CY1122556T1 - Υποκατεστημενα αναλογα ν-φαινυλπυριμιδιν-2- αμινης ως αναστολεις της κινασης axl - Google Patents
Υποκατεστημενα αναλογα ν-φαινυλπυριμιδιν-2- αμινης ως αναστολεις της κινασης axlInfo
- Publication number
- CY1122556T1 CY1122556T1 CY20191101262T CY191101262T CY1122556T1 CY 1122556 T1 CY1122556 T1 CY 1122556T1 CY 20191101262 T CY20191101262 T CY 20191101262T CY 191101262 T CY191101262 T CY 191101262T CY 1122556 T1 CY1122556 T1 CY 1122556T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- phenylpyrimidine
- substituted
- kinase inhibitors
- amine analogs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
Abstract
Σε μια εκδοχή, η εφεύρεση αναφέρεται σε ανάλογα Ν-φαινυλπυριμιδίν-2- αμίνης, παράγωγα αυτής, και σχετικές ενώσεις, οι οποίες είναι χρήσιμες ως αναστολείς της κινάσης ΑxI, σε συνθετικές μεθόδους για τη κατασκευή των ενώσεων, σε φαρμακευτικές παρασκευές που περιέχουν τις ενώσεις, και σε μεθόδους χρήσης των ενώσεων και των συνθέσεων για τη θεραπεία διαταραχών που σχετίζονται με τη δυσλειτουργία της κινάσης ΑxI. Αυτή η σύνοψη έχει το ρόλο ενός εργαλείου διερεύνησης που εξυπηρετεί στην αναζήτηση στον συγκεκριμένο τομέα της τεχνολογίας και δεν προορίζεται να δεσμεύσει τη παρούσα εφεύρεση.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161471090P | 2011-04-01 | 2011-04-01 | |
PCT/US2012/031768 WO2012135800A1 (en) | 2011-04-01 | 2012-03-31 | Substituted n-phenylpyrimidin-2-amine analogs as inhibitors of the axl kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122556T1 true CY1122556T1 (el) | 2021-01-27 |
Family
ID=46931967
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191101262T CY1122556T1 (el) | 2011-04-01 | 2019-12-03 | Υποκατεστημενα αναλογα ν-φαινυλπυριμιδιν-2- αμινης ως αναστολεις της κινασης axl |
Country Status (11)
Country | Link |
---|---|
US (1) | US8901120B2 (el) |
EP (2) | EP3628665B1 (el) |
JP (2) | JP6118794B2 (el) |
BR (1) | BR112013025387B1 (el) |
CY (1) | CY1122556T1 (el) |
DK (1) | DK2693881T3 (el) |
ES (2) | ES2937952T3 (el) |
HU (1) | HUE046988T2 (el) |
PL (1) | PL2693881T3 (el) |
PT (1) | PT2693881T (el) |
WO (1) | WO2012135800A1 (el) |
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KR101867110B1 (ko) | 2010-08-10 | 2018-06-12 | 시오노기 앤드 컴파니, 리미티드 | 트라이아진 유도체 및 그것을 함유하는 진통 작용을 갖는 의약 조성물 |
CN103140221A (zh) | 2010-08-10 | 2013-06-05 | 盐野义制药株式会社 | 新型杂环衍生物和含有其的药物组合物 |
EP2694486B1 (en) | 2011-04-01 | 2018-01-10 | University of Utah Research Foundation | Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors |
PL2693881T3 (pl) | 2011-04-01 | 2020-03-31 | University Of Utah Research Foundation | Podstawione analogi N-fenylopirymidyno-2-aminy jako inhibitory kinazy AXL |
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KR102194611B1 (ko) | 2012-10-04 | 2020-12-23 | 유니버시티 오브 유타 리서치 파운데이션 | 티로신 수용체 키나아제 btk 억제제로서 치환된 n-(3-(피리미딘-4-일)페닐)아크릴아미드 유사체 |
CN104822663B (zh) | 2012-10-04 | 2017-03-08 | 犹他大学研究基金会 | 作为酪氨酸受体激酶btk抑制剂的取代的n‑(3‑(嘧啶‑4‑基)苯基)丙烯酰胺类似物 |
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CN114456176A (zh) | 2016-03-28 | 2022-05-10 | 因赛特公司 | 作为tam抑制剂的吡咯并三嗪化合物 |
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JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
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KR101794695B1 (ko) * | 2017-02-15 | 2017-11-07 | 한국바이오팜 주식회사 | 항염 효과가 우수한 기능성 식품 조성물 |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
US20200197385A1 (en) | 2017-08-23 | 2020-06-25 | Ono Pharmaceutical Co., Ltd. | Therapeutic agent for cancer containing axl inhibitor as active ingredient |
PE20210002A1 (es) | 2017-09-27 | 2021-01-05 | Incyte Corp | Sales de derivados de pirrolotriazina utiles como inhibidores tam |
TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
WO2019074116A1 (ja) | 2017-10-13 | 2019-04-18 | 小野薬品工業株式会社 | Axl阻害剤を有効成分として含む固形がん治療剤 |
WO2019120121A1 (zh) * | 2017-12-21 | 2019-06-27 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制激酶活性的二苯氨基嘧啶类化合物 |
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BR112020020246A8 (pt) * | 2018-04-05 | 2022-10-18 | Sumitomo Dainippon Pharma Oncology Inc | Inibidores de cinase axl e uso dos mesmos |
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CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
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CN113061117B (zh) * | 2021-03-30 | 2023-02-10 | 长治学院 | 一种2-((5-氯-2-(4-吗啉甲基苯胺基)嘧啶-4-基)氨基)苯甲酰胺衍生物 |
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WO2012135641A2 (en) * | 2011-03-30 | 2012-10-04 | H. Lee Moffitt Cancer Center And Research Institute | Aurora kinase inhibitors and methods of making and using thereof |
PL2693881T3 (pl) | 2011-04-01 | 2020-03-31 | University Of Utah Research Foundation | Podstawione analogi N-fenylopirymidyno-2-aminy jako inhibitory kinazy AXL |
EP2694486B1 (en) | 2011-04-01 | 2018-01-10 | University of Utah Research Foundation | Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors |
-
2012
- 2012-03-31 PL PL12763555T patent/PL2693881T3/pl unknown
- 2012-03-31 BR BR112013025387-8A patent/BR112013025387B1/pt active IP Right Grant
- 2012-03-31 US US13/436,910 patent/US8901120B2/en active Active
- 2012-03-31 ES ES19189727T patent/ES2937952T3/es active Active
- 2012-03-31 ES ES12763555T patent/ES2759615T3/es active Active
- 2012-03-31 WO PCT/US2012/031768 patent/WO2012135800A1/en active Application Filing
- 2012-03-31 EP EP19189727.1A patent/EP3628665B1/en active Active
- 2012-03-31 DK DK12763555T patent/DK2693881T3/da active
- 2012-03-31 PT PT127635555T patent/PT2693881T/pt unknown
- 2012-03-31 EP EP12763555.5A patent/EP2693881B1/en active Active
- 2012-03-31 HU HUE12763555A patent/HUE046988T2/hu unknown
- 2012-03-31 JP JP2014502897A patent/JP6118794B2/ja active Active
-
2017
- 2017-02-03 JP JP2017018561A patent/JP2017075188A/ja not_active Withdrawn
-
2019
- 2019-12-03 CY CY20191101262T patent/CY1122556T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP3628665B1 (en) | 2022-11-02 |
JP6118794B2 (ja) | 2017-04-19 |
EP2693881B1 (en) | 2019-09-04 |
BR112013025387B1 (pt) | 2021-07-27 |
PL2693881T3 (pl) | 2020-03-31 |
ES2759615T3 (es) | 2020-05-11 |
EP3628665A1 (en) | 2020-04-01 |
US20120283261A1 (en) | 2012-11-08 |
DK2693881T3 (da) | 2019-12-09 |
US8901120B2 (en) | 2014-12-02 |
ES2937952T3 (es) | 2023-04-03 |
BR112013025387A2 (pt) | 2016-07-19 |
PT2693881T (pt) | 2019-12-09 |
EP2693881A4 (en) | 2014-11-19 |
HUE046988T2 (hu) | 2020-04-28 |
JP2017075188A (ja) | 2017-04-20 |
EP2693881A1 (en) | 2014-02-12 |
WO2012135800A1 (en) | 2012-10-04 |
JP2014509661A (ja) | 2014-04-21 |
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