PE20220504A1 - Formas en estado solido - Google Patents

Formas en estado solido

Info

Publication number
PE20220504A1
PE20220504A1 PE2021001930A PE2021001930A PE20220504A1 PE 20220504 A1 PE20220504 A1 PE 20220504A1 PE 2021001930 A PE2021001930 A PE 2021001930A PE 2021001930 A PE2021001930 A PE 2021001930A PE 20220504 A1 PE20220504 A1 PE 20220504A1
Authority
PE
Peru
Prior art keywords
forms
solid state
state forms
fluoro
methyl
Prior art date
Application number
PE2021001930A
Other languages
English (en)
Inventor
Mary Chaves
Patricia Lopez
Prashant Agarwal
Albert Amegadzie
Stephanie Azali
Roman Shimanovich
Ron C Kelly
Darren Leonard Reid
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of PE20220504A1 publication Critical patent/PE20220504A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente divulgacion proporciona formas cristalinas y amorfas de 6-fluoro-7-(2-fluoro-6-hidroxifenil)-1-(4-metil-2-(2-propanil)-3-piridinil)-4-((2S)-2-metil-4-(2-propenil)-1-piperazinil)pirido[2,3-d]pirimidin-2(1H)-ona, incluyendo varias formas anhidras, de hidrato y de solvato, y formas en estado solido de las mismas, composiciones farmaceuticas y metodos de tratamiento de una enfermedad mediada por la inhibicion de KRAS G12C.
PE2021001930A 2019-05-21 2020-05-20 Formas en estado solido PE20220504A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962851044P 2019-05-21 2019-05-21
PCT/US2020/033831 WO2020236947A1 (en) 2019-05-21 2020-05-20 Solid state forms

Publications (1)

Publication Number Publication Date
PE20220504A1 true PE20220504A1 (es) 2022-04-07

Family

ID=71083699

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2021001930A PE20220504A1 (es) 2019-05-21 2020-05-20 Formas en estado solido

Country Status (20)

Country Link
US (3) US11236091B2 (es)
EP (1) EP3972973A1 (es)
JP (3) JP7092935B2 (es)
KR (1) KR20220011670A (es)
CN (1) CN114144414A (es)
AR (1) AR118978A1 (es)
AU (1) AU2020280024A1 (es)
BR (1) BR112021023277A2 (es)
CA (2) CA3140392A1 (es)
CL (1) CL2021003064A1 (es)
CO (1) CO2021017366A2 (es)
CR (1) CR20210665A (es)
IL (1) IL288077A (es)
JO (1) JOP20210310A1 (es)
MX (1) MX2021014126A (es)
PE (1) PE20220504A1 (es)
SG (1) SG11202112855WA (es)
TW (1) TW202110835A (es)
UY (1) UY38710A (es)
WO (1) WO2020236947A1 (es)

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JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
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JP2020090482A (ja) 2018-11-16 2020-06-11 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
AU2019384118A1 (en) 2018-11-19 2021-05-27 Amgen Inc. KRAS G12C inhibitors and methods of using the same
JP2022517222A (ja) 2019-01-10 2022-03-07 ミラティ セラピューティクス， インコーポレイテッド Ｋｒａｓ ｇ１２ｃ阻害剤
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WO2020236947A1 (en) 2019-05-21 2020-11-26 Amgen Inc. Solid state forms
BR112022003543A2 (pt) 2019-08-29 2022-05-24 Array Biopharma Inc Inibidores de kras g12
US11890285B2 (en) 2019-09-24 2024-02-06 Mirati Therapeutics, Inc. Combination therapies
AU2020405170A1 (en) 2019-12-20 2022-06-30 Mirati Therapeutics, Inc. SOS1 inhibitors
EP4153588A1 (en) * 2020-05-20 2023-03-29 Teva Pharmaceuticals International GmbH Solid state forms of amg-510 and process for preparation thereof
TW202229278A (zh) * 2020-11-26 2022-08-01 大陸商上海翰森生物醫藥科技有限公司 含氮雜環類衍生物的鹽、晶型及其製備方法和應用
MX2023007918A (es) 2021-01-08 2023-07-13 Amgen Inc Uso de un inhibidor de kras g12c en el tratamiento de canceres.
KR20230157379A (ko) * 2021-03-17 2023-11-16 암젠 인크 소토라십 투약 요법
EP4341260A1 (en) 2021-05-19 2024-03-27 Teva Pharmaceuticals International GmbH Process for preparation of sotorasib and solid state form thereof
EP4359410A1 (en) 2021-06-24 2024-05-01 Sandoz Ag Crystalline form of sotorasib
EP4227305A1 (en) 2022-02-10 2023-08-16 Sandoz AG Crystalline form of sotorasib
CN114605406B (zh) * 2021-09-18 2023-05-26 都创(上海)医药开发有限公司 Amg510化合物的晶型及其制备方法和用途
TW202340202A (zh) 2021-12-22 2023-10-16 美國加利福尼亞大學董事會 Gtp酶抑制劑及其用途
CN115368358A (zh) * 2022-09-01 2022-11-22 浙江九洲药业股份有限公司 一种Sotorasib新晶型及其制备方法与应用

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