NO20053470L - Triazolopyridaziner som proteinkinase-inhibitorer - Google Patents
Triazolopyridaziner som proteinkinase-inhibitorerInfo
- Publication number
- NO20053470L NO20053470L NO20053470A NO20053470A NO20053470L NO 20053470 L NO20053470 L NO 20053470L NO 20053470 A NO20053470 A NO 20053470A NO 20053470 A NO20053470 A NO 20053470A NO 20053470 L NO20053470 L NO 20053470L
- Authority
- NO
- Norway
- Prior art keywords
- protein kinase
- triazolopyridazines
- kinase inhibitors
- compounds
- pharmaceutically acceptable
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/503—Pyridazines; Hydrogenated pyridazines spiro-condensed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
Abstract
Foreliggende oppfinnelse tilveiebringer en forbindelse med formel (I): eller et farmasøytisk akseptabelt salt derav. Disse forbindelser er inhibitorer av proteinkinaser, spesielt er de inhibitorer av PIM-1-, CDK-2-, GSK-3- og SRC-proteinkinaser fra pattedyr. Oppfinnelsen tilveiebringer også farmasøytisk akseptable sammensetninger omfattende forbindelsene ifølge oppfinnelsen og metoder for å utnytte forbindelsene og sammensetningene i behandlingen av forskjellige proteinkinase-medierte forstyrrelser.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43512402P | 2002-12-18 | 2002-12-18 | |
PCT/US2003/039990 WO2004058769A2 (en) | 2002-12-18 | 2003-12-17 | Triazolopyridazines as protein kinases inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20053470L true NO20053470L (no) | 2005-09-02 |
Family
ID=32682164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20053470A NO20053470L (no) | 2002-12-18 | 2005-07-15 | Triazolopyridaziner som proteinkinase-inhibitorer |
Country Status (15)
Country | Link |
---|---|
US (1) | US7268136B2 (no) |
EP (1) | EP1575959B1 (no) |
JP (1) | JP4817661B2 (no) |
KR (1) | KR101075812B1 (no) |
CN (1) | CN100567296C (no) |
AT (1) | ATE473980T1 (no) |
AU (1) | AU2003297161B8 (no) |
CA (1) | CA2510534C (no) |
DE (1) | DE60333387D1 (no) |
HK (1) | HK1087700A1 (no) |
MX (1) | MXPA05006478A (no) |
NO (1) | NO20053470L (no) |
NZ (1) | NZ541151A (no) |
RU (1) | RU2005122484A (no) |
WO (1) | WO2004058769A2 (no) |
Families Citing this family (51)
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EP1624073A4 (en) * | 2003-04-03 | 2006-05-17 | Oncorex Inc | DRUG |
FR2876584B1 (fr) * | 2004-10-15 | 2007-04-13 | Centre Nat Rech Scient Cnrse | Utilisation de la kenpaullone pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
DE102005042742A1 (de) * | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
WO2007044724A2 (en) * | 2005-10-06 | 2007-04-19 | Exelixis, Inc. | Aminopyrimidine, aminopyridine and aniline derivatives inhibitors of pim-i and/or pim-3 |
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KR20090071612A (ko) * | 2006-10-23 | 2009-07-01 | 에스지엑스 파마슈티컬스, 인코포레이티드 | 단백질 키나제 조정제로서의 바이시클릭 트리아졸 |
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KR20090031122A (ko) * | 2007-09-21 | 2009-03-25 | 주식회사 중외제약 | 인다졸 골격을 함유하는 화합물, 이의 제조방법 및 상기화합물을 함유하는 약제학적 조성물 |
PL2193133T3 (pl) | 2007-09-27 | 2016-01-29 | Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii | Imidazolotiadiazole do stosowania jako inhibitory kinazy białkowej |
MX2010012718A (es) | 2008-05-21 | 2011-04-04 | Incyte Corp | Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b ][1,2,4] triazin-2-il]benzamida y procesos relacionados con la preparacion de las mismas. |
US8895550B2 (en) | 2008-08-19 | 2014-11-25 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
US8987251B2 (en) | 2008-08-19 | 2015-03-24 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
WO2010022081A1 (en) * | 2008-08-19 | 2010-02-25 | Array Biopharma Inc. | Triazolopyridine compounds as pim kinase inhibitors |
TWI496779B (zh) * | 2008-08-19 | 2015-08-21 | Array Biopharma Inc | 作為pim激酶抑制劑之***吡啶化合物 |
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SI2414369T1 (sl) | 2009-04-02 | 2015-12-31 | Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii | Derivati imidazo(2,1-b)(1,3,4)tiadiazola |
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CN109651253B (zh) * | 2017-10-12 | 2022-03-25 | 上海医药工业研究院 | 苯丙烯酸酯衍生物及其作为神经保护药物的应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2153902A1 (de) * | 1971-10-29 | 1973-05-03 | Boehringer Mannheim Gmbh | Antimikrobiell wirksame nitrofuranderivate und verfahren zur herstellung derselben |
DE2261693A1 (de) * | 1972-04-01 | 1974-06-20 | Boehringer Mannheim Gmbh | Nitroimidazolyl-triazolo-pyridazine und verfahren zu ihrer herstellung |
DE2215999B2 (de) | 1972-04-01 | 1977-10-20 | Boehnnger Mannheim GmbH, 6800 Mannheim | 3-(5-nitro-2-imidazolyl)-s-triazolo eckige klammer auf 4,3-b eckige klammer zu pyridazine, verfahren zu ihrer herstellung und arzneimittel |
PL91799B1 (no) * | 1972-04-01 | 1977-03-31 | ||
DE2261735A1 (de) * | 1972-04-01 | 1974-06-20 | Boehringer Mannheim Gmbh | Nitroimidazolyl-triazolo-pyridazine und verfahren zu ihrer herstellung |
DE2254783A1 (de) * | 1972-04-01 | 1974-05-16 | Boehringer Mannheim Gmbh | Nitroimidazolyl-triazolo-pyridazine und verfahren zu ihrer herstellung |
DE2418435A1 (de) * | 1974-04-17 | 1975-10-30 | Boehringer Mannheim Gmbh | Nitroimidazolyl-triazolo-pyridazine und verfahren zu ihrer herstellung |
FR2668151A1 (fr) * | 1990-10-23 | 1992-04-24 | Rhone Poulenc Agrochimie | Composes a groupe triazolopyridazine leurs preparations et compositions herbicides les contenant. |
YU2899A (sh) * | 1996-07-25 | 2000-03-21 | Merck Sharp & Dohme Limited | Supstituisani triazolo-piridazin derivati kao ligandi za gaba receptore |
GB9813576D0 (en) | 1998-06-24 | 1998-08-19 | Merck Sharp & Dohme | Therapeutic agents |
GB9828640D0 (en) | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
DE10038019A1 (de) * | 2000-08-04 | 2002-02-14 | Bayer Ag | Substituierte Triazolopyrid(az)ine |
WO2002083139A1 (en) * | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibitors of akt activity |
WO2002083675A2 (en) * | 2001-04-10 | 2002-10-24 | Merck Sharp & Dohme Limited | Inhibitors of akt activity |
JP4385620B2 (ja) * | 2002-03-01 | 2009-12-16 | アステラス製薬株式会社 | 含窒素複素環化合物 |
CA2476757A1 (en) * | 2002-03-01 | 2003-09-12 | Yamanouchi Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compound |
-
2003
- 2003-12-17 WO PCT/US2003/039990 patent/WO2004058769A2/en active Application Filing
- 2003-12-17 US US10/738,956 patent/US7268136B2/en not_active Expired - Fee Related
- 2003-12-17 NZ NZ541151A patent/NZ541151A/en unknown
- 2003-12-17 KR KR1020057011467A patent/KR101075812B1/ko not_active IP Right Cessation
- 2003-12-17 CN CNB2003801091296A patent/CN100567296C/zh not_active Expired - Fee Related
- 2003-12-17 MX MXPA05006478A patent/MXPA05006478A/es active IP Right Grant
- 2003-12-17 DE DE60333387T patent/DE60333387D1/de not_active Expired - Lifetime
- 2003-12-17 RU RU2005122484/04A patent/RU2005122484A/ru not_active Application Discontinuation
- 2003-12-17 AT AT03814020T patent/ATE473980T1/de not_active IP Right Cessation
- 2003-12-17 CA CA2510534A patent/CA2510534C/en not_active Expired - Fee Related
- 2003-12-17 AU AU2003297161A patent/AU2003297161B8/en not_active Ceased
- 2003-12-17 JP JP2004563592A patent/JP4817661B2/ja not_active Expired - Fee Related
- 2003-12-17 EP EP03814020A patent/EP1575959B1/en not_active Expired - Lifetime
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2005
- 2005-07-15 NO NO20053470A patent/NO20053470L/no not_active Application Discontinuation
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2006
- 2006-07-14 HK HK06107864.2A patent/HK1087700A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2004058769A3 (en) | 2004-09-30 |
AU2003297161B2 (en) | 2011-03-10 |
KR20050084428A (ko) | 2005-08-26 |
MXPA05006478A (es) | 2005-09-08 |
NZ541151A (en) | 2008-09-26 |
ATE473980T1 (de) | 2010-07-15 |
JP2006513208A (ja) | 2006-04-20 |
KR101075812B1 (ko) | 2011-10-25 |
CN1742012A (zh) | 2006-03-01 |
US7268136B2 (en) | 2007-09-11 |
AU2003297161B8 (en) | 2011-03-31 |
CN100567296C (zh) | 2009-12-09 |
EP1575959A2 (en) | 2005-09-21 |
EP1575959B1 (en) | 2010-07-14 |
AU2003297161A1 (en) | 2004-07-22 |
CA2510534A1 (en) | 2004-07-15 |
US20040192696A1 (en) | 2004-09-30 |
DE60333387D1 (de) | 2010-08-26 |
JP4817661B2 (ja) | 2011-11-16 |
WO2004058769A2 (en) | 2004-07-15 |
RU2005122484A (ru) | 2006-01-20 |
CA2510534C (en) | 2011-09-20 |
HK1087700A1 (en) | 2006-10-20 |
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