ES2502490T3 - Compuestos aminoheteroarílicos como inhibidores de proteín quinasas - Google Patents
Compuestos aminoheteroarílicos como inhibidores de proteín quinasas Download PDFInfo
- Publication number
- ES2502490T3 ES2502490T3 ES12163855.5T ES12163855T ES2502490T3 ES 2502490 T3 ES2502490 T3 ES 2502490T3 ES 12163855 T ES12163855 T ES 12163855T ES 2502490 T3 ES2502490 T3 ES 2502490T3
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- Spain
- Prior art keywords
- inhibition
- aryl
- membered
- protein kinase
- cr6r7
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 125000005214 aminoheteroaryl group Chemical group 0.000 title 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- KIWSYRHAAPLJFJ-DNZSEPECSA-N n-[(e,2z)-4-ethyl-2-hydroxyimino-5-nitrohex-3-enyl]pyridine-3-carboxamide Chemical compound [O-][N+](=O)C(C)C(/CC)=C/C(=N/O)/CNC(=O)C1=CC=CN=C1 KIWSYRHAAPLJFJ-DNZSEPECSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 description 156
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Un compuesto de fórmula**Fórmula** en la que: R1 está seleccionado entre arilo C6-12, y hetero arilo de 5-12 miembros, y cada hidrógeno en R' está opcionalmente sustituido con uno o más grupos R3; R3 es halógeno, alquilo C1-12, alquenilo C2-12, alquinilo C2-12, cicloalquilo C3-12, arilo C6-12, heteroalicíclico de 3-12 miembros, heteroarilo de 5-12 miembros, -S(O)mR4, -SO2NR4R5, -S(O)2OR4, -NO2, -NR4R5, - (CR6R7)nOR4, -CN, -C(O)R4, -OC(O)R4, -O(CR6R7)nR4, -NR4C(O)R5, -(CR6R7)nC(O)OR4, -C(>=NR6)NR4R5, -NR4C(O)NR5R6, -NR4S(O)pR5 o -C(O)NR4R5; cada R4, R5, R6 y R7 es independientemente hidrógeno, halógeno, alquilo C1-12, alquenilo C2-12, alquinilo C2- 12, cicloalquilo C3-12, arilo C6-12, heteroalicíclico de 3-12 miembros o heteroarilo de 5-12 miembros; cada R9 y R10 es independientemente hidrógeno o alquilo C1-12; A2 es arilo C6-12, o heteroarilo de 5-12 miembros, y A2 está opcionalmente sustituido con uno o más grupos R3; m es 0, 1 o 2; n es 0, 1, 2, 3 o 4; y p es 1 o 2; o una sal, solvato o hidrato farmacéuticamente aceptable del mismo.
Description
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–
'
'
'
“
'
‒
‒
~
‒
‒
‒
‒
‒
‒
‒
'
–
–
– – –
–
–
––
––
(continuación)
- Sección B: Ejemplos L–17 a L–32
- imagen252
-
imagen253 imagen254 imagen255
- % de inhibición = 86
- % de inhibición = 64 % de inhibición = 72 % de inhibición = 71
- imagen256
-
imagen257 imagen258 imagen259
- % de inhibición = 77
- % de inhibición = 2 % de inhibición = 74 % de inhibición = 64
- imagen260
-
imagen261 imagen262
- % de inhibición = 86
- % de inhibición = 80 % de inhibición = 85 % de inhibición = 92
- Sección C: Ejemplos L–33 a L–48
- imagen263
-
imagen264
- % de inhibición = 63
- % de inhibición = 62 % de inhibición = 55 % de inhibición = 62
- imagen265
-
imagen266 imagen267
- % de inhibición = 75
- % de inhibición = 88 % de inhibición = 77 % de inhibición = 55
––
––––
––––
––––
––––
––
(continuación)
- Sección J: Ejemplos L–145 a L–160
- imagen273
-
imagen274 imagen275 imagen276
- % de inhibición = 70
- % de inhibición = 81 % de inhibición = 58 % de inhibición = 53
- imagen277
-
imagen278 imagen279 imagen280
- % de inhibición = 95
- % de inhibición = 77 % de inhibición = 66 % de inhibición = 73
- imagen281
-
imagen282 imagen283
- % de inhibición = 77
- % de inhibición = 63 % de inhibición = 78 % de inhibición = 59
- Sección K: Ejemplos L–161 a L–176
- imagen284
-
imagen285 imagen286
- % de inhibición = 79
- % de inhibición = 66 % de inhibición = 83 % de inhibición = 61
- imagen287
-
imagen288 imagen289
- % de inhibición = 88
- % de inhibición = 67 % de inhibición = 66 % de inhibición = 90
––
–––– ––––––––––––––––
Tabla 7 ––
- Sección A: Ejemplos L–353 a L–368
- imagen302
-
imagen303 imagen304 imagen305
- % de inhibición = 24
- % de inhibición = 19 % de inhibición = 32 % de inhibición = 22
- imagen306
-
imagen307 imagen308 imagen309
- % de inhibición = 20
- % de inhibición = 14 % de inhibición = 24 % de inhibición = 10
- imagen310
-
imagen311 imagen312 imagen313
- % de inhibición = 8
- % de inhibición = 37 % de inhibición = 36 % de inhibición = 6
- imagen314
-
imagen315 imagen316 imagen317
- % de inhibición = 8
- % de inhibición = 9 % de inhibición = 6 % de inhibición = 27
- Sección B: Ejemplos L–369 a L–384
- imagen318
-
imagen319 imagen320 imagen321
- % de inhibición = 10
- % de inhibición = 19 % de inhibición = 10 % de inhibición = 49
- imagen322
-
imagen323 imagen324
- % de inhibición = 19
- % de inhibición = 5 % de inhibición = 10 % de inhibición = 10
––
(continuación)
- Sección D: Ejemplos L–401 a L–416
- imagen326
-
imagen327 imagen328
- % de inhibición = 9
- % de inhibición = 11 % de inhibición = 4 % de inhibición = 41
- imagen329
-
imagen330 imagen331
- % de inhibición = 21
- % de inhibición = 14 % de inhibición = 13 % de inhibición = 12
- imagen332
-
imagen333 imagen334
- % de inhibición = 31
- % de inhibición = 19 % de inhibición = 27 % de inhibición = 25
- imagen335
-
imagen336 imagen337
- % de inhibición = 31
- % de inhibición = 45 % de inhibición = 11 % de inhibición = 77
- Sección E: Ejemplos L–417 a L–432
- imagen338
-
imagen339 imagen340
- % de inhibición = 11
- % de inhibición = 9 % de inhibición = 12 % de inhibición = 7
- imagen341
-
imagen342 imagen343
- % de inhibición = 10
- % de inhibición = 14 % de inhibición = 10 % de inhibición = 12
––
––––
––
(continuación)
- Sección H: Ejemplos L–465 a L–480
- imagen346
-
imagen347 imagen348 imagen349
- % de inhibición = 14
- % de inhibición = 18 % de inhibición = 13 % de inhibición = 13
- imagen350
-
imagen351 imagen352 imagen353
- % de inhibición = 10
- % de inhibición = 9 % de inhibición = 10 % de inhibición = 9
- imagen354
-
imagen355 imagen356 imagen357
- % de inhibición = 50
- % de inhibición = 39 % de inhibición = 51 % de inhibición = 27
- imagen358
-
imagen359 imagen360 imagen361
- % de inhibición = 29
- % de inhibición = 24 % de inhibición = 15 % de inhibición = 17
- Sección I: Ejemplos L–481 a L–496
- imagen362
-
imagen363 imagen364 imagen365
- % de inhibición = 18
- % de inhibición = 20 % de inhibición = 19 % de inhibición = 16
- imagen366
-
imagen367 imagen368
- % de inhibición = 18
- % de inhibición = 22 % de inhibición = 63 % de inhibición = 17
––
––
(continuación) (continuación)
- Sección K: Ejemplos L–513 a L–528
- imagen370
-
imagen371 imagen372 imagen373
- % de inhibición = 16
- % de inhibición = 17 % de inhibición = 17
- % de inhibición = 16
- imagen374
-
imagen375 imagen376 imagen377
- % de inhibición = 19
- % de inhibición = 15 % de inhibición = 8 % de inhibición = 14
- imagen378
-
imagen379
- % de inhibición = 23
- % de inhibición = 7 % de inhibición = 9 % de inhibición = 5
- imagen380
-
imagen381
- % de inhibición = 5
- % de inhibición = 10 % de inhibición = 9 % de inhibición = 9
- Sección L: Ejemplos L–529 a L–548
- imagen382
-
imagen383 imagen384
- % de inhibición = 9
- % de inhibición = 8 % de inhibición = 8 % de inhibición = 27
- imagen385
-
imagen386 imagen387
- % de inhibición = 12
- % de inhibición = 18 % de inhibición = 4 % de inhibición = 10
- Sección L: Ejemplos L–529 a L–548
- imagen388
-
imagen389 imagen390 imagen391
- % de inhibición = 12
- % de inhibición = ‒2 % de inhibición = 28 % de inhibición = 11
- imagen392
-
imagen393 imagen394 imagen395
- % de inhibición = 5
- % de inhibición = 6 % de inhibición = 7 % de inhibición = 6
- imagen396
-
imagen397 imagen398
- % de inhibición = 11
- % de inhibición = 11
- % de inhibición = 64 % de inhibición = 16
Tabla 8
- Sección A: Ejemplos L–549 a L–561
- imagen399
-
imagen400 imagen401
- % de inhibición = 11
- % de inhibición = 13 % de inhibición = 11 % de inhibición = 20
- imagen402
-
imagen403 imagen404
- % de inhibición = 25
- % de inhibición = 14 % de inhibición = 21 % de inhibición = 12
––
––––
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Claims (1)
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imagen1 imagen2
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44958803P | 2003-02-26 | 2003-02-26 | |
US449588P | 2003-02-26 | ||
US54022904P | 2004-01-29 | 2004-01-29 | |
US540229P | 2004-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2502490T3 true ES2502490T3 (es) | 2014-10-03 |
Family
ID=32930516
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES12163855.5T Expired - Lifetime ES2502490T3 (es) | 2003-02-26 | 2004-02-26 | Compuestos aminoheteroarílicos como inhibidores de proteín quinasas |
ES04715001T Expired - Lifetime ES2401330T3 (es) | 2003-02-26 | 2004-02-26 | Compuesto de heteroarilamino inhibidores de proteín quinasas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES04715001T Expired - Lifetime ES2401330T3 (es) | 2003-02-26 | 2004-02-26 | Compuesto de heteroarilamino inhibidores de proteín quinasas |
Country Status (29)
Country | Link |
---|---|
US (2) | US7230098B2 (es) |
EP (2) | EP1603570B9 (es) |
JP (1) | JP4695588B2 (es) |
KR (1) | KR101106905B1 (es) |
CN (1) | CN103265477B (es) |
AP (1) | AP2114A (es) |
AU (1) | AU2004215428B2 (es) |
BR (1) | BRPI0407827B8 (es) |
CA (1) | CA2517256C (es) |
CY (2) | CY1113837T1 (es) |
DK (2) | DK2476667T3 (es) |
EA (1) | EA010727B1 (es) |
EC (1) | ECSP055988A (es) |
ES (2) | ES2502490T3 (es) |
GE (1) | GEP20084341B (es) |
HR (1) | HRP20050714B1 (es) |
IL (1) | IL170291A (es) |
IS (1) | IS2910B (es) |
MA (1) | MA27713A1 (es) |
ME (1) | MEP52808A (es) |
MX (1) | MXPA05009063A (es) |
NO (1) | NO332188B1 (es) |
NZ (1) | NZ541861A (es) |
OA (1) | OA13151A (es) |
PL (1) | PL216368B1 (es) |
PT (2) | PT2476667E (es) |
RS (1) | RS53118B (es) |
TN (1) | TNSN05208A1 (es) |
WO (1) | WO2004076412A2 (es) |
Families Citing this family (179)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS53118B (en) * | 2003-02-26 | 2014-06-30 | Sugen Inc. | AMINOHETEROARYL UNITS AS PROTEIN KINASE INHIBITORS |
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