AR125782A1 - Inhibidores de ras - Google Patents

Inhibidores de ras

Info

Publication number
AR125782A1
AR125782A1 ARP220101182A ARP220101182A AR125782A1 AR 125782 A1 AR125782 A1 AR 125782A1 AR P220101182 A ARP220101182 A AR P220101182A AR P220101182 A ARP220101182 A AR P220101182A AR 125782 A1 AR125782 A1 AR 125782A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
membered
alkyl
heteroalkyl
formula
Prior art date
Application number
ARP220101182A
Other languages
English (en)
Inventor
Elena S Koltun
James Cregg
Adrian L Gill
John E Knox
Yang Liu
G Leslie Burnett
Original Assignee
Revolution Medicines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Revolution Medicines Inc filed Critical Revolution Medicines Inc
Publication of AR125782A1 publication Critical patent/AR125782A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D421/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms
    • C07D421/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Abstract

La divulgación presenta compuestos macrocíclicos, y composiciones farmacéuticas y complejos proteicos de los mismos, capaces de inhibir las proteínas Ras, y sus usos en el tratamiento de cánceres. Reivindicación 1: Un compuesto, o una de sus sales farmacéuticamente aceptables, que tenga la estructura de la fórmula (1), en donde A es heterocicloalquileno de 3 a 6 miembros opcionalmente sustituido, cicloalquileno de 3 a 6 miembros opcionalmente sustituido, arileno de 6 miembros opcionalmente sustituido o heteroarileno de 5 a 10 miembros opcionalmente sustituido; L¹ está ausente o es un enlazador; W es un grupo reticulante que comprende una vinilcetona, una vinilsulfona, una inona o una alquilsulfona; R¹ es hidrógeno, heterocicloalquilo de 3 a 10 miembros opcionalmente sustituido, o heteroalquilo C₁-C₆ opcionalmente sustituido; R² es un alquilo C₁-C₆ opcionalmente sustituido; y R³ es un alquilo C₁-C₆ opcionalmente sustituido o un heteroalquilo C₁-C₃ opcionalmente sustituido. Reivindicación 20: Un conjugado, o una sal del mismo, que comprende la estructura de la fórmula (5): M-L-P (5), en donde L es un enlazador; P es un resto orgánico monovalente; y M tiene la estructura de la fórmula (6a), donde A es heterocicloalquileno de 3 a 6 miembros opcionalmente sustituido, cicloalquileno de 3 a 6 miembros opcionalmente sustituido, arileno de 6 miembros opcionalmente sustituido o heteroarileno de 5 a 10 miembros opcionalmente sustituido; R² es un alquilo C₁-C₆ opcionalmente sustituido; R³ es un alquilo C₁-C₆ opcionalmente sustituido o un heteroalquilo C₁-C₃ opcionalmente sustituido; X² es O, C(R¹¹)₂, NR¹², S o SO₂; r es 1 o 2; cada t es, de modo independiente, 0, 1 o 2; cada R¹¹ y R¹² son, de modo independiente, hidrógeno, alquilo C₁-C₄ opcionalmente sustituido, heteroalquilo C₂-C₄ opcionalmente sustituido o cicloalquilo de 3 a 5 miembros opcionalmente sustituido cada R¹³ es, de modo independiente, -CH₃; y R⁴, R⁵ y R⁶ se seleccionan cada uno, de modo independiente, de hidrógeno, alquilo C₁-C₆ opcionalmente sustituido, heteroalquilo C₁-C₆ opcionalmente sustituido, cicloalquilo de 3 a 6 miembros opcionalmente sustituido, heterocicloalquilo de 3 a 6 miembros opcionalmente sustituido; o R⁴ y R⁵ se combinan con los átomos a los que están unidos para formar un cicloalquilo de 3 a 8 miembros opcionalmente sustituido o un heterocicloalquilo de 3 a 8 miembros opcionalmente sustituido; o R⁴ y R⁶ se combinan con los átomos a los que están unidos para formar un cicloalquilo de 3 a 8 miembros opcionalmente sustituido o un heterocicloalquilo de 3 a 8 miembros opcionalmente sustituido. Reivindicación 21: Un conjugado, o una sal del mismo, que comprende la estructura de la fórmula (5): M-L-P (5), en donde L es un enlazador; P es un resto orgánico monovalente; y M tiene la estructura de la fórmula (6b), donde A es heterocicloalquileno de 3 a 6 miembros opcionalmente sustituido, cicloalquileno de 3 a 6 miembros opcionalmente sustituido, arileno de 6 miembros opcionalmente sustituido o heteroarileno de 5 a 10 miembros opcionalmente sustituido; R² es un alquilo C₁-C₆ opcionalmente sustituido; R³ es alquilo C₁-C₆ opcionalmente sustituido o heteroalquilo C₁-C₃ opcionalmente sustituido; R¹⁴ es fluoro, hidrógeno o alquilo C₁-C₃; u es 0 o 1; y R⁴, R⁵ y R⁶ se seleccionan cada uno, de modo independiente, de hidrógeno, alquilo C₁-C₆ opcionalmente sustituido, heteroalquilo C₁-C₆ opcionalmente sustituido, cicloalquilo de 3 a 6 miembros opcionalmente sustituido, heterocicloalquilo de 3 a 6 miembros opcionalmente sustituido; o R⁴ y R⁵ se combinan con los átomos a los que están unidos para formar un cicloalquilo de 3 a 8 miembros opcionalmente sustituido o un heterocicloalquilo de 3 a 8 miembros opcionalmente sustituido; o R⁴ y R⁶ se combinan con los átomos a los que están unidos para formar un cicloalquilo de 3 a 8 miembros opcionalmente sustituido o un heterocicloalquilo de 3 a 8 miembros opcionalmente sustituido. Reivindicación 22: Un conjugado, o una sal del mismo, que comprende la estructura de la fórmula (5): M-L-P (5), en donde L es un enlazador; P es un resto orgánico monovalente; y M tiene la estructura de la fórmula (6c), donde A es heterocicloalquileno de 3 a 6 miembros opcionalmente sustituido, cicloalquileno de 3 a 6 miembros opcionalmente sustituido, arileno de 6 miembros opcionalmente sustituido o heteroarileno de 5 a 10 miembros opcionalmente sustituido; R² es un alquilo C₁-C₆ opcionalmente sustituido; R³ es un alquilo C₁-C₆ opcionalmente sustituido o un heteroalquilo C₁-C₃ opcionalmente sustituido; y R⁴, R⁵ y R⁶ se seleccionan, de modo independiente, de hidrógeno, alquilo C₁-C₆ opcionalmente sustituido, heteroalquilo C₁-C₆ opcionalmente sustituido, cicloalquilo de 3 a 6 miembros opcionalmente sustituido, heterocicloalquilo de 3 a 6 miembros opcionalmente sustituido; o R⁴ y R⁵ se combinan con los átomos a los que están unidos para formar un cicloalquilo de 3 a 8 miembros opcionalmente sustituido o un heterocicloalquilo de 3 a 8 miembros opcionalmente sustituido; o R⁴ y R⁶ se combinan con los átomos a los que están unidos para formar un cicloalquilo de 3 a 8 miembros opcionalmente sustituido o un heterocicloalquilo de 3 a 8 miembros opcionalmente sustituido. Reivindicación 23: Un conjugado, o una sal del mismo, que comprende la estructura de la fórmula (5): M-L-P (5), en donde L es un enlazador; P es un resto orgánico monovalente; y M tiene la estructura de la fórmula (6d), donde A es heterocicloalquileno de 3 a 6 miembros opcionalmente sustituido, cicloalquileno de 3 a 6 miembros opcionalmente sustituido, arileno de 6 miembros opcionalmente sustituido o heteroarileno de 5 a 10 miembros opcionalmente sustituido; R² es un alquilo C₁-C₆ opcionalmente sustituido; R³ es un alquilo C₁-C₆ opcionalmente sustituido o un heteroalquilo C₁-C₃ opcionalmente sustituido; y R⁴, R⁵ y R⁶ se seleccionan, de modo independiente, de hidrógeno, alquilo C₁-C₆ opcionalmente sustituido, heteroalquilo C₁-C₆ opcionalmente sustituido, cicloalquilo de 3 a 6 miembros opcionalmente sustituido, heterocicloalquilo de 3 a 6 miembros opcionalmente sustituido; o R⁴ y R⁵ se combinan con los átomos a los que están unidos para formar un cicloalquilo de 3 a 8 miembros opcionalmente sustituido o un heterocicloalquilo de 3 a 8 miembros opcionalmente sustituido; o R⁴ y R⁶ se combinan con los átomos a los que están unidos para formar un cicloalquilo de 3 a 8 miembros opcionalmente sustituido o un heterocicloalquilo de 3 a 8 miembros opcionalmente sustituido.
ARP220101182A 2021-05-05 2022-05-05 Inhibidores de ras AR125782A1 (es)

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US202163184599P 2021-05-05 2021-05-05

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US (1) US20230106174A1 (es)
EP (1) EP4334321A1 (es)
KR (1) KR20240004960A (es)
AR (1) AR125782A1 (es)
AU (1) AU2022270116A1 (es)
BR (1) BR112023022819A2 (es)
CA (1) CA3217393A1 (es)
CO (1) CO2023016820A2 (es)
CR (1) CR20230570A (es)
IL (1) IL308193A (es)
PE (1) PE20240088A1 (es)
TW (1) TW202309052A (es)
WO (1) WO2022235864A1 (es)

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WO2023172940A1 (en) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Methods for treating immune refractory lung cancer
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