EA201490567A1 - Новые бициклические производные дигидрохинолин-2-она - Google Patents
Новые бициклические производные дигидрохинолин-2-онаInfo
- Publication number
- EA201490567A1 EA201490567A1 EA201490567A EA201490567A EA201490567A1 EA 201490567 A1 EA201490567 A1 EA 201490567A1 EA 201490567 A EA201490567 A EA 201490567A EA 201490567 A EA201490567 A EA 201490567A EA 201490567 A1 EA201490567 A1 EA 201490567A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- dihydrochinolin
- bicyclic derivatives
- new bicyclic
- compounds
- new
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
В изобретении предложены новые соединения общей формулы (I)в которых R, R, R, R, R, R, R, R, R, R, R, R, А, ААи n являются такими, как раскрыто в описании изобретения, композиции, включающие эти соединения, и способы применения указанных соединений.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011080078 | 2011-09-23 | ||
| PCT/EP2012/068472 WO2013041591A1 (en) | 2011-09-23 | 2012-09-20 | New bicyclic dihydroquinoline-2-one derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201490567A1 true EA201490567A1 (ru) | 2014-07-30 |
| EA035108B1 EA035108B1 (ru) | 2020-04-28 |
Family
ID=46963698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201490567A EA035108B1 (ru) | 2011-09-23 | 2012-09-20 | Бициклические производные дигидрохинолин-2-она |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US9353081B2 (ru) |
| EP (1) | EP2758388B1 (ru) |
| JP (1) | JP6012737B2 (ru) |
| KR (1) | KR101723276B1 (ru) |
| CN (1) | CN103827101B (ru) |
| AR (1) | AR087984A1 (ru) |
| AU (1) | AU2012311582B2 (ru) |
| BR (1) | BR112014006660B1 (ru) |
| CA (1) | CA2845170C (ru) |
| CL (1) | CL2014000663A1 (ru) |
| CO (1) | CO6870035A2 (ru) |
| CR (1) | CR20140089A (ru) |
| DK (1) | DK2758388T3 (ru) |
| EA (1) | EA035108B1 (ru) |
| EC (1) | ECSP14013264A (ru) |
| ES (1) | ES2666802T3 (ru) |
| HR (1) | HRP20180592T1 (ru) |
| HU (1) | HUE038773T2 (ru) |
| IL (1) | IL230874A (ru) |
| LT (1) | LT2758388T (ru) |
| MX (1) | MX366095B (ru) |
| MY (1) | MY186165A (ru) |
| NO (1) | NO2758388T3 (ru) |
| PE (2) | PE20141042A1 (ru) |
| PL (1) | PL2758388T3 (ru) |
| PT (1) | PT2758388T (ru) |
| RS (1) | RS57139B1 (ru) |
| SG (1) | SG2014010599A (ru) |
| SI (1) | SI2758388T1 (ru) |
| TW (1) | TWI576342B (ru) |
| UA (1) | UA115972C2 (ru) |
| WO (1) | WO2013041591A1 (ru) |
| ZA (1) | ZA201401577B (ru) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA117092C2 (uk) | 2011-09-06 | 2018-06-25 | Байєр Інтеллектуал Проперті Гмбх | Амінозаміщені імідазопіридазини |
| PL2838883T3 (pl) * | 2012-04-17 | 2018-05-30 | F.Hoffmann-La Roche Ag | Nowe pochodne fenylo-tetrahydroizochinoliny |
| CN104797585B (zh) | 2012-11-19 | 2017-08-15 | 拜耳医药股份公司 | 氨基咪唑并哒嗪 |
| EP2970198B1 (en) * | 2013-03-14 | 2020-08-05 | F.Hoffmann-La Roche Ag | Dihydroquinoline-2-one derivatives for use as aldosterone synthase inhibitors |
| AR096424A1 (es) * | 2013-05-27 | 2015-12-30 | Hoffmann La Roche | Compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona |
| RU2689421C2 (ru) * | 2013-05-27 | 2019-05-28 | Ф.Хоффманн-Ля Рош Аг | Новые 3,4-дигидро-2н-изохинолин-1-оны и 2,3-дигидро-изоиндол-1-оны |
| WO2014191340A1 (en) * | 2013-05-27 | 2014-12-04 | F. Hoffmann-La Roche Ag | New 3,4-dihydro-2h-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds |
| CN105593212B (zh) * | 2013-10-17 | 2019-06-04 | 豪夫迈·罗氏有限公司 | 作为醛固酮合酶抑制剂的苯基-二氢吡啶衍生物 |
| WO2015055604A1 (en) * | 2013-10-17 | 2015-04-23 | F. Hoffmann-La Roche Ag | New phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors |
| CN105531263B (zh) | 2013-10-17 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 作为醛固酮合酶抑制剂的苯基-二氢吡啶衍生物 |
| EP3212630B1 (en) * | 2014-10-31 | 2022-05-18 | F. Hoffmann-La Roche AG | New dihydroquinoline pyrazolyl compounds |
| EP3212631B1 (en) * | 2014-10-31 | 2020-02-12 | F.Hoffmann-La Roche Ag | Pyrazolyl-3,4-dihydroquinolin-2-one aldosterone synthase inhibitors |
| EP3212638B1 (en) * | 2014-10-31 | 2019-11-20 | F.Hoffmann-La Roche Ag | New dihydroquinoline pyrazolyl compounds as aldosterone synthase inhibitors |
| JP6707084B2 (ja) * | 2014-12-02 | 2020-06-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルドステロンシンターゼ阻害薬 |
| EP3470091A4 (en) | 2016-06-10 | 2019-06-19 | Nihon Medi-Physics Co., Ltd. | NON-INVASIVE DIAGNOSTIC IMAGING AGENT FOR CARDIAC DISEASE |
| WO2020223267A1 (en) | 2019-05-01 | 2020-11-05 | Boehringer Ingelheim International Gmbh | (r)-(2-methyloxiran-2-yl)methyl 4-bromobenzenesulfonate |
| CA3223211A1 (en) * | 2021-06-24 | 2022-12-29 | Cincor Pharma, Inc. | Methods of using aldosterone synthase inhibitors |
| WO2023063851A1 (en) * | 2021-10-13 | 2023-04-20 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
| WO2024049885A1 (en) | 2022-09-02 | 2024-03-07 | Apnimed, Inc. (Delaware) | Methods and compositions for treating sleep apnea |
| WO2024061371A1 (zh) * | 2022-09-23 | 2024-03-28 | 广州威诺森医药科技有限公司 | 一种骈环吡啶类甾体合成酶抑制剂及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792561A (en) * | 1986-05-29 | 1988-12-20 | Syntex (U.S.A.) Inc. | Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors |
| GB8709448D0 (en) * | 1987-04-21 | 1987-05-28 | Pfizer Ltd | Heterobicyclic quinoline derivatives |
| US5246944A (en) * | 1991-08-13 | 1993-09-21 | Merck & Co., Inc. | Quinoline angiotensin ii antagonists incorporating a substituted benzyl element |
| WO2005065050A2 (ja) * | 2003-12-25 | 2005-07-21 | Asahi Kasei Pharma Corporation | ２環化合物 |
| US7728130B2 (en) | 2005-12-09 | 2010-06-01 | Amgen Inc. | Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
-
2012
- 2012-09-14 US US13/615,901 patent/US9353081B2/en active Active
- 2012-09-20 BR BR112014006660-4A patent/BR112014006660B1/pt active IP Right Grant
- 2012-09-20 CN CN201280045785.3A patent/CN103827101B/zh active Active
- 2012-09-20 SG SG2014010599A patent/SG2014010599A/en unknown
- 2012-09-20 PT PT127666287T patent/PT2758388T/pt unknown
- 2012-09-20 PE PE2014000393A patent/PE20141042A1/es active IP Right Grant
- 2012-09-20 KR KR1020147010662A patent/KR101723276B1/ko active IP Right Grant
- 2012-09-20 PL PL12766628T patent/PL2758388T3/pl unknown
- 2012-09-20 MY MYPI2014700679A patent/MY186165A/en unknown
- 2012-09-20 LT LTEP12766628.7T patent/LT2758388T/lt unknown
- 2012-09-20 AU AU2012311582A patent/AU2012311582B2/en active Active
- 2012-09-20 HU HUE12766628A patent/HUE038773T2/hu unknown
- 2012-09-20 ES ES12766628.7T patent/ES2666802T3/es active Active
- 2012-09-20 PE PE2018001330A patent/PE20181378A1/es unknown
- 2012-09-20 NO NO12766628A patent/NO2758388T3/no unknown
- 2012-09-20 DK DK12766628.7T patent/DK2758388T3/en active
- 2012-09-20 SI SI201231277T patent/SI2758388T1/en unknown
- 2012-09-20 JP JP2014531214A patent/JP6012737B2/ja active Active
- 2012-09-20 MX MX2014002624A patent/MX366095B/es active IP Right Grant
- 2012-09-20 EP EP12766628.7A patent/EP2758388B1/en active Active
- 2012-09-20 CA CA2845170A patent/CA2845170C/en active Active
- 2012-09-20 UA UAA201404207A patent/UA115972C2/uk unknown
- 2012-09-20 RS RS20180446A patent/RS57139B1/sr unknown
- 2012-09-20 EA EA201490567A patent/EA035108B1/ru not_active IP Right Cessation
- 2012-09-20 WO PCT/EP2012/068472 patent/WO2013041591A1/en active Application Filing
- 2012-09-21 TW TW101134790A patent/TWI576342B/zh active
- 2012-09-21 AR ARP120103485A patent/AR087984A1/es active IP Right Grant
-
2014
- 2014-01-31 CO CO14020664A patent/CO6870035A2/es active IP Right Grant
- 2014-02-06 IL IL230874A patent/IL230874A/en active IP Right Grant
- 2014-02-25 CR CR20140089A patent/CR20140089A/es unknown
- 2014-02-28 ZA ZA2014/01577A patent/ZA201401577B/en unknown
- 2014-03-19 CL CL2014000663A patent/CL2014000663A1/es unknown
- 2014-03-21 EC ECSP14013264 patent/ECSP14013264A/es unknown
-
2018
- 2018-04-13 HR HRP20180592TT patent/HRP20180592T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |