BR112021023277A2 - Formas em estado sólido - Google Patents

Formas em estado sólido

Info

Publication number
BR112021023277A2
BR112021023277A2 BR112021023277A BR112021023277A BR112021023277A2 BR 112021023277 A2 BR112021023277 A2 BR 112021023277A2 BR 112021023277 A BR112021023277 A BR 112021023277A BR 112021023277 A BR112021023277 A BR 112021023277A BR 112021023277 A2 BR112021023277 A2 BR 112021023277A2
Authority
BR
Brazil
Prior art keywords
solid state
forms
fluoro
methyl
state shapes
Prior art date
Application number
BR112021023277A
Other languages
English (en)
Inventor
Albert Amegadzie
Leonard Reid Darren
Mary Chaves
Patricia Lopez
Prashant Agarwal
Roman Shimanovich
C Kelly Ron
Stephanie Azali
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BR112021023277A2 publication Critical patent/BR112021023277A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

formas em estado sólido. a presente divulgação proporciona formas cristalinas e amorfas de 6-fluoro-7-(2-fluoro-6-hidroxifenil)-1-(4-metil-2-(2-propanil)-3-piridinil)-4-((2s)-2-metil-4-(2-propenoil)-1-piperazinil)pirido[2,3-d]pirimidin-2(1h)-ona, incluindo várias formas anidras, de hidrato e de solvato, e suas formas em estado sólido, composições farmacêuticas e métodos de tratamento de uma doença mediada por inibição de kras g12c.
BR112021023277A 2019-05-21 2020-05-20 Formas em estado sólido BR112021023277A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962851044P 2019-05-21 2019-05-21
PCT/US2020/033831 WO2020236947A1 (en) 2019-05-21 2020-05-20 Solid state forms

Publications (1)

Publication Number Publication Date
BR112021023277A2 true BR112021023277A2 (pt) 2022-01-04

Family

ID=71083699

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021023277A BR112021023277A2 (pt) 2019-05-21 2020-05-20 Formas em estado sólido

Country Status (20)

Country Link
US (3) US11236091B2 (pt)
EP (1) EP3972973A1 (pt)
JP (2) JP7092935B2 (pt)
KR (1) KR20220011670A (pt)
CN (1) CN114144414A (pt)
AR (1) AR118978A1 (pt)
AU (1) AU2020280024A1 (pt)
BR (1) BR112021023277A2 (pt)
CA (2) CA3225293A1 (pt)
CL (1) CL2021003064A1 (pt)
CO (1) CO2021017366A2 (pt)
CR (1) CR20210665A (pt)
IL (1) IL288077A (pt)
JO (1) JOP20210310A1 (pt)
MX (1) MX2021014126A (pt)
PE (1) PE20220504A1 (pt)
SG (1) SG11202112855WA (pt)
TW (1) TW202110835A (pt)
UY (1) UY38710A (pt)
WO (1) WO2020236947A1 (pt)

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WO2021236920A1 (en) * 2020-05-20 2021-11-25 Teva Pharmaceuticals International Gmbh Solid state forms of amg-510 and process for preparation thereof
TW202229278A (zh) * 2020-11-26 2022-08-01 大陸商上海翰森生物醫藥科技有限公司 含氮雜環類衍生物的鹽、晶型及其製備方法和應用
CA3206523A1 (en) 2021-01-08 2022-07-14 Amgen Inc. Use of a kras g12c inhibitor in treating cancers
JP2024510612A (ja) * 2021-03-17 2024-03-08 アムジエン・インコーポレーテツド ソトラシブ投与レジメン
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CN114605406B (zh) * 2021-09-18 2023-05-26 都创(上海)医药开发有限公司 Amg510化合物的晶型及其制备方法和用途
WO2023122662A1 (en) 2021-12-22 2023-06-29 The Regents Of The University Of California Covalently binding inhibitors of g12s, g12d and/or g12e mutants of k-ras gtpase
CN115368358A (zh) * 2022-09-01 2022-11-22 浙江九洲药业股份有限公司 一种Sotorasib新晶型及其制备方法与应用

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