MXPA03007166A - Pirido-pirimidinas 6-sustituidas. - Google Patents
Pirido-pirimidinas 6-sustituidas.Info
- Publication number
- MXPA03007166A MXPA03007166A MXPA03007166A MXPA03007166A MXPA03007166A MX PA03007166 A MXPA03007166 A MX PA03007166A MX PA03007166 A MXPA03007166 A MX PA03007166A MX PA03007166 A MXPA03007166 A MX PA03007166A MX PA03007166 A MXPA03007166 A MX PA03007166A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrimidines
- substituted pyrido
- pyrido
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26837501P | 2001-02-12 | 2001-02-12 | |
US33465401P | 2001-11-30 | 2001-11-30 | |
PCT/EP2002/001106 WO2002064594A2 (en) | 2001-02-12 | 2002-02-04 | 6-substituted pyrido-pyrimidines |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03007166A true MXPA03007166A (es) | 2003-11-18 |
Family
ID=26953040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03007166A MXPA03007166A (es) | 2001-02-12 | 2002-02-04 | Pirido-pirimidinas 6-sustituidas. |
Country Status (32)
Country | Link |
---|---|
US (3) | US6696566B2 (es) |
EP (1) | EP1361880B1 (es) |
JP (1) | JP4064818B2 (es) |
KR (1) | KR100639772B1 (es) |
CN (1) | CN100376571C (es) |
AR (1) | AR035854A1 (es) |
AT (1) | ATE305303T1 (es) |
AU (1) | AU2002256615B2 (es) |
BR (1) | BRPI0207172B8 (es) |
CA (1) | CA2434834C (es) |
CZ (1) | CZ20032416A3 (es) |
DE (1) | DE60206363T2 (es) |
DK (1) | DK1361880T3 (es) |
ES (1) | ES2249574T3 (es) |
HK (1) | HK1066170A1 (es) |
HR (1) | HRP20030624B1 (es) |
HU (1) | HU229604B1 (es) |
IL (2) | IL156872A0 (es) |
JO (1) | JO2410B1 (es) |
MA (1) | MA26993A1 (es) |
MX (1) | MXPA03007166A (es) |
MY (1) | MY131518A (es) |
NO (1) | NO326133B1 (es) |
NZ (1) | NZ526961A (es) |
PA (1) | PA8539201A1 (es) |
PE (1) | PE20020976A1 (es) |
PL (1) | PL366918A1 (es) |
RU (1) | RU2269527C2 (es) |
SK (1) | SK11322003A3 (es) |
WO (1) | WO2002064594A2 (es) |
YU (1) | YU63703A (es) |
ZA (1) | ZA200305938B (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7053070B2 (en) * | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
HU229604B1 (en) | 2001-02-12 | 2014-02-28 | Hoffmann La Roche | 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them |
ATE314370T1 (de) * | 2002-01-22 | 2006-01-15 | Warner Lambert Co | 2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one |
EP1492790A1 (en) | 2002-04-03 | 2005-01-05 | F. Hoffmann-La Roche Ag | Imidazo fused compounds |
DE60316581T2 (de) | 2002-08-06 | 2008-07-03 | F. Hoffmann-La Roche Ag | 6-alkoxypyridopyrimidine als inhibitoren der p-38-map-kinase |
US20040225077A1 (en) | 2002-12-30 | 2004-11-11 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
ES2401330T3 (es) * | 2003-02-26 | 2013-04-18 | Sugen, Inc. | Compuesto de heteroarilamino inhibidores de proteín quinasas |
RU2005135329A (ru) * | 2003-04-16 | 2006-08-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Замещенные 7-азахиназолины |
DK1685131T3 (da) * | 2003-11-13 | 2007-07-09 | Hoffmann La Roche | Hydroxyalkylsubstituerede pyrido-7-pyrimidin-7-oner |
WO2006056863A1 (en) * | 2004-11-23 | 2006-06-01 | Ranbaxy Laboratories Limited | Pyrido’2, 3-d!pyrimidines as anti-inflammatory agents |
US20060142312A1 (en) * | 2004-12-23 | 2006-06-29 | Pfizer Inc | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones |
WO2006082492A1 (en) * | 2005-02-02 | 2006-08-10 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as anti-inflammatory agents |
ES2552804T3 (es) * | 2005-05-04 | 2015-12-02 | Evotec Ag | Compuestos heterocíclicos condensados, y sus composiciones y usos |
CN101243081A (zh) * | 2005-07-21 | 2008-08-13 | 霍夫曼-拉罗奇有限公司 | 作为PTP1B抑制剂的吡啶并[2,3-d]嘧啶-2,4-二胺化合物 |
RU2008108898A (ru) * | 2005-08-09 | 2009-09-20 | Айрм Ллк (Bm) | Соединения и композиции в качестве ингибиторов протеинкиназы |
US8686002B2 (en) | 2005-08-21 | 2014-04-01 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as binding partners for 5-HT5 receptors |
JO2783B1 (en) * | 2005-09-30 | 2014-03-15 | نوفارتيس ايه جي | Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones |
WO2008150260A1 (en) * | 2007-06-06 | 2008-12-11 | Gpc Biotech, Inc. | 8-oxy-2-aminopyrido (2, 3-d) pyrimidin-7-one derivatives as kinase inhibitors and anticancer agents |
WO2008078249A1 (en) * | 2006-12-21 | 2008-07-03 | Ranbaxy Laboratories Limited | Anti-inflammatory agents |
EP2152706A1 (en) | 2007-05-07 | 2010-02-17 | Amgen Inc. | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as p38 modulators, process for their preparation, and their pharmaceutical use |
JP2010529973A (ja) | 2007-06-15 | 2010-09-02 | エフ.ホフマン−ラ ロシュ アーゲー | 3−アミノ−ペンタン−1,5−ジオールの新規製造方法 |
US8367671B2 (en) | 2008-03-21 | 2013-02-05 | Amgen Inc. | Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents |
EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
CN102177161A (zh) * | 2008-10-22 | 2011-09-07 | 霍夫曼-拉罗奇有限公司 | Jnk的嘧啶基吡啶酮抑制剂 |
US8674095B2 (en) | 2008-12-19 | 2014-03-18 | Afraxis Holdings, Inc. | Compounds for treating neuropsychiatric conditions |
US8372970B2 (en) * | 2009-10-09 | 2013-02-12 | Afraxis, Inc. | 8-ethyl-6-(aryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders |
CA2784749C (en) | 2009-12-18 | 2017-12-12 | E. Premkumar Reddy | Substituted pyrido[2,3-d]pyrimidin-7(8h)-ones and therapeutic uses thereof |
JP6631616B2 (ja) | 2014-07-26 | 2020-01-15 | ノース・アンド・サウス・ブラザー・ファーマシー・インベストメント・カンパニー・リミテッド | CDK阻害剤としての2−アミノ−ピリド[2,3−d]ピリミジン−7(8H)−オン誘導体及びその使用 |
CN115105601A (zh) * | 2016-06-08 | 2022-09-27 | 投资支持有限公司 | 用于治疗癌症的药物组合 |
LT3497103T (lt) | 2016-08-15 | 2021-07-26 | Pfizer Inc. | Piridopirimidinono cdk2/4/6 inhibitoriai |
EP3500258A1 (en) * | 2016-08-17 | 2019-06-26 | Support-Venture GmbH | Method of preventing or treating hearing loss |
WO2018132550A1 (en) * | 2017-01-11 | 2018-07-19 | The General Hospital Corporation | Voltage gated sodium channel imaging agents |
MY202289A (en) * | 2017-04-04 | 2024-04-22 | Kinarus Ag | Methods of preventing or treating ophthalmic diseases |
AU2018325442B2 (en) * | 2017-08-31 | 2023-04-13 | Dana-Farber Cancer Institute, Inc. | Inhibitors of EGFR and/or HER2 and methods of use |
CA3128468A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
WO2020006210A1 (en) * | 2018-06-27 | 2020-01-02 | Tufts Medical Center, Inc. | Pyridopyrimidine compounds and methods of their use |
AU2019300135A1 (en) | 2018-07-13 | 2021-01-28 | Kinarus Ag | Combinations of PPAR agonists and p38 kinase inhibitors for preventing or treating fibrotic diseases |
TW202112368A (zh) | 2019-06-13 | 2021-04-01 | 荷蘭商法西歐知識產權股份有限公司 | 用於治療有關dux4表現之疾病的抑制劑組合 |
US20230263803A1 (en) | 2020-08-11 | 2023-08-24 | Kinarus Ag | Methods of preventing or treating covid-19 and related viral diseases or disorders |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4215216A (en) | 1979-04-18 | 1980-07-29 | American Home Products Corporation | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives |
US5037826A (en) | 1986-10-15 | 1991-08-06 | Schering Corporation | 1-substituted naphthyridine and pyridopyrazine derivatives |
GB8702758D0 (en) * | 1987-02-06 | 1987-03-11 | Wellcome Found | Treatment of disease |
EP0278686A1 (en) | 1987-02-07 | 1988-08-17 | The Wellcome Foundation Limited | Pyridopyrimidines methods for their preparation and pharmaceutical formulations thereof |
WO1993017682A1 (en) | 1992-03-04 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
EP0790997B1 (en) * | 1994-11-14 | 2000-03-22 | Warner-Lambert Company | 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION |
IL115256A0 (en) | 1994-11-14 | 1995-12-31 | Warner Lambert Co | 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use |
IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
US5620981A (en) | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
US5945422A (en) | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
JP2001509805A (ja) | 1997-02-05 | 2001-07-24 | ワーナー−ランバート・コンパニー | 細胞増殖阻害剤としてのピリド〔2,3−d〕ピリミジンおよび4−アミノピリミジン |
IL131618A0 (en) | 1997-04-16 | 2001-01-28 | Abbott Lab | 5,7-Disubstituted aminopyrido [2,3-D] pyrimidine compounds and their use as adenosine kinase inhibitors |
TW458977B (en) * | 1997-04-16 | 2001-10-11 | Abbott Lab | 6,7-disubstituted-4-aminopyrido[2,3-D] pyrimidine compounds |
AU741033B2 (en) | 1997-04-16 | 2001-11-22 | Abbott Laboratories | 5,6,7-trisubstituted-4-aminopyridol(2,3-d)pyrimidine compounds |
ID27589A (id) | 1998-05-26 | 2001-04-12 | Warner Lambert Comapny | Pirimidina bisiklik dan dihidropirimidina bisiklik 3,4 sebagai penghambat proliferasi selular |
KR100415791B1 (ko) | 1998-06-19 | 2004-01-24 | 화이자 프로덕츠 인코포레이티드 | 피롤로[2,3-디]피리미딘 화합물 |
ES2258431T3 (es) | 1999-08-02 | 2006-09-01 | F. Hoffmann-La Roche Ag | Proceso para la preparacion de derivados de benzotiofeno. |
US7053070B2 (en) * | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
IL151480A0 (en) * | 2000-03-06 | 2003-04-10 | Warner Lambert Co | 5-alkylpyrido[2,3-d] pyrimidines tyrosine kinase inhibitors |
US6518276B2 (en) * | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
HU229604B1 (en) | 2001-02-12 | 2014-02-28 | Hoffmann La Roche | 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them |
ATE314370T1 (de) * | 2002-01-22 | 2006-01-15 | Warner Lambert Co | 2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one |
-
2002
- 2002-02-04 HU HU0303458A patent/HU229604B1/hu unknown
- 2002-02-04 CZ CZ20032416A patent/CZ20032416A3/cs unknown
- 2002-02-04 KR KR1020037010562A patent/KR100639772B1/ko active IP Right Grant
- 2002-02-04 PL PL02366918A patent/PL366918A1/xx not_active Application Discontinuation
- 2002-02-04 SK SK11322003A patent/SK11322003A3/sk unknown
- 2002-02-04 NZ NZ526961A patent/NZ526961A/en unknown
- 2002-02-04 YU YU63703A patent/YU63703A/sh unknown
- 2002-02-04 DK DK02726103T patent/DK1361880T3/da active
- 2002-02-04 IL IL15687202A patent/IL156872A0/xx unknown
- 2002-02-04 DE DE60206363T patent/DE60206363T2/de not_active Expired - Lifetime
- 2002-02-04 BR BRPI0207172-0 patent/BRPI0207172B8/pt not_active IP Right Cessation
- 2002-02-04 ES ES02726103T patent/ES2249574T3/es not_active Expired - Lifetime
- 2002-02-04 AU AU2002256615A patent/AU2002256615B2/en not_active Expired
- 2002-02-04 AT AT02726103T patent/ATE305303T1/de active
- 2002-02-04 EP EP02726103A patent/EP1361880B1/en not_active Expired - Lifetime
- 2002-02-04 WO PCT/EP2002/001106 patent/WO2002064594A2/en not_active Application Discontinuation
- 2002-02-04 CA CA2434834A patent/CA2434834C/en not_active Expired - Lifetime
- 2002-02-04 RU RU2003125887/04A patent/RU2269527C2/ru not_active IP Right Cessation
- 2002-02-04 JP JP2002564525A patent/JP4064818B2/ja not_active Expired - Lifetime
- 2002-02-04 MX MXPA03007166A patent/MXPA03007166A/es active IP Right Grant
- 2002-02-04 CN CNB028048342A patent/CN100376571C/zh not_active Expired - Lifetime
- 2002-02-06 JO JO200212A patent/JO2410B1/en active
- 2002-02-08 PA PA20028539201A patent/PA8539201A1/es unknown
- 2002-02-08 PE PE2002000097A patent/PE20020976A1/es not_active Application Discontinuation
- 2002-02-11 AR ARP020100430A patent/AR035854A1/es unknown
- 2002-02-11 MY MYPI20020491A patent/MY131518A/en unknown
- 2002-02-11 US US10/073,845 patent/US6696566B2/en not_active Expired - Lifetime
-
2003
- 2003-07-10 IL IL156872A patent/IL156872A/en unknown
- 2003-07-31 ZA ZA2003/05938A patent/ZA200305938B/en unknown
- 2003-08-01 HR HR20030624A patent/HRP20030624B1/xx not_active IP Right Cessation
- 2003-08-11 NO NO20033540A patent/NO326133B1/no not_active IP Right Cessation
- 2003-08-11 MA MA27273A patent/MA26993A1/fr unknown
- 2003-11-25 US US10/722,703 patent/US7169794B2/en not_active Expired - Lifetime
-
2004
- 2004-11-19 HK HK04109141A patent/HK1066170A1/xx not_active IP Right Cessation
-
2007
- 2007-01-09 US US11/651,302 patent/US7449581B2/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |