SK287761B6 - Use of IL-18 inhibitor, use of an expressing vector which contains a sequence encoding IL-18 inhibitor, use of the vector for induction and/or amplifying endogenic production of IL-18 inhibitor in a cell and use a cell with production of IL-18 inhibitor - Google Patents

Use of IL-18 inhibitor, use of an expressing vector which contains a sequence encoding IL-18 inhibitor, use of the vector for induction and/or amplifying endogenic production of IL-18 inhibitor in a cell and use a cell with production of IL-18 inhibitor Download PDF

Info

Publication number: SK287761B6
Authority: SK; Slovakia
Prior art keywords: inhibitor; medicament; use according; body weight; treatment
Prior art date: 2000-05-05

Application number

SK1556-2002A

Other languages

English (en)

Slovak (sk)

Other versions

SK15562002A3 (sk

Inventor

Yolande Chvatchko

Ziad Mallat

Alain Tedgui

Original Assignee

Applied Research Systems Ars Holding N. V.

Institut National De La Sante Et De La Recherche Medicale

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-05

Filing date

2001-04-30

Publication date

2011-09-05

2001-04-30 Application filed by Applied Research Systems Ars Holding N. V., Institut National De La Sante Et De La Recherche Medicale filed Critical Applied Research Systems Ars Holding N. V.

2003-05-02 Publication of SK15562002A3 publication Critical patent/SK15562002A3/sk

2011-09-05 Publication of SK287761B6 publication Critical patent/SK287761B6/sk

Links

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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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SK1556-2002A 2000-05-05 2001-04-30 Use of IL-18 inhibitor, use of an expressing vector which contains a sequence encoding IL-18 inhibitor, use of the vector for induction and/or amplifying endogenic production of IL-18 inhibitor in a cell and use a cell with production of IL-18 inhibitor SK287761B6 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00109606		2000-05-05
PCT/EP2001/004843 WO2001085201A2 (en)	2000-05-05	2001-04-30	Use of il-18 inhibitors for the treatment and/or prevention of atherosclerosis

Publications (2)

Publication Number	Publication Date
SK15562002A3 SK15562002A3 (sk)	2003-05-02
SK287761B6 true SK287761B6 (en)	2011-09-05

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ID=8168631

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SK1556-2002A SK287761B6 (en)	2000-05-05	2001-04-30	Use of IL-18 inhibitor, use of an expressing vector which contains a sequence encoding IL-18 inhibitor, use of the vector for induction and/or amplifying endogenic production of IL-18 inhibitor in a cell and use a cell with production of IL-18 inhibitor

Country Status (33)

Country	Link
US (1)	US20040076628A1 (ru)
EP (1)	EP1278540B1 (ru)
JP (1)	JP5122053B2 (ru)
KR (2)	KR100798545B1 (ru)
CN (2)	CN1841066B (ru)
AR (1)	AR035640A1 (ru)
AT (1)	ATE395075T1 (ru)
AU (2)	AU6739001A (ru)
BG (1)	BG65881B1 (ru)
BR (1)	BRPI0110506B8 (ru)
CA (1)	CA2407895C (ru)
CY (1)	CY1110385T1 (ru)
CZ (1)	CZ300792B6 (ru)
DE (1)	DE60134009D1 (ru)
DK (1)	DK1278540T3 (ru)
EA (2)	EA005410B1 (ru)
EE (1)	EE05056B1 (ru)
ES (1)	ES2305082T3 (ru)
HK (2)	HK1055681A1 (ru)
HR (1)	HRP20020828A2 (ru)
HU (1)	HU229375B1 (ru)
IL (2)	IL152567A0 (ru)
ME (1)	ME00554B (ru)
MX (1)	MXPA02010895A (ru)
NO (1)	NO329821B1 (ru)
PL (1)	PL209371B1 (ru)
PT (1)	PT1278540E (ru)
RS (1)	RS50926B (ru)
SI (1)	SI1278540T1 (ru)
SK (1)	SK287761B6 (ru)
UA (2)	UA87658C2 (ru)
WO (1)	WO2001085201A2 (ru)
ZA (1)	ZA200208228B (ru)

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CA2435466C (en) *	2001-01-29	2012-04-03	Applied Research Systems Ars Holding N.V.	Use of il-18 inhibitors for the treatment and/or prevention of heart disease
CN1305529C (zh) *	2001-05-25	2007-03-21	阿雷斯贸易股份有限公司	Il－18抑制剂在治疗或预防中枢神经***损伤中的应用
US6797727B2 (en)	2001-07-16	2004-09-28	Transition Therapeutics Inc.	Use of rhein or diacerhein compounds for the treatment or prevention of vascular diseases
US8729124B2 (en)	2002-03-05	2014-05-20	Pronova Biopharma Norge As	Use of EPA and DHA in secondary prevention
GB0210212D0 (en) *	2002-05-03	2002-06-12	Univ Southampton	Effects of dietary N-3 and N-6 pufa intake on atheromatous plaque stability
ME00548B (me) *	2002-03-22	2011-10-10	Serono Lab	Korišćenje inhibitora il-18 za liječenje i/ili prevenciju perifernih vaskularnih bolesti
ATE399872T1 (de) *	2003-03-11	2008-07-15	Serono Lab	Expressionvektoren, die den promotor des ie2-gens des maus cytomegalovirus enthalten
SI1622939T1 (sl)	2003-05-13	2012-06-29	Merck Serono Sa	Akrivne variante il-18 vezavnega proteina in medicinske uporabe le-tega
US7968684B2 (en)	2003-11-12	2011-06-28	Abbott Laboratories	IL-18 binding proteins
PT1755642E (pt) *	2004-04-15	2010-04-20	Athera Biotechnologies Ab	Anexina v para prevenção de aterotrombose e da ruptura de placas
CN101219208B (zh) *	2005-01-04	2010-08-11	健能隆医药技术（上海）有限公司	白介素-22的医药用途
AU2006254103B2 (en)	2005-06-03	2012-09-06	Ares Trading S.A.	Production of recombinant IL-18 binding protein
RS52273B (en)	2005-06-10	2012-10-31	Ares Trading S.A.	PROCESS FOR PURIFICATION OF IL-18 BINDING PROTEIN
RU2013110874A (ru)	2010-08-25	2014-09-27	Ф.Хоффманн-Ля Рош Аг	Антитела против il-18r1 и их применения
JOP20200308A1 (ar)	2012-09-07	2017-06-16	Novartis Ag	جزيئات إرتباط il-18
MD707Z (ru) *	2013-01-18	2014-07-31	Институт Зоологии Академии Наук Молдовы	Метод идентификации полиморфных последовательностей 4а/4б гена эндотелиальной синтетазы оксида азота
HUE055608T2 (hu)	2013-09-05	2021-12-28	Ab2 Bio Sa	IL-18-kötõ fehérje (IL-18BP) gyulladásos betegségekben
MX2017010919A (es)	2015-03-05	2017-12-07	Ab2 Bio Sa	Proteina de union il-18 (il-18bp) y anticuerpos en enfermedades inflamatorias.
CN110273591B (zh)	2019-08-13	2023-12-12	上海杉脉电子科技发展有限公司	一种单动力微型智能锁
TW202233675A (zh)	2020-10-29	2022-09-01	瑞士商諾華公司	Ｉｌ－１８拮抗劑用於治療和／或預防異位性皮炎或相關病症之用途
CN112972655A (zh) *	2021-04-16	2021-06-18	武汉大学	白细胞介素12在制备预防、缓解和/或治疗主动脉瘤药物中的应用

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US5877197A (en) *	1996-12-16	1999-03-02	Karanewsky; Donald S.	C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
IL121860A0 (en) *	1997-08-14	1998-02-22	Yeda Res & Dev	Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) *	1998-06-24	1999-12-24	Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo	An artificial peptide capable of neutralizing the biological activity of interleukin-18
EP0987552A3 (en) *	1998-08-31	2000-06-07	Pfizer Products Inc.	Diarylsulfonylurea binding proteins
KR100537558B1 (ko) *	1998-09-01	2005-12-19	가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조	인터류킨-18 결합 단백질

2001
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- 2001-04-30 PL PL365697A patent/PL209371B1/pl unknown
- 2001-04-30 SI SI200130832T patent/SI1278540T1/sl unknown
- 2001-04-30 EA EA200201175A patent/EA005410B1/ru not_active IP Right Cessation
- 2001-04-30 EE EEP200200620A patent/EE05056B1/xx unknown
- 2001-04-30 EA EA200401183A patent/EA007014B1/ru not_active IP Right Cessation
- 2001-04-30 AU AU6739001A patent/AU6739001A/xx active Pending
- 2001-04-30 CA CA2407895A patent/CA2407895C/en not_active Expired - Lifetime
- 2001-04-30 AT AT01945064T patent/ATE395075T1/de active
- 2001-04-30 WO PCT/EP2001/004843 patent/WO2001085201A2/en active IP Right Grant
- 2001-04-30 UA UA2002129704A patent/UA78492C2/uk unknown
- 2001-04-30 RS YUP-826/02A patent/RS50926B/sr unknown
- 2001-04-30 EP EP01945064A patent/EP1278540B1/en not_active Expired - Lifetime
- 2001-04-30 ES ES01945064T patent/ES2305082T3/es not_active Expired - Lifetime
- 2001-04-30 MX MXPA02010895A patent/MXPA02010895A/es active IP Right Grant
- 2001-04-30 KR KR1020027014755A patent/KR20030016254A/ko not_active Application Discontinuation
- 2001-04-30 AU AU2001267390A patent/AU2001267390B2/en not_active Expired
- 2001-04-30 CN CNB018090540A patent/CN1250286C/zh not_active Expired - Lifetime
- 2001-05-04 AR ARP010102129A patent/AR035640A1/es unknown
2002
- 2002-10-11 ZA ZA2002/08228A patent/ZA200208228B/en unknown
- 2002-10-16 HR HRP20020828 patent/HRP20020828A2/hr not_active Application Discontinuation
- 2002-10-24 BG BG107218A patent/BG65881B1/bg unknown
- 2002-10-31 IL IL152567A patent/IL152567A/en active IP Right Grant
- 2002-11-05 NO NO20025307A patent/NO329821B1/no not_active IP Right Cessation
2003
- 2003-11-05 HK HK03107981A patent/HK1055681A1/xx not_active IP Right Cessation
2007
- 2007-03-02 HK HK07102380.7A patent/HK1094909A1/xx not_active IP Right Cessation
2008
- 2008-06-30 CY CY20081100684T patent/CY1110385T1/el unknown

Also Published As

Publication number	Publication date
PL365697A1 (en)	2005-01-10
HUP0301991A3 (en)	2006-11-28
AR035640A1 (es)	2004-06-23
EP1278540B1 (en)	2008-05-14
BG107218A (bg)	2003-06-30
DE60134009D1 (de)	2008-06-26
MEP64008A (en)	2011-12-20
HU229375B1 (en)	2013-11-28
MXPA02010895A (es)	2003-03-27
BG65881B1 (bg)	2010-04-30
HRP20020828A2 (en)	2004-12-31
NO20025307L (no)	2002-12-18
AU2001267390B2 (en)	2005-09-22
UA87658C2 (ru)	2009-08-10
AU6739001A (en)	2001-11-20
BR0110506A (pt)	2003-04-01
EA005410B1 (ru)	2005-02-24
ME00554B (me)	2012-03-20
SK15562002A3 (sk)	2003-05-02
RS50926B (sr)	2010-08-31
CN1841066A (zh)	2006-10-04
KR100798545B1 (ko)	2008-01-28
EA007014B1 (ru)	2006-06-30
WO2001085201A2 (en)	2001-11-15
PT1278540E (pt)	2008-07-03
CZ300792B6 (cs)	2009-08-12
CY1110385T1 (el)	2015-04-29
KR20070073989A (ko)	2007-07-10
SI1278540T1 (sl)	2008-10-31
ATE395075T1 (de)	2008-05-15
JP2003532685A (ja)	2003-11-05
DK1278540T3 (da)	2008-07-21
WO2001085201A3 (en)	2002-05-10
NO329821B1 (no)	2010-12-27
ES2305082T3 (es)	2008-11-01
CZ20023644A3 (cs)	2003-03-12
UA78492C2 (en)	2007-04-10
YU82602A (sh)	2006-01-16
IL152567A0 (en)	2003-05-29
NO20025307D0 (no)	2002-11-05
CN1841066B (zh)	2012-08-29
BRPI0110506B1 (pt)	2015-05-19
ZA200208228B (en)	2005-07-27
CA2407895C (en)	2012-12-18
HK1055681A1 (en)	2004-01-21
CN1434722A (zh)	2003-08-06
KR20030016254A (ko)	2003-02-26
EA200201175A1 (ru)	2003-04-24
PL209371B1 (pl)	2011-08-31
JP5122053B2 (ja)	2013-01-16
EP1278540A2 (en)	2003-01-29
HUP0301991A2 (hu)	2003-09-29
US20040076628A1 (en)	2004-04-22
EE200200620A (et)	2004-06-15
IL152567A (en)	2010-12-30
CN1250286C (zh)	2006-04-12
BRPI0110506B8 (pt)	2021-05-25
HK1094909A1 (en)	2007-04-13
EE05056B1 (et)	2008-08-15
EA200401183A1 (ru)	2004-12-30
CA2407895A1 (en)	2001-11-15

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2012-08-06

PC4A

Assignment and transfer of rights

Owner name: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERC, FR

Free format text: FORMER OWNER: APPLIED RESEARCH SYSTEMS ARS HOLDING N. V., CURACAO, AN; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), PARIS CEDEX, FR

Effective date: 20120423

Owner name: LABORATOIRES SERONO SA, COINSINS, VAUD, CH

Free format text: FORMER OWNER: APPLIED RESEARCH SYSTEMS ARS HOLDING N. V., CURACAO, AN; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), PARIS CEDEX, FR

Effective date: 20120423

2012-08-06

TC4A

Change of owner's name

Owner name: MERCK SERONO SA, COINSINS, VAUD, CH

Effective date: 20120709

2021-05-26

MK4A

Patent expired

Expiry date: 20210430

Publication	Publication Date	Title
SK287761B6 (en)	2011-09-05	Use of IL-18 inhibitor, use of an expressing vector which contains a sequence encoding IL-18 inhibitor, use of the vector for induction and/or amplifying endogenic production of IL-18 inhibitor in a cell and use a cell with production of IL-18 inhibitor
AU2001267390A1 (en)	2002-02-07	Use of IL-18 inhibitors for the treatment and/or prevention of atherosclerosis
JP2004517918A (ja)	2004-06-17	Ｉｌ−１７アンタゴニストを使用する慢性関節リューマチの治療法
EA009125B1 (ru)	2007-10-26	Применение ингибиторов il-18 для лечения и/или предупреждения заболеваний, характерных для синдрома системной воспалительной реакции
HRP20040758A2 (en)	2005-02-28	Use of il-18 inhibitors for the treatment and/or prevention of peripheral vascular diseases
US20110177065A1 (en)	2011-07-21	Methods of treating/preventing inflammation using combination of il-1 antagonist and il-18 binding protein
BG66483B1 (bg)	2015-03-31	Използване на инхибитори на интерлевкин -18 за лечение и/или профилактика на сърдечни заболявания
AU2005211606B2 (en)	2007-02-22	Use of IL-18 inhibitors for the treatment and/or prevention of atherosclerosis