DK3008168T3 - Sc-celler og sammensætninger og fremgangsmåde til dannelse deraf - Google Patents
Sc-celler og sammensætninger og fremgangsmåde til dannelse deraf Download PDFInfo
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- DK3008168T3 DK3008168T3 DK14819763.5T DK14819763T DK3008168T3 DK 3008168 T3 DK3008168 T3 DK 3008168T3 DK 14819763 T DK14819763 T DK 14819763T DK 3008168 T3 DK3008168 T3 DK 3008168T3
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- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- C12N2501/10—Growth factors
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- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361833898P | 2013-06-11 | 2013-06-11 | |
US201461972212P | 2014-03-28 | 2014-03-28 | |
PCT/US2014/041988 WO2015002724A2 (en) | 2013-06-11 | 2014-06-11 | SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME |
Publications (1)
Publication Number | Publication Date |
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DK3008168T3 true DK3008168T3 (da) | 2020-05-04 |
Family
ID=52022750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14819763.5T DK3008168T3 (da) | 2013-06-11 | 2014-06-11 | Sc-celler og sammensætninger og fremgangsmåde til dannelse deraf |
Country Status (17)
Country | Link |
---|---|
US (13) | US20170029778A1 (da) |
EP (3) | EP3008170A4 (da) |
JP (6) | JP6677634B2 (da) |
KR (12) | KR102232650B1 (da) |
CN (4) | CN112226402A (da) |
AU (6) | AU2014284677B2 (da) |
BR (2) | BR112015030946A8 (da) |
CA (2) | CA2915088A1 (da) |
DE (2) | DE112014002780T5 (da) |
DK (1) | DK3008168T3 (da) |
GB (3) | GB2531952C (da) |
HK (1) | HK1257187B (da) |
MX (2) | MX2015017103A (da) |
PH (1) | PH12015502767A1 (da) |
RU (2) | RU2016100219A (da) |
SG (3) | SG11201510176VA (da) |
WO (2) | WO2014201167A1 (da) |
Families Citing this family (86)
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JP5769965B2 (ja) | 2007-07-31 | 2015-08-26 | ライフスキャン・インコーポレイテッドLifescan,Inc. | ヒト胚性幹細胞の分化 |
CA3123528A1 (en) | 2007-11-27 | 2009-06-04 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
CA2860107C (en) | 2011-12-22 | 2021-06-01 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
DK2938723T3 (da) | 2012-12-31 | 2023-02-20 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til pancreatiske endokrine celler under anvendelse af hb9-regulatorer |
US10092627B2 (en) * | 2013-04-08 | 2018-10-09 | President And Fellows Of Harvard College | Methods and compositions for rejuvenating skeletal muscle stem cells |
RU2016100219A (ru) | 2013-06-11 | 2017-07-17 | Президент Энд Феллоус Оф Гарвард Колледж | КЛЕТКИ SC-β И КОМПОЗИЦИИ, И СПОСОБЫ ДЛЯ ИХ СОЗДАНИЯ |
SG10201810739VA (en) | 2014-05-16 | 2019-01-30 | Janssen Biotech Inc | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
WO2016100921A1 (en) * | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
WO2016100930A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
EP3234110B1 (en) | 2014-12-18 | 2024-02-28 | President and Fellows of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED ß CELLS AND USES THEREOF |
WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
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US10975355B2 (en) | 2015-04-23 | 2021-04-13 | The Regents Of The University Of California | Controlled induction of human pancreatic progenitors produces functional beta-like cells |
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EP3285572B1 (en) * | 2015-04-24 | 2020-12-02 | University of Copenhagen | Method for production of insulin-producing cells |
WO2017019702A1 (en) | 2015-07-27 | 2017-02-02 | The Regents Of The University Of California | Methods and compositions for producing pancreatic beta cells |
JP6862347B2 (ja) * | 2015-10-29 | 2021-04-21 | 学校法人順天堂 | 膵内分泌細胞の製造方法、及び分化転換剤 |
US11116777B2 (en) | 2015-11-10 | 2021-09-14 | City Of Hope | Conditioning regimens and methods for inducing mixed chimerism |
WO2017116569A1 (en) * | 2015-12-31 | 2017-07-06 | City Of Hope | Methods for treating diabetes |
ES2893813T3 (es) | 2016-01-06 | 2022-02-10 | Harvard College | El tratamiento con GDF11 previene el aumento de peso, mejora la tolerancia a la glucosa y reduce la hepatoesteatosis |
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JP7123802B2 (ja) * | 2016-02-24 | 2022-08-23 | ノヴォ ノルディスク アー/エス | ヒト多能性幹細胞由来内分泌前駆細胞からの機能的ベータ細胞の産生 |
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IL308644A (en) * | 2018-03-02 | 2024-01-01 | Vertex Pharma | Methods for improving the differentiation of stem cells into beta cells |
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AU2018439389A1 (en) * | 2018-08-30 | 2021-02-18 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
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