AR051388A1 - Analogos de 17-hidroxiwortmanina como inhibidores de pi3k - Google Patents
Analogos de 17-hidroxiwortmanina como inhibidores de pi3kInfo
- Publication number
- AR051388A1 AR051388A1 ARP050104294A ARP050104294A AR051388A1 AR 051388 A1 AR051388 A1 AR 051388A1 AR P050104294 A ARP050104294 A AR P050104294A AR P050104294 A ARP050104294 A AR P050104294A AR 051388 A1 AR051388 A1 AR 051388A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- aryl
- aralkyl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
Abstract
Composiciones farmacéuticas que los contienen y usos como agentes antitumorales. Reivindicacion 1: Un compuesto de formula (1) donde: R1 se selecciona del grupo que consiste en NR4R5, SR6 y OR7; R2 se selecciona del grupo que consiste en H, formilo y acilo; R3 se selecciona del grupo que consiste en H, hidroxi, alcoxi, alcanoiloxi, =O, aciloxi y carbonilo; R4 y R5 se seleccionan independientemente del grupo que consiste en H, hidroxilo, alquilo, alquenilo, heterocíclico, arilo, heteroarilo, aralquilo y PEG; y donde R4 y R5 se unen opcionalmente para formar un anillo; R6 se selecciona del grupo que consiste en alquilo, arilo, heteroarilo, aralquilo y PEG; y R7 se selecciona del grupo que consiste en H, alquilo, arilo, heteroarilo, aralquilo y PEG; R8 se selecciona del grupo que consiste en hidroxi, aciloxi y alcoxi; y sales, solvatos e hidratos del mismo, con la condicion de que el compuesto no sea un compuesto de formula (2) donde R9 es alquilo o un conjugado fármaco- polímero de una formula unica no repetitiva (3) donde R10 es -O-, -NH-, o -S-; R11 es alquilo, un cicloalquilo, o arilo; R3 es H, =O, -O-COC4Hq u OR12; R12 es H. COR13 o alquilo; R13 es alquilo, H, arilo o -CH2-arilo; y n es 1-1000.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61765404P | 2004-10-13 | 2004-10-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR051388A1 true AR051388A1 (es) | 2007-01-10 |
Family
ID=35502459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050104294A AR051388A1 (es) | 2004-10-13 | 2005-10-13 | Analogos de 17-hidroxiwortmanina como inhibidores de pi3k |
Country Status (13)
Country | Link |
---|---|
US (1) | US7666901B2 (es) |
EP (1) | EP1799699A1 (es) |
JP (1) | JP2008515984A (es) |
CN (1) | CN101039952A (es) |
AR (1) | AR051388A1 (es) |
AU (1) | AU2005295859A1 (es) |
BR (1) | BRPI0516592A (es) |
CA (1) | CA2582163A1 (es) |
GT (1) | GT200500287A (es) |
MX (1) | MX2007004489A (es) |
PE (1) | PE20060608A1 (es) |
TW (1) | TW200626610A (es) |
WO (1) | WO2006044453A1 (es) |
Families Citing this family (83)
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DE602006021142D1 (de) | 2005-02-03 | 2011-05-19 | Gen Hospital Corp | Verfahren zur behandlung von gefitinib-resistentem krebs |
EP1919979B2 (en) * | 2005-08-25 | 2017-03-29 | Creabilis Therapeutics S.P.A. | Polymer conjugates of k-252a and derivatives thereof |
CN103110948A (zh) | 2005-11-04 | 2013-05-22 | 惠氏公司 | mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合 |
PL1965790T3 (pl) | 2005-12-30 | 2012-05-31 | Arizona Board Of Regents Acting On Behalf Of The Univ Of Arizona | Metabolity analogów wortmaniny i sposoby ich stosowania |
JP2009539988A (ja) * | 2006-06-12 | 2009-11-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルの調節因子として有用なチエノピリミジン |
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2005
- 2005-10-13 WO PCT/US2005/036664 patent/WO2006044453A1/en active Application Filing
- 2005-10-13 BR BRPI0516592-0A patent/BRPI0516592A/pt not_active IP Right Cessation
- 2005-10-13 AR ARP050104294A patent/AR051388A1/es not_active Application Discontinuation
- 2005-10-13 TW TW094135618A patent/TW200626610A/zh unknown
- 2005-10-13 AU AU2005295859A patent/AU2005295859A1/en not_active Abandoned
- 2005-10-13 JP JP2007536835A patent/JP2008515984A/ja not_active Withdrawn
- 2005-10-13 CN CNA2005800349346A patent/CN101039952A/zh active Pending
- 2005-10-13 PE PE2005001208A patent/PE20060608A1/es not_active Application Discontinuation
- 2005-10-13 CA CA002582163A patent/CA2582163A1/en not_active Abandoned
- 2005-10-13 GT GT200500287A patent/GT200500287A/es unknown
- 2005-10-13 EP EP05807576A patent/EP1799699A1/en not_active Withdrawn
- 2005-10-13 US US11/248,510 patent/US7666901B2/en not_active Expired - Fee Related
- 2005-10-13 MX MX2007004489A patent/MX2007004489A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2007004489A (es) | 2007-09-21 |
GT200500287A (es) | 2006-04-17 |
TW200626610A (en) | 2006-08-01 |
BRPI0516592A (pt) | 2008-09-23 |
AU2005295859A1 (en) | 2006-04-27 |
PE20060608A1 (es) | 2006-08-22 |
WO2006044453A1 (en) | 2006-04-27 |
CN101039952A (zh) | 2007-09-19 |
US7666901B2 (en) | 2010-02-23 |
US20060128793A1 (en) | 2006-06-15 |
EP1799699A1 (en) | 2007-06-27 |
JP2008515984A (ja) | 2008-05-15 |
CA2582163A1 (en) | 2006-04-27 |
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