ATE395075T1 - Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose - Google Patents

Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose

Info

Publication number
ATE395075T1
ATE395075T1 AT01945064T AT01945064T ATE395075T1 AT E395075 T1 ATE395075 T1 AT E395075T1 AT 01945064 T AT01945064 T AT 01945064T AT 01945064 T AT01945064 T AT 01945064T AT E395075 T1 ATE395075 T1 AT E395075T1
Authority
AT
Austria
Prior art keywords
inhibitors
treat
prevent atherosclerosis
atherosclerosis
prevent
Prior art date
Application number
AT01945064T
Other languages
English (en)
Inventor
Yolande Chvatchko
Alain Tedgui
Ziad Mallat
Original Assignee
Serono Lab
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Lab, Inst Nat Sante Rech Med filed Critical Serono Lab
Application granted granted Critical
Publication of ATE395075T1 publication Critical patent/ATE395075T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT01945064T 2000-05-05 2001-04-30 Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose ATE395075T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00109606 2000-05-05

Publications (1)

Publication Number Publication Date
ATE395075T1 true ATE395075T1 (de) 2008-05-15

Family

ID=8168631

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01945064T ATE395075T1 (de) 2000-05-05 2001-04-30 Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose

Country Status (33)

Country Link
US (1) US20040076628A1 (de)
EP (1) EP1278540B1 (de)
JP (1) JP5122053B2 (de)
KR (2) KR100798545B1 (de)
CN (2) CN1250286C (de)
AR (1) AR035640A1 (de)
AT (1) ATE395075T1 (de)
AU (2) AU2001267390B2 (de)
BG (1) BG65881B1 (de)
BR (1) BRPI0110506B8 (de)
CA (1) CA2407895C (de)
CY (1) CY1110385T1 (de)
CZ (1) CZ300792B6 (de)
DE (1) DE60134009D1 (de)
DK (1) DK1278540T3 (de)
EA (2) EA005410B1 (de)
EE (1) EE05056B1 (de)
ES (1) ES2305082T3 (de)
HK (2) HK1055681A1 (de)
HR (1) HRP20020828A2 (de)
HU (1) HU229375B1 (de)
IL (2) IL152567A0 (de)
ME (1) ME00554B (de)
MX (1) MXPA02010895A (de)
NO (1) NO329821B1 (de)
PL (1) PL209371B1 (de)
PT (1) PT1278540E (de)
RS (1) RS50926B (de)
SI (1) SI1278540T1 (de)
SK (1) SK287761B6 (de)
UA (2) UA78492C2 (de)
WO (1) WO2001085201A2 (de)
ZA (1) ZA200208228B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001236807A1 (en) * 2000-02-10 2001-08-20 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
EE05534B1 (et) * 2001-01-29 2012-04-16 Applied Research Systems Ars Holding N.V. IL-18 inhibiitorite kasutamine ravimi valmistamiseks kardiomopaatia raviks ja/v?i ennetamiseks
BR0210007A (pt) * 2001-05-25 2004-08-10 Ares Trading Sa Uso de inibidores de il-18 para tratamento ou prevenção de lesões do sistema nervoso central
US6797727B2 (en) 2001-07-16 2004-09-28 Transition Therapeutics Inc. Use of rhein or diacerhein compounds for the treatment or prevention of vascular diseases
GB0210212D0 (en) * 2002-05-03 2002-06-12 Univ Southampton Effects of dietary N-3 and N-6 pufa intake on atheromatous plaque stability
US8729124B2 (en) 2002-03-05 2014-05-20 Pronova Biopharma Norge As Use of EPA and DHA in secondary prevention
US9592267B2 (en) * 2002-03-22 2017-03-14 Merck Serono Sa Use of IL-18BP for treatment of peripheral vascular diseases
CN100429315C (zh) * 2003-03-11 2008-10-29 雪兰诺实验室有限公司 含有mcmv ie2启动子的表达载体
JP5074030B2 (ja) 2003-05-13 2012-11-14 メルク セローノ ソシエテ アノニム Ｉｌ−１８結合タンパク質の活性変異体とその医学的応用
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
CA2563408C (en) * 2004-04-15 2015-08-25 Athera Biotechnologies Ab Annexin v for preventing atherothrombois and plaque rupture
CN101219208B (zh) * 2005-01-04 2010-08-11 健能隆医药技术（上海）有限公司 白介素-22的医药用途
CA2609060C (en) 2005-06-03 2014-07-15 Urs Weber Production of recombinant il-18 binding protein
JP5091127B2 (ja) 2005-06-10 2012-12-05 アレス トレーディング ソシエテ アノニム Ｉｌ−１８結合タンパク質の精製のための方法
CN103080132B (zh) 2010-08-25 2016-06-08 弗·哈夫曼-拉罗切有限公司 抗il-18r1的抗体及其用途
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
MD707Z (ro) * 2013-01-18 2014-07-31 Институт Зоологии Академии Наук Молдовы Metodă de identificare a secvenţelor polimorfe 4a/4b ale genei sintetazei endoteliale a oxidului nitric
MX2016002719A (es) 2013-09-05 2016-09-06 Ab2 Bio Sa Proteina de union a interleucina 18 (il-18bp) en enfermedades inflamatorias.
EP3265807A1 (de) 2015-03-05 2018-01-10 AB2 Bio SA Il-18-bindendes protein (il-18bp) und antikörper bei entzündungskrankheiten
CN110273591B (zh) 2019-08-13 2023-12-12 上海杉脉电子科技发展有限公司 一种单动力微型智能锁
TW202233675A (zh) 2020-10-29 2022-09-01 瑞士商諾華公司 Ｉｌ－１８拮抗劑用於治療和／或預防異位性皮炎或相關病症之用途
CN112972655A (zh) * 2021-04-16 2021-06-18 武汉大学 白细胞介素12在制备预防、缓解和/或治疗主动脉瘤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985863A (en) * 1996-09-12 1999-11-16 Vertex Pharmaceuticals, Inc. Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
EP0987552A3 (de) * 1998-08-31 2000-06-07 Pfizer Products Inc. Diarylsulphonylharnstoff-Bindungsproteine
EP1110969A4 (de) * 1998-09-01 2002-01-09 Hayashibara Biochem Lab Interleukin 18-bindende proteine

Also Published As

Publication number Publication date
CN1841066B (zh) 2012-08-29
CN1250286C (zh) 2006-04-12
KR100798545B1 (ko) 2008-01-28
SK15562002A3 (sk) 2003-05-02
EA200401183A1 (ru) 2004-12-30
EA007014B1 (ru) 2006-06-30
CN1841066A (zh) 2006-10-04
CZ20023644A3 (cs) 2003-03-12
ME00554B (me) 2012-03-20
CN1434722A (zh) 2003-08-06
BG107218A (bg) 2003-06-30
MXPA02010895A (es) 2003-03-27
YU82602A (sh) 2006-01-16
AU2001267390B2 (en) 2005-09-22
DK1278540T3 (da) 2008-07-21
BRPI0110506B1 (pt) 2015-05-19
UA78492C2 (en) 2007-04-10
HK1094909A1 (en) 2007-04-13
US20040076628A1 (en) 2004-04-22
HK1055681A1 (en) 2004-01-21
SK287761B6 (en) 2011-09-05
IL152567A0 (en) 2003-05-29
HUP0301991A3 (en) 2006-11-28
ZA200208228B (en) 2005-07-27
DE60134009D1 (de) 2008-06-26
AU6739001A (en) 2001-11-20
KR20070073989A (ko) 2007-07-10
WO2001085201A2 (en) 2001-11-15
BRPI0110506B8 (pt) 2021-05-25
EE200200620A (et) 2004-06-15
PT1278540E (pt) 2008-07-03
BG65881B1 (bg) 2010-04-30
HUP0301991A2 (hu) 2003-09-29
AR035640A1 (es) 2004-06-23
EP1278540A2 (de) 2003-01-29
NO20025307D0 (no) 2002-11-05
JP2003532685A (ja) 2003-11-05
CA2407895A1 (en) 2001-11-15
WO2001085201A3 (en) 2002-05-10
NO329821B1 (no) 2010-12-27
RS50926B (sr) 2010-08-31
EP1278540B1 (de) 2008-05-14
CZ300792B6 (cs) 2009-08-12
CY1110385T1 (el) 2015-04-29
EE05056B1 (et) 2008-08-15
EA200201175A1 (ru) 2003-04-24
NO20025307L (no) 2002-12-18
IL152567A (en) 2010-12-30
PL209371B1 (pl) 2011-08-31
HRP20020828A2 (en) 2004-12-31
SI1278540T1 (sl) 2008-10-31
BR0110506A (pt) 2003-04-01
ES2305082T3 (es) 2008-11-01
MEP64008A (en) 2011-12-20
EA005410B1 (ru) 2005-02-24
PL365697A1 (en) 2005-01-10
CA2407895C (en) 2012-12-18
JP5122053B2 (ja) 2013-01-16
UA87658C2 (uk) 2009-08-10
KR20030016254A (ko) 2003-02-26
HU229375B1 (en) 2013-11-28

Similar Documents

Publication Publication Date Title
ATE395075T1 (de) Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose
ATE473753T1 (de) Verwendung von botulinum toxin zur behandlung von post-operative schmerzen
ATE414556T1 (de) Verwendung von il-18-inhibitoren zur behandlung und/oder prävention von peripheren gefässkrankheiten
ATE308364T1 (de) Verwendung von cyanochinolinen zur behandlung oder inhibierung von dickdarmpolypen
ATE288748T1 (de) Verwendung von retigabin zur behandlung von neuropathischen schmerzen
ATE338557T1 (de) Verwendung von cox2 inhibitoren zur behandlung von schizophrenia und des ticks
ATE245032T1 (de) Verwendung von neurotoxinen in medikamenten zur behandlung von thyroidstörungen
ATE307597T1 (de) Verwendung von peg-ifn-alpha und ribavirin zur behandlung chronischer hepatitis c
ATE323661T1 (de) Behandlung von mineralischen stoffen
ATE365042T1 (de) Verwendung von morpholinol zur behandlung von sexuellen funktionsstörungen
ATE257013T1 (de) Verwendung von botulinum-toxin zur behandlung von diabetes
ATE410421T1 (de) P38 inhibitor und anwendungsverfahren dafür
DE60021266D1 (de) Verwendungen von zusammensetzungen zur behandlung oder vermeidung von schlafstörungen mit sehr niedrigdosierten cyclobenzaprine
DE60221798D1 (de) Kombinationen von gallensäuresequestriermitteln und hemmern der sterolabsorption zur behandlung von kardiovaskulären indikationen
ATE353218T1 (de) Verwendung von epinastin zur behandlung von allergischer rhinitis/konjunktivitis
DE60129330D1 (de) Verwendung von cox-2 inhibitoren als immunostimulantien zur behandlung von hiv oder aids
ATE380558T1 (de) Verwendung von il-18 hemmern zur behandlung und/oder prävention von herzkrankheiten
DE60322898D1 (de) Verwendung von isoflavonen zur förderung des schlankheitseffekts
ATE418337T1 (de) Verwendung von dihydroimidazolonen zur behandlung von epilepsie bei hunden
ATE317261T1 (de) Verwendung von mirtazapin zur behandlung von schlafstörungen
ATE465728T1 (de) Verwendung von endothelin antagonisten zur behandlung von knochenkrebs und damit verbundenen schmerzen
ATE338566T1 (de) Aldosteronantagonist und cyclooxygenase-2 hemmer- kombinationstherapie zur verhinderung oder behandlung von entzündungsverwandten kardiovaskulären krankheiten
ATE376416T1 (de) Verwendung von ambroxol zur behandlung von chronischen schmerzen
ATE285235T1 (de) Verwendung von phanquinon zur behandlung und vorbeugung von gedächtnisschwund
ATE302023T1 (de) Verwendung von stickstoffoxid zur behandlung von atemwegs-verengungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1278540

Country of ref document: EP

EEFA Change of the company name