 true BRPI0116444B8 (pt) 2021-05-25

Family

ID=7668836

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0116444A BRPI0116444B8 (pt) 2000-12-22 2001-12-12 processo para a preparação de brometo de tiotrópio anticolinérgico, bem como uso de éster de tropenol como material de partida

Country Status (42)

Country Link
US (1) US6486321B2 (pt)
EP (2) EP1426373B1 (pt)
JP (1) JP4198991B2 (pt)
KR (1) KR100853109B1 (pt)
CN (2) CN1244581C (pt)
AR (1) AR033599A1 (pt)
AT (2) ATE337314T1 (pt)
AU (1) AU2002229650B2 (pt)
BG (1) BG66373B1 (pt)
BR (1) BRPI0116444B8 (pt)
CA (1) CA2433518C (pt)
CY (1) CY1105210T1 (pt)
CZ (1) CZ294958B6 (pt)
DE (3) DE10064816A1 (pt)
DK (2) DK1426373T3 (pt)
EA (1) EA005533B1 (pt)
EC (1) ECSP034652A (pt)
EE (1) EE04495B1 (pt)
EG (1) EG23914A (pt)
ES (2) ES2271722T3 (pt)
HK (2) HK1060570A1 (pt)
HR (1) HRP20030502B1 (pt)
HU (1) HU230320B1 (pt)
IL (2) IL156351A0 (pt)
ME (1) MEP40608A (pt)
MX (1) MXPA03005426A (pt)
MY (1) MY129525A (pt)
NO (1) NO327739B1 (pt)
NZ (1) NZ527066A (pt)
PE (1) PE20020755A1 (pt)
PL (1) PL202478B1 (pt)
PT (2) PT1345936E (pt)
RS (1) RS50271B (pt)
SA (1) SA01220589B1 (pt)
SI (1) SI1345936T1 (pt)
SK (1) SK287318B6 (pt)
TR (1) TR200401127T4 (pt)
TW (1) TWI234564B (pt)
UA (1) UA74409C2 (pt)
UY (1) UY27079A1 (pt)
WO (1) WO2002051840A1 (pt)
ZA (1) ZA200304707B (pt)

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US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
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US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
IL159238A0 (en) * 2001-06-22 2004-06-01 Boehringer Ingelheim Pharma Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
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US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
RS20060293A (en) * 2003-11-03 2008-08-07 Boehringer Ingelheim International Gmbh., Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
SI2067779T1 (sl) * 2003-11-03 2013-08-30 Boehringer Ingelheim International Gmbh Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo
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RU2007144531A (ru) * 2005-05-02 2009-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Новые кристаллические формы тиотропийбромида
DK1881980T3 (da) 2005-05-02 2012-10-01 Boehringer Ingelheim Int Nye krystalline former af tiotropiumbromid
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CN101863885B (zh) * 2010-06-03 2012-05-30 南京金丹呈医药技术有限公司 一种噻托溴铵的制备方法
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
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Also Published As

Publication number Publication date
RS50271B (sr) 2009-07-15
ZA200304707B (en) 2004-04-20
DK1345936T3 (da) 2004-07-19
BG107910A (bg) 2004-02-27
DE10064816A1 (de) 2002-06-27
EA005533B1 (ru) 2005-04-28
YU50903A (sh) 2006-05-25
HK1096683A1 (en) 2007-06-08
UA74409C2 (uk) 2005-12-15
MXPA03005426A (es) 2005-04-20
HRP20030502A2 (en) 2005-04-30
ECSP034652A (es) 2003-07-25
SA01220589B1 (ar) 2006-10-31
SI1345936T1 (en) 2004-08-31
CZ294958B6 (cs) 2005-04-13
EE200300309A (et) 2003-10-15
JP4198991B2 (ja) 2008-12-17
ATE266661T1 (de) 2004-05-15
PL202478B1 (pl) 2009-06-30
WO2002051840A1 (de) 2002-07-04
SK9352003A3 (en) 2003-10-07
EP1345936A1 (de) 2003-09-24
AR033599A1 (es) 2003-12-26
DK1426373T3 (da) 2006-12-18
HRP20030502B1 (en) 2011-09-30
TR200401127T4 (tr) 2004-07-21
AU2002229650B2 (en) 2006-12-21
CN1840529A (zh) 2006-10-04
KR100853109B1 (ko) 2008-08-21
DE50102299D1 (de) 2004-06-17
NZ527066A (en) 2004-12-24
PL361837A1 (en) 2004-10-04
EP1345936B1 (de) 2004-05-12
BRPI0116444B1 (pt) 2015-09-01
BR0116444A (pt) 2003-12-23
EP1426373A1 (de) 2004-06-09
HUP0301457A2 (hu) 2003-10-28
IL156351A (en) 2011-09-27
BG66373B1 (bg) 2013-10-31
IL156351A0 (en) 2004-01-04
EG23914A (en) 2007-12-30
DE50110835D1 (de) 2006-10-05
NO20032827L (no) 2003-06-20
SK287318B6 (sk) 2010-07-07
CN100393719C (zh) 2008-06-11
KR20030062439A (ko) 2003-07-25
CA2433518C (en) 2007-03-20
CZ20031685A3 (cs) 2003-10-15
CY1105210T1 (el) 2010-03-03
UY27079A1 (es) 2002-07-31
CN1244581C (zh) 2006-03-08
ATE337314T1 (de) 2006-09-15
PE20020755A1 (es) 2002-09-24
PT1426373E (pt) 2006-11-30
CN1481383A (zh) 2004-03-10
NO20032827D0 (no) 2003-06-20
EP1426373B1 (de) 2006-08-23
HUP0301457A3 (en) 2006-05-29
PT1345936E (pt) 2004-09-30
ES2271722T3 (es) 2007-04-16
US20020133010A1 (en) 2002-09-19
EA200300666A1 (ru) 2003-12-25
JP2004525099A (ja) 2004-08-19
TWI234564B (en) 2005-06-21
EE04495B1 (et) 2005-06-15
HU230320B1 (hu) 2016-01-28
HK1060570A1 (en) 2004-08-13
NO327739B1 (no) 2009-09-14
MEP40608A (en) 2011-02-10
CA2433518A1 (en) 2002-07-04
ES2221658T3 (es) 2005-01-01
MY129525A (en) 2007-04-30
US6486321B2 (en) 2002-11-26

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