MX2021014126A - Formas en estado solido. - Google Patents

Formas en estado solido.

Info

Publication number
MX2021014126A
MX2021014126A MX2021014126A MX2021014126A MX2021014126A MX 2021014126 A MX2021014126 A MX 2021014126A MX 2021014126 A MX2021014126 A MX 2021014126A MX 2021014126 A MX2021014126 A MX 2021014126A MX 2021014126 A MX2021014126 A MX 2021014126A
Authority
MX
Mexico
Prior art keywords
solid state
state forms
forms
fluoro
methyl
Prior art date
Application number
MX2021014126A
Other languages
English (en)
Inventor
Albert Amegadzie
Patricia Lopez
Mary Chaves
Stephanie Azali
Ron C Kelly
Prashant Agarwal
Roman Shimanovich
Darren Leonard Reid
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2021014126A publication Critical patent/MX2021014126A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente divulgación proporciona formas cristalinas y amorfas de 6-fluoro-7-(2-fluoro-6-hidroxifenil)-1-(4-metil-2-(2-propanil)- 3-piridinil)-4-((2S)-2-metil-4-(2-propenil)-1-piperazinil)pirido[ 2,3-d]pirimidin-2(1H)-ona, incluyendo varias formas anhidras, de hidrato y de solvato, y formas en estado sólido de las mismas, composiciones farmacéuticas y métodos de tratamiento de una enfermedad mediada por la inhibición de KRAS G12C.
MX2021014126A 2019-05-21 2020-05-20 Formas en estado solido. MX2021014126A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962851044P 2019-05-21 2019-05-21
PCT/US2020/033831 WO2020236947A1 (en) 2019-05-21 2020-05-20 Solid state forms

Publications (1)

Publication Number Publication Date
MX2021014126A true MX2021014126A (es) 2022-01-04

Family

ID=71083699

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021014126A MX2021014126A (es) 2019-05-21 2020-05-20 Formas en estado solido.

Country Status (20)

Country Link
US (3) US11236091B2 (es)
EP (1) EP3972973A1 (es)
JP (2) JP7092935B2 (es)
KR (1) KR20220011670A (es)
CN (1) CN114144414A (es)
AR (1) AR118978A1 (es)
AU (1) AU2020280024A1 (es)
BR (1) BR112021023277A2 (es)
CA (2) CA3225293A1 (es)
CL (1) CL2021003064A1 (es)
CO (1) CO2021017366A2 (es)
CR (1) CR20210665A (es)
IL (1) IL288077A (es)
JO (1) JOP20210310A1 (es)
MX (1) MX2021014126A (es)
PE (1) PE20220504A1 (es)
SG (1) SG11202112855WA (es)
TW (1) TW202110835A (es)
UY (1) UY38710A (es)
WO (1) WO2020236947A1 (es)

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US11096939B2 (en) 2018-06-01 2021-08-24 Amgen Inc. KRAS G12C inhibitors and methods of using the same
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JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
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CN115135315A (zh) 2019-12-20 2022-09-30 米拉蒂治疗股份有限公司 Sos1抑制剂
EP4153588A1 (en) * 2020-05-20 2023-03-29 Teva Pharmaceuticals International GmbH Solid state forms of amg-510 and process for preparation thereof
TW202229278A (zh) * 2020-11-26 2022-08-01 大陸商上海翰森生物醫藥科技有限公司 含氮雜環類衍生物的鹽、晶型及其製備方法和應用
TW202241442A (zh) 2021-01-08 2022-11-01 美商安進公司 Ｋｒａｓ ｇ１２ｃ抑制劑在治療癌症中之用途
KR20230157379A (ko) * 2021-03-17 2023-11-16 암젠 인크 소토라십 투약 요법
EP4341260A1 (en) * 2021-05-19 2024-03-27 Teva Pharmaceuticals International GmbH Process for preparation of sotorasib and solid state form thereof
WO2022269008A1 (en) 2021-06-24 2022-12-29 Sandoz Ag Crystalline form of sotorasib
EP4227305A1 (en) 2022-02-10 2023-08-16 Sandoz AG Crystalline form of sotorasib
CN114605406B (zh) * 2021-09-18 2023-05-26 都创(上海)医药开发有限公司 Amg510化合物的晶型及其制备方法和用途
TW202340202A (zh) 2021-12-22 2023-10-16 美國加利福尼亞大學董事會 Gtp酶抑制劑及其用途
CN115368358A (zh) * 2022-09-01 2022-11-22 浙江九洲药业股份有限公司 一种Sotorasib新晶型及其制备方法与应用

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