CN103209695A - 氮杂苯并噻唑化合物、组合物及应用方法 - Google Patents
氮杂苯并噻唑化合物、组合物及应用方法 Download PDFInfo
- Publication number
- CN103209695A CN103209695A CN2011800547253A CN201180054725A CN103209695A CN 103209695 A CN103209695 A CN 103209695A CN 2011800547253 A CN2011800547253 A CN 2011800547253A CN 201180054725 A CN201180054725 A CN 201180054725A CN 103209695 A CN103209695 A CN 103209695A
- Authority
- CN
- China
- Prior art keywords
- thiazole
- amino
- pyridin
- pyridine
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- AMFIIFAHJOFHRY-UHFFFAOYSA-N Cc1cc(Nc(c2c3nc(-c(c(C#N)ccc4)c4F)[s]2)ncc3C#N)ncn1 Chemical compound Cc1cc(Nc(c2c3nc(-c(c(C#N)ccc4)c4F)[s]2)ncc3C#N)ncn1 AMFIIFAHJOFHRY-UHFFFAOYSA-N 0.000 description 1
- UGQIGLPWZUNSID-UHFFFAOYSA-N Cc1cc(Nc2c3[s]c(-c(c(Cl)ccc4)c4Cl)nc3ccn2)nc(N2CCOCC2)n1 Chemical compound Cc1cc(Nc2c3[s]c(-c(c(Cl)ccc4)c4Cl)nc3ccn2)nc(N2CCOCC2)n1 UGQIGLPWZUNSID-UHFFFAOYSA-N 0.000 description 1
- SZYJIERYCKJHCM-UHFFFAOYSA-N Cc1ncnc(Nc2nccc3c2[s]c(-c(c(Cl)cc(CN)c2)c2Cl)n3)c1 Chemical compound Cc1ncnc(Nc2nccc3c2[s]c(-c(c(Cl)cc(CN)c2)c2Cl)n3)c1 SZYJIERYCKJHCM-UHFFFAOYSA-N 0.000 description 1
- YJXHYAFNOLTHQV-UHFFFAOYSA-N NCc1cc(Cl)c(-c2nc(ccnc3Nc4cc(N)ncn4)c3[s]2)c(Cl)c1 Chemical compound NCc1cc(Cl)c(-c2nc(ccnc3Nc4cc(N)ncn4)c3[s]2)c(Cl)c1 YJXHYAFNOLTHQV-UHFFFAOYSA-N 0.000 description 1
- ODQGHVXCUOKZEA-UHFFFAOYSA-N O=C(C1CC1)Nc1ncnc2c1[s]c(-c(c(Cl)ccc1)c1Cl)n2 Chemical compound O=C(C1CC1)Nc1ncnc2c1[s]c(-c(c(Cl)ccc1)c1Cl)n2 ODQGHVXCUOKZEA-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38327310P | 2010-09-15 | 2010-09-15 | |
| US61/383,273 | 2010-09-15 | ||
| PCT/EP2011/065892 WO2012035039A1 (en) | 2010-09-15 | 2011-09-14 | Azabenzothiazole compounds, compositions and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103209695A true CN103209695A (zh) | 2013-07-17 |
Family
ID=44651779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011800547253A Pending CN103209695A (zh) | 2010-09-15 | 2011-09-14 | 氮杂苯并噻唑化合物、组合物及应用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8697708B2 (es) |
| EP (1) | EP2616072A1 (es) |
| JP (1) | JP5822934B2 (es) |
| KR (1) | KR20130051507A (es) |
| CN (1) | CN103209695A (es) |
| AR (1) | AR082974A1 (es) |
| BR (1) | BR112013006016A2 (es) |
| CA (1) | CA2812087A1 (es) |
| MX (1) | MX2013003019A (es) |
| RU (1) | RU2013114352A (es) |
| TW (1) | TW201217387A (es) |
| WO (1) | WO2012035039A1 (es) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108373476A (zh) * | 2017-01-13 | 2018-08-07 | 成都地奥制药集团有限公司 | 一种激酶抑制剂及其制备和应用 |
| CN110461830A (zh) * | 2017-01-17 | 2019-11-15 | 阿斯利康(瑞典)有限公司 | Jak1选择性抑制剂 |
| CN112424187A (zh) * | 2018-07-18 | 2021-02-26 | 阿斯利康(瑞典)有限公司 | 抑制jak的化合物的昔萘酸盐 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010083161A1 (en) | 2009-01-13 | 2010-07-22 | Konarka Technologies, Inc. | Photovoltaic module |
| WO2010138414A1 (en) | 2009-05-27 | 2010-12-02 | Konarka Technologies, Inc. | Reflective multilayer electrode |
| WO2012035039A1 (en) * | 2010-09-15 | 2012-03-22 | F. Hoffmann-La Roche Ag | Azabenzothiazole compounds, compositions and methods of use |
| JP2013542966A (ja) * | 2010-11-19 | 2013-11-28 | エフ．ホフマン−ラ ロシュ アーゲー | ピラゾロピリジンならびにｔｙｋ２阻害剤としてのピラゾロピリジン及びそれらの使用 |
| RU2641895C2 (ru) | 2012-05-24 | 2018-01-23 | Целльзом Лимитид | ГЕТЕРОЦИКЛИЛЬНЫЕ ПИРИМИДИНОВЫЕ АНАЛОГИ В КАЧЕСТВЕ ИНГИБИТОРОВ Tук2 |
| KR102195194B1 (ko) * | 2012-11-08 | 2020-12-24 | 브리스톨-마이어스 스큅 컴퍼니 | ＩＬ-12, ＩＬ-23 및/또는 ＩＦＮα 반응의 조절제로서 유용한 아미드-치환된 헤테로시클릭 화합물 |
| EP4008328A1 (en) | 2013-06-26 | 2022-06-08 | AbbVie Inc. | Primary carboxamides as btk inhibitors |
| WO2015091584A1 (en) | 2013-12-18 | 2015-06-25 | F. Hoffmann-La Roche Ag | Thiazolopyridine compounds, compositions and their use as tyk2 kinase inhibitors |
| CN106279211B (zh) * | 2015-06-03 | 2020-09-15 | 北京大学 | 一种噻唑并嘧啶酮化合物及其制备方法和应用 |
| EP3317258A4 (en) * | 2015-07-01 | 2019-06-26 | Pharmakea, Inc. | LYSYL OXIDASE LIKE 2 INHIBITORS AND USES THEREOF |
| JP2017114820A (ja) * | 2015-12-25 | 2017-06-29 | 宇部興産株式会社 | １−アミノ−３，５−ジメチルアダマンタン塩酸塩の製造方法 |
| US20190086392A1 (en) | 2016-03-21 | 2019-03-21 | Inserm (Institut National De La Sante Et De La Recherch Medicale) | Methods for diagnosis and treatment of solar lentigo |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| TW202208347A (zh) | 2020-05-06 | 2022-03-01 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基***化合物 |
| EP3944859A1 (en) | 2020-07-30 | 2022-02-02 | Assistance Publique Hôpitaux de Paris | Method for treating immune toxicities induced by immune checkpoint inhibitors |
| AU2022335669A1 (en) | 2021-08-25 | 2024-02-01 | Bayer Aktiengesellschaft | Novel pyrazinyl-triazole compounds as pesticides |
| WO2023055901A2 (en) | 2021-09-30 | 2023-04-06 | Bristol-Myers Squibb Company | Methods for determining responsiveness to tyk2 inhibitors |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101316853A (zh) * | 2005-08-04 | 2008-12-03 | 西特里斯药业公司 | 作为sirtuin调节剂的苯并噻唑和噻唑并吡啶 |
| WO2009042607A1 (en) * | 2007-09-24 | 2009-04-02 | Genentech, Inc. | Thiazolopyrimidine p13k inhibitor compounds and methods of use |
| WO2009061453A1 (en) * | 2007-11-08 | 2009-05-14 | Sirtris Pharmaceuticals, Inc. | Solubilized thiazolopyridines |
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| CN108373476A (zh) * | 2017-01-13 | 2018-08-07 | 成都地奥制药集团有限公司 | 一种激酶抑制剂及其制备和应用 |
| CN108373476B (zh) * | 2017-01-13 | 2021-06-01 | 成都地奥制药集团有限公司 | 一种激酶抑制剂及其制备和应用 |
| CN110461830A (zh) * | 2017-01-17 | 2019-11-15 | 阿斯利康(瑞典)有限公司 | Jak1选择性抑制剂 |
| CN110461830B (zh) * | 2017-01-17 | 2022-11-01 | 阿斯利康(瑞典)有限公司 | Jak1选择性抑制剂 |
| CN115925693A (zh) * | 2017-01-17 | 2023-04-07 | 阿斯利康(瑞典)有限公司 | Jak1选择性抑制剂 |
| CN112424187A (zh) * | 2018-07-18 | 2021-02-26 | 阿斯利康(瑞典)有限公司 | 抑制jak的化合物的昔萘酸盐 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5822934B2 (ja) | 2015-11-25 |
| EP2616072A1 (en) | 2013-07-24 |
| RU2013114352A (ru) | 2014-10-20 |
| US20120202788A1 (en) | 2012-08-09 |
| US8697708B2 (en) | 2014-04-15 |
| US20140171408A1 (en) | 2014-06-19 |
| CA2812087A1 (en) | 2012-03-22 |
| MX2013003019A (es) | 2013-05-28 |
| JP2013538223A (ja) | 2013-10-10 |
| TW201217387A (en) | 2012-05-01 |
| BR112013006016A2 (pt) | 2016-06-07 |
| KR20130051507A (ko) | 2013-05-20 |
| AR082974A1 (es) | 2013-01-23 |
| WO2012035039A1 (en) | 2012-03-22 |
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