EA200501236A1 - Аминогетероарильные соединения в качестве ингибиторов протеинкиназ - Google Patents

Аминогетероарильные соединения в качестве ингибиторов протеинкиназ

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Publication number
EA200501236A1
EA200501236A1 EA200501236A EA200501236A EA200501236A1 EA 200501236 A1 EA200501236 A1 EA 200501236A1 EA 200501236 A EA200501236 A EA 200501236A EA 200501236 A EA200501236 A EA 200501236A EA 200501236 A1 EA200501236 A1 EA 200501236A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
proteinkinaz
aminoheteroarylic
connections
compounds
Prior art date
Application number
EA200501236A
Other languages
English (en)
Other versions
EA010727B1 (ru
Inventor
Джингджонг Джин Куй
Дилип Бумралькар
Айрини Ботрос
Джи Ю Чу
Ли А. Фанк
Кэтлин Элизабет Ханау
Мл. Джи Дейвис Харрис
Ли Джиа
Джоанна Джонсон
Стивен А. Колодзей
Пей-Пей Канг
Ксяоюан Ли (Шерон)
Джейсон Лин (Кишен)
Джерри Джиалун Менг
Митчелл Дейвид Нэмбу
Кристофер Джи. Нелсон
Мейсон Алан Пэйриш
Хонг Шен
Мишель Тран-Дюб
Эллисон Уолтер
Фанг-Джи Жанг
Дженнифер Жанг
Original Assignee
Суджен, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32930516&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200501236(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Суджен, Инк. filed Critical Суджен, Инк.
Publication of EA200501236A1 publication Critical patent/EA200501236A1/ru
Publication of EA010727B1 publication Critical patent/EA010727B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Предложены аминопиридиновые и аминопиразиновые соединения формулы (1), композиции, включающие эти соединения, и способы их применения. Предпочтительные соединения формулы 1 обладают активностью ингибиторов протеинкиназ, в том числе с-МЕТ ингибиторов.
EA200501236A 2003-02-26 2004-02-26 Аминогетероарильные соединения в качестве ингибиторов протеинкиназ EA010727B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44958803P 2003-02-26 2003-02-26
US54022904P 2004-01-29 2004-01-29
PCT/US2004/005495 WO2004076412A2 (en) 2003-02-26 2004-02-26 Aminoheteroaryl compounds as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
EA200501236A1 true EA200501236A1 (ru) 2006-04-28
EA010727B1 EA010727B1 (ru) 2008-10-30

Family

ID=32930516

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501236A EA010727B1 (ru) 2003-02-26 2004-02-26 Аминогетероарильные соединения в качестве ингибиторов протеинкиназ

Country Status (29)

Country Link
US (2) US7230098B2 (ru)
EP (2) EP1603570B9 (ru)
JP (1) JP4695588B2 (ru)
KR (1) KR101106905B1 (ru)
CN (1) CN103265477B (ru)
AP (1) AP2114A (ru)
AU (1) AU2004215428B2 (ru)
BR (1) BRPI0407827B8 (ru)
CA (1) CA2517256C (ru)
CY (2) CY1113837T1 (ru)
DK (2) DK1603570T5 (ru)
EA (1) EA010727B1 (ru)
EC (1) ECSP055988A (ru)
ES (2) ES2401330T3 (ru)
GE (1) GEP20084341B (ru)
HR (1) HRP20050714B1 (ru)
IL (1) IL170291A (ru)
IS (1) IS2910B (ru)
MA (1) MA27713A1 (ru)
ME (1) MEP52808A (ru)
MX (1) MXPA05009063A (ru)
NO (1) NO332188B1 (ru)
NZ (1) NZ541861A (ru)
OA (1) OA13151A (ru)
PL (1) PL216368B1 (ru)
PT (2) PT2476667E (ru)
RS (1) RS53118B (ru)
TN (1) TNSN05208A1 (ru)
WO (1) WO2004076412A2 (ru)

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