SG11201605699QA - FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX - Google Patents

FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX

Info

Publication number
SG11201605699QA
SG11201605699QA SG11201605699QA SG11201605699QA SG11201605699QA SG 11201605699Q A SG11201605699Q A SG 11201605699QA SG 11201605699Q A SG11201605699Q A SG 11201605699QA SG 11201605699Q A SG11201605699Q A SG 11201605699QA SG 11201605699Q A SG11201605699Q A SG 11201605699QA
Authority
SG
Singapore
Prior art keywords
inhibitors
complex
fused pyrimidines
pyrimidines
fused
Prior art date
Application number
SG11201605699QA
Inventor
Han-Jie Zhou
David Wustrow
Original Assignee
Cleave Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52478057&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201605699Q(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cleave Biosciences Inc filed Critical Cleave Biosciences Inc
Publication of SG11201605699QA publication Critical patent/SG11201605699QA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
SG11201605699QA 2014-01-20 2015-01-19 FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX SG11201605699QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461929382P 2014-01-20 2014-01-20
PCT/US2015/011921 WO2015109285A1 (en) 2014-01-20 2015-01-19 FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX

Publications (1)

Publication Number Publication Date
SG11201605699QA true SG11201605699QA (en) 2016-08-30

Family

ID=52478057

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201605699QA SG11201605699QA (en) 2014-01-20 2015-01-19 FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX

Country Status (19)

Country Link
US (2) US9828363B2 (en)
EP (1) EP3097092B1 (en)
JP (1) JP6387111B2 (en)
KR (1) KR101922317B1 (en)
CN (1) CN106458996B (en)
AR (1) AR099138A1 (en)
AU (1) AU2015206292B2 (en)
BR (1) BR112016016421B1 (en)
CA (1) CA2936559C (en)
CL (1) CL2016001840A1 (en)
EA (1) EA031317B1 (en)
ES (1) ES2819867T3 (en)
IL (1) IL246692B (en)
MX (1) MX2016009465A (en)
NZ (1) NZ722624A (en)
SG (1) SG11201605699QA (en)
TW (1) TWI640516B (en)
WO (1) WO2015109285A1 (en)
ZA (1) ZA201605107B (en)

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US11236091B2 (en) 2019-05-21 2022-02-01 Amgen Inc. Solid state forms
CN110078749B (en) * 2019-06-04 2021-01-01 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 3a, 3a' -difuran [2,3-b ] indoline compound, preparation method, pharmaceutical composition and application
CN110872291B (en) * 2019-11-26 2021-06-25 五邑大学 Tetrahydropyridopyrimidine compound and preparation method and application thereof
WO2021231322A1 (en) * 2020-05-11 2021-11-18 Cleave Therapeutics, Inc. Crystalline forms and formulations of a vcp/p97 inhibitor
JP2023526223A (en) * 2020-05-11 2023-06-21 クリーブ セラピューティクス，インク． VCP/p97 inhibitors for cancer treatment
GB202111193D0 (en) * 2021-08-03 2021-09-15 Phoremost Ltd Pharmaceutical compounds
WO2023086419A1 (en) * 2021-11-10 2023-05-19 Cleave Therapeutics, Inc. Vcp/p97 inhibitor for the treatment of cancer
CN116178374A (en) * 2023-01-13 2023-05-30 河北医科大学 Small-conductance calcium-activated potassium ion channel agonist, synthesis and application thereof

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