SG10202009423QA - Pyrrolotriazine compounds as tam inhibitors - Google Patents

Pyrrolotriazine compounds as tam inhibitors

Info

Publication number
SG10202009423QA
SG10202009423QA SG10202009423QA SG10202009423QA SG10202009423QA SG 10202009423Q A SG10202009423Q A SG 10202009423QA SG 10202009423Q A SG10202009423Q A SG 10202009423QA SG 10202009423Q A SG10202009423Q A SG 10202009423QA SG 10202009423Q A SG10202009423Q A SG 10202009423QA
Authority
SG
Singapore
Prior art keywords
pyrrolotriazine compounds
tam inhibitors
tam
inhibitors
pyrrolotriazine
Prior art date
Application number
SG10202009423QA
Other languages
English (en)
Inventor
Yun-Long Li
xiaozhao Wang
Joseph Barbosa
David M Burns
Hao Feng
Joseph Glenn
Chunhong He
Taisheng Huang
Song Mei
Jincong Zhuo
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of SG10202009423QA publication Critical patent/SG10202009423QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
SG10202009423QA 2016-03-28 2017-03-27 Pyrrolotriazine compounds as tam inhibitors SG10202009423QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662314066P 2016-03-28 2016-03-28
US201662362934P 2016-07-15 2016-07-15
US201662438750P 2016-12-23 2016-12-23

Publications (1)

Publication Number Publication Date
SG10202009423QA true SG10202009423QA (en) 2020-11-27

Family

ID=58489114

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201808582RA SG11201808582RA (en) 2016-03-28 2017-03-27 Pyrrolotriazine compounds as tam inhibitors
SG10202009423QA SG10202009423QA (en) 2016-03-28 2017-03-27 Pyrrolotriazine compounds as tam inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201808582RA SG11201808582RA (en) 2016-03-28 2017-03-27 Pyrrolotriazine compounds as tam inhibitors

Country Status (31)

Country Link
US (5) US9981975B2 (pt)
EP (2) EP3436461B1 (pt)
JP (3) JP7034084B2 (pt)
KR (3) KR102558066B1 (pt)
CN (3) CN114456176A (pt)
AU (3) AU2017241524B2 (pt)
BR (1) BR112018069612A2 (pt)
CA (1) CA3019145A1 (pt)
CL (1) CL2018002759A1 (pt)
CO (1) CO2018011550A2 (pt)
CR (1) CR20180516A (pt)
DK (1) DK3436461T3 (pt)
EC (2) ECSP18081153A (pt)
ES (1) ES2967866T3 (pt)
FI (1) FI3436461T3 (pt)
HR (1) HRP20231614T1 (pt)
HU (1) HUE064656T2 (pt)
IL (2) IL293496B2 (pt)
LT (1) LT3436461T (pt)
MX (1) MX2018011792A (pt)
MY (1) MY202022A (pt)
PE (1) PE20190175A1 (pt)
PH (1) PH12018502102A1 (pt)
PL (1) PL3436461T3 (pt)
PT (1) PT3436461T (pt)
RS (1) RS65129B1 (pt)
SG (2) SG11201808582RA (pt)
SI (1) SI3436461T1 (pt)
TW (2) TWI828027B (pt)
UA (1) UA123785C2 (pt)
WO (1) WO2017172596A1 (pt)

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KR20200088308A (ko) * 2017-09-27 2020-07-22 인사이트 코포레이션 Tam 억제제로서 유용한 피롤로트리아진 유도체의 염
JP7223998B2 (ja) 2017-10-13 2023-02-17 小野薬品工業株式会社 Ａｘｌ阻害剤を有効成分として含む固形がん治療剤
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CN110156836A (zh) * 2019-06-10 2019-08-23 成家钢 一种环丙基羰基亚甲基三苯基磷的制备方法
JPWO2021020362A1 (pt) * 2019-07-29 2021-02-04
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CN113336758B (zh) * 2020-03-03 2022-08-19 北京桦冠医药科技有限公司 化合物7-碘吡咯并[2，1-f][1，2，4]三嗪-4-胺的一种新合成方法
JP2023516441A (ja) 2020-03-06 2023-04-19 インサイト・コーポレイション Ａｘｌ／ｍｅｒ阻害剤及びｐｄ－１／ｐｄ－ｌ１阻害剤を含む併用療法
CN111233870A (zh) * 2020-03-11 2020-06-05 中国科学技术大学 用于快速制备瑞德西韦药物中间体的方法
CN113683629B (zh) * 2020-05-18 2023-07-04 北京范恩柯尔生物科技有限公司 取代的杂芳基化合物及其组合物和用途
WO2022007921A1 (zh) * 2020-07-10 2022-01-13 北京范恩柯尔生物科技有限公司 三嗪类化合物及其组合物和用途
CN116583287A (zh) * 2021-02-05 2023-08-11 四川科伦博泰生物医药股份有限公司 一类哒嗪酮杂环化合物及其制备方法和用途
WO2023016296A1 (zh) * 2021-08-12 2023-02-16 四川科伦博泰生物医药股份有限公司 一类杂环化合物及其制备方法和用途
TW202330519A (zh) * 2021-09-29 2023-08-01 香港商德琪研發有限公司 作為ｔａｍ抑制劑的吡唑并吡啶化合物
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